NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

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Clinical Trial

¹ Numbers reported are subjects by age

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Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Discovery and CRISPR validation of genetic factors associated with antipsychotic-induced weight gain and cardiometabolic risk	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

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URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

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Structural Development of Human Fetal Brain #2508

General
Experiments (0)
Shared Data
Publications (48)
Data Expected (3)
Associated Studies (0)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Structural Development of Human Fetal Brain
Collection Investigators:	Hao Huang
Collection Description:	Despite its critical significance, little is known about the most dynamic phase of brain development in infancy 0-2 years. To change the status quo, comprehensive and quantitative infant brain atlases as reference standards for precision health are needed. In addition, diffusion MRI dMRI has entered a new era in which dynamic cortical internal microstructural complexity, indexed by e.g. cortical mean kurtosis derived from diffusion kurtosis imaging DKI, can be studied in the living infant brain noninvasively using more advanced multi-shell dMRI. Furthermore, multi-modality measures offer unparalleled insights into mechanistic structure function and structure-behavior relationships. Work in the current cycle has focused on structural development of human fetal and preterm brains. Based on high resolution diffusion tensor imaging DTI of 150 brains, we have established the atlases and quantified cortical microstructure with cortical fractional anisotropy, validated by histological images and correlated with transcriptomic RNA expression. Building upon this work, in the next cycle, we will focus on brain development in infancy, immediately after the fetal period. Specifically, the goal is to establish next-generation dMRI atlases quantitative U Penn-CHOP infant brain atlases and to harness a more advanced cortical microstructural mean kurtosis measurement by delineating its 4D spatiotemporal frameworks as well as uncovering its relationship to brain function and behavior during infancy 0-2 years. 160 typically developing infants at 1, 3, 6, 12, 18, 24 months will be recruited. Advanced connectome-quality multi-band high-resolution multi-shell dMRI, resting state fMRI rs-fMRI and structural MRI will be acquired. High-quality whole-head magnetoencephalography MEG will also be acquired. Anatomical labels of all 122 major gray and white matter structures will be built up based on high contrasts from DTI-derived maps. The measurements of DTI-derived metrics will be used for the quantitative components of DTI atlases and age-dependent white matter tract trajectories Aim 1. Mean kurtosis of the 4th order kurtosis tensor has been shown to be sensitive to cortical internal microstructural changes of infant brains. The spatiotemporal sensitivity of mean kurtosis measures to infant age and cortical region will be investigated Aim 2. Furthermore, we will establish mechanistic structure-function relationships with multimodality imaging, including not only multi-shell dMRI, but also rs-fMRI and MEG, all optimized for infant brains Aim 3. The quantitative