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1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

Collection - Use Existing Experiment
To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.
SelectExperiment IdExperiment NameExperiment Type
Created On
24HI-NGS_R1Omics02/16/2011
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
506PVPREFOmics08/05/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
26ASD_MethylationOmics03/01/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
41ImmunofluorescenceOmics05/11/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
519RestingfMRI11/08/2016
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
145AGRE/FMR1_Illumina.JHUOmics04/14/2014
146AGRE/MECP2_Sanger.JHUOmics04/14/2014
147AGRE/MECP2_Junior.JHUOmics04/14/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
154Math Autism Study - Vinod MenonfMRI07/15/2014
155RestingfMRI07/25/2014
156SpeechfMRI07/25/2014
159EmotionfMRI07/25/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
Collection - Add Experiment
Add Supporting Documentation
Select File

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Perturbation of the treatment resistant depression connectome by fast-acting therapies
Katherine Narr 
Depression affects a large portion of the world's population. Though treatable, two thirds of patients will not respond sufficiently to two or more standard pharmacotherapies and will be defined as treatment resistant (TRD). Quality of life for these individuals is extremely low and unremitting symptoms lead to loss of productivity, impaired social relationships, high health care costs, and in some cases, loss of life by suicide. Though several different brain networks are implicated, despite much research, the mechanisms causal to depression and its successful treatment remain unclear. The overarching goal of the current proposal is to leverage optimized non-invasive MRI technologies and normative data available through the NIMH/NIA-funded Human Connectome Project (HCP, U54 MH091657) to 1) identify connectome-specific correlates and predictors of successful treatment outcome to 3 therapeutic interventions, each with a rapid onset of action and to 2) characterize alterations in neural connectivity associated with individual clinical, behavioral and physiological differences across TRD. Following harmonization of HCP MRI protocols, structural, functional and diffusion MRI data and behavioral testing batteries modeled from the HCP Lifespan protocol with added clinical assessments will be collected. Arterial spin labeling (ASL) perfusion MRI, measuring cerebral blood flow, and peripheral blood measures of gene function will supplement these protocols. Our first aim is longitudinal and will determine whether changes in brain network connectivity relate to and predict response to fast-acting perturbations known to elicit robust antidepressant effects. These perturbations include electroconvulsive therapy (ECT), serial ketamine infusion and total sleep deprivation (TSD). Since TRD includes different categorical diagnoses such as unipolar and bipolar depression and other comorbidities, our second specific aim is cross-sectional and will determine if heterogeneity in behavioral and symptom profiles, clinical histories and sex and age contribute to variations in the patterns of altered structural and functional connectivity in TRD. Subjects will include 200 patients clinically eligible to receive ECT (n=60), serial ketamine (n=60) or TSD (n=80) and 140 controls, combining control data collected locally (n=40) with control data from the HCP resource (n=100). Each patient will receive MRI, behavioral/cognitive testing and a blood draw before and after completing one of the interventions. Behavioral constructs and sub-constructs of interest will include cognitive control, negativity bias and rumination and reward hypersensitivity, widely implicated in depression, functions that are governed by prefrontal and anterior cingulate cortex (cognitive control, mood regulation) and amygdala, hippocampus, ventral striatum/pallidum (emotion and reward) regions and circuitry. Data will be released to the scientific community through the Connectome Coordination Facility. The infrastructure of the HCP provides an unprecedented opportunity for to discover the mechanisms of disease and treatment response, which could lead to more effective treatment strategies based on individual connectivity profiles.
Connectome Coordination Facility
01/29/2018
Human Connectome Project (HCP)
Funding Completed
Close Out
No
$5,525,791.00
231
Loading Chart...
