NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

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Clinical Trial

¹ Numbers reported are subjects by age

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Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

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URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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2/3 Integrative Genomic Analysis of Human Brain Development and Autism #2467

General
Experiments (2)
Shared Data
Publications (73)
Data Expected (2)
Associated Studies (0)

Collection Title	Collection Investigators	Collection Description
Collection Title:	2/3 Integrative Genomic Analysis of Human Brain Development and Autism
Collection Investigators:	Daniel Geschwind
Collection Description:	Genetic and genomic investigations have yielded important findings as to the genetic contributions to major psychiatric illnesses, illustrating significant etiological heterogeneity, as well as cross-disorder overlap. It has also become clear that understanding how this genetic variation leads to alterations in brain development and function that underlies psychiatric disease pathophysiology will be greatly advanced by a roadmap of the transcriptomic and epigenetic landscape of the human cerebral cortex across key developmental windows. Here, we propose, via a highly collaborative group of investigators, each with distinct areas of expertise and research focus, to create a scaffold of genomic data for understanding ASD pathophysiology, and psychiatric disorders more broadly. The work proposed here represents an ambitious multi-PI project Yale, UCLA, and UCSF that brings together three principal investigators and collaborators with strong publication records and expertise in all approaches necessary to perform this work using state-of-the-art and novel methodologies. We will perform time-, region-, and cell type-specific molecular profiling of control and ASD brains Aim 1,including RNA-seq based transcriptomics, identifying cis-regulatory elements via ChIP-seq, and use Hi-C to determine the 3D chromatin architecture and physical relationships that underlie transcriptional regulation in three major regions implicated in neuropsychiatric disease frontal and temporal cortex and striatum across five major epochs representing disease-relevant stages in human brain development. This will include complementary genomic analyses in controls and matched post mortem ASD brain to identify genetic mechanisms underlying processes altered in ASD brain. We will address cellular heterogeneity via fluorescence-activated nuclear sorting FANS so as to profile neurons and non-neural cells separately, which will complement the whole tissue analyses. We will analyze and integrate these datasets to identify regional, developmental, and ASD-related processes to gain insight into underlying mechanisms, harmonizing these multi-omic data with other psych ENCODE studies, as well as other large scale data sets, such as BrainSpan, ENCODE, GTEx and Roadmap Epigenomics Project Aim 2. We will perform integrated analysis of germ-line ASD variations identified in more than 1000 families from the Simon's Simplex Collection to characterize causal enrichments in developmental periods, brain regions, and cell types to better characterize the mechanisms by which genetic variation in humans alters brain development and function in health and disease Aim 3. Completion of these aims will lead to a well-integrated resource across major periods in human cortical and striatal development that will permit generation of concrete testable hypotheses of ASD mechanisms, and inform our pathophysiological understanding of other related neuropsychiatric disorders.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	09/19/2016
NIH Research Initiative:	PsychENCODE Consortium
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$2,073,628.00
Subjects Shared:	0
Collection DOI:	10.15154/mkwy-1k61

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH110927-01	2/3 Integrative Genomic Analysis of Human Brain Development and Autism	08/10/2016	04/30/2020	04/30/2020	Not Reported	Not Reported	UNIVERSITY OF CALIFORNIA LOS ANGELES	$2,073,628.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
2969	ATAC-Seq	06/26/2025	Approved	Omics
3040	Hi-C	07/28/2025	Approved	Omics

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
