NIMH Data Archive - Data

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¹ Numbers reported are subjects by age

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

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1/5 to 5/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome #2959

General
Experiments (1)
Shared Data
Publications (120)
Data Expected (2)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	1/5 to 5/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
Collection Investigators:	Raquel Gur, Stephen T. Warren
Collection Description:	The International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome (22q11DS) is a collaborative RO1 of 22 institutions, with one genomic and four phenotyping leading sites. The collaboration combines genomic with neuropsychiatric and neurobehavioral paradigms to advance the understanding of the pathogenesis of schizophrenia (SZ) and related phenotypes. The Consortium provides the largest available sample to date of 1000 genetically and phenotypically characterized individuals with 22q11DS. There is a substantial risk for developing SZ in adolescents and young adults with 22q11DS (~25-30%), with illness presentation and course similar to SZ in the general population (~1%). Consortium sites have established collaborations with extensive experience in applying integrative genomic and brain-behavior strategies to study 22q11DS and SZ across the lifespan. We will examine neuropsychiatric features through an integrated consensus focusing on SZ and emergence of psychosis. Neurobehavioral measures will be investigated across domains, establishing their relation to psychosis (Specific Aim 1). We will conduct whole genome sequencing (WGS) on 600 individuals with 22q11DS to uncover genetic variation that may contribute to the heterogeneity of neuropsychiatric and neurobehavioral phenotypes of SZ and psychosis. The convergence of phenotypic and genomic measures in adult and pediatric populations will permit examination of shared genetic variants that influence the expression of SZ and early psychosis. We will perform WGS on 300 adults using phenotypic "extremes": 150 22q11DS individuals with SZ and 150 22q11DS individuals without psychotic symptoms, as well as 300 pediatric participants with 22q11DS phenotyped by cognitive decline and psychosis proneness. This will be followed by association analysis on all common SNPs and CNVs in the entire sample. The discovered genomic variation will be followed in non-deleted SZ GWAS (Specific Aim 2). As diverse approaches and instruments are applied in assessing neuropsychiatric and neurobehavioral phenotypes in 22q11DS, the Consortium can advance the field by developing and piloting common measures that tap major dimensions of psychopathology and brain function. This will enhance the integration of phenotypic and genomic data, lay the foundation for a systematic approach internationally and provide a framework for longitudinal studies. This approach will cohere with RDoC and integration of genomic and neuroscience paradigms (Specific Aim 3). The resource built by the international Consortium will be a platform for data sharing as tools created, specimens collected and high fidelity data are placed in the public domain (Specific Aim 4). The proposed project will be an unprecedented international initiative to examine a common deletion associated with SZ and elucidate its genomic and behavioral substrates. Beyond the potential for yielding a better understanding of a severe manifestation of 22q11DS, the results will help identify pathways leading to SZ in the general population in a way that will inform novel treatments.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	07/06/2018
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$11,874,116.00
Subjects Shared:	1,058

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
U01MH101719-01	1/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	09/26/2013	07/31/2018	20	1789	UNIVERSITY OF PENNSYLVANIA	$2,794,609.00
U01MH101720-01	2/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	09/26/2013	07/31/2018	1000	1829	EMORY UNIVERSITY	$6,242,940.00
U01MH101722-01	"4/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome"	09/26/2013	07/31/2018	0	1789	KATHOLIEKE UNIVERSITEIT LEUVEN	$1,271,767.00
U01MH101724-01	5/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	09/26/2013	07/31/2018	341	317	CARDIFF UNIVERSITY	$743,751.00
U01MH101723-01	3/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	09/26/2013	07/31/2018	1000	1789	CENTRE FOR ADDICTION AND MENTAL HEALTH	$821,049.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
1591	Phenotypic Characterization of Psychosis Dimensions in 22q11.2 Deletion Syndrome	08/12/2020	Approved	Omics

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

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Shared Data:

Title	Type	Number of Subjects
Genomics Sample	Genomics	1058