NIH - Extramural None



U01MH110008-01 Perturbation of the treatment resistant depression connectome by fast-acting therapies 09/02/2016 05/31/2022 240 230 UNIVERSITY OF CALIFORNIA LOS ANGELES $5,525,791.00

helpcenter.collection.general-tab

NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType
1860CARIT (Go/NoGo Task)11/03/2021ApprovedfMRI
1861Resting State11/03/2021ApprovedfMRI
1862Face-Matching Task11/03/2021ApprovedfMRI
helpcenter.collection.experiments-tab

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.
Apathy Evaluation Scale Clinical Assessments 230
Behavioral Inhibition Scale/Behavioral Activation Scale Clinical Assessments 230
Depression, Anxiety, and Stress Scale Clinical Assessments 230
Dimensional Change Card Sort Test (DCCS) Clinical Assessments 214
Edinburgh Handedness Inventory Clinical Assessments 230
Fagerstrom Test for Nicotine Dependence Clinical Assessments 230
Flanker Task Clinical Assessments 214
Hamilton Rating Scale for Depression Clinical Assessments 230
Imaging Collection Imaging 227
Munich ChronoType Questionnaire Clinical Assessments 230
NIH Toolbox List Sorting Working Memory Test Clinical Assessments 214
NIH Toolbox Oral Reading Recognition Test Clinical Assessments 214
NIH Toolbox Picture Vocabulary Test Clinical Assessments 214
Pattern Comparison Processing Speed Clinical Assessments 214
Penn Emotion Recognition Task Clinical Assessments 229
Picture Sequence Memory Clinical Assessments 214
Pittsburgh Sleep Quality Index Clinical Assessments 230
Processed MRI Data Imaging 218
Quick Inventory of Depressive Symptomatology Clinical Assessments 230
Research Subject Clinical Assessments 230
Self Administered Comorbidity Questionairre Clinical Assessments 230
Snaith-Hamilton Pleasure Scale Clinical Assessments 230
WHO Disability Assessment Schedule Clinical Assessments 230
helpcenter.collection.shared-data-tab

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
38894648Create StudyModulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression.Brain and behaviorTaraku, Brandon; Loureiro, Joana R; Sahib, Ashish K; Zavaliangos-Petropulu, Artemis; Al-Sharif, Noor; Leaver, Amber M; Wade, Benjamin; Joshi, Shantanu; Woods, Roger P; Espinoza, Randall; Narr, Katherine LJune 1, 2024Not Determined
38106178Create StudyKetamine treatment modulates habenular and nucleus accumbens static and dynamic functional connectivity in major depression.medRxiv : the preprint server for health sciencesTaraku, Brandon; Loureiro, Joana R; Sahib, Ashish K; Zavaliangos-Petropulu, Artemis; Al-Sharif, Noor; Leaver, Amber; Wade, Benjamin; Joshi, Shantanu; Woods, Roger P; Espinoza, Randall; Narr, Katherine LDecember 4, 2023Not Determined
37876623Create StudyHippocampal subfield volumes in treatment resistant depression and serial ketamine treatment.Frontiers in psychiatryZavaliangos-Petropulu, Artemis; McClintock, Shawn M; Joshi, Shantanu H; Taraku, Brandon; Al-Sharif, Noor B; Espinoza, Randall T; Narr, Katherine LJanuary 1, 2023Not Determined
37356226Create StudyAmygdala subfield and prefrontal cortex abnormalities in patients with functional seizures.Epilepsy & behavior : E&BNasrullah, Nilab; Kerr, Wesley T; Stern, John M; Wang, Yanlu; Tatekawa, Hiroyuki; Lee, John K; Karimi, Amir H; Sreenivasan, Siddhika S; Engel Jr, Jerome; Eliashiv, Dawn E; Feusner, Jamie D; Salamon, Noriko; Savic, IvankaAugust 1, 2023Not Determined
37060953Create StudyNeurocognitive effects of subanesthetic serial ketamine infusions in treatment resistant depression.Journal of affective disordersZavaliangos-Petropulu, Artemis; McClintock, Shawn M; Khalil, Jacqueline; Joshi, Shantanu H; Taraku, Brandon; Al-Sharif, Noor B; Espinoza, Randall T; Narr, Katherine LJuly 15, 2023Not Determined
36775711Create StudyNeuroimaging-Derived Biomarkers of the Antidepressant Effects of Ketamine.Biological psychiatry. Cognitive neuroscience and neuroimagingZavaliangos-Petropulu, Artemis; Al-Sharif, Noor B; Taraku, Brandon; Leaver, Amber M; Sahib, Ashish K; Espinoza, Randall T; Narr, Katherine LApril 1, 2023Not Determined
36715291Create StudyChanges in white matter microstructure following serial ketamine infusions in treatment resistant depression.Human brain mappingTaraku, Brandon; Woods, Roger P; Boucher, Michael; Espinoza, Randall; Jog, Mayank; Al-Sharif, Noor; Narr, Katherine L; Zavaliangos-Petropulu, ArtemisApril 15, 2023Not Determined
35944604Create StudyMultimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes.Brain stimulationvan de Mortel, L A; Bruin, W B; Thomas, R M; Abbott, C; Argyelan, M; van Eijndhoven, P; Mulders, P; Narr, K L; Tendolkar, I; Verdijk, J P A J; van Waarde, J A; Bartsch, H; Oltedal, L; van Wingen, G AJanuary 1, 2022Not Determined
35933959Create StudyClinical MRI morphological analysis of functional seizures compared to seizure-naïve and psychiatric controls.Epilepsy & behavior : E&BKerr, Wesley T; Tatekawa, Hiroyuki; Lee, John K; Karimi, Amir H; Sreenivasan, Siddhika S; O'Neill, Joseph; Smith, Jena M; Hickman, L Brian; Savic, Ivanka; Nasrullah, Nilab; Espinoza, Randall; Narr, Katherine; Salamon, Noriko; Beimer, Nicholas J; Hadjiiski, Lubomir M; Eliashiv, Dawn S; Stacey, William C; Engel Jr, Jerome; Feusner, Jamie D; Stern, John MSeptember 1, 2022Not Determined
35779673Create StudyAssociation between peripheral inflammation and free-water imaging in Major Depressive Disorder before and after ketamine treatment - A pilot study.Journal of affective disordersLanghein, Mina; Seitz-Holland, Johanna; Lyall, Amanda E; Pasternak, Ofer; Chunga, Natalia; Cetin-Karayumak, Suheyla; Kubicki, Antoni; Mulert, Christoph; Espinoza, Randall T; Narr, Katherine L; Kubicki, MarekOctober 1, 2022Not Determined
35578581Create StudyAnterior default mode network and posterior insular connectivity is predictive of depressive symptom reduction following serial ketamine infusion.Psychological medicineWade, Benjamin S C; Loureiro, Joana; Sahib, Ashish; Kubicki, Antoni; Joshi, Shantanu H; Hellemann, Gerhard; Espinoza, Randall T; Woods, Roger P; Congdon, Eliza; Narr, Katherine LSeptember 1, 2022Not Determined
35523776Create StudyLongitudinal trajectory of response to electroconvulsive therapy associated with transient immune response & white matter alteration post-stimulation.Translational psychiatryAndreou, Blake; Reid, Benjamin; Lyall, Amanda E; Cetin-Karayumak, Suheyla; Kubicki, Antoni; Espinoza, Randall; Kruse, Jennifer; Narr, Katherine L; Kubicki, MarekMay 7, 2022Not Determined
35120710Create StudyParsing the Network Mechanisms of Electroconvulsive Therapy.Biological psychiatryLeaver, Amber M; Espinoza, Randall; Wade, Benjamin; Narr, Katherine LAugust 1, 2022Not Determined
34887623Create StudyAcute changes in cerebral blood flow after single-infusion ketamine in major depression: a pilot study.Neurology, psychiatry, and brain researchGonzalez, Sara; Vasavada, Megha; Njau, Stephanie; Sahib, Ashish K; Espinoza, Randall; Narr, Katherine L; Leaver, Amber MDecember 1, 2020Not Determined
34732328Create StudyConvergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders.NeuroImageTozzi, Leonardo; Anene, Esther T; Gotlib, Ian H; Wintermark, Max; Kerr, Adam B; Wu, Hua; Seok, Darsol; Narr, Katherine L; Sheline, Yvette I; Whitfield-Gabrieli, Susan; Williams, Leanne MDecember 15, 2021Not Determined
34555822Create StudyA novel technique for accurate electrode placement over cortical targets for transcranial electrical stimulation (tES) clinical trials.Journal of neural engineeringJog, Mayank; Anderson, Cole; Kim, Elizabeth; Garrett, Avery; Kubicki, Antoni; Gonzalez, Sara; Jann, Kay; Iacoboni, Marco; Woods, Roger; Wang, Danny Jj; Narr, Katherine LOctober 11, 2021Not Determined
34390089Create StudyAccounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy.Human brain mappingWade, Benjamin S C; Hellemann, Gerhard; Espinoza, Randall T; Woods, Roger P; Joshi, Shantanu H; Redlich, Ronny; Dannlowski, Udo; Jorgensen, Anders; Abbott, Christopher C; Oltedal, Leif; Narr, Katherine LNovember 1, 2021Not Determined
34223741Create StudyElevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy.Journal of psychiatry & neuroscience : JPNOpel, Nils; Narr, Katherine L.; Abbott, Christopher; Argyelan, Miklos; Espinoza, Randall; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Vandenbulcke, Mathieu; Nordanskog, Pia; Repple, Jonathan; Kavakbasi, Erhan; Jorgensen, Martin B.; Paulson, Olaf B.; Hanson, Lars G.; Dols, Annemieke; van Exel, Eric; Oudega, Mardien L.; Takamiya, Akihiro; Kishimoto, Taishiro; Ousdal, Olga Therese; Haavik, Jan; Hammar, Åsa; Oedegaard, Ketil Joachim; Kessler, Ute; Bartsch, Hauke; Dale, Anders M.; Baune, Bernhard T.; Dannlowski, Udo; Oltedal, Leif; Redlich, RonnyJuly 5, 2021Not Determined
34139457Create StudyInterleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression.Journal of psychiatric researchKruse, Jennifer L; Olmstead, Richard; Hellemann, Gerhard; Breen, Elizabeth C; Tye, Susannah J; Brooks 3rd, John O; Wade, Benjamin; Congdon, Eliza; Espinoza, Randall; Narr, Katherine L; Irwin, Michael RAugust 1, 2021Not Determined
33723220Create StudyDepression treatment response to ketamine: sex-specific role of interleukin-8, but not other inflammatory markers.Translational psychiatryKruse, Jennifer L; Vasavada, Megha M; Olmstead, Richard; Hellemann, Gerhard; Wade, Benjamin; Breen, Elizabeth C; Brooks, John O; Congdon, Eliza; Espinoza, Randall; Narr, Katherine L; Irwin, Michael RMarch 15, 2021Not Determined
33267926Create StudyModulation of the functional connectome in major depressive disorder by ketamine therapy.Psychological medicineSahib, Ashish K; Loureiro, Joana R; Vasavada, Megha; Anderson, Cole; Kubicki, Antoni; Wade, Benjamin; Joshi, Shantanu H; Woods, Roger P; Congdon, Eliza; Espinoza, Randall; Narr, Katherine LOctober 1, 2022Not Determined
32900657Create StudyEffects of Serial Ketamine Infusions on Corticolimbic Functional Connectivity in Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimagingVasavada, Megha M; Loureiro, Joana; Kubicki, Antoni; Sahib, Ashish; Wade, Benjamin; Hellemann, Gerhard; Espinoza, Randall T; Congdon, Eliza; Narr, Katherine L; Leaver, Amber MJuly 1, 2021Not Determined
32741703Create StudySubcallosal Cingulate Structural Connectivity Differs in Responders and Nonresponders to Electroconvulsive Therapy.Biological psychiatry. Cognitive neuroscience and neuroimagingTsolaki, Evangelia; Narr, Katherine L; Espinoza, Randall; Wade, Benjamin; Hellemann, Gerhard; Kubicki, Antoni; Vasavada, Megha; Njau, Stephanie; Pouratian, NaderJanuary 1, 2021Not Determined
32732915Create StudyModulation of inhibitory control networks relate to clinical response following ketamine therapy in major depression.Translational psychiatrySahib, Ashish K; Loureiro, Joana Ra; Vasavada, Megha M; Kubicki, Antoni; Wade, Benjamin; Joshi, Shantanu H; Woods, Roger P; Congdon, Eliza; Espinoza, Randall; Narr, Katherine LJuly 30, 2020Not Determined
32513391Create StudyNeural Subtypes of Euthymic Bipolar I Disorder Characterized by Emotion Regulation Circuitry.Biological psychiatry. Cognitive neuroscience and neuroimagingNjau, Stephanie; Townsend, Jennifer; Wade, Benjamin; Hellemann, Gerhard; Bookheimer, Susan; Narr, Katherine; Brooks 3rd, John OJune 1, 2020Not Determined
32479994Create StudyInflammation and depression treatment response to electroconvulsive therapy: Sex-specific role of interleukin-8.Brain, behavior, and immunityKruse, Jennifer L; Olmstead, Richard; Hellemann, Gerhard; Wade, Benjamin; Jiang, Janina; Vasavada, Megha M; Brooks Iii, John O; Congdon, Eliza; Espinoza, Randall; Narr, Katherine L; Irwin, Michael ROctober 1, 2020Not Determined
32289700Create StudyStructural changes induced by electroconvulsive therapy are associated with clinical outcome.Brain stimulationMulders, Peter C R; Llera, Alberto; Beckmann, Christian F; Vandenbulcke, Mathieu; Stek, Max; Sienaert, Pascal; Redlich, Ronny; Petrides, Georgios; Oudega, Mardien Leoniek; Oltedal, Leif; Oedegaard, Ketil J; Narr, Katherine L; Magnusson, Peter O; Kessler, Ute; Jorgensen, Anders; Espinoza, Randall; Enneking, Verena; Emsell, Louise; Dols, Annemieke; Dannlowski, Udo; Bolwig, Tom G; Bartsch, Hauke; Argyelan, Miklos; Anand, Amit; Abbott, Christopher C; van Eijndhoven, Philip F P; Tendolkar, IndiraMay 1, 2020Not Determined
32115848Create StudyModulation of amygdala reactivity following rapidly acting interventions for major depression.Human brain mappingLoureiro, Joana R A; Leaver, Amber; Vasavada, Megha; Sahib, Ashish K; Kubicki, Antoni; Joshi, Shantanu; Woods, Roger P; Wade, Benjamin; Congdon, Eliza; Espinoza, Randall; Narr, Katherine LMay 1, 2020Not Determined
32061453Create StudySingle and repeated ketamine treatment induces perfusion changes in sensory and limbic networks in major depressive disorder.European neuropsychopharmacology : the journal of the European College of NeuropsychopharmacologySahib, Ashish K; Loureiro, Joana R A; Vasavada, Megha M; Kubicki, Antoni; Joshi, Shantanu H; Wang, Kai; Woods, Roger P; Congdon, Eliza; Wang, Danny J J; Boucher, Michael L; Espinoza, Randall; Narr, Katherine LApril 1, 2020Not Determined
32029885Create StudyHippocampal subregions and networks linked with antidepressant response to electroconvulsive therapy.Molecular psychiatryLeaver, Amber M; Vasavada, Megha; Kubicki, Antoni; Wade, Benjamin; Loureiro, Joana; Hellemann, Gerhard; Joshi, Shantanu H; Woods, Roger P; Espinoza, Randall; Narr, Katherine LAugust 1, 2021Not Determined
31938757Create StudyA review of transcranial direct current stimulation (tDCS) for the individualized treatment of depressive symptoms.Personalized medicine in psychiatryJog, Mayank V; Wang, Danny J J; Narr, Katherine LNovember 1, 2019Not Determined
31735637Create StudyPreliminary prediction of individual response to electroconvulsive therapy using whole-brain functional magnetic resonance imaging data.NeuroImage. ClinicalSun, Hailun; Jiang, Rongtao; Qi, Shile; Narr, Katherine L; Wade, Benjamin Sc; Upston, Joel; Espinoza, Randall; Jones, Tom; Calhoun, Vince D; Abbott, Christopher C; Sui, JingJanuary 1, 2020Not Determined
31644424Create StudyElectric field causes volumetric changes in the human brain.eLifeArgyelan, Miklos; Oltedal, Leif; Deng, Zhi-De; Wade, Benjamin; Bikson, Marom; Joanlanne, Andrea; Sanghani, Sohag; Bartsch, Hauke; Cano, Marta; Dale, Anders M; Dannlowski, Udo; Dols, Annemiek; Enneking, Verena; Espinoza, Randall; Kessler, Ute; Narr, Katherine L; Oedegaard, Ketil J; Oudega, Mardien L; Redlich, Ronny; Stek, Max L; Takamiya, Akihiro; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Pujol, Jesus; Tendolkar, Indira; van Eijndhoven, Philip; Petrides, Georgios; Malhotra, Anil K; Abbott, ChristopherOctober 23, 2019Not Determined
31464814Create StudyDepressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy.The journal of ECTWade, Benjamin S C; Hellemann, Gerhard; Espinoza, Randall T; Woods, Roger P; Joshi, Shantanu H; Redlich, Ronny; Jørgensen, Anders; Abbott, Christopher C; Oedegaard, Ketil J; McClintock, Shawn M; Oltedal, Leif; Narr, Katherine LJune 1, 2020Not Determined
31106303Create StudyElastic Registration of Single Subject Task Based fMRI Signals.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionLee, David S; Loureiro, Joana; Narr, Katherine L; Woods, Roger P; Joshi, Shantanu HSeptember 1, 2018Not Determined
30658916Create StudyVariations in Hippocampal White Matter Diffusivity Differentiate Response to Electroconvulsive Therapy in Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimagingKubicki, Antoni; Leaver, Amber M; Vasavada, Megha; Njau, Stephanie; Wade, Benjamin; Joshi, Shantanu H; Loureiro, Joana; Hellemann, Gerhard; Woods, Roger P; Espinoza, Randall; Narr, Katherine LMarch 1, 2019Not Determined
30424864Create StudyMechanisms of Antidepressant Response to Electroconvulsive Therapy Studied With Perfusion Magnetic Resonance Imaging.Biological psychiatryLeaver, Amber M; Vasavada, Megha; Joshi, Shantanu H; Wade, Benjamin; Woods, Roger P; Espinoza, Randall; Narr, Katherine LMarch 15, 2019Not Determined
30006199Create StudyVolume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy.Biological psychiatryOltedal, Leif; Narr, Katherine L; Abbott, Christopher; Anand, Amit; Argyelan, Miklos; Bartsch, Hauke; Dannlowski, Udo; Dols, Annemieke; van Eijndhoven, Philip; Emsell, Louise; Erchinger, Vera Jane; Espinoza, Randall; Hahn, Tim; Hanson, Lars G; Hellemann, Gerhard; Jorgensen, Martin Balslev; Kessler, Ute; Oudega, Mardien L; Paulson, Olaf B; Redlich, Ronny; Sienaert, Pascal; Stek, Max L; Tendolkar, Indira; Vandenbulcke, Mathieu; Oedegaard, Ketil J; Dale, Anders MOctober 15, 2018Not Determined
29953126Create StudyMeasuring Brain Connectivity via Shape Analysis of fMRI Time Courses and Spectra.Connectomics in neuroimaging : first International Workshop, CNI 2017, held in conjunction with MICCAI 2017, Quebec City, QC, Canada, September 14, 2017, Proceedings. CNI (Workshop) (1st : 2017 : Quebec, Quebec)Lee DS, Leaver A, Narr KL, Woods RP, Joshi SHSeptember 2017Not Determined
29754022Create StudyResilience and amygdala function in older healthy and depressed adults.Journal of affective disordersLeaver, Amber M; Yang, Hongyu; Siddarth, Prabha; Vlasova, Roza M; Krause, Beatrix; St Cyr, Natalie; Narr, Katherine L; Lavretsky, HelenSeptember 1, 2018Not Determined
29618992Create StudyFronto-Temporal Connectivity Predicts ECT Outcome in Major Depression.Frontiers in psychiatryLeaver, Amber M; Wade, Benjamin; Vasavada, Megha; Hellemann, Gerhard; Joshi, Shantanu H; Espinoza, Randall; Narr, Katherine LJanuary 1, 2018Not Determined
29489077Create StudyInflammation and Improvement of Depression Following Electroconvulsive Therapy in Treatment-Resistant Depression.The Journal of clinical psychiatryKruse, Jennifer L; Congdon, Eliza; Olmstead, Richard; Njau, Stephanie; Breen, Elizabeth C; Narr, Katherine L; Espinoza, Randall; Irwin, Michael R2018Not Determined
29217832Create StudyInter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study.Translational psychiatryWade, Benjamin S C; Sui, Jing; Hellemann, Gerhard; Leaver, Amber M; Espinoza, Randall T; Woods, Roger P; Abbott, Christopher C; Joshi, Shantanu H; Narr, Katherine LDecember 2017Not Determined
28275543Create StudyThe Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy.NeuroImage. ClinicalOltedal, Leif; Bartsch, Hauke; Sørhaug, Ole Johan Evjenth; Kessler, Ute; Abbott, Christopher; Dols, Annemieke; Stek, Max L; Ersland, Lars; Emsell, Louise; van Eijndhoven, Philip; Argyelan, Miklos; Tendolkar, Indira; Nordanskog, Pia; Hamilton, Paul; Jorgensen, Martin Balslev; Sommer, Iris E; Heringa, Sophie M; Draganski, Bogdan; Redlich, Ronny; Dannlowski, Udo; Kugel, Harald; Bouckaert, Filip; Sienaert, Pascal; Anand, Amit; Espinoza, Randall; Narr, Katherine L; Holland, Dominic; Dale, Anders M; Oedegaard, Ketil JJanuary 1, 2017Not Determined
helpcenter.collection.publications-tab

NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
101/15/2020
230
Approved
To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.
Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Penn Emotion Recognition Task-40 info icon
19501/15/2020
229
Approved
Medical History info icon
24001/15/2020
230
Approved
Physical Exam info icon
24001/15/2020
230
Approved
Depression, Anxiety, and Stress Scale info icon
24001/15/2020
230
Approved
Pittsburgh Sleep Quality Index info icon
24001/15/2020
230
Approved
Fagerstrom Test for Nicotine Dependence info icon
24001/15/2020
230
Approved
List Sorting Working Memory Test info icon
24001/15/2020
214
Approved
WHO Disability Assessment Schedule info icon
24001/15/2020
230
Approved
Hamilton Rating Scale for Depression info icon
24001/15/2020
230
Approved
Quick Inventory of Depressive Symptomatology info icon
24001/15/2020
230
Approved
Behavioral Inhibition Scale/Behavioral Activation Scale info icon
24001/15/2020
230
Approved
Snaith-Hamilton Pleasure Scale info icon
24001/15/2020
230
Approved
NIH Toolbox Oral Reading Recognition Test info icon
24001/15/2020
214
Approved
Picture Vocabulary Test info icon
24001/15/2020
214
Approved
Structure not yet defined
No Status history for this Data Expected has been recorded yet
helpcenter.collection.data-expected-tab

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Sex-differential markers of psychiatric risk and treatment response based on premature aging of functional brain network dynamics and peripheral physiology Background Aging is a multilevel process of gradual decline that predicts morbidity and mortality. Independent investigations have implicated senescence of brain and peripheral physiology in psychiatric risk, but it is unclear whether these effects stem from unique or shared mechanisms. Methods To address this question, we analyzed clinical, blood chemistry and resting state functional neuroimaging data in a healthy aging cohort (N= 427; age 36-100 years) and two disorder-specific samples encompassing patients with early psychosis (100 patients, 16-35 years) and major depressive disorder (MDD) (104 patients, 20-76 years). Results We identified sex-dependent coupling between blood chemistry markers of metabolic senescence (i.e., homeostatic dysregulation), functional brain network aging, and psychiatric risk. In females, premature aging of frontoparietal and somatomotor networks was linked to greater homeostatic dysregulation. It also predicted the severity and treatment resistance of mood symptoms (depression/anxiety [all three samples], anhedonia [MDD]) and social withdrawal/behavioral inhibition (avoidant personality disorder [healthy aging]; negative symptoms [early psychosis]). In males, premature aging of the default mode, cingulo-opercular, and visual networks was linked to reduced homeostatic dysregulation and predicted severity and treatment resistance of symptoms relevant to hostility/aggression (antisocial personality disorder [healthy aging]; mania/positive symptoms [early psychosis]), impaired thought processes (early psychosis, MDD) and somatic problems (healthy aging, MDD). Conclusions Our findings identify sexually dimorphic relationships between brain dynamics, peripheral physiology, and risk for psychiatric illness, suggesting that the specificity of putative risk biomarkers and precision therapeutics may be improved by considering sex and other relevant personal characteristics. 104/631Secondary AnalysisShared
Perturbation of the treatment resistant depression connectome by fast-acting therapies (PDC) Release 1.0The Perturbation of the treatment resistant depression connectome by fast-acting therapies study leveraged the optimized MRI technologies of the NIH-funded Human Connectome Project (HCP) to address how interventions with rapid and robust effects on mood and behavior modulate brain networks (or the connectome) in major depression. This study was part of the broader Connectomes Related to Human Diseases (CRHD) initiative subsumed under the parent HCP. The data being shared include multimodal MRI data collected using image acquisition protocols identical to the Human Connectome Lifespan Project for Aging (HCP-A, U01AG052564), with the exception of one of the two fMRI tasks administered. Demographic and behavioral measures collected for this CRHD cohort also overlap with the HCP-A project, though the diagnostic and clinical assessments collected are unique to this project, which includes patients with major depressive disorder (MDD). However, some of these MDD-specific assessments are similar to those used for other CRHD projects focused on mood and anxiety disorders. The specific objectives of this CRHD project are to 1) identify connectome-specific correlates and predictors of treatment outcome to electroconvulsive therapy (ECT), serial ketamine treatment and experimental total sleep deprivation (TSD), which each have rapidly-acting antidepressant effects via neurostimulation, pharmacological or behavioral perturbation, and to 2) characterize alterations in neural connectivity associated with individual clinical, behavioral or physiological factors that distinguish patients with severe depression from non-depressed controls. 230/230Primary AnalysisShared
* Data not on individual level
helpcenter.collection.associated-studies-tab

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.
Edit