41394650	Create Study	High cell-type specificity of eQTLs revealed by single-nucleus analyses of brain and blood.	bioRxiv : the preprint server for biology	Vochteloo, Martijn; Kooijmans, Anoek; Bakker, Joost; Oelen, Roy; Niewold, Jelmer; Kaptijn, Dan; Bonder, Marc Jan; van der Wijst, Monique; Huang, Yunfeng; Bryois, Julien; Tsai, Ellen A; Franke, Lude; Westra, Harm-Jan	November 28, 2025	Not Determined
40739630	Create Study	Integrative multi-omics data from early development to identify the genes and cell types underlying attention-deficit/hyperactivity disorder.	BMC psychiatry	Jiao, Shufen; Bao, Li; Lu, Xiaowen; Wu, Yong; Li, Yichen	July 30, 2025	Not Determined
40468385	Create Study	Identifying associations of de novo noncoding variants with autism through integration of gene expression, sequence, and sex information.	Genome biology	Li, Runjia; Ernst, Jason	June 4, 2025	Not Determined
39107272	Create Study	Single-cell multiomics analysis reveals cell/tissue-specific associations in bipolar disorder.	Translational psychiatry	Wei, Wenming; Cheng, Bolun; Yang, Xuena; Chu, Xiaoge; He, Dan; Qin, Xiaoyue; Zhang, Na; Zhao, Yijing; Shi, Sirong; Cai, Qingqing; Hui, Jingni; Wen, Yan; Liu, Huan; Jia, Yumeng; Zhang, Feng	August 6, 2024	Not Determined
38913688	Create Study	The Human Developing Cerebral Cortex Is Characterized by an Elevated De Novo Expression of Long Noncoding RNAs in Excitatory Neurons.	Molecular biology and evolution	Morales-Vicente, David A; Tahira, Ana C; Woellner-Santos, Daisy; Amaral, Murilo S; Berzoti-Coelho, Maria G; Verjovski-Almeida, Sergio	July 3, 2024	Not Determined
38781390	Create Study	Massively parallel characterization of regulatory elements in the developing human cortex.	Science (New York, N.Y.)	Deng, Chengyu; Whalen, Sean; Steyert, Marilyn; Ziffra, Ryan; Przytycki, Pawel F; Inoue, Fumitaka; Pereira, Daniela A; Capauto, Davide; Norton, Scott; Vaccarino, Flora M; PsychENCODE Consortium‡; Pollen, Alex A; Nowakowski, Tomasz J; Ahituv, Nadav; Pollard, Katherine S; PsychENCODE Consortium	May 24, 2024	Not Determined
38781388	Create Study	Single-cell multi-cohort dissection of the schizophrenia transcriptome.	Science (New York, N.Y.)	Ruzicka, W Brad; Mohammadi, Shahin; Fullard, John F; Davila-Velderrain, Jose; Subburaju, Sivan; Tso, Daniel Reed; Hourihan, Makayla; Jiang, Shan; Lee, Hao-Chih; Bendl, Jaroslav; PsychENCODE Consortium§; Voloudakis, Georgios; Haroutunian, Vahram; Hoffman, Gabriel E; Roussos, Panos; Kellis, Manolis; PsychENCODE Consortium	May 24, 2024	Not Determined
38781370	Create Study	A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex.	Science (New York, N.Y.)	Huuki-Myers, Louise A; Spangler, Abby; Eagles, Nicholas J; Montgomery, Kelsey D; Kwon, Sang Ho; Guo, Boyi; Grant-Peters, Melissa; Divecha, Heena R; Tippani, Madhavi; Sriworarat, Chaichontat; Nguyen, Annie B; Ravichandran, Prashanthi; Tran, Matthew N; Seyedian, Arta; PsychENCODE Consortium†; Hyde, Thomas M; Kleinman, Joel E; Battle, Alexis; Page, Stephanie C; Ryten, Mina; Hicks, Stephanie C; Martinowich, Keri; Collado-Torres, Leonardo; Maynard, Kristen R; PsychENCODE Consortium	May 24, 2024	Not Determined
38781369	Create Study	Single-cell genomics and regulatory networks for 388 human brains.	Science (New York, N.Y.)	Emani, Prashant S; Liu, Jason J; Clarke, Declan; Jensen, Matthew; Warrell, Jonathan; Gupta, Chirag; Meng, Ran; Lee, Che Yu; Xu, Siwei; Dursun, Cagatay; Lou, Shaoke; Chen, Yuhang; Chu, Zhiyuan; Galeev, Timur; Hwang, Ahyeon; Li, Yunyang; Ni, Pengyu; Zhou, Xiao; PsychENCODE Consortium‡; Bakken, Trygve E; Bendl, Jaroslav; Bicks, Lucy; Chatterjee, Tanima; Cheng, Lijun; Cheng, Yuyan; Dai, Yi; Duan, Ziheng; Flaherty, Mary; Fullard, John F; Gancz, Michael; Garrido-Martín, Diego; Gaynor-Gillett, Sophia; Grundman, Jennifer; Hawken, Natalie; Henry, Ella; Hoffman, Gabriel E; Huang, Ao; Jiang, Yunzhe; Jin, Ting; Jorstad, Nikolas L; Kawaguchi, Riki; Khullar, Saniya; Liu, Jianyin; Liu, Junhao; Liu, Shuang; Ma, Shaojie; Margolis, Michael; Mazariegos, Samantha; Moore, Jill; Moran, Jennifer R; Nguyen, Eric; Phalke, Nishigandha; Pjanic, Milos; Pratt, Henry; Quintero, Diana; Rajagopalan, Ananya S; Riesenmy, Tiernon R; Shedd, Nicole; Shi, Manman; Spector, Megan; Terwilliger, Rosemarie; Travaglini, Kyle J; Wamsley, Brie; Wang, Gaoyuan; Xia, Yan; Xiao, Shaohua; Yang, Andrew C; Zheng, Suchen; Gandal, Michael J; Lee, Donghoon; Lein, Ed S; Roussos, Panos; Sestan, Nenad; Weng, Zhiping; White, Kevin P; Won, Hyejung; Girgenti, Matthew J; Zhang, Jing; Wang, Daifeng; Geschwind, Daniel; Gerstein, Mark; PsychENCODE Consortium	May 24, 2024	Not Determined
