NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

Use/Modify Existing Data Structure

Request New Data Structure

Targeted Enrollment:

Initial Submission Date:

Initial Share Date:

Data Structure Search:

Data Structures:

Submit

Request Submission Exemption

Not Eligible

The Data Expected list for this Collection shows some raw data as missing. Contact the NDA Help Desk with any questions.

Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

[CMS] Error

[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

You have requested to move the sharing dates for the following assessments:

Data Expected Item	Original Sharing Date	New Sharing Date

Please provide a reason for this change, which will be sent to the Program Officers listed within this collection:

Explanation must be between 20 and 200 characters in length.

Please press Save or Cancel

Study of early brain alterations that predict development of chronic PTSD #2541

General
Experiments (4)
Shared Data
Publications (23)
Data Expected (29)
Associated Studies (13)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Study of early brain alterations that predict development of chronic PTSD
Collection Investigators:	Xin Wang
Collection Description:	Millions of Americans survive traumatic events 1. Symptom trajectories over the initial year after trauma can lead to development of chronic post-traumatic stress disorder PTSD or to a recovery free of PTSD 2-16. Neuroimaging studies indicate chronic PTSD symptoms are associated with changes in brain function and structure 17-32 consequently, recognition of early post-trauma brain changes provides an opportunity to predict chronic PTSD 33-35. Identification of brain changes that underlie post-trauma symptom progressions will also provide insight into mechanisms that distinguish PTSD development from PTSD free recovery 27, 36- 38. Surprisingly, progressive brain changes early after trauma have rarely been studied in trauma survivors who subsequently develop PTSD 33, 34. Recent results from the PIs R21 grant provide indications of both early and progressive brain differences in trauma survivors who were subsequently diagnosed with PTSD at 3 months as compared to non-PTSD survivors. These differences include smaller volumes of left hippocampus HC and rostral anterior cingulate cortex rACC and greater prefrontal cortex PFC activation to an fMRI emotion appraisal task within 10 days after trauma. Furthermore, in survivors who developed PTSD at 3 months, progressive decreases in PFC structure and fear appraisal activation and increases in emotional responses in insular cortex IC were found over 3 months. Based on these findings we developed a working hypothesis on early and progressive emotion circuit changes that lead to PTSD development. To test this hypothesis, we propose to use a cohort of trauma survivors to identify early and progressive brain changes that contribute to, and that can be used to predict, chronic PTSD. Trauma survivors recruited in Emergency Departments EDs will be longitudinally studied, starting within 2 weeks and out to 1 year after trauma. Functional MRI fMRI activation associated with processing, memory, and regulation of negative emotions will be studied in PTSD and non-PTSD trauma survivors using Shifted- attention Emotion Appraisal SEAT and Fear Conditioning FCT tasks. Structural MRI sMRI will examine structures in brain emotion circuits. Early brain functional and structural differences and symptoms in survivors who do versus do not develop PTSD at 1 year after trauma will be identified and analyzed using machine learning approaches to predict PTSD versus non-PTSD outcomes. Differences over time in brain function and structure in PTSD and non-PTSD survivors will be identified, and associations between these differences and progressions of symptoms will be examined. The proposed work fills an important gap in current understanding by identifying early and progressive brain changes that contribute to PTSD development. Our approach can serve to identify brain-based markers for PTSD development and to identify trauma survivors at high risk for chronic PTSD.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	09/30/2016
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$2,128,851.00
Subjects Shared:	291

{"values":[]}

Loading Chart...

Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

File Name	File Type	Description	Audience
QA-notification.txt	Other	Quality Assurance Notification	Qualified Researchers

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH110483-01	Study of early brain alterations that predict development of chronic PTSD	09/23/2016	06/30/2021	283	283	UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS	$2,128,851.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
1569	Fear Conditioning Task	06/25/2020	Approved	fMRI
1570	Shifted-attention Emotion Appraisal Task (SEAT)	06/25/2020	Approved	fMRI
2006	Resting State fMRI	05/13/2022	Approved	fMRI
2014	EEfRT-UToledo	06/03/2022	Approved	fMRI

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Childhood Trauma Questionnaire	Clinical Assessments	224
Mini International Neuropsychiatric Interview. Part I	Clinical Assessments	90
Short Form Health Survey	Clinical Assessments	102

