All Participants

  • Knee Radiographs (Bilateral PA Fixed Flexion)
    • Time points: baseline, 12m, 24m, 36m, 48m, 72m, 96m
  • Pelvis Radiographs
    • Time points: baseline, 48m
  • Hand Radiographs
    • Time points: baseline, 48m
  • Full Limb Radiographs (Bilateral AP)
    • Time point: 12m, 24m OR 36m
  • Knee MRI (3T, Right and Left Knees separately)
    • Time points: baseline, 12m, 24m, 36m, 48m, 72m, 96m
    • Sagittal 3D DESS WE (Coronal / Axial MPRs)
    • Coronal IW 2D TSE
    • Sagittal IW 2D TSE Fat Suppressed
    • Coronal 3D FLASH WE (Incidence Knee only)
    • Sagittal 2D multi-echo SE (T2 Map; Incidence Knee only)
  • Thigh MRI (3T, Bilateral)
    • Time points: 12m, 24m, 48m, 96m
    • Axial T1W
  • Knee MRI (3T, Incident Knee only, Trabecular Series)
    • Time points: 30m OR 36m, 48m, 96m
    • Coronal 3D FISP
    • Progression cohort only

Unilateral Right Hand Radiograph.

Frontal hip radiograph

bilateral fixed flexion knee radiograph

Fixed flexion radiograph of valgus knees cross calibrated for alignment analysis.

Iranpour-Boroujeni T, Li J, Lynch JA, Nevitt M, Duryea J. A new method to measure anatomic knee alignment for large studies of OA: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014; 22: 1668-1674.

Participant Subsets

  • Knee Radiographs (Fluoroscopy-guided PA, Right and Left Knees separately)
    • Time points: baseline, 12m, 24m, 36m, 48m, 72m, 96m
    • Subset of progression cohort
  • Knee Radiographs (Lateral, Right and Left Knees separately)
    • Time points: baseline, 36m
    • Control cohort
  • Knee MRI (3T, Incident Knee only)
    • Time point: 18m OR 30m
    • Subset of progression cohort (287 subjects at 18m and 500 at 30m interim visits)