infant brain atlases and normal developmental trajectories will provide reference standards for pre-diagnostic risk assessment, filling a gap towards precision health for infants e.g. Z-score maps. Infant cortical microstructure will be delineated noninvasively with 4D spatiotemporal frameworks. With multi-modality strength, the fundamental structure-function and structure-behavior mechanistic relations will set the stage for understanding aberrant brain development in neurodevelopmental disorders such as autistic spectrum disorder and intellectual disabilities in general.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	09/22/2016
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$2,673,477.00
Subjects Shared:	232
Collection DOI:	10.15154/5m6g-0s44

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Title	Start Date	Original End Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH092535-06	Structural Development of Human Fetal Brain	09/26/2016	08/31/2021	08/31/2024	160	235	CHILDRENS HOSP OF PHILADELPHIA	$2,673,477.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

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Shared Data:

Title	Type	Number of Subjects
Bayley-III Scales of Infant Development	Clinical Assessments	182
Research Subject	Clinical Assessments	232
Vineland I	Clinical Assessments	201

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
40008568	Create Study	Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.	Magnetic resonance in medicine	Jelescu, Ileana O; Grussu, Francesco; Ianus, Andrada; Hansen, Brian; Barrett, Rachel L C; Aggarwal, Manisha; Michielse, Stijn; Nasrallah, Fatima; Syeda, Warda; Wang, Nian; Veraart, Jelle; Roebroeck, Alard; Bagdasarian, Andrew F; Eichner, Cornelius; Sepehrband, Farshid; Zimmermann, Jan; Soustelle, Lucas; Bowman, Christien; Tendler, Benjamin C; Hertanu, Andreea; Jeurissen, Ben; Verhoye, Marleen; Frydman, Lucio; van de Looij, Yohan; Hike, David; Dunn, Jeff F; Miller, Karla; Landman, Bennett A; Shemesh, Noam; Anderson, Adam; McKinnon, Emilie; Farquharson, Shawna; Dell'Acqua, Flavio; Pierpaoli, Carlo; Drobnjak, Ivana; Leemans, Alexander; Harkins, Kevin D; Descoteaux, Maxime; Xu, Duan; Huang, Hao; Santin, Mathieu D; Grant, Samuel C; Obenaus, Andre; Kim, Gene S; Wu, Dan; Le Bihan, Denis; Blackband, Stephen J; Ciobanu, Luisa; Fieremans, Els; Bai, Ruiliang; Leergaard, Trygve B; Zhang, Jiangyang; Dyrby, Tim B; Johnson, G Allan; Cohen-Adad, Julien; Budde, Matthew D; Schilling, Kurt G	June 1, 2025	Not Determined
39733499	Create Study	The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance.	Developmental cognitive neuroscience	Otten, Katharina; Edgar, J Christopher; Green, Heather L; Mol, Kylie; McNamee, Marybeth; Kuschner, Emily S; Kim, Mina; Liu, Song; Huang, Hao; Nordt, Marisa; Konrad, Kerstin; Chen, Yuhan	January 1, 2025	Not Determined
39528363	Create Study	Machine-learning based prediction of future outcome using multimodal MRI during early childhood.	Seminars in fetal & neonatal medicine	Ouyang, Minhui; Whitehead, Matthew T; Mohapatra, Sovesh; Zhu, Tianjia; Huang, Hao	November 1, 2024	Not Determined
39414859	Create Study	Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy.	Nature communications	Ouyang, Minhui; Detre, John A; Hyland, Jessica L; Sindabizera, Kay L; Kuschner, Emily S; Edgar, J Christopher; Peng, Yun; Huang, Hao	October 17, 2024	Not Determined
