NIMH Data Archive - Data

Genomics

Neuroimaging

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¹ Numbers reported are subjects by age

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

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Neural, Physiological, Behavioral, and Environmental Risk Markers of Anxiety from Infancy to Adolescence #2655

General
Experiments (8)
Shared Data
Publications (44)
Data Expected (26)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Neural, Physiological, Behavioral, and Environmental Risk Markers of Anxiety from Infancy to Adolescence
Collection Investigators:	Charles Nelson; BOSQUET ENLOW; MICHELLE A
Collection Description:	Anxiety disorders are the most common psychiatric illnesses and are often resistant to treatment. Adolescence is a core risk period for the development and exacerbation of anxiety, which often has a chronic course, negatively affecting academic, social, and adaptive functioning, and increasing the risk for mental illness through adulthood. Research has highlighted a number of risk factors that likely contribute to the development and maintenance of anxiety. However, there is limited understanding of the earliest precursors of anxiety or how multiple risk factors interact within and across development to influence anxiety risk. Prospective studies beginning in infancy are needed to explicate the origins of anxiety so that (a) biomarkers can be discovered that identify at-risk youth prior to the emergence of symptoms and (b) preventive strategies can be developed and implemented with those at risk. The overall goal of the current project is to test the combined effects of neural, physiological, behavioral, and environmental risk factors on anxiety from infancy through adolescence. The study aims will be accomplished by following our established longitudinal cohort (R01 MH078829; N=807), who have provided a rich dataset, including repeated assessments of neurophysiology (EEG, ERP), physiological stress reactivity, behavioral indicators of threat reactivity, and environmental risk (e.g., maternal psychopathology, negative life events, COVID-19 related stressors) between infancy and age 7 years. In the current proposal, we seek funds to support a follow-up study to age 13 years. We will phenotype our cohort for anxiety symptomatology and diagnoses, across multiple phenotypes, and implement a battery of brain-based measures, physiological and behavioral protocols, and assessments of environmental exposures, including exposures of particular relevance in adolescence and exposures related to the COVID-19 pandemic. We will apply a combination of established and novel analysis approaches to develop diagnostic neural biomarkers of anxiety in adolescence; identify positive and negative environmental characteristics that influence anxiety- relevant neural signatures in adolescence, that affect anxiety-related neural trajectories from infancy to adolescence, and that moderate the effects of neural reactivity on anxiety risk; determine how COVID-19 related stressors interact with childhood pre-pandemic characteristics (neural and behavioral threat reactivity, physiological stress reactivity) to influence adolescent anxiety risk; and to develop assay profiles comprising neural, physiological, behavioral, and/or environmental characteristics from infancy through adolescence that robustly predict anxiety trajectories across development. We expect that the findings will (a) improve our understanding of the neural circuitry underlying anxiety risk in youth, (b) contribute to the discovery of robust developmentally-informed multi-modal profiles that can identify at-risk children, and (c) inform the design of innovative strategies to prevent the emergence of anxiety and to treat more precisely symptomatic youth by addressing and correcting atypical neural processes and their downstream behavioral manifestations.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	05/15/2017
Collection Phase:	Enrolling
Blinded Clinical Trial:	No
Total Funded Amount:	$8,284,937.00
Subjects Shared:	1,116
Collection DOI:	10.15154/cnnc-2245

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH078829-20	Neurophysiological and Metabolic Risk Markers of Childhood Anxiety	05/03/2017	04/30/2022	05/31/2027	390	1272	BOSTON CHILDRENS HOSPITAL	$4,899,505.00
R01MH078829-25	Neural, Physiological, Behavioral, and Environmental Risk Markers of Anxiety from Infancy to Adolescence	08/01/2022	05/31/2027	05/31/2027	400	984	BOSTON CHILDRENS HOSPITAL	$3,385,432.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
805	Infant ERP	11/01/2017	Approved	EEG
806	Child ERP	11/01/2017	Approved	EEG
807	Infant fNIRS	11/03/2017	Approved	EEG
808	Child fNIRS	11/03/2017	Approved	EEG
809	Eye Tracking	11/17/2017	Approved	Eye Tracking
1872	Child ERP (5yr)	12/03/2021	Approved	EEG
1873	Child fNIRS (5/7yr)	12/03/2021	Approved	EEG
2026	Child fNIRS (5/7yr)	06/16/2022	Approved	fMRI