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38298781	Create Study	Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium.	Biological psychiatry global open science	Suarez-Jimenez, Benjamin; Lazarov, Amit; Zhu, Xi; Zilcha-Mano, Sigal; Kim, Yoojean; Marino, Claire E; Rjabtsenkov, Pavel; Bavdekar, Shreya Y; Pine, Daniel S; Bar-Haim, Yair; Larson, Christine L; Huggins, Ashley A; Terri deRoon-Cassini; Tomas, Carissa; Fitzgerald, Jacklynn; Kennis, Mitzy; Varkevisser, Tim; Geuze, Elbert; Quidé, Yann; El Hage, Wissam; Wang, Xin; O'Leary, Erin N; Cotton, Andrew S; Xie, Hong; Shih, Chiahao; Disner, Seth G; Davenport, Nicholas D; Sponheim, Scott R; Koch, Saskia B J; Frijling, Jessie L; Nawijn, Laura; van Zuiden, Mirjam; Olff, Miranda; Veltman, Dick J; Gordon, Evan M; May, Geoffery; Nelson, Steven M; Jia-Richards, Meilin; Neria, Yuval; Morey, Rajendra A	January 1, 2024	Not Determined
38076693	Create Study	Changes in fear-associated learning task brain activation over the COVID-19 pandemic period: a preliminary longitudinal analysis.	Frontiers in psychiatry	Popovich, Claire; Grau, Aaron S; Shih, Chia-Hao; Chidiac, Neejad T; Zhou, Adrian; Wang, Xin; Xie, Hong	January 1, 2023	Not Determined
37542036	Create Study	Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma.	Translational psychiatry	Xie, Hong; Shih, Chia-Hao; Aldoohan, Sulaiman D; Wall, John T; Wang, Xin	August 4, 2023	Relevant
37283956	Create Study	Association of age of adverse childhood experiences with thalamic volumes and post-traumatic stress disorder in adulthood.	Frontiers in behavioral neuroscience	Huffman, Nickelas; Shih, Chia-Hao; Cotton, Andrew S; Lewis, Terrence J; Grider, Stephen; Wall, John T; Wang, Xin; Xie, Hong	January 1, 2023	Relevant
37096440	Create Study	Emotion dysregulation mediates the association between acute sleep disturbance and later posttraumatic stress symptoms in trauma exposed adults.	European journal of psychotraumatology	Zhou, Adrian; McDaniel, Mitchell; Hong, Xie; Mattin, Michael; Wang, Xin; Shih, Chia-Hao	January 1, 2023	Relevant
36700253	Create Study	Early self-reported post-traumatic stress symptoms after trauma exposure and associations with diagnosis of post-traumatic stress disorder at 3 months: latent profile analysis.	BJPsych open	Shih, Chia-Hao; Zhou, Adrian; Grider, Stephen; Xie, Hong; Wang, Xin; Elhai, Jon D	January 26, 2023	Relevant
35917919	Create Study	A comparison of methods to harmonize cortical thickness measurements across scanners and sites.	NeuroImage	Sun, Delin; Rakesh, Gopalkumar; Haswell, Courtney C; Logue, Mark; Baird, C Lexi; O'Leary, Erin N; Cotton, Andrew S; Xie, Hong; Tamburrino, Marijo; Chen, Tian; Dennis, Emily L; Jahanshad, Neda; Salminen, Lauren E; Thomopoulos, Sophia I; Rashid, Faisal; Ching, Christopher R K; Koch, Saskia B J; Frijling, Jessie L; Nawijn, Laura; van Zuiden, Mirjam; Zhu, Xi; Suarez-Jimenez, Benjamin; Sierk, Anika; Walter, Henrik; Manthey, Antje; Stevens, Jennifer S; Fani, Negar; van Rooij, Sanne J H; Stein, Murray; Bomyea, Jessica; Koerte, Inga K; Choi, Kyle; van der Werff, Steven J A; Vermeiren, Robert R J M; Herzog, Julia; Lebois, Lauren A M; Baker, Justin T; Olson, Elizabeth A; Straube, Thomas; Korgaonkar, Mayuresh S; Andrew, Elpiniki; Zhu, Ye; Li, Gen; Ipser, Jonathan; Hudson, Anna R; Peverill, Matthew; Sambrook, Kelly; Gordon, Evan; Baugh, Lee; Forster, Gina; Simons, Raluca M; Simons, Jeffrey S; Magnotta, Vincent; Maron-Katz, Adi; du Plessis, Stefan; Disner, Seth G; Davenport, Nicholas; Grupe, Daniel W; Nitschke, Jack B; deRoon-Cassini, Terri A; Fitzgerald, Jacklynn M; Krystal, John H; Levy, Ifat; Olff, Miranda; Veltman, Dick J; Wang, Li; Neria, Yuval; De Bellis, Michael D; Jovanovic, Tanja; Daniels, Judith K; Shenton, Martha; van de Wee, Nic J A; Schmahl, Christian; Kaufman, Milissa L; Rosso, Isabelle M; Sponheim, Scott R; Hofmann, David Bernd; Bryant, Richard A; Fercho, Kelene A; Stein, Dan J; Mueller, Sven C; Hosseini, Bobak; Phan, K Luan; McLaughlin, Katie A; Davidson, Richard J; Larson, Christine L; May, Geoffrey; Nelson, Steven M; Abdallah, Chadi G; Gomaa, Hassaan; Etkin, Amit; Seedat, Soraya; Harpaz-Rotem, Ilan; Liberzon, Israel; van Erp, Theo G M; Quidé, Yann; Wang, Xin; Thompson, Paul M; Morey, Rajendra A	November 1, 2022	Not Relevant
35503040	Create Study	Effects of acute pain medications on posttraumatic stress symptoms in early aftermath of trauma.	International clinical psychopharmacology	Grau, Aaron S; Xie, Hong; Redfern, Roberta E; Moussa, Mohamad; Wang, Xin; Shih, Chia-Hao	September 1, 2022	Relevant
