All Participants

 

  • Knee Radiographs (Bilateral PA Fixed Flexion)
    • Time points:  baseline, 12m, 24m, 36m, 48m, 72m, 96m
  • Pelvis Radiographs
    • Time points:  baseline, 48m
  • Hand Radiographs
    • Time points:  baseline, 48m
  • Full Limb Radiographs (Bilateral AP)
    • Time point:  12m, 24m OR 36m
  • Knee MRI (3T, Right and Left Knees separately) 
    • Time points:  baseline, 12m, 24m, 36m, 48m, 72m, 96m
    •  Sagittal 3D DESS WE (Coronal / Axial MPRs)
    • Coronal IW 2D TSE
    • Sagittal IW 2D TSE Fat Suppressed
    • Coronal 3D FLASH WE (Incidence Knee only)
    • Sagittal 2D multi-echo SE (T2 Map; Incidence Knee only)
  • Thigh MRI (3T, Bilateral) 
    • Time points:  12m, 24m, 48m, 96m
    •  Axial T1W
  • Knee MRI (3T, Incident Knee only, Trabecular Series) 
    • Time points:  30m OR 36m, 48m, 96m
    • Coronal 3D FISP
    • Progression cohort only

 

 

Participant Subsets

 

  • Knee Radiographs (Fluoroscopy-guided PA, Right and Left Knees separately)
    • Time points:  baseline, 12m, 24m, 36m, 48m, 72m, 96m
    • Subset of progression cohort
  • Knee Radiographs (Lateral, Right and Left Knees separately)
    • Time points:  baseline, 36m
    • Control cohort
  • Knee MRI (3T, Incident Knee only) 
    • Time point:  18m OR 30m
    • Subset of progression cohort (287 subjects at 18m and 500 at 30m interim visits)