The NIH NeuroBioBank provides high-quality, well-characterized post-mortem human brain samples and biospecimens for investigators conducting research to better understand the conditions of the central nervous system.

The NeuroBioBank Data Repository, within the NIMH Data Archive (NDA), currently houses genome wide array genotypes and whole genome short-read sequencing datasets obtained from specimens in the NeuroBioBank inventory (Collection #3917). Furthermore, additional genomic and transcriptomic data generated by investigators using NeuroBioBank specimens are housed in NDA as associated collections. Each collection will have an attached translation table spreadsheet in the Supporting Documentation tab that allows translation from NeuroBioBank sample ID to NDA pseudoGUID. We continue to encourage investigators conducting studies using NeuroBioBank specimens to share their data on NDA.

Access to NeuroBioBank dataset collections require an approved NDA Data Use Certification (DUC).

The NDA Computational Credits pilot program awards credits for compute resources and short-term data storage to be used in support of the approved research purpose on NDA. Please visit the NDA Computational Credits page for more information on request process and approval requirements.

Further information on sample availability, clinical and neuropathological diagnoses, and clinical genetic testing is available in the NeuroBioBank portal. For more information, please visit the NeuroBioBank webpage or contact neurobiobank@mail.nih.gov for assistance.

NeuroBioBank collections

• C3917 - Whole-Genome Sequence Analysis of Postmortem Human Brains from the NIH NeuroBioBank
• C3151 - Human Brain Collection Core genomics data in post-mortem brain of psychiatric disorders
• C5073 - Molecular Brain Profiling of the Hippocampus of Children with Autism Spectrum Disorder
• C5120 - Contributions of Endothelial RNA-binding Protein Dysregulation to Blood Brain Barrier Defects and Neurodegenerative Disease
• C5489 - m6A RNA methylation in the amygdala of individuals with alcohol use disorder
• C5587 - Subcellular proteomic mapping of the insular cortex in alcohol use disorder (AUD)