38781356	Create Study	Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.	Science (New York, N.Y.)	Patowary, Ashok; Zhang, Pan; Jops, Connor; Vuong, Celine K; Ge, Xinzhou; Hou, Kangcheng; Kim, Minsoo; Gong, Naihua; Margolis, Michael; Vo, Daniel; Wang, Xusheng; Liu, Chunyu; Pasaniuc, Bogdan; Li, Jingyi Jessica; Gandal, Michael J; de la Torre-Ubieta, Luis	May 24, 2024	Not Determined
38781336	Create Study	Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data.	Science advances	Dai, Rujia; Chu, Tianyao; Zhang, Ming; Wang, Xuan; Jourdon, Alexandre; Wu, Feinan; Mariani, Jessica; Vaccarino, Flora M; Lee, Donghoon; Fullard, John F; Hoffman, Gabriel E; Roussos, Panos; Wang, Yue; Wang, Xusheng; Pinto, Dalila; Wang, Sidney H; Zhang, Chunling; PsychENCODE consortium; Chen, Chao; Liu, Chunyu	May 24, 2024	Not Determined
38781333	Create Study	Brain cell-type shifts in Alzheimer''s disease, autism, and schizophrenia interrogated using methylomics and genetics.	Science advances	Yap, Chloe X; Vo, Daniel D; Heffel, Matthew G; Bhattacharya, Arjun; Wen, Cindy; Yang, Yuanhao; Kemper, Kathryn E; Zeng, Jian; Zheng, Zhili; Zhu, Zhihong; Hannon, Eilis; Vellame, Dorothea Seiler; Franklin, Alice; Caggiano, Christa; Wamsley, Brie; Geschwind, Daniel H; Zaitlen, Noah; Gusev, Alexander; Pasaniuc, Bogdan; Mill, Jonathan; Luo, Chongyuan; Gandal, Michael J	May 24, 2024	Not Determined
38562822	Create Study	Single-cell genomics and regulatory networks for 388 human brains.	bioRxiv : the preprint server for biology	Emani, Prashant S; Liu, Jason J; Clarke, Declan; Jensen, Matthew; Warrell, Jonathan; Gupta, Chirag; Meng, Ran; Lee, Che Yu; Xu, Siwei; Dursun, Cagatay; Lou, Shaoke; Chen, Yuhang; Chu, Zhiyuan; Galeev, Timur; Hwang, Ahyeon; Li, Yunyang; Ni, Pengyu; Zhou, Xiao; PsychENCODE Consortium; Bakken, Trygve E; Bendl, Jaroslav; Bicks, Lucy; Chatterjee, Tanima; Cheng, Lijun; Cheng, Yuyan; Dai, Yi; Duan, Ziheng; Flaherty, Mary; Fullard, John F; Gancz, Michael; Garrido-Martín, Diego; Gaynor-Gillett, Sophia; Grundman, Jennifer; Hawken, Natalie; Henry, Ella; Hoffman, Gabriel E; Huang, Ao; Jiang, Yunzhe; Jin, Ting; Jorstad, Nikolas L; Kawaguchi, Riki; Khullar, Saniya; Liu, Jianyin; Liu, Junhao; Liu, Shuang; Ma, Shaojie; Margolis, Michael; Mazariegos, Samantha; Moore, Jill; Moran, Jennifer R; Nguyen, Eric; Phalke, Nishigandha; Pjanic, Milos; Pratt, Henry; Quintero, Diana; Rajagopalan, Ananya S; Riesenmy, Tiernon R; Shedd, Nicole; Shi, Manman; Spector, Megan; Terwilliger, Rosemarie; Travaglini, Kyle J; Wamsley, Brie; Wang, Gaoyuan; Xia, Yan; Xiao, Shaohua; Yang, Andrew C; Zheng, Suchen; Gandal, Michael J; Lee, Donghoon; Lein, Ed S; Roussos, Panos; Sestan, Nenad; Weng, Zhiping; White, Kevin P; Won, Hyejung; Girgenti, Matthew J; Zhang, Jing; Wang, Daifeng; Geschwind, Daniel; Gerstein, Mark	March 30, 2024	Not Determined
38562739	Create Study	Identifying associations of de novo noncoding variants with autism through integration of gene expression, sequence and sex information.	bioRxiv : the preprint server for biology	Li, Runjia; Ernst, Jason	March 21, 2024	Not Determined
38395959	Create Study	Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.	Translational psychiatry	Aranda, Selena; Muntané, Gerard; Vilella, Elisabet	February 23, 2024	Not Determined
38321095	Create Study	Network-based drug repurposing for schizophrenia.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Truong, Trang T T; Liu, Zoe S J; Panizzutti, Bruna; Kim, Jee Hyun; Dean, Olivia M; Berk, Michael; Walder, Ken	May 1, 2024	Not Determined
37715107	Create Study	Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Zhou, Dan-Yang; Su, Xi; Wu, Yong; Yang, Yongfeng; Zhang, Luwen; Cheng, Shumin; Shao, Minglong; Li, Wenqiang; Zhang, Zhaohui; Wang, Lu; Lv, Luxian; Li, Ming; Song, Meng	January 1, 2024	Not Determined
37620341	Create Study	Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways.	Nature communications	Zhang, Wendiao; Zhang, Ming; Xu, Zhenhong; Yan, Hongye; Wang, Huimin; Jiang, Jiamei; Wan, Juan; Tang, Beisha; Liu, Chunyu; Chen, Chao; Meng, Qingtuan	August 24, 2023	Not Determined
37270547	Create Study	Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition.	Nature communications	Zaghi, Mattia; Banfi, Federica; Massimino, Luca; Volpin, Monica; Bellini, Edoardo; Brusco, Simone; Merelli, Ivan; Barone, Cristiana; Bruni, Michela; Bossini, Linda; Lamparelli, Luigi Antonio; Pintado, Laura; D'Aliberti, Deborah; Spinelli, Silvia; Mologni, Luca; Colasante, Gaia; Ungaro, Federica; Cioni, Jean-Michel; Azzoni, Emanuele; Piazza, Rocco; Montini, Eugenio; Broccoli, Vania; Sessa, Alessandro	June 3, 2023	Not Determined
