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The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

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Mechanisms Underlying Emotion Regulation Abnormalities in Youth at Clinical High-Risk for Psychosis #3307

General
Experiments (2)
Shared Data
Publications (32)
Data Expected (9)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Mechanisms Underlying Emotion Regulation Abnormalities in Youth at Clinical High-Risk for Psychosis
Collection Investigators:	Gregory Strauss
Collection Description:	Psychotic disorders are serious and debilitating mental illnesses that incur substantial suffering for patients and present major challenges to our health care system. Given that few individuals achieve recovery after the onset of a psychotic disorder, there is increasing interest in the early identification and prevention of psychosis. Psychotic disorders are typically preceded by a prodromal phase characterized by functional decline and subtle attenuated symptoms that progressively worsen over the course of several months to years. This period is of interest both as a window for investigating processes involved in disease onset and as a potential point of intervention and prevention. The stress-vulnerability model remains one of the leading theories on the origins of psychosis. However, dysfunctional HPA axis activity and heightened stress reactivity alone only modestly predicts conversion to psychosis among CHR youth and has not led to breakthroughs in prevention. To develop novel targets for early intervention, the current project aims to test the central hypothesis that abnormalities in emotion regulation i.e., the ability to use strategies to decrease the intensity or frequency of negative emotion are a vulnerability factor that increases risk for developing a psychotic disorder. We propose to conduct a comprehensive evaluation of emotion regulation through the lens of Gross extended process model of emotion regulation. This model proposes that emotion regulation involves a series of stages, including identification i.e., detecting emotion and determining whether to regulate, selection i.e., choosing a strategy, and implementation i.e., executing the selected strategy. Our preliminary data in adults with schizophrenia SZ indicates that abnormalities at each of these stages contribute to state fluctuations in hallucinations and delusions. The current application proposes to extend this finding to 50 CHR youth and 50 healthy controls who will complete a cross-sectional evaluation consisting of a multimodal battery of emotion regulation laboratory tasks behavior, electrophysiology, eye tracking, pupillometry and 6 days of ecological momentary assessment EMA that will be submitted to mathematical modeling. This data will be used to complete the following specific aims 1 To evaluate the stress-vulnerability model and test the hypothesis that attenuated psychotic experiences are temporally preceded by abnormalities in autonomic nervous system reactivity 2 To define which stages of emotion regulation are abnormal in CHR youth and identify moderators of each stage 3 To identify whether abnormalities at each of the stages of emotion regulation are predictive of psychosis risk and determine whether the combination of emotion regulation abnormalities and stress reactivity will predict psychosis risk more so than either variable alone. Findings resulting from this study will benefit early identification and prevention efforts by identifying specific emotion regulation processes that can be targeted in psychosocial interventions. Such interventions have proven effective for treating other disorders, but have not yet been evaluated in the schizophrenia-spectrum to determine efficacy for prevention.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	09/20/2019
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$415,250.00
Subjects Shared:	118
Collection DOI:	10.15154/tkac-j272

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R21MH119438-01	Mechanisms Underlying Emotion Regulation Abnormalities in Youth at Clinical High-Risk for Psychosis	09/09/2019	06/30/2021	06/30/2022	100	112	UNIVERSITY OF GEORGIA	$415,250.00

Clinical Trials:

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Collection - General Tab

Fields available for edit on the top portion of the page include:

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Collection Description
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During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
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In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

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Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
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The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
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ID	Name	Created Date	Status	Type
1508	Reappraisal and Distraction ERP Task	01/23/2020	Approved	EEG
1517	Reappraisal and Distraction Eye Tracking Task	01/27/2020	Approved	Eye Tracking

helpcenter.collection.experiments-tab

Collection - Experiments

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Shared Data:

Title	Type	Number of Subjects
EEG Form	Imaging	61
EEG Subject Files	Imaging	61
Emotion Regulation Digital Phenotyping Measure	Clinical Assessments	118
Eye Tracking Subject-Experiment	Imaging	68
Genomics Subject	Genomics	118
Global Functioning Scales	Clinical Assessments	55
Medical Demographics	Clinical Assessments	118
NAPLS Risk Calculator	Clinical Assessments	55
Negative Symptom Inventory - Psychosis Risk	Clinical Assessments	55
Research Subject	Clinical Assessments	118
Structured Interview for Prodromal Syndromes/Scale of Prodromal Symptoms	Clinical Assessments	55

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

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Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

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The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