35452754	Create Study	Longitudinal PTSD symptom trajectories: Relative contributions of state anxiety, depression, and emotion dysregulation.	Journal of affective disorders	Rooney, Emily A; Hallauer, Caleb J; Xie, Hong; Shih, Chia-Hao; Rapport, Daniel; Elhai, Jon D; Wang, Xin	July 1, 2022	Relevant
35307575	Create Study	Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Sun, Delin; Rakesh, Gopalkumar; Clarke-Rubright, Emily K; Haswell, Courtney C; Logue, Mark W; O'Leary, Erin N; Cotton, Andrew S; Xie, Hong; Dennis, Emily L; Jahanshad, Neda; Salminen, Lauren E; Thomopoulos, Sophia I; Rashid, Faisal M; Ching, Christopher R K; Koch, Saskia B J; Frijling, Jessie L; Nawijn, Laura; van Zuiden, Mirjam; Zhu, Xi; Suarez-Jimenez, Benjamin; Sierk, Anika; Walter, Henrik; Manthey, Antje; Stevens, Jennifer S; Fani, Negar; van Rooij, Sanne J H; Stein, Murray B; Bomyea, Jessica; Koerte, Inga; Choi, Kyle; van der Werff, Steven J A; Vermeiren, Robert R J M; Herzog, Julia I; Lebois, Lauren A M; Baker, Justin T; Ressler, Kerry J; Olson, Elizabeth A; Straube, Thomas; Korgaonkar, Mayuresh S; Andrew, Elpiniki; Zhu, Ye; Li, Gen; Ipser, Jonathan; Hudson, Anna R; Peverill, Matthew; Sambrook, Kelly; Gordon, Evan; Baugh, Lee A; Forster, Gina; Simons, Raluca M; Simons, Jeffrey S; Magnotta, Vincent A; Maron-Katz, Adi; du Plessis, Stefan; Disner, Seth G; Davenport, Nicholas D; Grupe, Dan; Nitschke, Jack B; deRoon-Cassini, Terri A; Fitzgerald, Jacklynn; Krystal, John H; Levy, Ifat; Olff, Miranda; Veltman, Dick J; Wang, Li; Neria, Yuval; De Bellis, Michael D; Jovanovic, Tanja; Daniels, Judith K; Shenton, Martha E; van de Wee, Nic J A; Schmahl, Christian; Kaufman, Milissa L; Rosso, Isabelle M; Sponheim, Scott R; Hofmann, David Bernd; Bryant, Richard A; Fercho, Kelene A; Stein, Dan J; Mueller, Sven C; Phan, K Luan; McLaughlin, Katie A; Davidson, Richard J; Larson, Christine; May, Geoffrey; Nelson, Steven M; Abdallah, Chadi G; Gomaa, Hassaan; Etkin, Amit; Seedat, Soraya; Harpaz-Rotem, Ilan; Liberzon, Israel; Wang, Xin; Thompson, Paul M; Morey, Rajendra A	September 1, 2022	Not Relevant
34864509	Create Study	Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.	Psychiatry research. Neuroimaging	Xie, Hong; Huffman, Nickelas; Shih, Chia-Hao; Cotton, Andrew S; Buehler, Mark; Brickman, Kristopher R; Wall, John T; Wang, Xin	January 1, 2022	Relevant
34246885	Create Study	Fear of pain as a predictor of concurrent and downstream PTSD symptoms.	Journal of anxiety disorders	Barbano, Anna C; Tull, Matthew T; Christ, Nicole M; Xie, Hong; Kaminski, Brian; Wang, Xin	August 1, 2021	Relevant
33721659	Create Study	Dispositional optimism mediates relations between childhood maltreatment and PTSD symptom severity among trauma-exposed adults.	Child abuse & neglect	Chen, Jenny; Christ, Nicole M; Shih, Chia-Hao; Xie, Hong; Grider, Stephen R; Lewis, Chandani; Elhai, Jon D; Wang, Xin	May 1, 2021	Relevant
33409819	Create Study	Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.	Brain imaging and behavior	Tate, David F; Dennis, Emily L; Adams, John T; Adamson, Maheen M; Belanger, Heather G; Bigler, Erin D; Bouchard, Heather C; Clark, Alexandra L; Delano-Wood, Lisa M; Disner, Seth G; Eapen, Blessen C; Franz, Carol E; Geuze, Elbert; Goodrich-Hunsaker, Naomi J; Han, Kihwan; Hayes, Jasmeet P; Hinds 2nd, Sidney R; Hodges, Cooper B; Hovenden, Elizabeth S; Irimia, Andrei; Kenney, Kimbra; Koerte, Inga K; Kremen, William S; Levin, Harvey S; Lindsey, Hannah M; Morey, Rajendra A; Newsome, Mary R; Ollinger, John; Pugh, Mary Jo; Scheibel, Randall S; Shenton, Martha E; Sullivan, Danielle R; Taylor, Brian A; Troyanskaya, Maya; Velez, Carmen; Wade, Benjamin Sc; Wang, Xin; Ware, Ashley L; Zafonte, Ross; Thompson, Paul M; Wilde, Elisabeth A	April 1, 2021	Not Relevant