39149463	Create Study	Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy.	Research square	Ouyang, Minhui; Detre, John A; Hyland, Jessica L; Sindabizera, Kay L; Kuschner, Emily S; Edgar, J Christopher; Peng, Yun; Huang, Hao	August 8, 2024	Not Determined
38645183	Create Study	Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy.	bioRxiv : the preprint server for biology	Ouyang, Minhui; Detre, John A; Hyland, Jessica L; Sindabizera, Kay L; Kuschner, Emily S; Edgar, J Christopher; Peng, Yun; Huang, Hao	April 11, 2024	Not Determined
38327782	Create Study	Development of sensorimotor-visual connectome gradient at birth predicts neurocognitive outcomes at 2 years of age.	iScience	Xia, Yunman; Zhao, Jianlong; Xu, Yuehua; Duan, Dingna; Xia, Mingrui; Jeon, Tina; Ouyang, Minhui; Chalak, Lina; Rollins, Nancy; Huang, Hao; He, Yong	February 16, 2024	Not Determined
38280508	Create Study	Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest.	Resuscitation	Kirschen, Matthew P; Ouyang, Minhui; Patel, Bhavesh; Berman, Jeffrey I; Burnett, Ryan; Berg, Robert A; Diaz-Arrastia, Ramon; Topjian, Alexis; Huang, Hao; Vossough, Arastoo	March 1, 2024	Not Determined
37906015	Create Study	Brain Growth Charts for Quantitative Analysis of Pediatric Clinical Brain MRI Scans with Limited Imaging Pathology.	Radiology	Schabdach, Jenna M; Schmitt, J Eric; Sotardi, Susan; Vossough, Arastoo; Andronikou, Savvas; Roberts, Timothy P; Huang, Hao; Padmanabhan, Viveknarayanan; Ortiz-Rosa, Alfredo; Gardner, Margaret; Covitz, Sydney; Bedford, Saashi A; Mandal, Ayan S; Chaiyachati, Barbara H; White, Simon R; Bullmore, Edward; Bethlehem, Richard A I; Shinohara, Russell T; Billot, Benjamin; Iglesias, J Eugenio; Ghosh, Satrajit; Gur, Raquel E; Satterthwaite, Theodore D; Roalf, David; Seidlitz, Jakob; Alexander-Bloch, Aaron; Lifespan Brain Chart Consortium	October 1, 2023	Not Determined
37178820	Create Study	Maturation of auditory cortex neural responses during infancy and toddlerhood.	NeuroImage	Chen, Yuhan; Green, Heather L; Putt, Mary E; Allison, Olivia; Kuschner, Emily S; Kim, Mina; Blaskey, Lisa; Mol, Kylie; McNamee, Marybeth; Bloy, Luke; Liu, Song; Huang, Hao; Roberts, Timothy P L; Edgar, J Christopher	July 15, 2023	Not Determined
37099224	Create Study	Automating Angle Measurements on Foot Radiographs in Young Children: Feasibility and Performance of a Convolutional Neural Network Model.	Journal of digital imaging	Patton, Daniella; Ghosh, Adarsh; Farkas, Amy; Sotardi, Susan; Francavilla, Michael; Venkatakrishna, Shyam; Bose, Saurav; Ouyang, Minhui; Huang, Hao; Davidson, Richard; Sze, Raymond; Nguyen, Jie	August 1, 2023	Not Determined
36897422	Create Study	A Patch-Based Deep Learning Approach for Detecting Rib Fractures on Frontal Radiographs in Young Children.	Journal of digital imaging	Ghosh, Adarsh; Patton, Daniella; Bose, Saurav; Henry, M Katherine; Ouyang, Minhui; Huang, Hao; Vossough, Arastoo; Sze, Raymond; Sotardi, Susan; Francavilla, Michael	August 1, 2023	Not Determined
36814791	Create Study	Editorial: Imaging the developing connectome of perinatal brain.	Frontiers in neuroscience	Wu, Dan; Zheng, Weihao; Grant, Patricia Ellen; Huang, Hao	January 1, 2023	Not Determined
36802807	Create Study	Deep learning-based prediction of rib fracture presence in frontal radiographs of children under two years of age: a proof-of-concept study.	The British journal of radiology	Ghosh, Adarsh; Bose, Saurav; Patton, Daniella; Kumar, Ishaan; Khalkhali, Vahid; Henry, M Katherine; Ouyang, Minhui; Huang, Hao; Vossough, Arastoo; Sze, Raymond W; Sotardi, Susan; Francavilla, Michael	April 1, 2023	Not Determined