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38224541	Create Study	Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome.	Human brain mapping	Ge, Ruiyang; Ching, Christopher R K; Bassett, Anne S; Kushan, Leila; Antshel, Kevin M; van Amelsvoort, Therese; Bakker, Geor; Butcher, Nancy J; Campbell, Linda E; Chow, Eva W C; Craig, Michael; Crossley, Nicolas A; Cunningham, Adam; Daly, Eileen; Doherty, Joanne L; Durdle, Courtney A; Emanuel, Beverly S; Fiksinski, Ania; Forsyth, Jennifer K; Fremont, Wanda; Goodrich-Hunsaker, Naomi J; Gudbrandsen, Maria; Gur, Raquel E; Jalbrzikowski, Maria; Kates, Wendy R; Lin, Amy; Linden, David E J; McCabe, Kathryn L; McDonald-McGinn, Donna; Moss, Hayley; Murphy, Declan G; Murphy, Kieran C; Owen, Michael J; Villalon-Reina, Julio E; Repetto, Gabriela M; Roalf, David R; Ruparel, Kosha; Schmitt, J Eric; Schuite-Koops, Sanne; Angkustsiri, Kathleen; Sun, Daqiang; Vajdi, Ariana; van den Bree, Marianne; Vorstman, Jacob; Thompson, Paul M; Vila-Rodriguez, Fidel; Bearden, Carrie E	January 1, 2024	Not Determined
37661008	Create Study	Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.	Biological psychiatry	Boen, Rune; Kaufmann, Tobias; van der Meer, Dennis; Frei, Oleksandr; Agartz, Ingrid; Ames, David; Andersson, Micael; Armstrong, Nicola J; Artiges, Eric; Atkins, Joshua R; Bauer, Jochen; Benedetti, Francesco; Boomsma, Dorret I; Brodaty, Henry; Brosch, Katharina; Buckner, Randy L; Cairns, Murray J; Calhoun, Vince; Caspers, Svenja; Cichon, Sven; Corvin, Aiden P; Crespo-Facorro, Benedicto; Dannlowski, Udo; David, Friederike S; de Geus, Eco J C; de Zubicaray, Greig I; Desrivières, Sylvane; Doherty, Joanne L; Donohoe, Gary; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fisher, Simon E; Forstner, Andreas J; Fortaner-Uyà, Lidia; Frouin, Vincent; Fukunaga, Masaki; Ge, Tian; Glahn, David C; Goltermann, Janik; Grabe, Hans J; Green, Melissa J; Groenewold, Nynke A; Grotegerd, Dominik; Grøntvedt, Gøril Rolfseng; Hahn, Tim; Hashimoto, Ryota; Hehir-Kwa, Jayne Y; Henskens, Frans A; Holmes, Avram J; Håberg, Asta K; Haavik, Jan; Jacquemont, Sebastien; Jansen, Andreas; Jockwitz, Christiane; Jönsson, Erik G; Kikuchi, Masataka; Kircher, Tilo; Kumar, Kuldeep; Le Hellard, Stephanie; Leu, Costin; Linden, David E; Liu, Jingyu; Loughnan, Robert; Mather, Karen A; McMahon, Katie L; McRae, Allan F; Medland, Sarah E; Meinert, Susanne; Moreau, Clara A; Morris, Derek W; Mowry, Bryan J; Mühleisen, Thomas W; Nenadić, Igor; Nöthen, Markus M; Nyberg, Lars; Ophoff, Roel A; Owen, Michael J; Pantelis, Christos; Paolini, Marco; Paus, Tomas; Pausova, Zdenka; Persson, Karin; Quidé, Yann; Marques, Tiago Reis; Sachdev, Perminder S; Sando, Sigrid B; Schall, Ulrich; Scott, Rodney J; Selbæk, Geir; Shumskaya, Elena; Silva, Ana I; Sisodiya, Sanjay M; Stein, Frederike; Stein, Dan J; Straube, Benjamin; Streit, Fabian; Strike, Lachlan T; Teumer, Alexander; Teutenberg, Lea; Thalamuthu, Anbupalam; Tooney, Paul A; Tordesillas-Gutierrez, Diana; Trollor, Julian N; van 't Ent, Dennis; van den Bree, Marianne B M; van Haren, Neeltje E M; Vázquez-Bourgon, Javier; Völzke, Henry; Wen, Wei; Wittfeld, Katharina; Ching, Christopher R K; Westlye, Lars T; Thompson, Paul M; Bearden, Carrie E; Selmer, Kaja K; Alnæs, Dag; Andreassen, Ole A; Sønderby, Ida E; ENIGMA-CNV Working Group	January 15, 2024	Not Determined
37463940	Create Study	Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS.	NPJ genomic medicine	Zhao, Yingjie; Wang, Yujue; Shi, Lijie; McDonald-McGinn, Donna M; Crowley, T Blaine; McGinn, Daniel E; Tran, Oanh T; Miller, Daniella; Lin, Jhih-Rong; Zackai, Elaine; Johnston, H Richard; Chow, Eva W C; Vorstman, Jacob A S; Vingerhoets, Claudia; van Amelsvoort, Therese; Gothelf, Doron; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris R; Eliez, Stephan; Schneider, Maude; van den Bree, Marianne B M; Owen, Michael J; Kates, Wendy R; Repetto, Gabriela M; Shashi, Vandana; Schoch, Kelly; Bearden, Carrie E; Digilio, M Cristina; Unolt, Marta; Putotto, Carolina; Marino, Bruno; Pontillo, Maria; Armando, Marco; Vicari, Stefano; Angkustsiri, Kathleen; Campbell, Linda; Busa, Tiffany; Heine-Suñer, Damian; Murphy, Kieran C; Murphy, Declan; García-Miñaúr, Sixto; Fernández, Luis; International 22q11.2 Brain and Behavior Consortium (IBBC); Zhang, Zhengdong D; Goldmuntz, Elizabeth; Gur, Raquel E; Emanuel, Beverly S; Zheng, Deyou; Marshall, Christian R; Bassett, Anne S; Wang, Tao; Morrow, Bernice E	July 18, 2023	Not Determined
36631438	Create Study	Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions.	Translational psychiatry	Chawner, Samuel J R A; Evans, Alexandra; IMAGINE-ID consortium; Williams, Nigel; Owen, Michael J; Hall, Jeremy; van den Bree, Marianne B M	January 11, 2023	Not Determined
36446581	Create Study	Psychopathology in mothers of children with pathogenic Copy Number Variants.	Journal of medical genetics	Niarchou, Maria; Cunningham, Adam C; Chawner, Samuel J R A; Moulding, Hayley; Sopp, Matthew; IMAGINE-ID; Hall, Jeremy; Owen, Michael J; van den Bree, Marianne B M	July 1, 2023	Not Determined
36292685	Create Study	Influence of Parent-of-Origin on Intellectual Outcomes in the Chromosome 22q11.2 Deletion Syndrome.	Genes	McGinn, Daniel E; Crowley, T Blaine; Heung, Tracy; Tran, Oanh; Moss, Edward; Zackai, Elaine H; Emanuel, Beverly S; Chow, Eva W C; Morrow, Bernice E; Swillen, Ann; Bassett, Anne S; McDonald-McGinn, Donna M	October 5, 2022	Not Determined
36140839	Create Study	The Relationships between Dopaminergic, Glutamatergic, and Cognitive Functioning in 22q11.2 Deletion Syndrome: A Cross-Sectional, Multimodal 1H-MRS and 18F-Fallypride PET Study.	Genes	van Hooijdonk, Carmen F M; Tse, Desmond H Y; Roosenschoon, Julia; Ceccarini, Jenny; Booij, Jan; van Amelsvoort, Therese A M J; Vingerhoets, Claudia	September 19, 2022	Not Determined