33288872	Create Study	Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.	Molecular psychiatry	Wang, Xin; Xie, Hong; Chen, Tian; Cotton, Andrew S; Salminen, Lauren E; Logue, Mark W; Clarke-Rubright, Emily K; Wall, John; Dennis, Emily L; O'Leary, Brian M; Abdallah, Chadi G; Andrew, Elpiniki; Baugh, Lee A; Bomyea, Jessica; Bruce, Steven E; Bryant, Richard; Choi, Kyle; Daniels, Judith K; Davenport, Nicholas D; Davidson, Richard J; DeBellis, Michael; deRoon-Cassini, Terri; Disner, Seth G; Fani, Negar; Fercho, Kelene A; Fitzgerald, Jacklynn; Forster, Gina L; Frijling, Jessie L; Geuze, Elbert; Gomaa, Hassaan; Gordon, Evan M; Grupe, Dan; Harpaz-Rotem, Ilan; Haswell, Courtney C; Herzog, Julia I; Hofmann, David; Hollifield, Michael; Hosseini, Bobak; Hudson, Anna R; Ipser, Jonathan; Jahanshad, Neda; Jovanovic, Tanja; Kaufman, Milissa L; King, Anthony P; Koch, Saskia B J; Koerte, Inga K; Korgaonkar, Mayuresh S; Krystal, John H; Larson, Christine; Lebois, Lauren A M; Levy, Ifat; Li, Gen; Magnotta, Vincent A; Manthey, Antje; May, Geoffrey; McLaughlin, Katie A; Mueller, Sven C; Nawijn, Laura; Nelson, Steven M; Neria, Yuval; Nitschke, Jack B; Olff, Miranda; Olson, Elizabeth A; Peverill, Matthew; Phan, K Luan; Rashid, Faisal M; Ressler, Kerry; Rosso, Isabelle M; Sambrook, Kelly; Schmahl, Christian; Shenton, Martha E; Sierk, Anika; Simons, Jeffrey S; Simons, Raluca M; Sponheim, Scott R; Stein, Murray B; Stein, Dan J; Stevens, Jennifer S; Straube, Thomas; Suarez-Jimenez, Benjamin; Tamburrino, Marijo; Thomopoulos, Sophia I; van der Wee, Nic J A; van der Werff, Steven J A; van Erp, Theo G M; van Rooij, Sanne J H; van Zuiden, Mirjam; Varkevisser, Tim; Veltman, Dick J; Vermeiren, Robert R J M; Walter, Henrik; Wang, Li; Zhu, Ye; Zhu, Xi; Thompson, Paul M; Morey, Rajendra A; Liberzon, Israel	August 1, 2021	Not Relevant
33133419	Create Study	Preliminary study examining the mediational link between mild traumatic brain injury, acute stress, and post-traumatic stress symptoms following trauma.	European journal of psychotraumatology	Shih, Chia-Hao; Thalla, Palguna R; Elhai, Jon D; Mathews, Jeremy; Brickman, Kristopher R; Redfern, Roberta E; Xie, Hong; Wang, Xin	September 29, 2020	Relevant
32529732	Create Study	Emotion Dysregulation Prospectively Predicts Posttraumatic Stress Disorder Symptom Severity 3 Months After Trauma Exposure.	Journal of traumatic stress	Forbes, Courtney N; Tull, Matthew T; Rapport, Daniel; Xie, Hong; Kaminski, Brian; Wang, Xin	December 2020	Relevant
32297767	Create Study	The mediating effect of rumination between posttraumatic stress disorder symptoms and anger reactions.	Psychological trauma : theory, research, practice and policy	Christ NM, Contractor AA, Wang X, Elhai JD	September 2020	Not Relevant
31931273	Create Study	Emotional avoidance and social support interact to predict depression symptom severity one year after traumatic exposure.	Psychiatry research	Forbes, Courtney N; Tull, Matthew T; Xie, Hong; Christ, Nicole M; Brickman, Kristopher; Mattin, Mike; Wang, Xin	February 2020	Relevant
30409391	Create Study	Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms Over Early Posttrauma Periods.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Xie H, Claycomb Erwin M, Elhai JD, Wall JT, Tamburrino MB, Brickman KR, Kaminski B, Mclean SA, Liberzon I, Wang X	November 2018	Not Relevant
29217296	Create Study	Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.	Biological psychiatry	Logue, Mark W; van Rooij, Sanne J H; Dennis, Emily L; Davis, Sarah L; Hayes, Jasmeet P; Stevens, Jennifer S; Densmore, Maria; Haswell, Courtney C; Ipser, Jonathan; Koch, Saskia B J; Korgaonkar, Mayuresh; Lebois, Lauren A M; Peverill, Matthew; Baker, Justin T; Boedhoe, Premika S W; Frijling, Jessie L; Gruber, Staci A; Harpaz-Rotem, Ilan; Jahanshad, Neda; Koopowitz, Sheri; Levy, Ifat; Nawijn, Laura; O'Connor, Lauren; Olff, Miranda; Salat, David H; Sheridan, Margaret A; Spielberg, Jeffrey M; van Zuiden, Mirjam; Winternitz, Sherry R; Wolff, Jonathan D; Wolf, Erika J; Wang, Xin; Wrocklage, Kristen; Abdallah, Chadi G; Bryant, Richard A; Geuze, Elbert; Jovanovic, Tanja; Kaufman, Milissa L; King, Anthony P; Krystal, John H; Lagopoulos, Jim; Bennett, Maxwell; Lanius, Ruth; Liberzon, Israel; McGlinchey, Regina E; McLaughlin, Katie A; Milberg, William P; Miller, Mark W; Ressler, Kerry J; Veltman, Dick J; Stein, Dan J; Thomaes, Kathleen; Thompson, Paul M; Morey, Rajendra A	February 2018	Not Relevant
28989284	Create Study	An Exploration Into Short-Interval Maintenance of Adult Hemispheric Cortical Thickness at an Individual Brain Level.	Journal of experimental neuroscience	Wall, John; Xie, Hong; Wang, Xin	January 1, 2017	Not Relevant
27169480	Create Study	Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision.	Journal of neurotrauma	Wang, Xin; Xie, Hong; Cotton, Andrew S; Brickman, Kristopher R; Lewis, Terrence J; Wall, John T; Tamburrino, Marijo B; Bauer, William R; Law, Kenny; McLean, Samuel A; Liberzon, Israel	January 15, 2017	Not Relevant

