All Participants

Knee Radiographs (Bilateral PA Fixed Flexion)
- Time points: baseline, 12m, 24m, 36m, 48m, 72m, 96m
Pelvis Radiographs
- Time points: baseline, 48m
Hand Radiographs
- Time points: baseline, 48m
Full Limb Radiographs (Bilateral AP)
- Time point: 12m, 24m OR 36m
Knee MRI (3T, Right and Left Knees separately)
- Time points: baseline, 12m, 24m, 36m, 48m, 72m, 96m
- Sagittal 3D DESS WE (Coronal / Axial MPRs)
- Coronal IW 2D TSE
- Sagittal IW 2D TSE Fat Suppressed
- Coronal 3D FLASH WE (Incidence Knee only)
- Sagittal 2D multi-echo SE (T2 Map; Incidence Knee only)
Thigh MRI (3T, Bilateral)
- Time points: 12m, 24m, 48m, 96m
- Axial T1W
Knee MRI (3T, Incident Knee only, Trabecular Series)
- Time points: 30m OR 36m, 48m, 96m
- Coronal 3D FISP
- Progression cohort only

Unilateral Right Hand Radiograph.

Frontal hip radiograph

bilateral fixed flexion knee radiograph

Fixed flexion radiograph of valgus knees cross calibrated for alignment analysis.

Iranpour-Boroujeni T, Li J, Lynch JA, Nevitt M, Duryea J. A new method to measure anatomic knee alignment for large studies of OA: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014; 22: 1668-1674.

Participant Subsets

Knee Radiographs (Fluoroscopy-guided PA, Right and Left Knees separately)
- Time points: baseline, 12m, 24m, 36m, 48m, 72m, 96m
- Subset of progression cohort
Knee Radiographs (Lateral, Right and Left Knees separately)
- Time points: baseline, 36m
- Control cohort
Knee MRI (3T, Incident Knee only)
- Time point: 18m OR 30m
- Subset of progression cohort (287 subjects at 18m and 500 at 30m interim visits)