37188697	Create Study	Prioritization of potential causative genes for schizophrenia in placenta.	Nature communications	Ursini, Gianluca; Di Carlo, Pasquale; Mukherjee, Sreya; Chen, Qiang; Han, Shizhong; Kim, Jiyoung; Deyssenroth, Maya; Marsit, Carmen J; Chen, Jia; Hao, Ke; Punzi, Giovanna; Weinberger, Daniel R	May 15, 2023	Not Determined
37058565	Create Study	Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions.	Science advances	Pergola, Giulio; Parihar, Madhur; Sportelli, Leonardo; Bharadwaj, Rahul; Borcuk, Christopher; Radulescu, Eugenia; Bellantuono, Loredana; Blasi, Giuseppe; Chen, Qiang; Kleinman, Joel E; Wang, Yanhong; Sripathy, Srinidhi Rao; Maher, Brady J; Monaco, Alfonso; Rossi, Fabiana; Shin, Joo Heon; Hyde, Thomas M; Bertolino, Alessandro; Weinberger, Daniel R	April 14, 2023	Not Determined
37034773	Create Study	Human forebrain organoids-based multi-omics analyses reveal PCCB''s regulation on GABAergic system contributing to schizophrenia.	Research square	Zhang, Wendiao; Zhang, Ming; Xu, Zhenhong; Yan, Hongye; Wang, Huimin; Jiang, Jiamei; Wan, Juan; Tang, Beisha; Liu, Chunyu; Chen, Chao; Meng, Qingtuan	March 29, 2023	Not Determined
36993743	Create Study	Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data.	bioRxiv : the preprint server for biology	Dai, Rujia; Chu, Tianyao; Zhang, Ming; Wang, Xuan; Jourdon, Alexandre; Wu, Feinan; Mariani, Jessica; Vaccarino, Flora M; Lee, Donghoon; Fullard, John F; Hoffman, Gabriel E; Roussos, Panos; Wang, Yue; Wang, Xusheng; Pinto, Dalila; Wang, Sidney H; Zhang, Chunling; PsychENCODE consortium; Chen, Chao; Liu, Chunyu	March 15, 2023	Not Determined
36945630	Create Study	Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain.	medRxiv : the preprint server for health sciences	Wen, Cindy; Margolis, Michael; Dai, Rujia; Zhang, Pan; Przytycki, Pawel F; Vo, Daniel D; Bhattacharya, Arjun; Matoba, Nana; Jiao, Chuan; Kim, Minsoo; Tsai, Ellen; Hoh, Celine; Aygün, Nil; Walker, Rebecca L; Chatzinakos, Christos; Clarke, Declan; Pratt, Henry; Consortium, PsychENCODE; Peters, Mette A; Gerstein, Mark; Daskalakis, Nikolaos P; Weng, Zhiping; Jaffe, Andrew E; Kleinman, Joel E; Hyde, Thomas M; Weinberger, Daniel R; Bray, Nicholas J; Sestan, Nenad; Geschwind, Daniel H; Roeder, Kathryn; Gusev, Alexander; Pasaniuc, Bogdan; Stein, Jason L; Love, Michael I; Pollard, Katherine S; Liu, Chunyu; Gandal, Michael J	March 6, 2023	Not Determined
36824845	Create Study	Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex.	bioRxiv : the preprint server for biology	Deng, Chengyu; Whalen, Sean; Steyert, Marilyn; Ziffra, Ryan; Przytycki, Pawel F; Inoue, Fumitaka; Pereira, Daniela A; Capauto, Davide; Norton, Scott; Vaccarino, Flora M; Pollen, Alex; Nowakowski, Tomasz J; Ahituv, Nadav; Pollard, Katherine S	February 16, 2023	Not Determined
36790927	Create Study	Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.	Cell reports	Rheinberger, Mona; Costa, Ana Luisa; Kampmann, Martin; Glavas, Dunja; Shytaj, Iart Luca; Sreeram, Sheetal; Penzo, Carlotta; Tibroni, Nadine; Garcia-Mesa, Yoelvis; Leskov, Konstantin; Fackler, Oliver T; Vlahovicek, Kristian; Karn, Jonathan; Lucic, Bojana; Herrmann, Carl; Lusic, Marina	February 28, 2023	Not Determined
36652379	Create Study	The relationship between case-control differential gene expression from brain tissue and genetic associations in schizophrenia.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Clifton, Nicholas E; Schulmann, Anton; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Holmans, Peter A; O'Donovan, Michael C; Vawter, Marquis P	January 1, 2023	Not Determined
36447210	Create Study	Bidirectional genetic overlap between bipolar disorder and intelligence.	BMC medicine	Shang, Meng-Yuan; Wu, Yong; Zhang, Chu-Yi; Qi, Hao-Xiang; Zhang, Qing; Huo, Jin-Hua; Wang, Lu; Wang, Chuang; Li, Ming	November 30, 2022	Not Determined
36323788	Create Study	Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.	Nature	Gandal, Michael J; Haney, Jillian R; Wamsley, Brie; Yap, Chloe X; Parhami, Sepideh; Emani, Prashant S; Chang, Nathan; Chen, George T; Hoftman, Gil D; de Alba, Diego; Ramaswami, Gokul; Hartl, Christopher L; Bhattacharya, Arjun; Luo, Chongyuan; Jin, Ting; Wang, Daifeng; Kawaguchi, Riki; Quintero, Diana; Ou, Jing; Wu, Ye Emily; Parikshak, Neelroop N; Swarup, Vivek; Belgard, T Grant; Gerstein, Mark; Pasaniuc, Bogdan; Geschwind, Daniel H	November 1, 2022	Not Determined