36039635	Create Study	Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms.	eLife	Donnelly, Nicholas A; Bartsch, Ullrich; Moulding, Hayley A; Eaton, Christopher; Marston, Hugh; Hall, Jessica H; Hall, Jeremy; Owen, Michael J; van den Bree, Marianne B M; Jones, Matt W	August 30, 2022	Not Determined
36006005	Create Study	Decomposing the role of alpha oscillations during brain maturation.	eLife	Tröndle, Marius; Popov, Tzvetan; Dziemian, Sabine; Langer, Nicolas	August 25, 2022	Not Determined
35896619	Create Study	Longitudinal trajectories of cortical development in 22q11.2 copy number variants and typically developing controls.	Molecular psychiatry	Jalbrzikowski, Maria; Lin, Amy; Vajdi, Ariana; Grigoryan, Vardui; Kushan, Leila; Ching, Christopher R K; Schleifer, Charles; Hayes, Rebecca A; Chu, Stephanie A; Sugar, Catherine A; Forsyth, Jennifer K; Bearden, Carrie E	October 1, 2022	Not Determined
35641891	Create Study	Gastrointestinal Features of 22q11.2 Deletion Syndrome Include Chronic Motility Problems From Childhood to Adulthood.	Journal of pediatric gastroenterology and nutrition	Kotcher, Rebecca E; Chait, Daniel B; Heckert, Jason M; Crowley, T Blaine; Forde, Kimberly A; Ahuja, Nitin K; Mascarenhas, Maria R; Emanuel, Beverly S; Zackai, Elaine H; McDonald-McGinn, Donna M; Reynolds, James C	August 1, 2022	Not Determined
34841284	Create Study	Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression.	Brain, behavior, & immunity - health	Lin, Amy; Forsyth, Jennifer K; Hoftman, Gil D; Kushan-Wells, Leila; Jalbrzikowski, Maria; Dokuru, Deepika; Coppola, Giovanni; Fiksinski, Ania; Zinkstok, Janneke; Vorstman, Jacob; Nachun, Daniel; Bearden, Carrie E	December 1, 2021	Not Determined
34356046	Create Study	Genome-Wide Association Studies of Conotruncal Heart Defects with Normally Related Great Vessels in the United States.	Genes	Oluwafemi, Omobola O; Musfee, Fadi I; Mitchell, Laura E; Goldmuntz, Elizabeth; Xie, Hongbo M; Hakonarson, Hakon; Morrow, Bernice E; Guo, Tingwei; Taylor, Deanne M; McDonald-McGinn, Donna M; Emanuel, Beverly S; Agopian, A J	July 1, 2021	Not Determined
34328347	Create Study	Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot.	Circulation. Genomic and precision medicine	Reuter, Miriam S; Chaturvedi, Rajiv R; Jobling, Rebekah K; Pellecchia, Giovanna; Hamdan, Omar; Sung, Wilson W L; Nalpathamkalam, Thomas; Attaluri, Pratyusha; Silversides, Candice K; Wald, Rachel M; Marshall, Christian R; Williams, Simon G; Keavney, Bernard D; Thiruvahindrapuram, Bhooma; Scherer, Stephen W; Bassett, Anne S	August 1, 2021	Not Determined
34213087	Create Study	Relationship between intelligence quotient measures and computerized neurocognitive performance in 22q11.2 deletion syndrome.	Brain and behavior	Gur, Ruben C; Moore, Tyler M; Weinberger, Ronnie; Mekori-Domachevsky, Ehud; Gross, Raz; Emanuel, Beverly S; Zackai, Elaine H; Moss, Edward; Gallagher, Robert Sean; McGinn, Daniel E; Crowley, Terrence Blaine; McDonald-McGinn, Donna; Gothelf, Doron; Gur, Raquel E	August 1, 2021	Not Determined
34126928	Create Study	Inter-rater reliability of subthreshold psychotic symptoms in individuals with 22q11.2 deletion syndrome.	Journal of neurodevelopmental disorders	Moore, Tyler M; Salzer, Deby; Bearden, Carrie E; Calkins, Monica E; Kates, Wendy R; Kushan, Leila; Gallagher, Robert Sean; Frumer, Dafna Sofrin; Weinberger, Ronnie; McDonald-McGinn, Donna M; Gur, Raquel E; Gothelf, Doron	June 14, 2021	Not Determined
34115224	Create Study	Resilience and quality of life in young adults with a 22q11.2 deletion syndrome: a patient''s perspective.	European child & adolescent psychiatry	Van de Woestyne, Kris; Vandensande, Ans; Vansteelandt, Kristof; Maes, Bea; Vergaelen, Elfi; Swillen, Ann	December 1, 2022	Not Determined
33981004	Create Study	Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.	Molecular psychiatry	Rogdaki, Maria; Devroye, Céline; Ciampoli, Mariasole; Veronese, Mattia; Ashok, Abhishekh H; McCutcheon, Robert A; Jauhar, Sameer; Bonoldi, Ilaria; Gudbrandsen, Maria; Daly, Eileen; van Amelsvoort, Therese; Van Den Bree, Marianne; Owen, Michael J; Turkheimer, Federico; Papaleo, Francesco; Howes, Oliver D	May 1, 2023	Not Determined
33894539	Create Study	A binational study assessing risk and resilience factors in 22q11.2 deletion syndrome.	Journal of psychiatric research	Gur, Raquel E; White, Lauren K; Shani, Shachar; Barzilay, Ran; Moore, Tyler M; Emanuel, Beverly S; Zackai, Elaine H; McDonald-McGinn, Donna M; Matalon, Noam; Weinberger, Ronnie; Gur, Ruben C; Gothelf, Doron	June 1, 2021	Not Determined
33876226	Create Study	Disruption of the blood-brain barrier in 22q11.2 deletion syndrome.	Brain : a journal of neurology	Crockett, Alexis M; Ryan, Sean K; Vásquez, Adriana Hernandez; Canning, Caroline; Kanyuch, Nickole; Kebir, Hania; Ceja, Guadalupe; Gesualdi, James; Zackai, Elaine; McDonald-McGinn, Donna; Viaene, Angela; Kapoor, Richa; Benallegue, Naïl; Gur, Raquel; Anderson, Stewart A; Alvarez, Jorge I	June 22, 2021	Not Determined
33863277	Create Study	Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders.	Journal of neurodevelopmental disorders	Jalal, Rhideeta; Nair, Aarti; Lin, Amy; Eckfeld, Ariel; Kushan, Leila; Zinberg, Jamie; Karlsgodt, Katherine H; Cannon, Tyrone D; Bearden, Carrie E	April 17, 2021	Not Determined
33638978	Create Study	Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics.	Cerebral cortex (New York, N.Y. : 1991)	Forsyth, Jennifer K; Mennigen, Eva; Lin, Amy; Sun, Daqiang; Vajdi, Ariana; Kushan-Wells, Leila; Ching, Christopher R K; Villalon-Reina, Julio E; Thompson, Paul M; 22q11.2 ENIGMA Consortium; Bearden, Carrie E	June 10, 2021	Not Determined