36701153	Create Study	Association of Potentially Damaging De Novo Gene Variants With Neurologic Outcomes in Congenital Heart Disease.	JAMA network open	Morton, Sarah U; Norris-Brilliant, Ami; Cunningham, Sean; King, Eileen; Goldmuntz, Elizabeth; Brueckner, Martina; Miller, Thomas A; Thomas, Nina H; Liu, Chunyan; Adams, Heather R; Bellinger, David C; Cleveland, John; Cnota, James F; Dale, Anders M; Frommelt, Michele; Gelb, Bruce D; Grant, P Ellen; Goldberg, Caren S; Huang, Hao; Kuperman, Joshua M; Li, Jennifer S; McQuillen, Patrick S; Panigrahy, Ashok; Porter Jr, George A; Roberts, Amy E; Russell, Mark W; Seidman, Christine E; Tivarus, Madalina E; Anagnoustou, Evdokia; Hagler Jr, Donald J; Chung, Wendy K; Newburger, Jane W	January 3, 2023	Not Determined
36693116	Create Study	Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network.	eLife	Yu, Qinlin; Ouyang, Minhui; Detre, John; Kang, Huiying; Hu, Di; Hong, Bo; Fang, Fang; Peng, Yun; Huang, Hao	January 24, 2023	Not Determined
36577236	Create Study	Disrupted white matter microstructure correlates with impulsivity in children and adolescents with bipolar disorder.	Journal of psychiatric research	Zhu, Tianjia; Simonetti, Alessio; Ouyang, Minhui; Kurian, Sherin; Saxena, Johanna; Soares, Jair C; Saxena, Kirti; Huang, Hao	February 1, 2023	Not Determined
36313199	Create Study	A Simplified Paradigm of Late Gestation Transient Prenatal Hypoxia to Investigate Functional and Structural Outcomes from a Developmental Hypoxic Insult.	Bio-protocol	Gadra, Elyse C; Cristancho, Ana G	October 5, 2022	Not Determined
36028319	Create Study	Association Between Quantitative Diffusion-Weighted Magnetic Resonance Neuroimaging and Outcome After Pediatric Cardiac Arrest.	Neurology	Kirschen, Matthew P; Berman, Jeffrey I; Liu, Hongyan; Ouyang, Minhui; Mondal, Antara; Griffis, Heather; Levow, Cindee; Winters, Madeline; Lang, Shih-Shan; Huh, Jimmy; Huang, Hao; Berg, Robert A; Vossough, Arastoo; Topjian, Alexis	December 5, 2022	Not Determined
35388223	Create Study	Brain charts for the human lifespan.	Nature	Bethlehem, R A I; Seidlitz, J; White, S R; Vogel, J W; Anderson, K M; Adamson, C; Adler, S; Alexopoulos, G S; Anagnostou, E; Areces-Gonzalez, A; Astle, D E; Auyeung, B; Ayub, M; Bae, J; Ball, G; Baron-Cohen, S; Beare, R; Bedford, S A; Benegal, V; Beyer, F; Blangero, J; Blesa Cábez, M; Boardman, J P; Borzage, M; Bosch-Bayard, J F; Bourke, N; Calhoun, V D; Chakravarty, M M; Chen, C; Chertavian, C; Chetelat, G; Chong, Y S; Cole, J H; Corvin, A; Costantino, M; Courchesne, E; Crivello, F; Cropley, V L; Crosbie, J; Crossley, N; Delarue, M; Delorme, R; Desrivieres, S; Devenyi, G A; Di Biase, M A; Dolan, R; Donald, K A; Donohoe, G; Dunlop, K; Edwards, A D; Elison, J T; Ellis, C T; Elman, J A; Eyler, L; Fair, D A; Feczko, E; Fletcher, P C; Fonagy, P; Franz, C E; Galan-Garcia, L; Gholipour, A; Giedd, J; Gilmore, J H; Glahn, D C; Goodyer, I M; Grant, P E; Groenewold, N A; Gunning, F M; Gur, R E; Gur, R C; Hammill, C F; Hansson, O; Hedden, T; Heinz, A; Henson, R N; Heuer, K; Hoare, J; Holla, B; Holmes, A J; Holt, R; Huang, H; Im, K; Ipser, J; Jack Jr, C R; Jackowski, A P; Jia, T; Johnson, K A; Jones, P B; Jones, D T; Kahn, R S; Karlsson, H; Karlsson, L; Kawashima, R; Kelley, E A; Kern, S; Kim, K W; Kitzbichler, M G; Kremen, W S; Lalonde, F; Landeau, B; Lee, S; Lerch, J; Lewis, J D; Li, J; Liao, W; Liston, C; Lombardo, M V; Lv, J; Lynch, C; Mallard, T T; Marcelis, M; Markello, R D; Mathias, S R; Mazoyer, B; McGuire, P; Meaney, M