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Beck Depression Inventory	Clinical Assessments	695
Behavioral Inhibition	Clinical Assessments	217
Child Behavior Checklist (CBCL) 1-5	Clinical Assessments	362
Child Behavior Checklist (CBCL) 6-18	Clinical Assessments	411
Children's Behavior Questionnaire Parent	Clinical Assessments	477
Children's Behavior Questionnaire The Very Short Form	Clinical Assessments	201
Diagnostic Impression	Clinical Assessments	522
Diagnostic Infant and Preschool Assessment	Clinical Assessments	439
EEG Subject Files	Imaging	400
Early Childhood Behavior Questionnaire	Clinical Assessments	438
Eye Tracking Subject-Experiment	Imaging	479
Fear Survey Schedule	Clinical Assessments	178
Infant Behavior Questionnaire Revised	Clinical Assessments	491
PROMIS Pediatric Family Relationships	Clinical Assessments	178
RCADS-25 Youth Self-Assessment	Clinical Assessments	33
Recent Life Events Questionnaire	Clinical Assessments	459
Research Subject	Clinical Assessments	464
Screen for Child Anxiety Related Disorders (SCARED), Parent/Child	Clinical Assessments	798
State-Trait Anger Expression Inventory	Clinical Assessments	255
State-Trait Anxiety Inventory for Adults	Clinical Assessments	696
Vital Signs	Clinical Assessments	431

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
41028533	Create Study	A dynamical systems framework for precision psychiatry.	NPJ digital medicine	Bosl, William J; Enlow, Michelle Bosquet; Nelson, Charles A	September 30, 2025	Not Determined
40476357	Create Study	Longitudinal Trajectories of Aperiodic EEG Activity in Early to Middle Childhood.	Child development	Sacks, Dashiell D; Valdes, Viviane; Wilkinson, Carol L; Levin, April R; Nelson, Charles A; Bosquet Enlow, Michelle	January 1, 2025	Not Determined
40013320	Create Study	The association between temperament and polygenic score for psychopathology from infancy to middle childhood.	Journal of child psychology and psychiatry, and allied disciplines	Freitag, Eloise; Kelsey, Caroline; de Mendonça Filho, Euclides José; Pokhvisneva, Irina; Patel, Sachin; Silveira, Patricia Pelufo; Bosquet Enlow, Michelle; Nelson, Charles A	August 1, 2025	Not Determined
39956790	Create Study	EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood.	Journal of child psychology and psychiatry, and allied disciplines	Sacks, Dashiell D; Wang, Yiyi; Abron, Asja; Mulligan, Kaitlin M; Kelsey, Caroline M; Xie, Wanze; Nelson, Charles A; Bosquet Enlow, Michelle	August 1, 2025	Not Determined
39760248	Create Study	Associations Among EEG Aperiodic Slope, Infant Temperament, and Maternal Anxiety/Depression Symptoms in Infancy.	Psychophysiology	Sacks, Dashiell D; Levin, April R; Nelson, Charles A; Bosquet Enlow, Michelle	January 1, 2025	Not Determined
39740229	Create Study	Forming Connections: Functional Brain Connectivity is Associated With Executive Functioning Abilities in Early Childhood.	Developmental science	Kelsey, Caroline; Kamenetskiy, Adelia; Mulligan, Kaitlin; Tiras, Carly; Kent, Michaela; Bayet, Laurie; Richards, John; Bosquet Enlow, Michelle; Nelson, Charles A	March 1, 2025	Not Determined
39721149	Create Study	EEG-based brain age prediction in infants-toddlers: Implications for early detection of neurodevelopmental disorders.	Developmental cognitive neuroscience	An, Winko W; Bhowmik, Aprotim C; Nelson, Charles A; Wilkinson, Carol L	January 1, 2025	Not Determined
39663261	Create Study	The role of children''s neural responses to emotional faces in the intergenerational transmission of anxiety symptomatology.	Development and psychopathology	Kane-Grade, Finola E; Sacks, Dashiell; Petty, Carter R; Xie, Wanze; Nelson, Charles A; Bosquet Enlow, Michelle	August 1, 2025	Not Determined
39490845	Create Study	Prenatal buprenorphine/naloxone exposure and neonatal neurobehavioral functioning: A preliminary report.	Neurotoxicology and teratology	Velez, Martha L; McConnell, Krystle; Spencer, Nancy; Montoya, Lina M; Jansson, Lauren M	January 1, 2024	Not Determined
39468252	Create Study	Stress timing, trauma exposure, and family resilience differentially affect internalizing and externalizing symptoms at 3, 5, and 7 years of age.	Communications psychology	Valdes, Viviane; Sacks, Dashiell D; Nelson, Charles A; Enlow, Michelle Bosquet	October 29, 2024	Not Determined
39372924	Create Study	A QR Code for the Brain: A dynamical systems framework for computing neurophysiological biomarkers.	Research square	Bosl, William; Enlow, Michelle Bosquet; Nelson, Charles	September 18, 2024	Not Determined
39340803	Create Study	Longitudinal interactions between maternal depression symptoms and familial stressful life events on child anxiety symptoms at 5 years of age.	Infancy : the official journal of the International Society on Infant Studies	Valdes, Viviane; Craighead, Linda W; Nelson 3rd, Charles A; Bosquet Enlow, Michelle	January 1, 2025	Not Determined
39331278	Create Study	The Influence of Temperament, Theory of Mind, Inhibitory Control, and Prosocial Behavior on Child Anxiety Symptoms in the First Five Years of Life.	Research on child and adolescent psychopathology	Valdes, Viviane; Craighead, Linda W; Nelson, Charles A; Enlow, Michelle Bosquet	January 1, 2025	Not Determined
38987558	Create Study	Developmental trajectories of EEG aperiodic and periodic components in children 2-44 months of age.	Nature communications	Wilkinson, Carol L; Yankowitz, Lisa D; Chao, Jerry Y; Gutiérrez, Rodrigo; Rhoades, Jeff L; Shinnar, Shlomo; Purdon, Patrick L; Nelson, Charles A	July 10, 2024	Not Determined
38978327	Create Study	Caregiving stress and maternal mental health during the COVID-19 pandemic.	Family process	Quigley, Kelsey M; Kwon, Rachel; Nelson, Charles A; Bosquet Enlow, Michelle	March 1, 2025	Not Determined
38853932	Create Study	Prediction of chronological age from resting-state EEG power in the first three years of life.	medRxiv : the preprint server for health sciences	An, Winko W; Bhowmik, Aprotim C; Nelson, Charles A; Wilkinson, Carol L	June 1, 2024	Not Determined
38426330	Create Study	Temperament and sex as moderating factors of the effects of exposure to maternal depression on telomere length in early childhood.	Development and psychopathology	Bosquet Enlow, Michelle; De Vivo, Immaculata; Petty, Carter R; Nelson, Charles A	May 1, 2025	Not Determined
38111180	Create Study	Context-dependent approach and avoidance behavioral profiles as predictors of psychopathology.	Developmental science	Kelsey, Caroline M; Fasman, Anna; Quigley, Kelsey; Dickerson, Kelli; Enlow, Michelle Bosquet; Nelson, Charles A	May 1, 2024	Not Determined
37790544	Create Study	Developmental trajectories of EEG aperiodic and periodic power: Implications for understanding the timing of thalamocortical development during infancy.	Research square	Wilkinson, Carol L; Yankowitz, Lisa; Chao, Jerry Y; Gutiérrez, Rodrigo; Rhoades, Jeff L; Shinnar, Shlomo; Purdon, Patrick L; Nelson, Charles A	September 18, 2023	Not Determined
37768599	Create Study	Associations among temperament characteristics and telomere length and attrition rate in early childhood.	Developmental psychology	Bosquet Enlow, Michelle; De Vivo, Immaculata; Petty, Carter R; Cayon, Natalie; Nelson, Charles A	November 1, 2024	Not Determined
37546863	Create Study	Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy.	bioRxiv : the preprint server for biology	Wilkinson, Carol L; Yankowitz, Lisa; Chao, Jerry Y; Gutiérrez, Rodrigo; Rhoades, Jeff L; Shinnar, Shlomo; Purdon, Patrick L; Nelson, Charles A	March 9, 2024	Not Determined
37533889	Create Study	A biomarker discovery framework for childhood anxiety.	Frontiers in psychiatry	Bosl, William J; Bosquet Enlow, Michelle; Lock, Eric F; Nelson, Charles A	January 1, 2023	Not Determined
37162341	Create Study	Risk for internalizing symptom development in young children: Roles of child parasympathetic reactivity and maternal depression and anxiety exposure in early life.	Psychophysiology	Quigley, Kelsey M; Petty, Carter R; Sidamon-Eristoff, Anne Elizabeth; Modico, Margaret; Nelson 3rd, Charles A; Bosquet Enlow, Michelle	October 1, 2023	Not Determined
36428283	Create Study	Frontal asymmetry assessed in infancy using functional near-infrared spectroscopy is associated with emotional and behavioral problems in early childhood.	Child development	Kelsey, Caroline M; Modico, Margaret A; Richards, John E; Bosquet Enlow, Michelle; Nelson, Charles A	March 1, 2023	Not Determined
36336205	Create Study	In Context: A Developmental Model of Reward Processing, With Implications for Autism and Sensitive Periods.	Journal of the American Academy of Child and Adolescent Psychiatry	Clements, Caitlin C; Ascunce, Karina; Nelson, Charles A	November 1, 2023	Not Determined
35716637	Create Study	EEG functional connectivity analysis in the source space.	Developmental cognitive neuroscience	Xie, Wanze; Toll, Russell T; Nelson, Charles A	August 1, 2022	Not Determined
35226361	Create Study	Temperament and psychopathology: The "community" to which you belong matters.	Child development	Xie, Wanze; Bathelt, Joe; Fasman, Anna; Nelson, Charles A; Bosquet Enlow, Michelle	July 1, 2022	Not Determined
34292586	Create Study	Using different methods for calculating frontal alpha asymmetry to study its development from infancy to 3 years of age in a large longitudinal sample.	Developmental psychobiology	Vincent, Katherine M; Xie, Wanze; Nelson, Charles A	September 1, 2021	Not Determined
34246062	Create Study	Preferential responses to faces in superior temporal and medial prefrontal cortex in three-year-old children.	Developmental cognitive neuroscience	Richardson, H; Taylor, J; Kane-Grade, F; Powell, L; Bosquet Enlow, M; Nelson, C A	August 1, 2021	Not Determined
33993507	Create Study	Infants'' neural responses to emotional faces are related to maternal anxiety.	Journal of child psychology and psychiatry, and allied disciplines	Bowman, Lindsay C; McCormick, Sarah A; Kane-Grade, Finola; Xie, Wanze; Bosquet Enlow, Michelle; Nelson, Charles A	February 1, 2022	Not Determined
33482397	Create Study	Converging neural and behavioral evidence for a rapid, generalized response to threat-related facial expressions in 3-year-old children.	NeuroImage	Xie, Wanze; Leppänen, Jukka M; Kane-Grade, Finola E; Nelson, Charles A	April 1, 2021	Not Determined
33246304	Create Study	Neural responses to happy, fearful and angry faces of varying identities in 5- and 7-month-old infants.	Developmental cognitive neuroscience	Bayet, Laurie; Perdue, Katherine L; Behrendt, Hannah F; Richards, John E; Westerlund, Alissa; Cataldo, Julia K; Nelson 3rd, Charles A	February 1, 2021	Not Determined
32305734	Create Study	The influence of maternal anxiety and depression symptoms on fNIRS brain responses to emotional faces in 5- and 7-month-old infants.	Infant behavior & development	Porto, Juliana A; Bick, Johanna; Perdue, Katherine L; Richards, John E; Nunes, Magda L; Nelson, Charles A	May 2020	Not Determined
32120019	Create Study	Patterns of change in telomere length over the first three years of life in healthy children.	Psychoneuroendocrinology	Bosquet Enlow, Michelle; Kane-Grade, Finola; De Vivo, Immaculata; Petty, Carter R; Nelson, Charles A	May 2020	Not Determined
31345275	Create Study	Pathways to social-emotional functioning in the preschool period: The role of child temperament and maternal anxiety in boys and girls.	Development and psychopathology	Behrendt, Hannah F; Wade, Mark; Bayet, Laurie; Nelson, Charles A; Bosquet Enlow, Michelle	August 2020	Not Determined
31206778	Create Study	Rapid face processing for positive and negative emotions in 5-, 7-, and 12-month-old infants: An exploratory study.	The British journal of developmental psychology	Miguel, Helga O; McCormick, Sarah A; Westerlund, Alissa; Nelson, Charles A	November 1, 2019	Not Determined
31103019	Create Study	Cumulative psychosocial risk and early child development: validation and use of the Childhood Psychosocial Adversity Scale in global health research.	Pediatric research	Berens, Anne E; Kumar, Swapna; Tofail, Fahmida; Jensen, Sarah K G; Alam, Masud; Haque, Rashidul; Kakon, Shahria H; Petri, William A; Nelson 3rd, Charles A	December 2019	Not Determined
30889544	Create Study	Infant brain responses to social sounds: A longitudinal functional near-infrared spectroscopy study.	Developmental cognitive neuroscience	Mcdonald NM, Perdue KL, Eilbott J, Loyal J, Shic F, Pelphrey KA	April 2019	Not Determined
30335429	Create Study	Recognition of facial emotions of varying intensities by three-year-olds.	Developmental psychology	Bayet, Laurie; Behrendt, Hannah F; Cataldo, Julia K; Westerlund, Alissa; Nelson, Charles A	December 2018	Not Determined
30276933	Create Study	Neural correlates of facial emotion processing in infancy.	Developmental science	Xie, Wanze; McCormick, Sarah A; Westerlund, Alissa; Bowman, Lindsay C; Nelson, Charles A	May 2019	Not Determined
29768468	Create Study	Early development of attention to threat-related facial expressions.	PloS one	Leppänen, Jukka M; Cataldo, Julia K; Bosquet Enlow, Michelle; Nelson, Charles A	January 2018	Not Determined
29487875	Create Study	Motion correction for infant functional near-infrared spectroscopy with an application to live interaction data.	Neurophotonics	Behrendt, Hannah F; Firk, Christine; Nelson 3rd, Charles A; Perdue, Katherine L	January 2018	Not Determined
29371139	Create Study	The infant brain in the social world: Moving toward interactive social neuroscience with functional near-infrared spectroscopy.	Neuroscience and biobehavioral reviews	McDonald, Nicole M; Perdue, Katherine L	April 2018	Not Determined
28724431	Create Study	Biological embedding of childhood adversity: from physiological mechanisms to clinical implications.	BMC medicine	Berens AE, Jensen SKG, Nelson CA	July 2017	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	300	07/15/2018	464	11/15/2018	464	Approved
NIMH CDE - DSM-5 Crosscutting Youth	300	07/15/2023	0	11/15/2023	0	Approved
NIMH CDE - RCADS-25 Youth Self-Assessment	300	07/15/2023	33	11/15/2023	33	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
State-Trait Anger Expression Inventory	100	01/15/2023	255	07/15/2023	255	Approved
Perceived Stress Scale	150	01/15/2022	309	05/15/2023	0	Approved
Eye Tracking	100	07/15/2018	479	04/30/2023	479	Approved
Infant Behavior Questionnaire (IBQ)	300	07/15/2018	491	11/15/2018	491	Approved
Child Behavior Checklist (CBCL)	300	07/15/2018	513	11/15/2018	513	Approved
Vital Signs Assessment	6	07/15/2018	431	11/15/2018	431	Approved
Screen for Childhood Anxiety Related Emotional Disorders (SCARED)	300	07/15/2020	798	04/30/2022	798	Approved
Childrens Behavior Questionnaire (CBQ)	300	07/15/2018	480	11/15/2018	480	Approved
Diagnosis	80	07/15/2018	522	11/15/2018	522	Approved
Early Childhood Behavioral Questionnaire (ECBQ)	300	07/15/2018	438	11/15/2018	438	Approved
Beck Depression Inventory	300	07/15/2018	695	11/15/2018	695	Approved
State-Trait Anxiety Inventory for Adults	300	07/15/2018	696	11/15/2018	696	Approved
EEG	50	07/15/2018	400	04/30/2022	400	Approved
Olweus Bully Victim Questionnaire	100	01/15/2024	0	01/15/2025	0	Approved
PROMIS Family Relationship	100	01/15/2024	178	01/15/2025	178	Approved
Epidemic-Pandemic Impacts Inventory	50	01/15/2023	0	05/15/2023	0	Approved
Peer Relationships	100	01/15/2024	0	01/15/2025	0	Approved
Environmental Influences on Child Health Outcomes - Child Self-Report	100	01/15/2024	0	01/15/2025	0	Approved
Behavioral Inhibition Code	300	07/15/2018	217	04/30/2022	217	Approved
Fear Survey Schedule	100	01/15/2024	178	01/15/2025	178	Approved
Recent Life Events Questionnaire	300	07/15/2018	459	11/15/2018	459	Approved
Generalized Anxiety Disorder Severity Scale	100	01/15/2024	0	01/15/2025	0	Approved
Diagnostic Infant and Preschool Assessment	300	01/15/2019	439	04/30/2022	439	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Frontal asymmetry assessed in infancy using functional Near Infrared Spectroscopy is associated with emotional and behavioral problems in early childhood	10.15154/1528154	Frontal asymmetry (FA), the difference in brain activity between the left vs. right frontal areas, is thought to reflect approach versus avoidance motivation. This study (2012-2021) used functional Near Infrared Spectroscopy to investigate if infant (Mage = 7.63 months; N=90; n = 48 male; n = 75 White) FA in the dorsolateral prefrontal cortex relates to psychopathology in later childhood (Mage = 62.05 months). Greater right FA to happy faces was associated with increased internalizing (η2 = .09) and externalizing (η2 = .06) problems at age 5-years. Greater right FA to both happy and fearful faces was associated with an increased likelihood of a lifetime anxiety diagnosis (R2 > .13). FA may be an informative and early-emerging marker for psychopathology.	87/87	Primary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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