33615640	Create Study	Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs.	Human brain mapping	Sønderby, Ida E; Ching, Christopher R K; Thomopoulos, Sophia I; van der Meer, Dennis; Sun, Daqiang; Villalon-Reina, Julio E; Agartz, Ingrid; Amunts, Katrin; Arango, Celso; Armstrong, Nicola J; Ayesa-Arriola, Rosa; Bakker, Geor; Bassett, Anne S; Boomsma, Dorret I; Bülow, Robin; Butcher, Nancy J; Calhoun, Vince D; Caspers, Svenja; Chow, Eva W C; Cichon, Sven; Ciufolini, Simone; Craig, Michael C; Crespo-Facorro, Benedicto; Cunningham, Adam C; Dale, Anders M; Dazzan, Paola; de Zubicaray, Greig I; Djurovic, Srdjan; Doherty, Joanne L; Donohoe, Gary; Draganski, Bogdan; Durdle, Courtney A; Ehrlich, Stefan; Emanuel, Beverly S; Espeseth, Thomas; Fisher, Simon E; Ge, Tian; Glahn, David C; Grabe, Hans J; Gur, Raquel E; Gutman, Boris A; Haavik, Jan; Håberg, Asta K; Hansen, Laura A; Hashimoto, Ryota; Hibar, Derrek P; Holmes, Avram J; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E; Jalbrzikowski, Maria; Knowles, Emma E M; Kushan, Leila; Linden, David E J; Liu, Jingyu; Lundervold, Astri J; Martin-Brevet, Sandra; Martínez, Kenia; Mather, Karen A; Mathias, Samuel R; McDonald-McGinn, Donna M; McRae, Allan F; Medland, Sarah E; Moberget, Torgeir; Modenato, Claudia; Monereo Sánchez, Jennifer; Moreau, Clara A; Mühleisen, Thomas W; Paus, Tomas; Pausova, Zdenka; Prieto, Carlos; Ragothaman, Anjanibhargavi; Reinbold, Céline S; Reis Marques, Tiago; Repetto, Gabriela M; Reymond, Alexandre; Roalf, David R; Rodriguez-Herreros, Borja; Rucker, James J; Sachdev, Perminder S; Schmitt, James E; Schofield, Peter R; Silva, Ana I; Stefansson, Hreinn; Stein, Dan J; Tamnes, Christian K; Tordesillas-Gutiérrez, Diana; Ulfarsson, Magnus O; Vajdi, Ariana; van 't Ent, Dennis; van den Bree, Marianne B M; Vassos, Evangelos; Vázquez-Bourgon, Javier; Vila-Rodriguez, Fidel; Walters, G Bragi; Wen, Wei; Westlye, Lars T; Wittfeld, Katharina; Zackai, Elaine H; Stefánsson, Kári; Jacquemont, Sebastien; Thompson, Paul M; Bearden, Carrie E; Andreassen, Ole A; ENIGMA-CNV Working Group; ENIGMA 22q11.2 Deletion Syndrome Working Group	January 1, 2022	Not Determined
33571729	Create Study	Pathways to understanding psychosis through rare - 22q11.2DS - and common variants.	Current opinion in genetics & development	Gur, Raquel E; Roalf, David R; Alexander-Bloch, Aaron; McDonald-McGinn, Donna M; Gur, Ruben C	June 1, 2021	Not Determined
33384013	Create Study	A Genetics-First Approach to Dissecting the Heterogeneity of Autism: Phenotypic Comparison of Autism Risk Copy Number Variants.	The American journal of psychiatry	Chawner, Samuel J R A; Doherty, Joanne L; Anney, Richard J L; Antshel, Kevin M; Bearden, Carrie E; Bernier, Raphael; Chung, Wendy K; Clements, Caitlin C; Curran, Sarah R; Cuturilo, Goran; Fiksinski, Ania M; Gallagher, Louise; Goin-Kochel, Robin P; Gur, Raquel E; Hanson, Ellen; Jacquemont, Sebastien; Kates, Wendy R; Kushan, Leila; Maillard, Anne M; McDonald-McGinn, Donna M; Mihaljevic, Marina; Miller, Judith S; Moss, Hayley; Pejovic-Milovancevic, Milica; Schultz, Robert T; Green-Snyder, LeeAnne; Vorstman, Jacob A; Wenger, Tara L; IMAGINE-ID Consortium; Hall, Jeremy; Owen, Michael J; van den Bree, Marianne B M	January 1, 2021	Not Determined
33187471	Create Study	Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method.	Journal of neurodevelopmental disorders	Schneider, Maude; Vaessen, Thomas; van Duin, Esther D A; Kasanova, Zuzana; Viechtbauer, Wolfgang; Reininghaus, Ulrich; Vingerhoets, Claudia; Booij, Jan; Swillen, Ann; Vorstman, Jacob A S; van Amelsvoort, Thérèse; Myin-Germeys, Inez	November 13, 2020	Not Determined
33169016	Create Study	Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.	Nature medicine	Davies, Robert W; Fiksinski, Ania M; Breetvelt, Elemi J; Williams, Nigel M; Hooper, Stephen R; Monfeuga, Thomas; Bassett, Anne S; Owen, Michael J; Gur, Raquel E; Morrow, Bernice E; McDonald-McGinn, Donna M; Swillen, Ann; Chow, Eva W C; van den Bree, Marianne; Emanuel, Beverly S; Vermeesch, Joris R; van Amelsvoort, Therese; Arango, Celso; Armando, Marco; Campbell, Linda E; Cubells, Joseph F; Eliez, Stephan; Garcia-Minaur, Sixto; Gothelf, Doron; Kates, Wendy R; Murphy, Kieran C; Murphy, Clodagh M; Murphy, Declan G; Philip, Nicole; Repetto, Gabriela M; Shashi, Vandana; Simon, Tony J; Suñer, Damiàn Heine; Vicari, Stefano; Scherer, Stephen W; International 22q11.2 Brain and Behavior Consortium; Bearden, Carrie E; Vorstman, Jacob A S	December 1, 2020	Not Determined
32643597	Create Study	Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs.	Psychological medicine	Cunningham, Adam C; Hall, Jeremy; Einfeld, Stewart; Owen, Michael J; IMAGINE-ID consortium; van den Bree, Marianne B M	February 1, 2022	Not Determined
32407568	Create Study	Personalized medical information card for adults with 22q11.2 deletion syndrome: An initiative to improve communication between patients and healthcare providers.	Journal of applied research in intellectual disabilities : JARID	Loo, Joanne C Y; Boot, Erik; Corral, Maria; Bassett, Anne S	November 1, 2020	Not Determined
32379361	Create Study	Movement Disorder Phenotypes in Children With 22q11.2 Deletion Syndrome.	Movement disorders : official journal of the Movement Disorder Society	Cunningham, Adam C; Fung, Wilson; Massey, Thomas H; Hall, Jeremy; Owen, Michael J; van den Bree, Marianne B M; Peall, Kathryn J	July 1, 2020	Not Determined