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	283	11/01/2017	211	11/15/2017	0	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Childhood Trauma Questionnaire	283	11/01/2017	238	11/15/2017	224	Approved
Mood and Anxiety Symptom Questionnaire	51	06/01/2021	34	06/30/2022	0	Approved
Pittsburgh Sleep Quality Index	283	06/01/2021	215	06/30/2022	0	Approved
Difficulties in Emotion Regulation Scale	205	06/01/2021	249	06/01/2022	0	Approved
State-Trait Anxiety Inventory for Adults	283	11/01/2017	259	11/15/2017	0	Approved
Multidimensional Scale of Perceived Social Support	283	11/01/2017	254	11/15/2017	0	Approved
The Life Events Checklist for DSM-5	283	11/01/2017	156	11/15/2017	0	Approved
Mini-International Neuropsychiatric Interview (MINI)	283	11/01/2017	163	11/15/2017	90	Approved
PTSD Checklist - Civilian	283	11/01/2017	264	11/15/2017	0	Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)	283	08/11/2023	208	09/30/2023	0	Approved
Quick Inventory of Depressive Symptomatology	283	11/01/2017	264	11/15/2017	0	Approved
Short Form Health Survey	283	08/15/2017	308	11/15/2017	102	Approved
Motivation and Pleasure Scale-Self-Report	51	06/01/2021	68	06/30/2022	0	Approved
PTSD Scale for DSM-5	283	11/01/2017	122	11/15/2017	0	Approved
Behavioral Activation for Depression Scale (BADS)	51	06/01/2021	71	06/30/2022	0	Approved
Acute Stress Disorder Interview	283	11/01/2023	251	06/01/2024	0	Approved
Emergency Room Diagnosis	205	06/01/2021	445	06/30/2022	0	Approved
Life Orientation Test	205	06/01/2021	242	06/01/2022	0	Approved
Pain Survey	283	11/01/2023	455	06/01/2024	0	Approved
Questionnaire	205	06/01/2021	345	06/01/2022	0	Approved
TWEAK	283	06/01/2021	237	06/30/2022	0	Approved
Posttraumatic Growth Inventory	283	06/01/2021	244	06/30/2022	0	Approved
Health Service Utilization	283	06/01/2021	164	06/30/2022	0	Approved
Pain Catastrophizing Scale	283	06/01/2021	236	06/30/2022	0	Approved
Emergency Room Medications	205	06/01/2021	447	06/30/2022	0	Approved
Rivermead Post Concussion Symptoms Questionnaire	283	10/10/2023	254	06/01/2024	0	Approved
Pain Anxiety Symptoms Scale (PASS-20)	283	10/31/2018	0	06/01/2024	0	Approved
Emotion Avoidance questionnaire	283	11/01/2023	0	06/01/2024	0	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Longitudinal PTSD symptom trajectories: Relative contributions of state anxiety, depression, and emotion dysregulation.	BACKGROUND: Prospective research on the development and trajectory of PTSD symptoms after a traumatic event is crucial for assessment and early intervention. Further, examining predictors of PTSD pathology provides a better conceptualization of the temporal course of PTSD in trauma victims. METHODS: The present study examined PTSD symptom severity in individuals presenting to the emergency department (ED) following a traumatic event. Participants (N = 147) were assessed at four timepoints: 2-weeks, 3-months, between 6 and 9 months, and 12-months after ED admission. Growth curve modeling was conducted to examine changes in PTSD symptom severity over time. Age, sex, state anxiety, trait anxiety, emotion dysregulation, depression, and trauma type (motor vehicle accident [MVA] and assault), and PTSD diagnosis were included as covariates in the model. RESULTS: Results demonstrated that baseline PTSD symptom severity was positively associated with severity of depression and state (but not trait) anxiety, emotion dysregulation, and PTSD diagnosis. Results also revealed significant associations with PTSD symptom changes over time; greater state anxiety and depression symptoms at baseline were associated with steeper declines in PTSD symptoms over time. LIMITATIONS: Data were collected at only four timepoints over the course of 12-months. Results may be different with more measurement points over longer periods and inclusion of pre-, peri- and post-trauma risk factors. CONCLUSIONS: Results illustrate the relevance of assessing state anxiety, depression, and emotion dysregulation in following trauma victims for trauma-related psychopathology over the course of time to alleviate the negative impact of the same.	266/519	Primary Analysis	Shared
Fear of pain as a predictor of concurrent and downstream PTSD symptoms.	Pain anxiety has been associated with more severe posttraumatic stress disorder (PTSD) symptoms. However, the unique role of individual domains of pain anxiety has yet to be explored in the prediction of PTSD severity. This study examined whether specific pain anxiety domains (i.e., cognitive anxiety, escape/avoidance, fear of pain, and physiological anxiety) predict both concurrent and downstream PTSD symptoms above and beyond other PTSD risk factors. Participants were 63 survivors of traumatic events with moderate to high baseline pain treated in the emergency department and assessed for PTSD symptoms and pain anxiety at 3- and 12-months. Three-month pain anxiety domains of fear of pain and physiological anxiety (inversely related) significantly predicted concurrent 3-month PTSD symptoms above and beyond other established PTSD risk factors (i.e., sex, age, pain, and trauma type). However, only 3-month fear of pain significantly predicted 12-month PTSD symptoms. Findings highlight the relevance of specific pain anxiety domains in concurrent and future PTSD symptoms and suggest the importance of evaluating pain anxiety among patients with PTSD. Interventions focused on increasing willingness to experience and tolerate fear of pain may help mitigate this risk, thereby improving outcomes for individuals with acute PTSD symptoms.	158/514	Secondary Analysis	Shared
Emotional avoidance and social support interact to predict depression symptom severity one year after traumatic exposure.	Individuals exposed to a traumatic event commonly develop symptoms of depression, a psychiatric disorder associated with a number of negative clinical and public health consequences. Both intrapersonal and interpersonal risk factors have been associated with heightened risk for depression following traumatic event exposure; however, less is known about how these risk factors may interact to predict trauma-exposed individuals' risk of subsequently developing depression symptoms. This study examined the interactive influence of emotional avoidance (an intrapersonal risk factor) and perceived social support (an interpersonal risk factor) on the development of depression symptoms over a one-year period among N = 46 individuals recruited shortly after visiting a hospital emergency department for treatment following exposure to a traumatic event. Results revealed a significant main effect of emotional avoidance on 12-month depression symptoms. The main effect was qualified by an emotional avoidance by perceived social support interaction: the relation of emotional avoidance to 12-month depression symptoms was positive and significant only for individuals with low levels of perceived social support. Results highlight the need to consider both intrapersonal and interpersonal risk factors, as well as their interaction, when predicting which individuals may be most at risk to develop depression following traumatic event exposure.	264/513	Secondary Analysis	Shared
Effects of acute pain medications on posttraumatic stress symptoms in early aftermath of trauma.	Posttraumatic stress symptoms (PTSS) develop as sequelae from traumatic injuries. Limited studies suggest that using opioids to reduce acute pain immediately after trauma may also reduce subsequent PTSS, but other pain medications rarely have been examined for preventing acute PTSS. The current study examined the effects of commonly used pain medications, opioid and nonsteroidal anti-inflammatory drugs (NSAIDs), on PTSS after acute traumatic injuries. Participants ( n = 71) were categorized into opioid or NSAID group according to their medical records and self-reported medication use. Their PTSS were assessed using posttraumatic stress disorder checklist twice within 2 weeks after trauma. Participants' pain levels reduced from pretreatment to follow-up in both groups, F (1, 55) = 6.696, P = 0.012, partial η 2 = 0.109. Interestingly, a significant interaction between time and medication group on PTSS reached statistical significance, F (1, 69) = 6.014, P = 0.017, partial η 2 = 0.080. Follow-up analyses revealed that this interaction was driven by a significant PTSS reduction only in opioid but not in NSAID group. These findings suggested that pain reduction alone is not sufficient to reduce acute PTSS in the NSAID group, highlighting the need to continue further investigations into the mechanisms by which opioids reduce PTSS in the early posttrauma period.	463/463	Secondary Analysis	Shared
Emotion Dysregulation Prospectively Predicts Posttraumatic Stress Disorder Symptom Severity 3 Months After Trauma Exposure.	Despite growing evidence in support of emotion dysregulation as a risk factor for the development of posttraumatic stress disorder (PTSD) following trauma exposure, few studies have examined temporal relations between emotion dysregulation and the onset and/or worsening of PTSD symptoms over time. The aim of the present study was to extend research on temporal associations between emotion dysregulation and PTSD in a sample of individuals recruited from hospital emergency departments soon after a traumatic event. Adult participants (N = 85; 62.4% female) completed self-report measures of emotion dysregulation and PTSD symptoms within 2 weeks of experiencing a traumatic event. Symptoms of PTSD were assessed approximately 3 months posttrauma. The results of a hierarchical linear regression analysis demonstrated that the inclusion of emotion dysregulation accounted for a significant amount of unique variance, β = .23, ΔR2 = .04, p = .042, in 3-month PTSD symptom severity over and above other risk factors and baseline PTSD symptoms. No specific facet of emotion dysregulation emerged as a significant predictor of 3-month PTSD symptoms when all facets were included on the same step of the model, βs = -.04-.33, ps = .133-.954. These results demonstrate that posttraumatic emotion dysregulation may predict PTSD symptoms 3 months after trauma exposure. These findings are consistent with a growing body of literature that speaks to the relevance of emotional processes to the onset and maintenance of PTSD following exposure to a traumatic event.	400/400	Secondary Analysis	Shared
Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.	Adverse childhood experiences (ACEs) potentially contribute to posttraumatic stress disorder (PTSD) after adult trauma exposure, but underlying brain changes remain unclear. The present study tested relationships between ACEs, whole thalamus and thalamic nuclei volumes, and post-trauma stress symptoms (PTSS) after adult trauma. Trauma survivors (n = 101) completed the Childhood Trauma Questionnaire (CTQ), the PTSD checklist-special stressor version 5 (PCL), and a structural magnetic resonance imaging (sMRI) scan within post-trauma 2 weeks. At post-trauma 3 months, survivors completed a second PCL survey and a PTSD diagnosis interview using the Clinician-Administered PTSD Scale (CAPS). CTQ scores significantly positively correlated with PCL scores at post-trauma 2 weeks and 3 months (respective p's < 0.01 and < 0.001). CTQ scores significantly negatively correlated with whole thalamus and 7 thalamic nuclei volumes at post-trauma 2 weeks in the PTSD (N = 50), but not the non-PTSD (N = 51) group. Whole thalamus and 22 nuclei volumes significantly negatively correlated with PCL scores at post-trauma 3 months in the PTSD, but not the non-PTSD group. These results suggest ACEs negatively influence early post-trauma thalamic volumes which, in turn, are negatively associated with PTSS in survivors who develop PTSD.	278/279	Secondary Analysis	Shared
Association of age of adverse childhood experiences with thalamic volumes and post-traumatic stress disorder in adulthood.	BACKGROUND: Adverse childhood experiences (ACEs) have been linked to brain development and mental disorders, however, the impact of the age of occurrence of ACEs on thalamic volume and post-traumatic stress disorder (PTSD) after adult trauma remains unclear. This study assessed associations between ACEs at different ages to thalamic volumes and PTSD development following acute adult trauma. METHODS: Seventy-nine adult trauma survivors were recruited immediately after trauma. Within 2 weeks of the traumatic event, participants completed the PTSD Checklist (PCL) to assess PTSD symptoms, the Childhood Trauma Questionnaire (CTQ) and Childhood Age Range Stress Scale (CARSS) to evaluate ACEs and perceived stress level at preschool (<6 years old) and school (6-13 years old) ages, and structural magnetic resonance imaging (sMRI) to measure thalamic volumes. Participants were divided into three groups: those who experienced no childhood trauma or stress (non-ACEs), those who experienced childhood trauma and stress onset at preschool ages (Presch-ACEs), and those who experienced childhood trauma and stress onset at school ages (Sch-ACEs). At 3 months, participants underwent PTSD symptom evaluation using the Clinician Administered PTSD Scale (CAPS). RESULTS: Adult trauma survivors in the Presch-ACEs group had higher CTQ and CAPS scores. In addition, survivors in the Presch-ACEs group had smaller thalamic volume compared to survivors in the non-ACEs and Sch-ACEs groups. Furthermore, smaller thalamic volume moderated a positive association between post-trauma 2-week PCL and subsequent 3-month CAPS scores. DISCUSSION: Earlier occurrence of ACEs was associated with smaller thalamic volume, which appears to moderate a positive association between early posttraumatic stress symptom severity and PTSD development after adult trauma. This raises the possibility that early occurrence of ACEs may impact thalamic structure, specifically a reduction in thalamic volume, and that smaller thalamic volume may contribute to susceptibility to PTSD development after adult trauma.	278/278	Secondary Analysis	Shared
Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma.	The hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis and response to stress. Adverse childhood experience (ACE) can affect brain structure, which may contribute to development of posttraumatic stress disorder (PTSD) after subsequent adult trauma. It is unclear, however, if ACE history is particularly associated with aspects of hypothalamic structure which contribute to development of PTSD. To address this issue, the present study longitudinally assessed hypothalamic volumes and their associations with ACE and early post-trauma stress symptoms in subjects who did or did not develop PTSD during 12 months after adult trauma. 109 subjects (18-60 years, F/M = 75/34) completed the PTSD Checklist (PCL) questionnaire for post-trauma stress symptoms, the Childhood Trauma Questionnaire (CTQ) for ACE assessment, and an initial MRI brain scan for hypothalamic volume measurement, within 2 weeks after adult trauma. At post-trauma 12 months, subjects underwent a subsequent PTSD diagnosis interview using the Clinician-Administered PTSD Scale (CAPS), and a follow-up MRI scan. Left and right hypothalamus volumes at 2 weeks after adult trauma negatively correlated with CTQ scores. Right hypothalamus volume at this early time mediated an association between ACE and PTSD symptoms 12 months later. Right hypothalamus volumes also remained persistently smaller from 2 weeks to 12 months after trauma in survivors who developed PTSD. These results suggest that smaller right hypothalamus volume may be related to ACE history in ways that contribute to PTSD development after trauma in adulthood.	278/278	Secondary Analysis	Shared
Dispositional optimism mediates relations between childhood maltreatment and PTSD symptom severity among trauma-exposed adults.	Experiences of maltreatment in childhood, such as abuse and neglect, have been associated with poorer psychological well-being in adulthood, including elevated risk of revictimization and increased likelihood of developing posttraumatic stress disorder (PTSD) symptoms. Maltreatment has also been associated with reduced resources related to resilience, such as optimism, which may act as a protective factor for mental health. In this study, we examined the mediating role of dispositional optimism in the relationship between childhood maltreatment and PTSD symptom severity from recent trauma in a sample of adults (n = 108) who presented to their local emergency department following trauma. We analyzed six models to account for cumulative childhood maltreatment as well as five primary subtypes of maltreatment: emotional abuse, physical abuse, sexual abuse, emotional neglect, and physical neglect. = .056, SE = .029, 95 % CI [.009, .121]). Optimism also mediated relations between all maltreatment subtypes and PTSD severity, except sexual abuse. These results may suggest optimism and positive psychology interventions as effective techniques in reducing the likelihood of PTSD development and severity in trauma-exposed individuals.	253/270	Secondary Analysis	Shared
