The National Institute of Mental Health Data Archive (NDA) is a single infrastructure that was created through the integration of a set of research data repositories including the National Database for Autism Research (NDAR), the Research Domain Criteria Database (RDoCdb), the National Database for Clinical Trials related to Mental Illness (NDCT), and the NIH Pediatric MRI Repository (PedsMRI). The NDA infrastructure was established initially to support autism research, but has grown into an informatics platform that facilitates data sharing across all of mental health and other research communities, making data available from each of these repositories combined into a single resource with a single process for gaining access to all shared data.
The NIH and the NIMH seek to encourage the use of these resources to achieve accelerated scientific progress. In order to take full advantage of such resources and maximize their research value, it is important that data be made available, on appropriate terms and conditions, to the largest possible number of qualified investigators in a timely manner.
NDA is comprised of several data repositories with different access governance but combined and harmonized in one database for broad querying. Repositories currently supported include:
NIMH Data Archive (NDA)
The NIMH Data Archive (NDA) houses, harmonizes, and shares all human-subjects data collected as part of NIMH-funded projects with the goal of accelerating progress in the research of mental health. NDA is one database infrastructure that supports efforts to make data collected by different laboratories as consistent as possible, and allow other researchers to access those data for secondary use. The NDA stores and shares clinical/phenotypic, imaging, genomic, and other data from hundreds of thousands of research participants. NDA was formed by the combination of several databases that shared this infrastructure including the National Database for Autism Research (NDAR), the National Database for Clinical Trials related to Mental Illness (NDCT), the Research Domain Criteria Database (RDoC db), and the NIH Pediatric MRI Data Repository.
Adolescent Brain Cognitive Development Study (ABCD) Data Repository
The ABCD Study is a long-term study of brain development and child health in the United States. Multiple NIH Institutes and Centers and additional federal partners are supporting this ambitious project. The ABCD Consortium consists of a Coordinating Center, a Data Analysis and Informatics Center, and 21 research sites across the country where investigators will perform regular, comprehensive biological and behavioral assessments on more than 10,000 children beginning at ages 9 or 10 and continuing throughout adolescence into early adulthood. A more complete description of the study is available at https://ABCDStudy.org.
Connectome Coordination Facility (CCF)
The Connectome Coordination Facility (CCF) processes and distributes research data for a series of neuroimaging studies that focus on connections within the human brain. These are known as Human Connectome Projects (HCP). The CCF currently supports 19 NIH-funded human connectome studies. Visit http://www.humanconnectomeproject.org/ for a full description of the project. All data releases from CCF HCP studies are being made available on the NIMH Data Archive, under the same access governance as the data from the ABCD Data Repository.
The Osteoarthritis Initiative (OAI)
The Osteoarthritis Initiative (OAI) is a multi-center, longitudinal, prospective observational study of knee osteoarthritis (OA). The overall aim of the OAI is to develop a public domain research resource to facilitate the scientific evaluation of biomarkers for osteoarthritis as potential surrogate endpoints for disease onset and progression. The OAI will establish and maintain a natural history database for osteoarthritis that will include clinical evaluation data, radiological (x-ray and magnetic OMB Control Number: 0925-0667 Expiration Date: 11/30/2020 December 14, 2017 resonance) images, and a biospecimen repository from 4796 men and women ages 45-79 enrolled between February 2004 and May 2006. Four 3.0 Tesla MRI scanners, one at each clinical center, are dedicated to imaging the knees of OAI participants annually over four years. The seven-year project will recruit participants who have, and those who are at high risk for developing, symptomatic knee osteoarthritis. Access to biospecimens will be by application to the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS).
National Institute on Alcohol Abuse and Alcoholism Data Archive (NIAAADA)
The NIAAA Data Archive (NIAAADA) is a data repository that houses human-subjects data generated by NIAAA-funded grants, with the goal of accelerating research into alcohol abuse and alcoholism. NIAAA is one of the 27 institutes and centers that comprise the National Institutes of Health (NIH) and supports and conducts research on the impact of alcohol use on human health and well-being. NIAAA is the largest funder of alcohol research in the world. The NIAAADA is the main outcome of an NIAAA initiative to support data sharing and maximize its research value.
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