J; Mechelli, A; Medic, N; Misic, B; Morgan, S E; Mothersill, D; Nigg, J; Ong, M Q W; Ortinau, C; Ossenkoppele, R; Ouyang, M; Palaniyappan, L; Paly, L; Pan, P M; Pantelis, C; Park, M M; Paus, T; Pausova, Z; Paz-Linares, D; Pichet Binette, A; Pierce, K; Qian, X; Qiu, J; Qiu, A; Raznahan, A; Rittman, T; Rodrigue, A; Rollins, C K; Romero-Garcia, R; Ronan, L; Rosenberg, M D; Rowitch, D H; Salum, G A; Satterthwaite, T D; Schaare, H L; Schachar, R J; Schultz, A P; Schumann, G; Schöll, M; Sharp, D; Shinohara, R T; Skoog, I; Smyser, C D; Sperling, R A; Stein, D J; Stolicyn, A; Suckling, J; Sullivan, G; Taki, Y; Thyreau, B; Toro, R; Traut, N; Tsvetanov, K A; Turk-Browne, N B; Tuulari, J J; Tzourio, C; Vachon-Presseau, É; Valdes-Sosa, M J; Valdes-Sosa, P A; Valk, S L; van Amelsvoort, T; Vandekar, S N; Vasung, L; Victoria, L W; Villeneuve, S; Villringer, A; Vértes, P E; Wagstyl, K; Wang, Y S; Warfield, S K; Warrier, V; Westman, E; Westwater, M L; Whalley, H C; Witte, A V; Yang, N; Yeo, B; Yun, H; Zalesky, A; Zar, H J; Zettergren, A; Zhou, J H; Ziauddeen, H; Zugman, A; Zuo, X N; 3R-BRAIN; AIBL; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Repository Without Borders Investigators; CALM Team; Cam-CAN; CCNP; COBRE; cVEDA; ENIGMA Developmental Brain Age Working Group; Developing Human Connectome Project; FinnBrain; Harvard Aging Brain Study; IMAGEN; KNE96; Mayo Clinic Study of Aging; NSPN; POND; PREVENT-AD Research Group; VETSA; Bullmore, E T; Alexander-Bloch, A F	April 1, 2022	Not Determined
35279653	Create Study	Deficits in Seizure Threshold and Other Behaviors in Adult Mice without Gross Neuroanatomic Injury after Late Gestation Transient Prenatal Hypoxia.	Developmental neuroscience	Cristancho, Ana G; Gadra, Elyse C; Samba, Ima M; Zhao, Chenying; Ouyang, Minhui; Magnitsky, Sergey; Huang, Hao; Viaene, Angela N; Anderson, Stewart A; Marsh, Eric D	January 1, 2022	Not Determined
35237118	Create Study	Flattened Structural Network Changes and Association of Hyperconnectivity With Symptom Severity in 2-7-Year-Old Children With Autism.	Frontiers in neuroscience	Ouyang, Minhui; Peng, Yun; Sotardi, Susan; Hu, Di; Zhu, Tianjia; Cheng, Hua; Huang, Hao	January 1, 2021	Not Determined
34331117	Create Study	Single-direction diffusion-weighted imaging may be a simple complementary sequence for evaluating fetal corpus callosum.	European radiology	Sun, Cong; Zhang, Xinjuan; Chen, Xin; Zhu, Tianjia; Chen, Yufan; Zhu, Jinxia; Huang, Hao; Wang, Guangbin	February 1, 2022	Not Determined
34225373	Create Study	Cerebral Blood Flow of the Neonatal Brain after Hypoxic-Ischemic Injury.	American journal of perinatology	Tierradentro-García, Luis Octavio; Saade-Lemus, Sandra; Freeman, Colbey; Kirschen, Matthew; Huang, Hao; Vossough, Arastoo; Hwang, Misun	April 1, 2023	Not Determined
33836056	Create Study	Association between Quantitative MR Markers of Cortical Evolving Organization and Gene Expression during Human Prenatal Brain Development.	Cerebral cortex (New York, N.Y. : 1991)	Vasung, Lana; Zhao, Chenying; Barkovich, Matthew; Rollins, Caitlin K; Zhang, Jennings; Lepage, Claude; Corcoran, Teddy; Velasco-Annis, Clemente; Yun, Hyuk Jin; Im, Kiho; Warfield, Simon Keith; Evans, Alan Charles; Huang, Hao; Gholipour, Ali; Grant, Patricia Ellen	July 5, 2021	Not Determined