32327654	Create Study	22q11.2 deletion - a tiny piece leading to a big picture.	Nature reviews. Disease primers	McDonald-McGinn, Donna M	April 23, 2020	Not Determined
32143830	Create Study	Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder.	Biological psychiatry	Lin, Amy; Vajdi, Ariana; Kushan-Wells, Leila; Helleman, Gerhard; Hansen, Laura Pacheco; Jonas, Rachel K; Jalbrzikowski, Maria; Kingsbury, Lyle; Raznahan, Armin; Bearden, Carrie E	August 1, 2020	Not Determined
32115693	Create Study	Response to letter to editor: "Knowing when and how to use epilepsy screening questionnaires".	Epilepsia	Eaton, Christopher B; Thomas, Rhys H; Hamandi, Khalid; Payne, Gareth C; Kerr, Michael P; Linden, David E J; Owen, Michael J; Cunningham, Adam C; Bartsch, Ullrich; Struik, Siske S; van den Bree, Marianne B M	April 1, 2020	Not Determined
32066691	Create Study	Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology.	Translational psychiatry	Morrison, Sinead; Chawner, Samuel J R A; van Amelsvoort, Therese A M J; Swillen, Ann; Vingerhoets, Claudia; Vergaelen, Elfi; Linden, David E J; Linden, Stefanie; Owen, Michael J; van den Bree, Marianne B M	February 3, 2020	Not Determined
32046535	Create Study	Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness.	The American journal of psychiatry	Ching, Christopher R K; Gutman, Boris A; Sun, Daqiang; Villalon Reina, Julio; Ragothaman, Anjanibhargavi; Isaev, Dmitry; Zavaliangos-Petropulu, Artemis; Lin, Amy; Jonas, Rachel K; Kushan, Leila; Pacheco-Hansen, Laura; Vajdi, Ariana; Forsyth, Jennifer K; Jalbrzikowski, Maria; Bakker, Geor; van Amelsvoort, Therese; Antshel, Kevin M; Fremont, Wanda; Kates, Wendy R; Campbell, Linda E; McCabe, Kathryn L; Craig, Michael C; Daly, Eileen; Gudbrandsen, Maria; Murphy, Clodagh M; Murphy, Declan G; Murphy, Kieran C; Fiksinski, Ania; Koops, Sanne; Vorstman, Jacob; Crowley, T Blaine; Emanuel, Beverly S; Gur, Raquel E; McDonald-McGinn, Donna M; Roalf, David R; Ruparel, Kosha; Schmitt, J Eric; Zackai, Elaine H; Durdle, Courtney A; Goodrich-Hunsaker, Naomi J; Simon, Tony J; Bassett, Anne S; Butcher, Nancy J; Chow, Eva W C; Vila-Rodriguez, Fidel; Cunningham, Adam; Doherty, Joanne; Linden, David E; Moss, Hayley; Owen, Michael J; van den Bree, Marianne; Crossley, Nicolas A; Repetto, Gabriela M; Thompson, Paul M; Bearden, Carrie E	July 1, 2020	Not Determined
32015465	Create Study	Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.	Molecular psychiatry	Cleynen, Isabelle; Engchuan, Worrawat; Hestand, Matthew S; Heung, Tracy; Holleman, Aaron M; Johnston, H Richard; Monfeuga, Thomas; McDonald-McGinn, Donna M; Gur, Raquel E; Morrow, Bernice E; Swillen, Ann; Vorstman, Jacob A S; Bearden, Carrie E; Chow, Eva W C; van den Bree, Marianne; Emanuel, Beverly S; Vermeesch, Joris R; Warren, Stephen T; Owen, Michael J; Chopra, Pankaj; Cutler, David J; Duncan, Richard; Kotlar, Alex V; Mulle, Jennifer G; Voss, Anna J; Zwick, Michael E; Diacou, Alexander; Golden, Aaron; Guo, Tingwei; Lin, Jhih-Rong; Wang, Tao; Zhang, Zhengdong; Zhao, Yingjie; Marshall, Christian; Merico, Daniele; Jin, Andrea; Lilley, Brenna; Salmons, Harold I; Tran, Oanh; Holmans, Peter; Pardinas, Antonio; Walters, James T R; Demaerel, Wolfram; Boot, Erik; Butcher, Nancy J; Costain, Gregory A; Lowther, Chelsea; Evers, Rens; van Amelsvoort, Therese A M J; van Duin, Esther; Vingerhoets, Claudia; Breckpot, Jeroen; Devriendt, Koen; Vergaelen, Elfi; Vogels, Annick; Crowley, T Blaine; McGinn, Daniel E; Moss, Edward M; Sharkus, Robert J; Unolt, Marta; Zackai, Elaine H; Calkins, Monica E; Gallagher, Robert S; Gur, Ruben C; Tang, Sunny X; Fritsch, Rosemarie; Ornstein, Claudia; Repetto, Gabriela M; Breetvelt, Elemi; Duijff, Sasja N; Fiksinski, Ania; Moss, Hayley; Niarchou, Maria; Murphy, Kieran C; Prasad, Sarah E; Daly, Eileen M; Gudbrandsen, Maria; Murphy, Clodagh M; Murphy, Declan G; Buzzanca, Antonio; Fabio, Fabio Di; Digilio, Maria C; Pontillo, Maria; Marino, Bruno; Vicari, Stefano; Coleman, Karlene; Cubells, Joseph F; Ousley, Opal Y; Carmel, Miri; Gothelf, Doron; Mekori-Domachevsky, Ehud; Michaelovsky, Elena; Weinberger, Ronnie; Weizman, Abraham; Kushan, Leila; Jalbrzikowski, Maria; Armando, Marco; Eliez, Stéphan; Sandini, Corrado; Schneider, Maude; Béna, Frédérique Sloan; Antshel, Kevin M; Fremont, Wanda; Kates, Wendy R; Belzeaux, Raoul; Busa, Tiffany; Philip, Nicole; Campbell, Linda E; McCabe, Kathryn L; Hooper, Stephen R; Schoch, Kelly; Shashi, Vandana; Simon, Tony J; Tassone, Flora; Arango, Celso; Fraguas, David; García-Miñaúr, Sixto; Morey-Canyelles, Jaume; Rosell, Jordi; Suñer, Damià H; Raventos-Simic, Jasna; International 22q11.2DS Brain and Behavior Consortium; Epstein, Michael P; Williams, Nigel M; Bassett, Anne S	August 1, 2021	Not Determined
31884517	Create Study	Atypical chromosome 22q11.2 deletions are complex rearrangements and have different mechanistic origins.	Human molecular genetics	Vervoort, Lisanne; Demaerel, Wolfram; Rengifo, Laura Y; Odrzywolski, Adrian; Vergaelen, Elfi; Hestand, Matthew S; Breckpot, Jeroen; Devriendt, Koen; Swillen, Ann; McDonald-McGinn, Donna M; Fiksinski, Ania M; Zinkstok, Janneke R; Morrow, Bernice E; Heung, Tracy; Vorstman, Jacob A S; Bassett, Anne S; Chow, Eva W C; Shashi, Vandana; International 22q11.2 Brain; Behavior Consortium; Vermeesch, Joris R	November 15, 2019	Not Determined