Preliminary study examining the mediational link between mild traumatic brain injury, acute stress, and post-traumatic stress symptoms following trauma.	Background: The presence of mild traumatic brain injury (mTBI) increases post-traumatic stress disorder (PTSD) symptoms in the months following injury. However, factors that link mTBI and PTSD development are still unclear. Acute stress responses after trauma have been associated with PTSD development. mTBI may impair cognitive functions and increase anxiety immediately after trauma. Objective: This research aimed to test the possibility that mTBI increases acute stress symptoms rapidly, which in turn results in PTSD development in the subsequent months. Method: Fifty-nine patients were recruited from the emergency rooms of local hospitals. Post-mTBI, acute stress, and PTSD symptom severity were measured using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Acute Stress Disorder Scale (ASDS), and PTSD Checklist for DSM-5 (PCL-5), respectively. Results: Moderated mediation analysis indicated that ASDS, at 2 weeks post-trauma, mediated the relationship between RPQ scores at 2 weeks and PCL-5 scores at 3 months post-trauma, only for patients who met mTBI diagnostic criteria. Conclusions: These findings present preliminary evidence suggesting that acute stress disorder symptoms may be one of the mechanisms involved in the development of PTSD among trauma survivors who have experienced mTBI, which provides a theoretical basis for early intervention of PTSD prevention after mTBI.	264/265	Secondary Analysis	Shared
Emotion dysregulation mediates the association between acute sleep disturbance and later posttraumatic stress symptoms in trauma exposed adults.	Early post-trauma sleep disturbance is associated with PTSD symptoms over months, and acute emotion dysregulation explains part of this association. Those with limited emotion regulation strategies are at particular risk of developing PTSD symptoms. Early interventions focusing on the appropriate strategies for emotion regulation may be crucial for trauma-exposed individuals.	264/264	Secondary Analysis	Shared
Early self-reported post-traumatic stress symptoms after trauma exposure and associations with diagnosis of post-traumatic stress disorder at 3 months: latent profile analysis.	BACKGROUND: Trauma exposure can cause post-traumatic stress symptoms (PTSS), and persistently experiencing PTSS may lead to the development of post-traumatic stress disorder (PTSD). Research has shown that PTSS that emerged within days of trauma was a robust predictor of PTSD development. AIMS: To investigate patterns of early stress responses to trauma and their associations with development of PTSD. METHOD: We recruited 247 civilian trauma survivors from a local hospital emergency department. The PTSD Checklist for DSM-5 (PCL-5) and Acute Stress Disorder Scale (ASDS) were completed within 2 weeks after the traumatic event. Additionally, 3 months post-trauma 146 of these participants completed a PTSD diagnostic interview using the Clinician Administered PTSD Scale for DSM-5. RESULTS: analysis revealed that this association was driven by participants in the 'severe symptoms' profile, who had a greater likelihood of developing PTSD. CONCLUSIONS: These findings fill the knowledge gap of identifying possible subgroups of individuals based on their PTSS severity during the early post-trauma period and investigating the relationship between subgroup membership and PTSD development, which have important implications for clinical practice.	256/259	Primary Analysis	Shared
Early self-reported post-traumatic stress symptoms after trauma exposure and associations with diagnosis of post-traumatic stress disorder at 3 months: latent profile analysis.	BACKGROUND: Trauma exposure can cause post-traumatic stress symptoms (PTSS), and persistently experiencing PTSS may lead to the development of post-traumatic stress disorder (PTSD). Research has shown that PTSS that emerged within days of trauma was a robust predictor of PTSD development. AIMS: To investigate patterns of early stress responses to trauma and their associations with development of PTSD. METHOD: We recruited 247 civilian trauma survivors from a local hospital emergency department. The PTSD Checklist for DSM-5 (PCL-5) and Acute Stress Disorder Scale (ASDS) were completed within 2 weeks after the traumatic event. Additionally, 3 months post-trauma 146 of these participants completed a PTSD diagnostic interview using the Clinician Administered PTSD Scale for DSM-5. RESULTS: analysis revealed that this association was driven by participants in the 'severe symptoms' profile, who had a greater likelihood of developing PTSD. CONCLUSIONS: These findings fill the knowledge gap of identifying possible subgroups of individuals based on their PTSS severity during the early post-trauma period and investigating the relationship between subgroup membership and PTSD development, which have important implications for clinical practice.	256/256	Primary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

Edit

Choose File:	Select File
File Type:
Description:

Exemption Type*
From Date*
To Date*
Reason*	Characters Remaining:

Disclaimer

Filter Cart

Frequently Asked Questions

Glossary