33571846	Create Study	Maturation of hemispheric specialization for face encoding during infancy and toddlerhood.	Developmental cognitive neuroscience	Chen, Yuhan; Slinger, Michelle; Edgar, J Christopher; Bloy, Luke; Kuschner, Emily S; Kim, Mina; Green, Heather L; Chiang, Taylor; Yount, Tess; Liu, Song; Lebus, Jill; Lam, Samantha; Stephen, Julia M; Huang, Hao; Roberts, Timothy P L	April 1, 2021	Not Determined
33350380	Create Study	Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds.	eLife	Ouyang, Minhui; Peng, Qinmu; Jeon, Tina; Heyne, Roy; Chalak, Lina; Huang, Hao	December 22, 2020	Not Determined
33102411	Create Study	Cerebral Pulsed Arterial Spin Labeling Perfusion Weighted Imaging Predicts Language and Motor Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.	Frontiers in pediatrics	Zheng, Qiang; Martin-Saavedra, Juan Sebastian; Saade-Lemus, Sandra; Vossough, Arastoo; Zuccoli, Giulio; Gonçalves, Fabrício Guimarães; Freeman, Colbey W; Ouyang, Minhui; Singh, Varun; Padula, Michael A; Demauro, Sara B; Flibotte, John; Eichenwald, Eric C; Detre, John A; Sze, Raymond Wang; Huang, Hao; Hwang, Misun	January 1, 2020	Not Determined
33058286	Create Study	Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.	Magnetic resonance in medicine	Zhu, Tianjia; Peng, Qinmu; Ouyang, Austin; Huang, Hao	April 1, 2021	Not Determined
32593397	Create Study	Regularized-Ncut: Robust and homogeneous functional parcellation of neonate and adult brain networks.	Artificial intelligence in medicine	Peng, Qinmu; Ouyang, Minhui; Wang, Jiaojian; Yu, Qinlin; Zhao, Chenying; Slinger, Michelle; Li, Hongming; Fan, Yong; Hong, Bo; Huang, Hao	June 2020	Not Determined
31819951	Create Study	Differential White Matter Maturation from Birth to 8 Years of Age.	Cerebral cortex (New York, N.Y. : 1991)	Yu, Qinlin; Peng, Yun; Kang, Huiying; Peng, Qinmu; Ouyang, Minhui; Slinger, Michelle; Hu, Di; Shou, Haochang; Fang, Fang; Huang, Hao	April 2020	Not Determined
31473353	Create Study	Imaging baby brain development.	NeuroImage	Huang, Hao; Huppi, Petra S; He, Yong; Lerch, Jason	December 1, 2019	Not Determined
31038246	Create Study	Characterization of MRI techniques to assess neonatal brain oxygenation and blood flow.	NMR in biomedicine	Liu P, Parkinson C, Jiang D, Ouyang M, De Vis JB, Northington FJ, Tekes A, Huang H, Huisman TAGM, Golden WC	July 2019	Not Determined
30782802	Create Study	Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging.	Proceedings of the National Academy of Sciences of the United States of America	Ouyang M, Jeon T, Sotiras A, Peng Q, Mishra V, Halovanic C, Chen M, Chalak L, Rollins N, Roberts TPL, Davatzikos C, Huang H	March 2019	Not Determined
30534949	Create Study	Development and Emergence of Individual Variability in the Functional Connectivity Architecture of the Preterm Human Brain.	Cerebral cortex (New York, N.Y. : 1991)	Xu, Yuehua; Cao, Miao; Liao, Xuhong; Xia, Mingrui; Wang, Xindi; Jeon, Tina; Ouyang, Minhui; Chalak, Lina; Rollins, Nancy; Huang, Hao; He, Yong	September 13, 2019	Not Determined
29959046	Create Study	Age-specific gray and white matter DTI atlas for human brain at 33, 36 and 39 postmenstrual weeks.	NeuroImage	Feng, Lei; Li, Hang; Oishi, Kenichi; Mishra, Virendra; Song, Limei; Peng, Qinmu; Ouyang, Minhui; Wang, Jiaojian; Slinger, Michelle; Jeon, Tina; Lee, Lizette; Heyne, Roy; Chalak, Lina; Peng, Yun; Liu, Shuwei; Huang, Hao	January 2019	Not Determined
29913282	Create Study	Structural network maturation of the preterm human brain.	NeuroImage	Zhao, Tengda; Mishra, Virendra; Jeon, Tina; Ouyang, Minhui; Peng, Qinmu; Chalak, Lina; Wisnowski, Jessica Lee; Heyne, Roy; Rollins, Nancy; Shu, Ni; Huang, Hao	January 2019	Not Determined