35680911	Create Study	Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder.	Nature communications	Berto, Stefano; Treacher, Alex H; Caglayan, Emre; Luo, Danni; Haney, Jillian R; Gandal, Michael J; Geschwind, Daniel H; Montillo, Albert A; Konopka, Genevieve	June 9, 2022	Not Determined
34663447	Create Study	Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.	Genome medicine	Yousefi, Soheil; Deng, Ruizhi; Lanko, Kristina; Salsench, Eva Medico; Nikoncuk, Anita; van der Linde, Herma C; Perenthaler, Elena; van Ham, Tjakko J; Mulugeta, Eskeatnaf; Barakat, Tahsin Stefan	October 19, 2021	Not Determined
34416157	Create Study	Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis.	American journal of human genetics	Aygün, Nil; Elwell, Angela L; Liang, Dan; Lafferty, Michael J; Cheek, Kerry E; Courtney, Kenan P; Mory, Jessica; Hadden-Ford, Ellie; Krupa, Oleh; de la Torre-Ubieta, Luis; Geschwind, Daniel H; Love, Michael I; Stein, Jason L	September 2, 2021	Not Determined
34294919	Create Study	Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.	Nature neuroscience	Hartl, Christopher L; Ramaswami, Gokul; Pembroke, William G; Muller, Sandrine; Pintacuda, Greta; Saha, Ashis; Parsana, Princy; Battle, Alexis; Lage, Kasper; Geschwind, Daniel H	September 1, 2021	Not Determined
34172755	Create Study	Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.	Nature communications	Hu, Benxia; Won, Hyejung; Mah, Won; Park, Royce B; Kassim, Bibi; Spiess, Keeley; Kozlenkov, Alexey; Crowley, Cheynna A; Pochareddy, Sirisha; PsychENCODE Consortium; Li, Yun; Dracheva, Stella; Sestan, Nenad; Akbarian, Schahram; Geschwind, Daniel H	June 25, 2021	Not Determined
34017130	Create Study	Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.	Nature neuroscience	Liang, Dan; Elwell, Angela L; Aygün, Nil; Krupa, Oleh; Wolter, Justin M; Kyere, Felix A; Lafferty, Michael J; Cheek, Kerry E; Courtney, Kenan P; Yusupova, Marianna; Garrett, Melanie E; Ashley-Koch, Allison; Crawford, Gregory E; Love, Michael I; de la Torre-Ubieta, Luis; Geschwind, Daniel H; Stein, Jason L	July 1, 2021	Not Determined
33958802	Create Study	Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.	Nature neuroscience	Kim, Minsoo; Haney, Jillian R; Zhang, Pan; Hernandez, Leanna M; Wang, Lee-Kai; Perez-Cano, Laura; Loohuis, Loes M Olde; de la Torre-Ubieta, Luis; Gandal, Michael J	June 1, 2021	Not Determined
33947435	Create Study	Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson''s disease brain.	Molecular neurodegeneration	Toker, Lilah; Tran, Gia T; Sundaresan, Janani; Tysnes, Ole-Bjørn; Alves, Guido; Haugarvoll, Kristoffer; Nido, Gonzalo S; Dölle, Christian; Tzoulis, Charalampos	May 5, 2021	Not Determined
33272361	Create Study	Polygenicity in Psychiatry-Like It or Not, We Have to Understand It.	Biological psychiatry	Gandal, Michael J; Geschwind, Daniel H	January 1, 2021	Not Determined
33246552	Create Study	Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus.	Biological psychiatry	Chang, Hong; Cai, Xin; Li, Hui-Juan; Liu, Wei-Peng; Zhao, Li-Juan; Zhang, Chu-Yi; Wang, Jun-Yang; Liu, Jie-Wei; Ma, Xiao-Lei; Wang, Lu; Yao, Yong-Gang; Luo, Xiong-Jian; Li, Ming; Xiao, Xiao	February 1, 2021	Not Determined
32978376	Create Study	Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism.	Nature communications	Ramaswami, Gokul; Won, Hyejung; Gandal, Michael J; Haney, Jillian; Wang, Jerry C; Wong, Chloe C Y; Sun, Wenjie; Prabhakar, Shyam; Mill, Jonathan; Geschwind, Daniel H	September 25, 2020	Not Determined
32826963	Create Study	Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder.	Molecular psychiatry	Meng, Qingtuan; Wang, Le; Dai, Rujia; Wang, Jiawen; Ren, Zongyao; Liu, Sihan; Xia, Yan; Jiang, Yi; Duan, Fangyuan; Wang, Kangli; Liu, Chunyu; Chen, Chao	November 1, 2020	Not Determined
32791513	Create Study	Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Li, Wenqiang; Cai, Xin; Li, Hui-Juan; Song, Meng; Zhang, Chu-Yi; Yang, Yongfeng; Zhang, Luwen; Zhao, Lijuan; Liu, Weipeng; Wang, Lu; Shao, Minglong; Zhang, Yan; Zhang, Chen; Cai, Jun; Zhou, Dong-Sheng; Li, Xingxing; Hui, Li; Jia, Qiu-Fang; Qu, Na; Zhong, Bao-Liang; Zhang, Shu-Fang; Chen, Jing; Xia, Bin; Li, Yi; Song, Xueqin; Fan, Weixing; Tang, Wei; Tang, Wenxin; Tang, Jinsong; Chen, Xiaogang; Yue, Weihua; Zhang, Dai; Fang, Yiru; Xiao, Xiao; Li, Ming; Lv, Luxian; Chang, Hong	May 1, 2021	Not Determined