31870554	Create Study	Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects.	American journal of human genetics	Zhao, Yingjie; Diacou, Alexander; Johnston, H Richard; Musfee, Fadi I; McDonald-McGinn, Donna M; McGinn, Daniel; Crowley, T Blaine; Repetto, Gabriela M; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris R; Kates, Wendy R; Digilio, M Cristina; Unolt, Marta; Marino, Bruno; Pontillo, Maria; Armando, Marco; Di Fabio, Fabio; Vicari, Stefano; van den Bree, Marianne; Moss, Hayley; Owen, Michael J; Murphy, Kieran C; Murphy, Clodagh M; Murphy, Declan; Schoch, Kelly; Shashi, Vandana; Tassone, Flora; Simon, Tony J; Shprintzen, Robert J; Campbell, Linda; Philip, Nicole; Heine-Suñer, Damian; García-Miñaúr, Sixto; Fernández, Luis; International 22q11.2 Brain and Behavior Consortium; Bearden, Carrie E; Vingerhoets, Claudia; van Amelsvoort, Therese; Eliez, Stephan; Schneider, Maude; Vorstman, Jacob A S; Gothelf, Doron; Zackai, Elaine; Agopian, A J; Gur, Raquel E; Bassett, Anne S; Emanuel, Beverly S; Goldmuntz, Elizabeth; Mitchell, Laura E; Wang, Tao; Morrow, Bernice E	January 2, 2020	Not Determined
31739810	Create Study	Coordination difficulties, IQ and psychopathology in children with high-risk copy number variants.	Psychological medicine	Cunningham, Adam C; Hall, Jeremy; Owen, Michael J; van den Bree, Marianne B M	January 1, 2021	Not Determined
31668493	Create Study	Association of a functional Claudin-5 variant with schizophrenia in female patients with the 22q11.2 deletion syndrome.	Schizophrenia research	Guo, Yiran; Singh, Larry N; Zhu, Yuankun; Gur, Raquel E; Resnick, Adam; Anderson, Stewart A; Alvarez, Jorge I	January 1, 2020	Not Determined
31481461	Create Study	The 22q11 low copy repeats are characterized by unprecedented size and structural variability.	Genome research	Demaerel, Wolfram; Mostovoy, Yulia; Yilmaz, Feyza; Vervoort, Lisanne; Pastor, Steven; Hestand, Matthew S; Swillen, Ann; Vergaelen, Elfi; Geiger, Elizabeth A; Coughlin, Curtis R; Chow, Stephen K; McDonald-McGinn, Donna; Morrow, Bernice; Kwok, Pui-Yan; Xiao, Ming; Emanuel, Beverly S; Shaikh, Tamim H; Vermeesch, Joris R	September 1, 2019	Not Determined
31474763	Create Study	Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition.	Genetics in medicine : official journal of the American College of Medical Genetics	Unolt, Marta; Kammoun, Molka; Nowakowska, Beata; Graham, Gail E; Crowley, T Blaine; Hestand, Matthew S; Demaerel, Wolfram; Geremek, Maciej; Emanuel, Beverly S; Zackai, Elaine H; Vermeesch, Joris R; McDonald-McGinn, Donna	February 1, 2020	Not Determined
31395526	Create Study	Neurobiological perspective of 22q11.2 deletion syndrome.	The lancet. Psychiatry	Zinkstok, Janneke R; Boot, Erik; Bassett, Anne S; Hiroi, Noboru; Butcher, Nancy J; Vingerhoets, Claudia; Vorstman, Jacob A S; van Amelsvoort, Therese A M J	November 1, 2019	Not Determined
31363180	Create Study	A genetic model for multimorbidity in young adults.	Genetics in medicine : official journal of the American College of Medical Genetics	Malecki, Sarah L; Van Mil, Spencer; Graffi, Justin; Breetvelt, Elemi; Corral, Maria; Boot, Erik; Chow, Eva W C; Sanches, Marcos; Verma, Amol A; Bassett, Anne S	January 1, 2020	Not Determined
31358905	Create Study	Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.	Molecular psychiatry	Villalón-Reina, Julio E; Martínez, Kenia; Qu, Xiaoping; Ching, Christopher R K; Nir, Talia M; Kothapalli, Deydeep; Corbin, Conor; Sun, Daqiang; Lin, Amy; Forsyth, Jennifer K; Kushan, Leila; Vajdi, Ariana; Jalbrzikowski, Maria; Hansen, Laura; Jonas, Rachel K; van Amelsvoort, Therese; Bakker, Geor; Kates, Wendy R; Antshel, Kevin M; Fremont, Wanda; Campbell, Linda E; McCabe, Kathryn L; Daly, Eileen; Gudbrandsen, Maria; Murphy, Clodagh M; Murphy, Declan; Craig, Michael; Emanuel, Beverly; McDonald-McGinn, Donna M; Vorstman, Jacob A S; Fiksinski, Ania M; Koops, Sanne; Ruparel, Kosha; Roalf, David; Gur, Raquel E; Eric Schmitt, J; Simon, Tony J; Goodrich-Hunsaker, Naomi J; Durdle, Courtney A; Doherty, Joanne L; Cunningham, Adam C; van den Bree, Marianne; Linden, David E J; Owen, Michael; Moss, Hayley; Kelly, Sinead; Donohoe, Gary; Murphy, Kieran C; Arango, Celso; Jahanshad, Neda; Thompson, Paul M; Bearden, Carrie E	November 1, 2020	Not Determined
31330115	Create Study	Speech-Language Disorders in 22q11.2 Deletion Syndrome: Best Practices for Diagnosis and Management.	American journal of speech-language pathology	Solot, Cynthia B; Sell, Debbie; Mayne, Anne; Baylis, Adriane L; Persson, Christina; Jackson, Oksana; McDonald-McGinn, Donna M	August 9, 2019	Not Determined
31144615	Create Study	Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS).	Psychological medicine	Moulding, H A; Bartsch, U; Hall, J; Jones, M W; Linden, D E; Owen, M J; van den Bree, M B M	May 1, 2020	Not Determined
30977115	Create Study	Epilepsy and seizures in young people with 22q11.2 deletion syndrome: Prevalence and links with other neurodevelopmental disorders.	Epilepsia	Eaton, Christopher B; Thomas, Rhys H; Hamandi, Khalid; Payne, Gareth C; Kerr, Michael P; Linden, David E J; Owen, Michael J; Cunningham, Adam C; Bartsch, Ullrich; Struik, Siske S; van den Bree, Marianne B M	May 1, 2019	Not Determined
