The Osteoarthritis Initiative

The Osteoarthritis Initiative (OAI) is a multi-center, ten-year observational study of men and women, sponsored by the National Institutes of Health (part of the Department of Health and Human Services). The goals of the OAI are to provide resources to enable a better understanding of prevention and treatment of knee osteoarthritis, one of the most common causes of disability in adults.

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This website contains the permanent archive of the clinical data, patient reported outcomes, biospecimen analyses, quantitative image analyses, radiographs (X-Rays) and magnetic resonance images (MRIs) acquired during this study. There are longitudinal assessments and measurements from 4,796 subjects, with data from over 431,000 clinical and imaging visits, and almost 26,626,000 images in this archive. More than 400 research manuscripts have already been generated based on this data.

Sagittal proton density image from multi-slice multi-echo spin echo (T2 map) series (10ms TE / 2700ms TR)

Axial susceptibility weighted 3D fast imaging with steady state precession (T2*W 3D FISP or GRASS) Water Excitation image (2.5ms TE / 20ms TR / 50^o flip angle)

Sagittal 3D DESS Water Excitation image (4.7ms TE / 16.3ms TR / 25^o flip angle).

Coronal Intermediate-weighted 2D turbo spin echo (IW TSE)

The Osteoarthritis Initiative

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