32634676	Create Study	Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease.	Current opinion in genetics & development	Wamsley, Brie; Geschwind, Daniel H	December 1, 2020	Not Determined
32184385	Create Study	Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data.	Translational psychiatry	Li, Hui-Juan; Qu, Na; Hui, Li; Cai, Xin; Zhang, Chu-Yi; Zhong, Bao-Liang; Zhang, Shu-Fang; Chen, Jing; Xia, Bin; Wang, Lu; Jia, Qiu-Fang; Li, Wei; Chang, Hong; Xiao, Xiao; Li, Ming; Li, Yi	March 17, 2020	Not Determined
31819045	Create Study	The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population.	Translational psychiatry	Liu, Weipeng; Yan, Hao; Zhou, Danyang; Cai, Xin; Zhang, Yuyanan; Li, Shiyi; Li, Huijuan; Li, Shiwu; Zhou, Dong-Sheng; Li, Xingxing; Zhang, Chen; Sun, Yan; Dai, Jia-Pei; Zhong, Jingmei; Yao, Yong-Gang; Luo, Xiong-Jian; Fang, Yiru; Zhang, Dai; Ma, Yina; Yue, Weihua; Li, Ming; Xiao, Xiao	December 2019	Not Determined
31626773	Create Study	Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms.	Cell	Walker, Rebecca L; Ramaswami, Gokul; Hartl, Christopher; Mancuso, Nicholas; Gandal, Michael J; de la Torre-Ubieta, Luis; Pasaniuc, Bogdan; Stein, Jason L; Geschwind, Daniel H	October 2019	Not Determined
31563948	Create Study	Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.	The international journal of neuropsychopharmacology	Vawter, Marquis P; Schulmann, Anton; Alhassen, Lamees; Alhassen, Wedad; Hamzeh, Abdul Rezzak; Sakr, Jasmine; Pauluk, Lucas; Yoshimura, Ryan; Wang, Xuejie; Dai, Qi; Sanathara, Nayna; Civelli, Olivier; Alachkar, Amal	March 2020	Not Determined
31554518	Create Study	Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation.	Genome biology	Price, Amanda J; Collado-Torres, Leonardo; Ivanov, Nikolay A; Xia, Wei; Burke, Emily E; Shin, Joo Heon; Tao, Ran; Ma, Liang; Jia, Yankai; Hyde, Thomas M; Kleinman, Joel E; Weinberger, Daniel R; Jaffe, Andrew E	September 2019	Not Determined
31455884	Create Study	Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage.	Nature neuroscience	Lee, Changhoon; Kang, Eun Yong; Gandal, Michael J; Eskin, Eleazar; Geschwind, Daniel H	September 2019	Not Determined
31303374	Create Study	A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation.	Neuron	Polioudakis, Damon; de la Torre-Ubieta, Luis; Langerman, Justin; Elkins, Andrew G; Shi, Xu; Stein, Jason L; Vuong, Celine K; Nichterwitz, Susanne; Gevorgian, Melinda; Opland, Carli K; Lu, Daning; Connell, William; Ruzzo, Elizabeth K; Lowe, Jennifer K; Hadzic, Tarik; Hinz, Flora I; Sabri, Shan; Lowry, William E; Gerstein, Mark B; Plath, Kathrin; Geschwind, Daniel H	September 2019	Not Determined
31160561	Create Study	Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility.	Nature communications	Won, Hyejung; Huang, Jerry; Opland, Carli K; Hartl, Chris L; Geschwind, Daniel H	June 3, 2019	Not Determined
31056284	Create Study	Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.	Cell	Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR	May 2019	Not Determined
30901538	Create Study	Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders.	Cell	Sullivan, Patrick F; Geschwind, Daniel H	March 2019	Not Determined
30692689	Create Study	A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment.	Nature neuroscience	Schork, Andrew J; Won, Hyejung; Appadurai, Vivek; Nudel, Ron; Gandal, Mike; Delaneau, Olivier; Revsbech Christiansen, Malene; Hougaard, David M; Bækved-Hansen, Marie; Bybjerg-Grauholm, Jonas; Giørtz Pedersen, Marianne; Agerbo, Esben; Bøcker Pedersen, Carsten; Neale, Benjamin M; Daly, Mark J; Wray, Naomi R; Nordentoft, Merete; Mors, Ole; Børglum, Anders D; Bo Mortensen, Preben; Buil, Alfonso; Thompson, Wesley K; Geschwind, Daniel H; Werge, Thomas	March 1, 2019	Not Determined
30555922	Create Study	Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation.	Science advances	Rhie, Suhn K; Schreiner, Shannon; Witt, Heather; Armoskus, Chris; Lay, Fides D; Camarena, Adrian; Spitsyna, Valeria N; Guo, Yu; Berman, Benjamin P; Evgrafov, Oleg V; Knowles, James A; Farnham, Peggy J	December 2018	Not Determined
30545965	Create Study	The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes.	Science translational medicine	Meng, Qingtuan; Wang, Kangli; Brunetti, Tonya; Xia, Yan; Jiao, Chuan; Dai, Rujia; Fitzgerald, Dominic; Thomas, Amber; Jay, Lindsey; Eckart, Heather; Grennan, Kay; Imamura-Kawasawa, Yuka; Li, Mingfeng; Sestan, Nenad; White, Kevin P; Chen, Chao; Liu, Chunyu	December 19, 2018	Not Determined