30959234	Create Study	Lower cortisol levels and attenuated cortisol reactivity to daily-life stressors in adults with 22q11.2 deletion syndrome.	Psychoneuroendocrinology	van Duin, Esther D A; Vaessen, Thomas; Kasanova, Zuzana; Viechtbauer, Wolfgang; Reininghaus, Ulrich; Saalbrink, Peter; Vingerhoets, Claudia; Hernaus, Dennis; Booij, Jan; Swillen, Ann; Vorstman, Jacob; van Amelsvoort, Thérèse; Myin-Germeys, Inez	August 1, 2019	Not Determined
30935427	Create Study	Lower [18F]fallypride binding to dopamine D2/3 receptors in frontal brain areas in adults with 22q11.2 deletion syndrome: a positron emission tomography study.	Psychological medicine	van Duin, Esther D A; Ceccarini, Jenny; Booij, Jan; Kasanova, Zuzana; Vingerhoets, Claudia; van Huijstee, Jytte; Heinzel, Alexander; Mohammadkhani-Shali, Siamak; Winz, Oliver; Mottaghy, Felix; Myin-Germeys, Inez; van Amelsvoort, Thérèse	April 1, 2020	Not Determined
30710087	Create Study	Risk gene-set and pathways in 22q11.2 deletion-related schizophrenia: a genealogical molecular approach.	Translational psychiatry	Michaelovsky, Elena; Carmel, Miri; Frisch, Amos; Salmon-Divon, Mali; Pasmanik-Chor, Metsada; Weizman, Abraham; Gothelf, Doron	January 17, 2019	Not Determined
30458299	Create Study	The emergence of psychotic experiences in the early adolescence of 22q11.2 Deletion Syndrome.	Journal of psychiatric research	Chawner, Samuel J R A; Niarchou, Maria; Doherty, Joanne L; Moss, Hayley; Owen, Michael J; van den Bree, Marianne B M	February 1, 2019	Not Determined
30453155	Create Study	Psychiatric disorders and autism in young children with 22q11.2 deletion syndrome compared to children with idiopathic autism.	European psychiatry : the journal of the Association of European Psychiatrists	Serur, Yaffa; Sofrin Frumer, Dafna; Daon, Keren; Sobol-Havia, Dolly; Weinberger, Ronnie; Shulman, Cory; Gothelf, Doron	January 1, 2019	Not Determined
30444066	Create Study	Musical auditory processing, cognition, and psychopathology in 22q11.2 deletion syndrome.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Gao, Lucy; Tang, Sunny X; Yi, James J; McDonald-McGinn, Donna M; Zackai, Elaine H; Emanuel, Beverly S; Gur, Ruben C; Calkins, Monica E; Gur, Raquel E	December 1, 2018	Not Determined
30394904	Create Study	Recent developments in understanding the relationship between 22q11.2 deletion syndrome and psychosis.	Current opinion in psychiatry	O'Rourke, Linda; Murphy, Kieran C	March 1, 2019	Not Determined
30380195	Create Study	22q11.2 deletion syndrome: A tiny piece leading to a big picture.	American journal of medical genetics. Part A	McDonald-McGinn, Donna M	October 1, 2018	Not Determined
30380194	Create Study	Molecular genetics of 22q11.2 deletion syndrome.	American journal of medical genetics. Part A	Morrow, Bernice E; McDonald-McGinn, Donna M; Emanuel, Beverly S; Vermeesch, Joris R; Scambler, Peter J	October 1, 2018	Not Determined
30380191	Create Study	What is new with 22q? An update from the 22q and You Center at the Children''s Hospital of Philadelphia.	American journal of medical genetics. Part A	Campbell, Ian M; Sheppard, Sarah E; Crowley, T Blaine; McGinn, Daniel E; Bailey, Alice; McGinn, Michael J; Unolt, Marta; Homans, Jelle F; Chen, Erin Y; Salmons, Harold I; Gaynor, J William; Goldmuntz, Elizabeth; Jackson, Oksana A; Katz, Lorraine E; Mascarenhas, Maria R; Deeney, Vincent F X; Castelein, René M; Zur, Karen B; Elden, Lisa; Kallish, Staci; Kolon, Thomas F; Hopkins, Sarah E; Chadehumbe, Madeline A; Lambert, Michele P; Forbes, Brian J; Moldenhauer, Julie S; Schindewolf, Erica M; Solot, Cynthia B; Moss, Edward M; Gur, Raquel E; Sullivan, Kathleen E; Emanuel, Beverly S; Zackai, Elaine H; McDonald-McGinn, Donna M	October 1, 2018	Not Determined
30380188	Create Study	The impact of hypocalcemia on full scale IQ in patients with 22q11.2 deletion syndrome.	American journal of medical genetics. Part A	Grand, Katheryn; Levitt Katz, Lorraine E; Crowley, T Blaine; Moss, Edward; Lessig, Megan; Bamba, Vaneeta; Lord, Katherine; Zackai, Elaine H; Emanuel, Beverly S; Valverde, Kathleen; McDonald-McGinn, Donna M	October 1, 2018	Not Determined
30289625	Create Study	Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects.	American journal of medical genetics. Part A	Zhao, Yingjie; Guo, Tingwei; Fiksinski, Ania; Breetvelt, Elemi; McDonald-McGinn, Donna M; Crowley, Terrence B; Diacou, Alexander; Schneider, Maude; Eliez, Stephan; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris; Chow, Eva W C; Gothelf, Doron; Duijff, Sasja; Evers, Rens; van Amelsvoort, Thérèse A; van den Bree, Marianne; Owen, Michael; Niarchou, Maria; Bearden, Carrie E; Ornstein, Claudia; Pontillo, Maria; Buzzanca, Antonino; Vicari, Stefano; Armando, Marco; Murphy, Kieran C; Murphy, Clodagh; Garcia-Minaur, Sixto; Philip, Nicole; Campbell, Linda; Morey-Cañellas, Jaume; Raventos, Jasna; Rosell, Jordi; Heine-Suner, Damian; Shprintzen, Robert J; Gur, Raquel E; Zackai, Elaine; Emanuel, Beverly S; Wang, Tao; Kates, Wendy R; Bassett, Anne S; Vorstman, Jacob A S; Morrow, Bernice E; International 22q11.2 Brain and Behavior Consortium	October 1, 2018	Not Determined
30194907	Create Study	Understanding the pediatric psychiatric phenotype of 22q11.2 deletion syndrome.	American journal of medical genetics. Part A	Fiksinski, Ania M; Schneider, Maude; Murphy, Clodagh M; Armando, Marco; Vicari, Stefano; Canyelles, Jaume M; Gothelf, Doron; Eliez, Stephan; Breetvelt, Elemi J; Arango, Celso; Vorstman, Jacob A S	October 2018	Not Determined