29655938	Create Study	Delineation of early brain development from fetuses to infants with diffusion MRI and beyond.	NeuroImage	Ouyang, Minhui; Dubois, Jessica; Yu, Qinlin; Mukherjee, Pratik; Huang, Hao	January 2019	Not Determined
29625234	Create Study	Baby brain atlases.	NeuroImage	Oishi, Kenichi; Chang, Linda; Huang, Hao	January 2019	Not Determined
29081731	Create Study	Human Fetal Brain Connectome: Structural Network Development from Middle Fetal Stage to Birth.	Frontiers in neuroscience	Song, Limei; Mishra, Virendra; Ouyang, Minhui; Peng, Qinmu; Slinger, Michelle; Liu, Shuwei; Huang, Hao	January 2017	Not Determined
29024679	Create Study	Short-range connections in the developmental connectome during typical and atypical brain maturation.	Neuroscience and biobehavioral reviews	Ouyang, Minhui; Kang, Huiying; Detre, John A; Roberts, Timothy P L; Huang, Hao	December 2017	Not Determined
28684174	Create Study	Developmental Connectomics from Infancy through Early Childhood.	Trends in neurosciences	Cao, Miao; Huang, Hao; He, Yong	August 2017	Not Determined
28634624	Create Study	Population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space.	Brain structure & function	Feng, Lei; Jeon, Tina; Yu, Qiaowen; Ouyang, Minhui; Peng, Qinmu; Mishra, Virendra; Pletikos, Mihovil; Sestan, Nenad; Miller, Michael I; Mori, Susumu; Hsiao, Steven; Liu, Shuwei; Huang, Hao	December 2017	Not Relevant
28604606	Create Study	Evaluation of Visual-Evoked Cerebral Metabolic Rate of Oxygen as a Diagnostic Marker in Multiple Sclerosis.	Brain sciences	Hubbard, Nicholas A; Sanchez Araujo, Yoel; Caballero, Camila; Ouyang, Minhui; Turner, Monroe P; Himes, Lyndahl; Faghihahmadabadi, Shawheen; Thomas, Binu P; Hart, John; Huang, Hao; Okuda, Darin T; Rypma, Bart	June 11, 2017	Not Relevant
28496398	Create Study	Growth of Thalamocortical Fibers to the Somatosensory Cortex in the Human Fetal Brain.	Frontiers in neuroscience	Krsnik, Željka; Majić, Visnja; Vasung, Lana; Huang, Hao; Kostović, Ivica	2017	Not Relevant
27988320	Create Study	Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI.	NeuroImage	Ouyang, Minhui; Liu, Peiying; Jeon, Tina; Chalak, Lina; Heyne, Roy; Rollins, Nancy K; Licht, Daniel J; Detre, John A; Roberts, Timothy P L; Lu, Hanzhang; Huang, Hao	February 2017	Not Determined
26941380	Create Study	Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain.	Cerebral cortex (New York, N.Y. : 1991)	Cao, Miao; He, Yong; Dai, Zhengjia; Liao, Xuhong; Jeon, Tina; Ouyang, Minhui; Chalak, Lina; Bi, Yanchao; Rollins, Nancy; Dong, Qi; Huang, Hao	March 2017	Not Determined
26405055	Create Study	Structural Development of Human Fetal and Preterm Brain Cortical Plate Based on Population-Averaged Templates.	Cerebral cortex (New York, N.Y. : 1991)	Yu, Qiaowen; Ouyang, Austin; Chalak, Lina; Jeon, Tina; Chia, Jonathan; Mishra, Virendra; Sivarajan, Muraleedharan; Jackson, Greg; Rollins, Nancy; Liu, Shuwei; Huang, Hao	October 17, 2016	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	165	01/15/2018	232	05/15/2018	232	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Bayley Scales of Infant and Toddler Development, Third Edition (BSID)	165	07/15/2018	182	11/15/2018	182	Approved
Vineland (Parent and Caregiver)	187	01/15/2018	201	05/15/2018	201	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	DOIFilter by DOI	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
No records found.

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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Glossary