30545964	Create Study	The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.	Science translational medicine	Chen, Chao; Meng, Qingtuan; Xia, Yan; Ding, Chaodong; Wang, Le; Dai, Rujia; Cheng, Lijun; Gunaratne, Preethi; Gibbs, Richard A; Min, Shishi; Coarfa, Cristian; Reid, Jeffrey G; Zhang, Chunling; Jiao, Chuan; Jiang, Yi; Giase, Gina; Thomas, Amber; Fitzgerald, Dominic; Brunetti, Tonya; Shieh, Annie; Xia, Cuihua; Wang, Yongjun; Wang, Yunpeng; Badner, Judith A; Gershon, Elliot S; White, Kevin P; Liu, Chunyu	December 2018	Not Determined
30545857	Create Study	Comprehensive functional genomic resource and integrative model for the human brain.	Science (New York, N.Y.)	Wang, Daifeng; Liu, Shuang; Warrell, Jonathan; Won, Hyejung; Shi, Xu; Navarro, Fabio C P; Clarke, Declan; Gu, Mengting; Emani, Prashant; Yang, Yucheng T; Xu, Min; Gandal, Michael J; Lou, Shaoke; Zhang, Jing; Park, Jonathan J; Yan, Chengfei; Rhie, Suhn Kyong; Manakongtreecheep, Kasidet; Zhou, Holly; Nathan, Aparna; Peters, Mette; Mattei, Eugenio; Fitzgerald, Dominic; Brunetti, Tonya; Moore, Jill; Jiang, Yan; Girdhar, Kiran; Hoffman, Gabriel E; Kalayci, Selim; Gümüş, Zeynep H; Crawford, Gregory E; PsychENCODE Consortium; Roussos, Panos; Akbarian, Schahram; Jaffe, Andrew E; White, Kevin P; Weng, Zhiping; Sestan, Nenad; Geschwind, Daniel H; Knowles, James A; Gerstein, Mark B	December 2018	Not Determined
30545856	Create Study	Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.	Science (New York, N.Y.)	Gandal, Michael J; Zhang, Pan; Hadjimichael, Evi; Walker, Rebecca L; Chen, Chao; Liu, Shuang; Won, Hyejung; van Bakel, Harm; Varghese, Merina; Wang, Yongjun; Shieh, Annie W; Haney, Jillian; Parhami, Sepideh; Belmont, Judson; Kim, Minsoo; Moran Losada, Patricia; Khan, Zenab; Mleczko, Justyna; Xia, Yan; Dai, Rujia; Wang, Daifeng; Yang, Yucheng T; Xu, Min; Fish, Kenneth; Hof, Patrick R; Warrell, Jonathan; Fitzgerald, Dominic; White, Kevin; Jaffe, Andrew E; PsychENCODE Consortium; Peters, Mette A; Gerstein, Mark; Liu, Chunyu; Iakoucheva, Lilia M; Pinto, Dalila; Geschwind, Daniel H	December 2018	Not Determined
30545855	Create Study	Spatiotemporal transcriptomic divergence across human and macaque brain development.	Science (New York, N.Y.)	Zhu, Ying; Sousa, André M M; Gao, Tianliuyun; Skarica, Mario; Li, Mingfeng; Santpere, Gabriel; Esteller-Cucala, Paula; Juan, David; Ferrández-Peral, Luis; Gulden, Forrest O; Yang, Mo; Miller, Daniel J; Marques-Bonet, Tomas; Imamura Kawasawa, Yuka; Zhao, Hongyu; Sestan, Nenad	December 2018	Not Determined
30545854	Create Study	Integrative functional genomic analysis of human brain development and neuropsychiatric risks.	Science (New York, N.Y.)	Li, Mingfeng; Santpere, Gabriel; Imamura Kawasawa, Yuka; Evgrafov, Oleg V; Gulden, Forrest O; Pochareddy, Sirisha; Sunkin, Susan M; Li, Zhen; Shin, Yurae; Zhu, Ying; Sousa, André M M; Werling, Donna M; Kitchen, Robert R; Kang, Hyo Jung; Pletikos, Mihovil; Choi, Jinmyung; Muchnik, Sydney; Xu, Xuming; Wang, Daifeng; Lorente-Galdos, Belen; Liu, Shuang; Giusti-Rodríguez, Paola; Won, Hyejung; de Leeuw, Christiaan A; Pardiñas, Antonio F; BrainSpan Consortium; PsychENCODE Consortium; PsychENCODE Developmental Subgroup; Hu, Ming; Jin, Fulai; Li, Yun; Owen, Michael J; O'Donovan, Michael C; Walters, James T R; Posthuma, Danielle; Reimers, Mark A; Levitt, Pat; Weinberger, Daniel R; Hyde, Thomas M; Kleinman, Joel E; Geschwind, Daniel H; Hawrylycz, Michael J; State, Matthew W; Sanders, Stephan J; Sullivan, Patrick F; Gerstein, Mark B; Lein, Ed S; Knowles, James A; Sestan, Nenad	December 2018	Not Determined
30545853	Create Study	Transcriptome and epigenome landscape of human cortical development modeled in organoids.	Science (New York, N.Y.)	Amiri, Anahita; Coppola, Gianfilippo; Scuderi, Soraya; Wu, Feinan; Roychowdhury, Tanmoy; Liu, Fuchen; Pochareddy, Sirisha; Shin, Yurae; Safi, Alexias; Song, Lingyun; Zhu, Ying; Sousa, André M M; PsychENCODE Consortium; Gerstein, Mark; Crawford, Gregory E; Sestan, Nenad; Abyzov, Alexej; Vaccarino, Flora M	December 2018	Not Determined
30545852	Create Study	Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.	Science (New York, N.Y.)	An, Joon-Yong; Lin, Kevin; Zhu, Lingxue; Werling, Donna M; Dong, Shan; Brand, Harrison; Wang, Harold Z; Zhao, Xuefang; Schwartz, Grace B; Collins, Ryan L; Currall, Benjamin B; Dastmalchi, Claudia; Dea, Jeanselle; Duhn, Clif; Gilson, Michael C; Klei, Lambertus; Liang, Lindsay; Markenscoff-Papadimitriou, Eirene; Pochareddy, Sirisha; Ahituv, Nadav; Buxbaum, Joseph D; Coon, Hilary; Daly, Mark J; Kim, Young Shin; Marth, Gabor T; Neale, Benjamin M; Quinlan, Aaron R; Rubenstein, John L; Sestan, Nenad; State, Matthew W; Willsey, A Jeremy; Talkowski, Michael E; Devlin, Bernie; Roeder, Kathryn; Sanders, Stephan J	December 2018	Not Determined
30263963	Create Study	A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons.	Science advances	Kozlenkov, Alexey; Li, Junhao; Apontes, Pasha; Hurd, Yasmin L; Byne, William M; Koonin, Eugene V; Wegner, Michael; Mukamel, Eran A; Dracheva, Stella	September 2018	Not Determined
29632383	Create Study	Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.	Nature genetics	Gusev, Alexander; Mancuso, Nicholas; Won, Hyejung; Kousi, Maria; Finucane, Hilary K; Reshef, Yakir; Song, Lingyun; Safi, Alexias; Schizophrenia Working Group of the Psychiatric Genomics Consortium; McCarroll, Steven; Neale, Benjamin M; Ophoff, Roel A; O'Donovan, Michael C; Crawford, Gregory E; Geschwind, Daniel H; Katsanis, Nicholas; Sullivan, Patrick F; Pasaniuc, Bogdan; Price, Alkes L	April 2018	Not Determined
29562236	Create Study	De novo mutations in regulatory elements in neurodevelopmental disorders.	Nature	Short, Patrick J; McRae, Jeremy F; Gallone, Giuseppe; Sifrim, Alejandro; Won, Hyejung; Geschwind, Daniel H; Wright, Caroline F; Firth, Helen V; FitzPatrick, David R; Barrett, Jeffrey C; Hurles, Matthew E	March 2018	Not Determined
29483656	Create Study	Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.	Nature genetics	Pardiñas, Antonio F; Holmans, Peter; Pocklington, Andrew J; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L; Han, Jun; Hubbard, Leon; Lynham, Amy; Mantripragada, Kiran; Rees, Elliott; MacCabe, James H; McCarroll, Steven A; Baune, Bernhard T; Breen, Gerome; Byrne, Enda M; Dannlowski, Udo; Eley, Thalia C; Hayward, Caroline; Martin, Nicholas G; McIntosh, Andrew M; Plomin, Robert; Porteous, David J; Wray, Naomi R; Caballero, Armando; Geschwind, Daniel H; Huckins, Laura M; Ruderfer, Douglas M; Santiago, Enrique; Sklar, Pamela; Stahl, Eli A; Won, Hyejung; Agerbo, Esben; Als, Thomas D; Andreassen, Ole A; Bækvad-Hansen, Marie; Mortensen, Preben Bo; Pedersen, Carsten Bøcker; Børglum, Anders D; Bybjerg-Grauholm, Jonas; Djurovic, Srdjan; Durmishi, Naser; Pedersen, Marianne Giørtz; Golimbet, Vera; Grove, Jakob; Hougaard, David M; Mattheisen, Manuel; Molden, Espen; Mors, Ole; Nordentoft, Merete; Pejovic-Milovancevic, Milica; Sigurdsson, Engilbert; Silagadze, Teimuraz; Hansen, Christine Søholm; Stefansson, Kari; Stefansson, Hreinn; Steinberg, Stacy; Tosato, Sarah; Werge, Thomas; GERAD1 Consortium; CRESTAR Consortium; Collier, David A; Rujescu, Dan; Kirov, George; Owen, Michael J; O'Donovan, Michael C; Walters, James T R	March 2018	Not Determined
29439242	Create Study	Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.	Science (New York, N.Y.)	Gandal, Michael J; Haney, Jillian R; Parikshak, Neelroop N; Leppa, Virpi; Ramaswami, Gokul; Hartl, Chris; Schork, Andrew J; Appadurai, Vivek; Buil, Alfonso; Werge, Thomas M; Liu, Chunyu; White, Kevin P; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group; Horvath, Steve; Geschwind, Daniel H	February 2018	Not Determined
29307494	Create Study	The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.	Cell	de la Torre-Ubieta, Luis; Stein, Jason L; Won, Hyejung; Opland, Carli K; Liang, Dan; Lu, Daning; Geschwind, Daniel H	January 2018	Not Determined
29020636	Create Study	Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.	Cell reports	Watanabe M, Buth JE, Vishlaghi N, De La Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG	October 2017	Not Relevant
28533516	Create Study	ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains.	Molecular psychiatry	Cantor, R M; Navarro, L; Won, H; Walker, R L; Lowe, J K; Geschwind, D H	April 2018	Not Determined
27814521	Create Study	The Central Nervous System and the Gut Microbiome.	Cell	Sharon, Gil; Sampson, Timothy R; Geschwind, Daniel H; Mazmanian, Sarkis K	November 2016	Not Determined
27760116	Create Study	Chromosome conformation elucidates regulatory relationships in developing human brain.	Nature	Won H, De La Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH	October 2016	Not Relevant

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Genomics/omics	53	04/01/2020	48	04/01/2021	0	Approved
Research Subject and Pedigree	1	07/15/2017	48	11/15/2017	0	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
No Data Expected

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
No records found.

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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