30116778	Create Study	A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson''s disease and schizophrenia.	Science advances	Sumitomo, Akiko; Horike, Kouta; Hirai, Kazuko; Butcher, Nancy; Boot, Erik; Sakurai, Takeshi; Nucifora Jr, Frederick C; Bassett, Anne S; Sawa, Akira; Tomoda, Toshifumi	August 2018	Not Determined
30093352	Create Study	Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome.	Schizophrenia research	Niarchou, Maria; Chawner, Samuel J R A; Fiksinski, Ania; Vorstman, Jacob A S; Maeder, Johanna; Schneider, Maude; Eliez, Stephan; Armando, Marco; Pontillo, Maria; Vicari, Stefano; McDonald-McGinn, Donna M; Emanuel, Beverly S; Zackai, Elaine H; Bearden, Carrie E; Shashi, Vandana; Hooper, Stephen R; Owen, Michael J; Gur, Raquel E; Wray, Naomi R; van den Bree, Marianne B M; Thapar, Anita; International 22q11.2 Deletion Syndrome Brain and Behavior Consortium	February 1, 2019	Not Determined
29895892	Create Study	Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size.	Molecular psychiatry	Sun, Daqiang; Ching, Christopher R K; Lin, Amy; Forsyth, Jennifer K; Kushan, Leila; Vajdi, Ariana; Jalbrzikowski, Maria; Hansen, Laura; Villalon-Reina, Julio E; Qu, Xiaoping; Jonas, Rachel K; van Amelsvoort, Therese; Bakker, Geor; Kates, Wendy R; Antshel, Kevin M; Fremont, Wanda; Campbell, Linda E; McCabe, Kathryn L; Daly, Eileen; Gudbrandsen, Maria; Murphy, Clodagh M; Murphy, Declan; Craig, Michael; Vorstman, Jacob; Fiksinski, Ania; Koops, Sanne; Ruparel, Kosha; Roalf, David R; Gur, Raquel E; Schmitt, J Eric; Simon, Tony J; Goodrich-Hunsaker, Naomi J; Durdle, Courtney A; Bassett, Anne S; Chow, Eva W C; Butcher, Nancy J; Vila-Rodriguez, Fidel; Doherty, Joanne; Cunningham, Adam; van den Bree, Marianne B M; Linden, David E J; Moss, Hayley; Owen, Michael J; Murphy, Kieran C; McDonald-McGinn, Donna M; Emanuel, Beverly; van Erp, Theo G M; Turner, Jessica A; Thompson, Paul M; Bearden, Carrie E	August 2020	Not Determined
29777584	Create Study	Neuropsychiatric expression and catatonia in 22q11.2 deletion syndrome: An overview and case series.	American journal of medical genetics. Part A	Butcher, Nancy J; Boot, Erik; Lang, Anthony E; Andrade, Danielle; Vorstman, Jacob; McDonald-McGinn, Donna; Bassett, Anne S	October 2018	Not Determined
29752303	Create Study	Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2.	Neurology	Boot, Erik; Butcher, Nancy J; Udow, Sean; Marras, Connie; Mok, Kin Y; Kaneko, Satoshi; Barrett, Matthew J; Prontera, Paolo; Berman, Brian D; Masellis, Mario; Dufournet, Boris; Nguyen, Karine; Charles, Perrine; Mutez, Eugénie; Danaila, Teodor; Jacquette, Aurélia; Colin, Olivier; Drapier, Sophie; Borg, Michel; Fiksinski, Ania M; Vergaelen, Elfi; Swillen, Ann; Vogels, Annick; Plate, Annika; Perandones, Claudia; Gasser, Thomas; Clerinx, Kristien; Bourdain, Frédéric; Mills, Kelly; Williams, Nigel M; Wood, Nicholas W; Booij, Jan; Lang, Anthony E; Bassett, Anne S; International Research Group on 22q11.2DS-associated Parkinson's Disease	June 5, 2018	Not Determined
29703646	Create Study	Striatal dopamine release and impaired reinforcement learning in adults with 22q11.2 deletion syndrome.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology	van Duin, Esther D A; Kasanova, Zuzana; Hernaus, Dennis; Ceccarini, Jenny; Heinzel, Alexander; Mottaghy, Felix; Mohammadkhani-Shali, Siamak; Winz, Oliver; Frank, Michael; Beck, Merrit C H; Booij, Jan; Myin-Germeys, Inez; van Amelsvoort, Thérèse	June 1, 2018	Not Determined
29696780	Create Study	Neurodevelopmental outcome in 22q11.2 deletion syndrome and management.	American journal of medical genetics. Part A	Swillen, Ann; Moss, Edward; Duijff, Sasja	October 2018	Not Determined
29575622	Create Study	Elucidating the diagnostic odyssey of 22q11.2 deletion syndrome.	American journal of medical genetics. Part A	Palmer, Lisa D; Butcher, Nancy J; Boot, Erik; Hodgkinson, Kathleen A; Heung, Tracy; Chow, Eva W C; Guna, Alina; Crowley, T Blaine; Zackai, Elaine; McDonald-McGinn, Donna M; Bassett, Anne S	April 2018	Not Determined
29567371	Create Study	A pilot study on immuno-psychiatry in the 22q11.2 deletion syndrome: A role for Th17 cells in psychosis?	Brain, behavior, and immunity	Vergaelen, Elfi; Schiweck, Carmen; Van Steeland, Kristof; Counotte, Jacqueline; Veling, Wim; Swillen, Ann; Drexhage, Hemmo; Claes, Stephan	May 2018	Not Determined
29433607	Create Study	Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome.	The British journal of psychiatry : the journal of mental science	Cunningham, Adam C; Delport, Sue; Cumines, Wendy; Busse, Monica; Linden, David E J; Hall, Jeremy; Owen, Michael J; van den Bree, Marianne B M	January 1, 2018	Not Determined
29409527	Create Study	Bystro: rapid online variant annotation and natural-language filtering at whole-genome scale.	Genome biology	Kotlar, Alex V; Trevino, Cristina E; Zwick, Michael E; Cutler, David J; Wingo, Thomas S	February 2018	Not Determined
29363845	Create Study	Non-pharmacological treatment of psychiatric disorders in individuals with 22q11.2 deletion syndrome; a systematic review.	American journal of medical genetics. Part A	Buijs, Petra C M; Bassett, Anne S; Boot, Erik	August 2018	Not Determined
29361080	Create Study	Deletion size analysis of 1680 22q11.2DS subjects identifies a new recombination hotspot on chromosome 22q11.2.	Human molecular genetics	Guo, Tingwei; Diacou, Alexander; Nomaru, Hiroko; McDonald-McGinn, Donna M; Hestand, Matthew; Demaerel, Wolfram; Zhang, Liangtian; Zhao, Yingjie; Ujueta, Francisco; Shan, Jidong; Montagna, Cristina; Zheng, