NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

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¹ Numbers reported are subjects by age

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

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Developmental origins and early detection of ADHD and dysregulatory psychopathology #3779

General
Experiments (5)
Shared Data
Publications (31)
Data Expected (22)
Associated Studies (6)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Developmental origins and early detection of ADHD and dysregulatory psychopathology
Collection Investigators:	Joel Nigg
Collection Description:	The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral and emotional problems. To do so children are followed from before birth to 4.5 years of age on the cusp of school entry and well into the preschool period. ADHD and related problems with behavioral and emotional dysregulation are often not clinically identified until school age. By that point they are difficult to reverse. This proposal answers calls in the literature for earlier identification of risk and for discovery of early life mechanisms that can be targets for low-risk yet effective early life intervention to prevent the full onset of these problems. To do so we expand the study of an existing maternal-infant cohort by adding measures, time points, and an older outcome. We extend the cohort from the toddler years into the preschool period when psychopathology has begun to take shape and be able to be relatively reliably characterized. Key mechanisms to be examined are a biological signals in early life, focused on maternal inflammation and serotonergic metabolites during pregnancy and the trajectory of change in those signals in the first three years of life b brain development as indexed by EEG measures from birth to age 3 years lower cost and more readily clinically applicable than MRI at this stage and c behavioral dynamics in early caregiving, about which little is known regarding ADHD risk in the first 24 months of life. The inflammation hypothesis builds on striking preliminary data uncovered by the PIs in their prior work. The EEG metrics likewise are supported by preliminary evidence. The behavioral data also have strong preliminary data and build on multiple theorists proposals about the role of early emotional regulation in subsequent risk for dysregulatory psychopathology and ADHD. Both baseline intercept and change trajectory measures will be examined to help evaluate when in development a particular domain or level of analysis is most informative to subsequent outcome. Each of these hypotheses is examined in stand-alone fashion, and then with those findings in hand, an integrative developmental model will be tested. If successful the study will open new directions for low-risk yet potentially effective early intervention by identifying specific, measurable, and reversible risk factors or mechanisms as candidates for clinical trial follow up.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	12/28/2020
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$1,525,064.00
Subjects Shared:	0
Collection DOI:	10.15154/6d0y-sb76

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH124824-01	Developmental origins and early detection of ADHD and dysregulatory psychopathology	01/01/2021	10/31/2025	10/31/2025	270	268	OREGON HEALTH & SCIENCE UNIVERSITY	$1,525,064.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
3059	Resting Baseline (Bubbles)	09/03/2025	Approved	EEG
3060	Auditory Oddball	09/03/2025	Approved	EEG
3061	Arm Restraint	09/03/2025	Approved	EEG
3062	Mask Task	09/03/2025	Approved	EEG
3063	Still Face	09/03/2025	Approved	EEG

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

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helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
42536127	Create Study	Caregiver sensitivity moderates effects of gestational inflammation on child ADHD symptoms.	Journal of child psychology and psychiatry, and allied disciplines	Sullivan, Elinor L; Tipsord, Jessica M; Nousen, Elizabeth K; Williams, Julia; Shao, Sara; Duque, Diana Vazquez; Loftis, Jennifer M; Karalunas, Sarah L; Nigg, Joel T; Gustafsson, Hanna C	July 31, 2026	Not Determined
42437580	Create Study	The relationship between maternal adiposity during pregnancy and toddler ADHD symptoms is mediated by gestational inflammation.	Brain, behavior, and immunity	Gustafsson, Hanna C; Dunn, Geoffrey A; Loftis, Jennifer M; Karalunas, Sarah L; Nigg, Joel T; Sullivan, Elinor L	July 12, 2026	Not Determined
41215669	Create Study	Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect.	Journal of child psychology and psychiatry, and allied disciplines	Gustafsson, Hanna C; Wright, Hanna R; Schreeder, Jorden E Jacinto; Nigg, Joel T; Sullivan, Elinor L	June 1, 2026	Not Determined
40994922	Create Study	Honoring childhood agency in developmental research: Best practices, applications, and insights.	Methods in Psychology (Online)	Howery, Amanda N; Lashley, Olivia J; Wright, Hanna R; Williams, Julia L; Nomura, Olivia K; Lenne, Eline L; Wood, Elizabeth K; Gustafsson, Hanna C; Sullivan, Elinor L	December 1, 2025	Not Determined
40257895	Create Study	Reproducible structure with measurement invariance for the Parent-Report Early Adolescent Temperament Questionnaire: Findings from three independent samples.	Psychological assessment	Kozlowski, Michael B; Morton, Hannah E; Nigg, Joel T; Karalunas, Sarah L	May 1, 2025	Not Determined
40069302	Create Study	Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months.	Scientific reports	Wood, Elizabeth K; Nomura, Olivia; Ablow, Jennifer C; Elliot, Annaliese; Horgan, Angela; Nigg, Joel T; Gustafsson, Hanna C; Sullivan, Elinor L	March 11, 2025	Not Determined
39126821	Create Study	Capturing the complexity of child behavior and caregiver-child interactions in the HEALthy Brain and Child Development (HBCD) Study using a rigorous and equitable approach.	Developmental cognitive neuroscience	Edwards, Renee C; Planalp, Elizabeth M; Bosquet Enlow, Michelle; Akshoomoff, Natacha; Bodison, Stefanie C; Brennan, Marianne B; Ciciolla, Lucia; Eiden, Rina D; Fillipi, Courtney A; Gustafsson, Hanna C; McKelvey, Lorraine M; Morris, Amanda S; Peralta-Carcelén, Myriam; Poehlmann, Julie; Wakschlag, Lauren S; Wilson, Sylia; HBCD Child Behavior and Caregiver-Child Interactions Workgroup	October 1, 2024	Not Determined
38772428	Create Study	Adipokines measured during pregnancy and at birth are associated with infant negative affect.	Brain, behavior, and immunity	Sullivan, Elinor L; Molloy, Kelly R; Dunn, Geoffrey A; Balanzar, Adriana L; Young, Anna S; Loftis, Jennifer M; Ablow, Jennifer C; Nigg, Joel T; Gustafsson, Hanna C	August 1, 2024	Not Determined
38041982	Create Study	Assessment of substance exposures in nail clipping samples: A systematic review.	Drug and alcohol dependence	Bandoli, Gretchen; Anunziata, Florencia; Bogdan, Ryan; Zilverstand, Anna; Chaiyachati, Barbara H; Gurka, Kelly K; Sullivan, Elinor; Croff, Julie; Bakhireva, Ludmila N	January 1, 2024	Not Determined
37753147	Create Study	Delineating early developmental pathways to ADHD: Setting an international research agenda.	JCPP advances	Miller, Meghan; Arnett, Anne B; Shephard, Elizabeth; Charman, Tony; Gustafsson, Hanna C; Joseph, Heather M; Karalunas, Sarah; Nigg, Joel T; Polanczyk, Guilherme V; Sullivan, Elinor L; Jones, Emily J H	June 1, 2023	Not Relevant
37729720	Create Study	COVID-19 pandemic-related trauma symptoms are associated with postpartum alcohol consumption.	General hospital psychiatry	Doyle, Olivia; Wood, Elizabeth K; Sullivan, Elinor L; Mackiewicz-Seghete, Kristen; Graham, Alice; Gustafsson, Hanna C	January 1, 2023	Not Determined
37137940	Study (2069)	The association between food desert severity, socioeconomic status, and metabolic state during pregnancy in a prospective longitudinal cohort.	Scientific reports	Wood, Elizabeth K; Stamos, Gayle; Mitchell, A J; Gonoud, Rose; Horgan, Angela M; Nomura, Olivia; Young, Anna; Nigg, Joel T; Gustafsson, Hanna C; Sullivan, Elinor L	May 3, 2023	Relevant
37126061	Create Study	Considerations toward an epigenetic and common pathways theory of mental disorder.	Journal of psychopathology and clinical science	Nigg, Joel T	April 1, 2023	Not Relevant
36238202	Create Study	Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts.	Development and psychopathology	Gustafsson, Hanna C; Nolvi, Saara; Sullivan, Elinor L; Rasmussen, Jerod M; Gyllenhammer, Lauren E; Entringer, Sonja; Wadhwa, Pathik D; O'Connor, Thomas G; Karlsson, Linnea; Karlsson, Hasse; Korja, Riikka; Buss, Claudia; Graham, Alice M; Nigg, Joel T	December 1, 2021	Not Relevant
36188231	Create Study	Parsing ADHD with Temperament Traits.	Current directions in psychological science	Nigg, Joel	August 1, 2022	Not Determined
36174168	Create Study	Temperament in middle childhood questionnaire: New data on factor structure and applicability in a child clinical sample.	Psychological assessment	Kozlowski, Michael B; Antovich, Dylan; Karalunas, Sarah L; Nigg, Joel T	December 1, 2022	Not Relevant
35962855	Create Study	Geotemporal analysis of perinatal care changes and maternal mental health: an example from the COVID-19 pandemic.	Archives of women''s mental health	Hendrix, Cassandra L; Werchan, Denise; Lenniger, Carly; Ablow, Jennifer C; Amstadter, Ananda B; Austin, Autumn; Babineau, Vanessa; Bogat, G Anne; Cioffredi, Leigh-Anne; Conradt, Elisabeth; Crowell, Sheila E; Dumitriu, Dani; Elliott, Amy J; Fifer, William; Firestein, Morgan; Gao, Wei; Gotlib, Ian; Graham, Alice; Gregory, Kimberly D; Gustafsson, Hanna; Havens, Kathryn L; Hockett, Christine; Howell, Brittany R; Humphreys, Kathryn L; Jallo, Nancy; King, Lucy S; Kinser, Patricia A; Levendosky, Alytia A; Lonstein, Joseph S; Lucchini, Maristella; Marcus, Rachel; Monk, Catherine; Moyer, Sara; Muzik, Maria; Nuttall, Amy K; Potter, Alexandra S; Rogers, Cynthia; Salisbury, Amy; Shuffrey, Lauren C; Smith, Beth A; Smyser, Christopher D; Smith, Lynne; Sullivan, Elinor; Zhou, Judy; Brito, Natalie H; Thomason, Moriah E	October 1, 2022	Not Relevant
35935444	Create Study	The association between heightened ADHD symptoms and cytokine and fatty acid concentrations during pregnancy.	Frontiers in psychiatry	Gustafsson, Hanna C; Dunn, Geoffrey A; Mitchell, A J; Holton, Kathleen F; Loftis, Jennifer M; Nigg, Joel T; Sullivan, Elinor L	January 1, 2022	Not Relevant
35933504	Create Study	Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential.	Molecular diagnosis & therapy	Cecil, Charlotte A M; Nigg, Joel T	November 1, 2022	Not Relevant
35446163	Create Study	Impact of Fluoride on Associations between Free Sugars Intake and Dental Caries in US Children.	JDR clinical and translational research	Melough, M M; Sathyanarayana, S; Zohoori, F V; Gustafsson, H C; Sullivan, E L; Chi, D L; Levy, S M; McKinney, C M	July 1, 2023	Not Determined
35425871	Create Study	The Influence of Diet on Metabolism and Health Across the Lifespan in Nonhuman Primates.	Current opinion in endocrine and metabolic research	Wood, Elizabeth K; Sullivan, Elinor L	June 1, 2022	Not Relevant
35312046	Create Study	Electroencephalogram aperiodic power spectral slope can be reliably measured and predicts ADHD risk in early development.	Developmental psychobiology	Karalunas, Sarah L; Ostlund, Brendan D; Alperin, Brittany R; Figuracion, McKenzie; Gustafsson, Hanna C; Deming, Erika Michiko; Foti, Dan; Antovich, Dylan; Dude, Jason; Nigg, Joel; Sullivan, Elinor	April 1, 2022	Not Relevant
35277325	Create Study	COVID-19 in pregnancy: implications for fetal brain development.	Trends in molecular medicine	Shook, Lydia L; Sullivan, Elinor L; Lo, Jamie O; Perlis, Roy H; Edlow, Andrea G	April 1, 2022	Not Relevant
35217175	Create Study	Maternal diet and obesity shape offspring central and peripheral inflammatory outcomes in juvenile non-human primates.	Brain, behavior, and immunity	Dunn, Geoffrey A; Mitchell, A J; Selby, Matthew; Fair, Damien A; Gustafsson, Hanna C; Sullivan, Elinor L	May 1, 2022	Not Relevant
35075202	Create Study	Behavioral coping phenotypes and associated psychosocial outcomes of pregnant and postpartum women during the COVID-19 pandemic.	Scientific reports	Werchan, Denise M; Hendrix, Cassandra L; Ablow, Jennifer C; Amstadter, Ananda B; Austin, Autumn C; Babineau, Vanessa; Anne Bogat, G; Cioffredi, Leigh-Anne; Conradt, Elisabeth; Crowell, Sheila E; Dumitriu, Dani; Fifer, William; Firestein, Morgan R; Gao, Wei; Gotlib, Ian H; Graham, Alice M; Gregory, Kimberly D; Gustafsson, Hanna C; Havens, Kathryn L; Howell, Brittany R; Humphreys, Kathryn L; King, Lucy S; Kinser, Patricia A; Krans, Elizabeth E; Lenniger, Carly; Levendosky, Alytia A; Lonstein, Joseph S; Marcus, Rachel; Monk, Catherine; Moyer, Sara; Muzik, Maria; Nuttall, Amy K; Potter, Alexandra S; Salisbury, Amy; Shuffrey, Lauren C; Smith, Beth A; Smith, Lynne; Sullivan, Elinor L; Zhou, Judy; Thomason, Moriah E; Brito, Natalie H	January 24, 2022	Not Relevant

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	233	01/15/2022	570	10/21/2026	0	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Status
Perceived Stress Scale	233	01/15/2024	230	10/21/2026	Approved
Center for Epidemiologic Studies Depression Scale (CES-D)	233	07/15/2022	234	10/21/2026	Approved
Child Behavior Checklist (CBCL)	233	01/15/2024	211	10/21/2026	Approved
Ages and Stages Questionnaire	233	08/29/2023	153	10/21/2026	Approved
Difficulties in Emotion Regulation Scale	233	07/15/2023	230	10/21/2026	Approved
State-Trait Anxiety Inventory for Adults	233	07/15/2022	231	10/21/2026	Approved
ADHD Rating Scale	233	09/15/2025	192	10/21/2026	Approved
Multidimensional Scale of Perceived Social Support	233	01/15/2024	57	10/21/2026	Approved
Adult Self Report	233	07/15/2022	220	10/21/2026	Approved
Broad Psychopathology Form	233	07/15/2022	212	10/21/2026	Approved
Infant-Toddler Social-Emotional Assessment	233	07/15/2022	234	10/21/2026	Approved
Beck Anxiety Inventory	233	07/15/2022	229	10/21/2026	Approved
The Penn State Worry Questionnaire	233	07/15/2023	231	10/21/2026	Approved
EEG	233	07/15/2025	199	10/21/2026	Approved
Edinburgh Postnatal Depression Scale	233	01/15/2024	217	10/21/2026	Approved
Strengths and Weakness of ADHD Symptoms and Normal Behavior	233	08/29/2023	183	10/21/2026	Approved
Multidimensional Assessment of Preschool Disruptive Behavior	233	07/15/2022	240	10/21/2026	Approved
MacArthur Socioeconomic Status Questionnaire	233	01/15/2024	192	10/21/2026	Approved
Barkley Adult ADHD Rating Scale-IV (BAARS)	233	07/15/2024	339	10/21/2026	Approved
Quick Structured Clinical Interview for DSM-5 Disorders (Quick SCID-5)	270	01/15/2025	134	01/15/2026	Approved
Preschool Age Psychiatric Assessment (papa01)	233	05/31/2023	184	05/31/2024	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Adipokines measured during pregnancy and at birth are associated with infant negative affect	10.15154/94fs-tj13	Increased adiposity during pregnancy may be related to offspring risk for mental health disorders, although the biological mechanisms are poorly understood. One promising hypothesis is that factors secreted from adipocytes such as leptin and adiponectin may explain this association. The current study examined whether pregnancy or umbilical cord blood concentrations of leptin and/or adiponectin a) predict elevated infant negative affect at 6 months (an early life marker of risk for psychopathology); and b) help explain the association between pregnancy adiposity and increased infant negative affect. Data came from a prospective cohort (N = 305) of pregnant individuals and their offspring. Second trimester adiposity was assessed using air displacement plethysmography. Concentrations of leptin and adiponectin were measured in second trimester plasma and umbilical cord plasma. Infant negative affect was assessed by standardized observation at 6 months. Second trimester inflammation was assessed using a comprehensive panel of cytokines. Lower second trimester adiponectin was associated with elevated infant negative affect, and mediated the effect of pregnancy adiposity on infant negative affect. This association was independent of the effect of second trimester inflammation. Umbilical cord leptin also predicted higher infant negative affect and mediated the association between pregnancy adiposity and infant negative affect. This is the first study to link pregnancy adiponectin or cord blood leptin to infant markers of risk for psychopathology, and the first to demonstrate that these adipokines mediate the association between pregnancy adiposity and offspring behavioral outcomes, suggesting novel markers of risk and potential mechanisms of effect.	481/546	Primary Analysis	Shared
Gestational Kynurenine Metabolites Mediate Effects of Pregnancy Adiposity on Child Negative Affect	10.15154/t4s8-yz76	Background: Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions. We hypothesize that alterations in the kynurenine system of the pregnant person help to explain this association. Methods: Participants were recruited during pregnancy with repeated assessments through 24 months postpartum. Birthing parent adiposity was assessed using air displacement plethysmography. Liquid chromatography tandem mass spectrometry was used to measure kynurenine system metabolites in birthing parent plasma. Child negative affect was assessed using parent-report at 6, 12, and 24 months. Results: Participants (N=305) included birthing parents and their children (70% non-Hispanic White, 50% female). The ratio of Picolinic to Quinolinic Acid (PA:QA) predicted child fear (β=-.16, 95%CI -.28 to -.04, p=.009) and sadness (β=-.14, 95%CI -.28 to .01, p=.03) at 6 months. PA:QA mediated the effect of pregnancy adiposity on child fear (β=.03, bootstrapped 95%CI .004-.07, p=.04) and sadness (β=.04, bootstrapped 95%CI .002-.07, p=.05). Similar associations were observed when children were 12 and 24 months old, suggesting enduring effects. Conclusions: This is the first evidence that alterations in the kynurenine system during pregnancy are associated with increased child negative affectivity, an early life risk factor for psychopathology. Results further suggest that these kynurenine metabolites are a mechanistic link between pregnancy adiposity and child negative affect. Picolinic and Quinolinic Acid during pregnancy may be novel biomarkers for offspring behavioral risk, and novel targets for intervention.	483/545	Primary Analysis	Shared
Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months	10.15154/xpev-3j87	The dietary glycemic index (GI) reflects post-prandial plasma glucose generation rate, with higher-GI foods rapidly increasing blood sugar. Prenatal consumption of high-GI foods is associated with offspring risk for obesity and metabolic disorders. The impact of prenatal dietary GI exposure on infant neurodevelopment remains unclear. Maternal dietary intake, percent adiposity, and insulin resistance were prospectively assessed during the second and third trimesters in a sample of women with healthy, singleton pregnancies (N = 302). Infant negative affect was prospectively assessed at six months using observer ratings (Still Face Paradigm) and caregiver-reports (Infant-Behavior Questionnaire-Revised). Structural equation models assessed the independent effects of second and third trimester maternal dietary GI, adiposity, insulin resistance on infant negative affect, adjusted for relevant covariates. Higher third, but not second, trimester dietary GI was associated with increased observer-rated infant negative affect (β = 0.14, p = .04) and with higher caregiver-reported infant sadness (β = 0.17, p = .01), suggesting a programming effect of prenatal dietary GI on infant neurodevelopment. Targeted interventions that decrease dietary GI in later pregnancy may prove more effective for optimizing infant behavioral health compared to longer-term changes needed to alter metabolic state. Identifying modifiable early contributors to infant negative affect supports proactive strategies for mitigating future psychopathology risk.	481/544	Primary Analysis	Shared
The relationship between maternal adiposity during pregnancy and toddler ADHD symptoms is mediated by gestational inflammation	10.15154/g823-5744	Increased adiposity during pregnancy is associated with increased risk for child attention-deficit/hyperactivity disorder (ADHD), though few studies have examined the mechanisms responsible for conveying this risk. The current study tested whether increased inflammation during pregnancy was a statistical mediator of the association between maternal adiposity and child ADHD symptoms during toddlerhood. It also examined whether this association was independent of maternal distress and dietary quality during pregnancy, important confounding factors that have previously been linked with both pregnancy inflammation and child ADHD risk. Participants were N = 302 pregnant women and their children, assessed in the second trimester of pregnancy and at 2 years postpartum. Maternal adiposity was measured using air displacement plethysmography, dietary quality using the Health Eating Index (calculated using 24-hour dietary recalls), and maternal psychological distress via self-reported measures of depression, anxiety, and stress. Gestational inflammation was assessed in maternal blood during the second trimester using a comprehensive panel of cytokines. Child ADHD symptoms were measured using parent-report at 24 months. Maternal adiposity emerged as a particularly strong predictor of inflammation during pregnancy. Increased inflammation statistically mediated the association between maternal adiposity and child ADHD symptoms, independent of maternal distress, dietary quality, and other important confounds. This study reports evidence that increased gestational inflammation mediates the association between maternal adiposity during pregnancy and child ADHD symptoms. This indirect effect was observed to be independent of a number of prenatal and postnatal confounds, suggesting a robust and unique association. Results suggest that interventions that reduce inflammation during pregnancy may be helpful in reducing child ADHD risk, particularly in the context of increased maternal adiposity.	532/542	Primary Analysis	Shared
Trajectories of perinatal depressive symptoms in the context of the COVID-19 pandemic	10.15154/dkh0-9567	This study sought to advance understanding of the potential long-term consequences of the COVID-19 pandemic for child development by characterizing trajectories of maternal perinatal depression, a common and significant risk factor for adverse child outcomes. Data came from 393 women (86% White, 8% Latina; mean age = 33.51 years) recruited during pregnancy (n = 247; mean gestational age = 22.94 weeks) or during the first year postpartum (n = 146; mean child age = 4.50 months; 55% female). Rates of depression appear elevated, relative to published reports and to a pre-pandemic comparison group (N = 155). This study also provides evidence for subgroups of individuals who differ in their depressive symptom trajectories over the perinatal period. Subgroup membership was related to differences in maternal social support, but not to child birth outcomes. this NDA study/collection only covers the comparison group and does not contain the data for all cohorts and variables presented in the paper	236/282	Primary Analysis	Shared
The association between food desert severity, socioeconomic status, and metabolic state during pregnancy in a prospective longitudinal cohort	10.15154/1528786	Poor metabolic health during pregnancy is associated with health concerns for pregnant individuals and their offspring. Lower socioeconomic status (SES) is one risk factor for poor metabolic health, and may be related to limited access to healthful and affordable foods (e.g., living in a food desert). This study evaluates the respective contributions of SES and food desert severity on metabolic health during pregnancy. The food desert severity of 302 pregnant individuals was determined using the United States Department of Agriculture Food Access Research Atlas. SES was measured using total household income adjusted for household size, years of education, and amount of reserve savings. Information about participants’ glucose concentrations one hour following an oral glucose tolerance test during the second trimester was extracted from medical records and percent adiposity during the second trimester was assessed using air displacement plethysmography. Information about participants’ nutritional intake during the second trimester was obtained by trained nutritionists via three unannounced 24-h dietary recalls. Structural equation models showed that lower SES predicted higher food desert severity (β = − 0.20, p = 0.008) and higher adiposity (β = − 0.27, p = 0.016) and consumption of a more pro-inflammatory diet (β = − 0.25, p = 0.003) during the second trimester of pregnancy. Higher food desert severity also predicted higher percent adiposity during the second trimester (β = 0.17, p = 0.013). Food desert severity significantly mediated the relationship between lower SES and higher percent adiposity during the second trimester (βindirect = − 0.03, 95% CI [− 0.079, − 0.004]). These findings indicate that access to healthful and affordable foods is a mechanism by which SES contributes to adiposity during pregnancy and may inform interventions intended to improve metabolic health during pregnancy.	238/276	Primary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

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