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Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
42732427	Create Study	Subjective Perceptions of Digital Phenotyping Measures of Negative Symptoms Among Individuals At Clinical High Risk for Psychosis and Their Relatives.	Schizophrenia bulletin open	Zhang, Zhixin; Hutcheson, Ada L; Arnold, Lauren E; Carter, Zachary A; Barolette, Justin T; Luck, Josephine E; Kundert-Obando, Kimberly; Knippenberg, Anna R; Walker, Elaine F; Mittal, Vijay A; Strauss, Gregory P	January 1, 2026	Not Determined
42487730	Create Study	Psychosis Risk is Associated with Increased Multimodal Reports of Socially Salient Content in Degraded Stimuli.	Schizophrenia bulletin open	Pokorny, Victor; Williams, Trevor; Pratt, Danielle; Kenney, Joshua; Ellman, Lauren M; Strauss, Gregory P; Walker, Elaine F; Woods, Scott W; Powers, Albert R; Corlett, Philip R; Thompson, Judy L; Silverstein, Steven M; Waltz, James A; Gold, James M; Schiffman, Jason; Mittal, Vijay A	January 1, 2026	Not Determined
42475772	Create Study	The effect of monetary versus point-based rewards on effort-cost decision making in individuals at clinical high risk for psychosis.	Schizophrenia research	Anderson, Zachary; Pokorny, Victor; Kenney, Joshua; Gold, James M; Waltz, James A; Schiffman, Jason; Ellman, Lauren M; Walker, Elaine F; Corlett, Philip R; Woods, Scott W; Powers, Albert R; Silverstein, Steven M; Strauss, Gregory P; Mittal, Vijay A	October 1, 2026	Not Determined
42207669	Create Study	Humanizing "multimodal" digital phenotyping of serious mental illness.	Journal of psychopathology and clinical science	Cohen, Alex S; Masucci, Michael D; Granrud, Ole E; Warren, Kiara K; Corporandy, Aubree T; Zollicoffer, Ashley N; Strauss, Gregory P	August 1, 2026	Not Determined
41691110	Create Study	Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample.	Molecular psychiatry	Luther, Lauren; Cooper, Jessica A; Treadway, Michael T; Knippenberg, Anna R; Walker, Elaine F; Gold, James M; Waltz, James A; Schiffman, Jason; Ellman, Lauren M; Mittal, Vijay A; Zinbarg, Richard E; Silverstein, Steve M; Corlett, Philip R; Powers, Albert R; Woods, Scott W; Allen, Daniel N; Lahti, Adrienne C; Strauss, Gregory P	June 1, 2026	Not Determined
41212304	Create Study	Elevated defeatist performance beliefs predict state increases in negative symptoms in daily life in clinical high-risk for psychosis youth: implications for mobile health treatments.	European archives of psychiatry and clinical neuroscience	Luther, Lauren; Raugh, Ian M; Webber, Luca Bela G; Grant, Paul M; Beck, Aaron T; Mittal, Vijay A; Walker, Elaine; Strauss, Gregory P	September 1, 2026	Not Determined
41053030	Create Study	Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics.	Schizophrenia (Heidelberg, Germany)	Farina, Emily A; Mourgues-Codern, Catalina; Stimler, Katie; Kenney, Joshua; Saxena, Abhishek; Mukhtar, Hesham; Addington, Jean; Bearden, Carrie E; Cadenhead, Kristin S; Cannon, Tyrone D; Cornblatt, Barbara; Ellman, Lauren; Gold, James; Keshavan, Matcheri; Mathalon, Daniel H; Mittal, Vijay A; Perkins, Diana O; Schiffman, Jason; Silverstein, Steven M; Strauss, Gregory P; Stone, William S; Walker, Elaine F; Waltz, James; Corlett, Philip; Powers, Albert R; Woods, Scott W	October 6, 2025	Not Determined
40355455	Create Study	Increased face perception in individuals at clinical high-risk for psychosis: mechanisms, sex differences, and clinical correlates.	Schizophrenia (Heidelberg, Germany)	Tran, Tanya; Keane, Brian P; Thompson, Judy L; Robinson, Ben; Kenney, Joshua; Williams, Trevor F; Waltz, James A; Levin, Jason A; Kafadar, Eren; Gold, James M; Schiffman, Jason; Ellman, Lauren M; Walker, Elaine F; Strauss, Gregory P; Mittal, Vijay A; Zinbarg, Richard E; Corlett, Philip R; Powers, Albert R; Woods, Scott W; Silverstein, Steven M	May 12, 2025	Not Determined
40318309	Create Study	Digital phenotyping evidence for the reduced positivity offset as a mechanism underlying anhedonia among individuals at clinical high-risk for psychosis.	Schizophrenia research	Bartolomeo, Lisa A; James, Sydney H; Berglund, Alysia M; Raugh, Ian M; Mittal, Vijay A; Walker, Elaine F; Strauss, Gregory P	July 1, 2025	Not Determined
40285828	Create Study	Neurophysiological evidence for emotion regulation abnormalities in individuals at clinical high-risk for psychosis.	European archives of psychiatry and clinical neuroscience	Strauss, Gregory P; Bartolomeo, Lisa A; Ayawvi, Gifty	April 1, 2026	Not Determined
40193439	Create Study	Functional correlates of atypical visuoperceptual organization in a multisite clinical high-risk sample.	Journal of psychopathology and clinical science	Pokorny, Victor; Tran, Tanya; Williams, Trevor F; Kenney, Joshua; Silverstein, Steven M; Gold, James M; Waltz, James A; Schiffman, Jason; Ellman, Lauren M; Strauss, Gregory P; Walker, Elaine F; Woods, Scott W; Powers, Albert R; Corlett, Philip R; Mittal, Vijay A	July 1, 2025	Not Determined
40184931	Create Study	Interpersonal difficulties and suicidal ideation in young people at clinical high-risk for psychosis and help-seeking clinical controls.	Psychiatry research	Bailey, Annamarie; Bauer, Brian W; Mittal, Vijay A; Ellman, Lauren M; Strauss, Gregory P; Walker, Elaine F; Powers, Albert R; Kenney, Joshua; Corlett, Philip R; Woods, Scott W; Gold, James M; Schiffman, Jason; Waltz, James A; Silverstein, Steven M	June 1, 2025	Not Determined
40170392	Create Study	Digital Phenotyping Measurement of Smartphone Social Behavior is Associated with Illness Progression Risk Scores in Young People at Clinical High Risk for Psychosis.	Schizophrenia bulletin	Kuhney, Franchesca S; Strauss, Gregory P; Walker, Elaine F; James, Sydney H; Mittal, Vijay A	November 10, 2025	Not Determined
39749462	Create Study	Revisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis.	Schizophrenia bulletin	Luther, Lauren; Ahmed, Anthony O; Grant, Paul M; Granholm, Eric; Gold, James M; Williams, Trevor F; Pratt, Danielle; Holden, Jason; Walker, Elaine F; Arnold, Lauren; Ellman, Lauren M; Mittal, Vijay A; Zinbarg, Richard; Silverstein, Steve M; Corlett, Philip R; Powers, Albert R; Woods, Scott W; Waltz, James A; Schiffman, Jason; Strauss, Gregory P	November 10, 2025	Not Determined
37868160	Create Study	Comparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic.	Schizophrenia bulletin open	Pratt, Danielle N; Luther, Lauren; Kinney, Kyle S; Osborne, Kenneth Juston; Corlett, Philip R; Powers 3rd, Albert R; Woods, Scott W; Gold, James M; Schiffman, Jason; Ellman, Lauren M; Strauss, Gregory P; Walker, Elaine F; Zinbarg, Richard; Waltz, James A; Silverstein, Steven M; Mittal, Vijay A	January 1, 2023	Not Determined
37843512	Create Study	Integrating mindfulness into the extended process model of emotion regulation: The dual-mode model of mindful emotion regulation.	Emotion (Washington, D.C.)	Raugh, Ian M; Strauss, Gregory P	April 1, 2024	Not Determined
37716206	Create Study	Environmental resource reductions predict greater severity of negative symptoms in schizophrenia.	Schizophrenia research	Zhang, Luyu; James, Sydney H; Strauss, Gregory P	November 1, 2023	Not Determined
37467481	Create Study	Temporal Interactions Between Social Motivation and Behavior In Daily Life Among Individuals at Clinical High-Risk for Psychosis.	Schizophrenia bulletin	Strauss, Gregory P; Raugh, Ian M; Luther, Lauren; Walker, Elaine F; Mittal, Vijay A	September 7, 2023	Not Determined
37434396	Create Study	Racial differences in attenuated psychotic symptoms during the COVID-19 pandemic.	Early intervention in psychiatry	James, Sydney H; Strauss, Gregory P	February 1, 2024	Not Determined
37246568	Create Study	Environmental context predicts state fluctuations in negative symptoms in youth at clinical high risk for psychosis.	Psychological medicine	Luther, Lauren; Raugh, Ian M; Collins, Delaney E; Berglund, Alysia; Knippenberg, Anna R; Mittal, Vijay A; Walker, Elaine F; Strauss, Gregory P	December 1, 2023	Not Determined
37041742	Create Study	The association between early traumatic experiences and the five domains of negative symptoms in participants at clinical high risk for psychosis.	Early intervention in psychiatry	Ayawvi, Gifty; Berglund, Alysia M; James, Sydney H; Luther, Lauren; Walker, Elaine F; Mittal, Vijay A; Strauss, Gregory P	November 1, 2023	Not Determined
35597134	Create Study	Three prominent self-report risk measures show unique and overlapping utility in characterizing those at clinical high-risk for psychosis.	Schizophrenia research	Williams, Trevor F; Powers, Albert R; Ellman, Lauren M; Corlett, Philip R; Strauss, Gregory P; Schiffman, Jason; Waltz, James A; Silverstein, Steven M; Woods, Scott W; Walker, Elaine F; Gold, James M; Mittal, Vijay A	June 1, 2022	Not Determined
35362242	Create Study	Emotion regulation and social knowledge in youth at clinical high-risk for psychosis and outpatients with chronic schizophrenia: Associations with functional outcome and negative symptoms.	Early intervention in psychiatry	Macfie, William G; Spilka, Michael J; Bartolomeo, Lisa A; Gonzalez, Cristina M; Strauss, Gregory P	January 1, 2023	Not Determined
34334286	Create Study	Adherence to recommended health and social distancing precautions during the COVID-19 pandemic in individuals with schizophrenia and youth at clinical high-risk for psychosis.	Schizophrenia research	Macdonald, Kelsey I; Spilka, Michael J; Bartolomeo, Lisa A; Raugh, Ian M; Berglund, Alysia M; Strauss, Gregory P	May 1, 2022	Not Determined
34307899	Create Study	Computerized Assessment of Psychosis Risk.	Journal of psychiatry and brain science	Mittal, Vijay A; Ellman, Lauren M; Strauss, Gregory P; Walker, Elaine F; Corlett, Philip R; Schiffman, Jason; Woods, Scott W; Powers, Albert R; Silverstein, Steven M; Waltz, James A; Zinbarg, Richard; Chen, Shuo; Williams, Trevor; Kenney, Joshua; Gold, James M	January 1, 2021	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	100	01/15/2021	118	05/15/2021	118	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Medical History	100	01/15/2021	118	05/15/2021	118	Approved
Eye Tracking	70	01/15/2021	68	05/15/2021	68	Approved
Structured Interview for Prodromal Syndromes/Scale of Prodromal Symptoms	50	01/15/2021	55	05/15/2021	55	Approved
EEG	61	01/15/2021	61	05/15/2021	61	Approved
Global Functioning Scales	50	01/15/2021	55	05/15/2021	55	Approved
Negative Symptom Inventory - Psychosis Risk (NSI-PR)	50	01/15/2021	55	05/15/2021	55	Approved
Emotion Regulation Digital Phenotyping Measure	100	01/15/2021	118	05/15/2021	118	Approved
NAPLS Risk Calculator	50	01/15/2021	55	05/15/2021	55	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Morphosyntactic Speech Markers Are Associated With Anhedonia in Clinical High Risk for Psychosis: Evidence from the AMP®SCZ data release	10.15154/ffq5-2740	This study is a secondary analysis of AMP-SCZ Data Release 3.0. No data were generated by the investigators; all variables, including the language features, were obtained in already-processed form from the NIMH Data Archive under an approved Data Use Certification. The analysis addresses two questions. First, how far the elicitation protocol and transcript length determine the values of released morphosyntactic speech features, by comparing an open-ended conversational interview with the PSYCHS diagnostic interview in the same cohort. Second, whether any morphosyntactic feature is associated with clinician-rated anhedonia within clinical high-risk participants, independently of alogia, and whether such an association reflects stable differences between participants or change within participants over the two-month follow-up. All 102 released morphosyntactic features were converted to densities per word and standardised within protocol. Baseline group comparisons used ordinary least squares regression with and without log transcript length as a covariate, adjusting for age, sex and Full-Scale IQ. Symptom associations used random-intercept linear mixed-effects models across the two available waves, with each feature decomposed into a participant mean and a person-mean-centred deviation. Benjamini-Hochberg false-discovery-rate correction was applied across the 102-feature family within each analysis. Sensitivity analyses additionally modelled study site and non-linear length effects (quadratic and cubic-spline terms).	3/765	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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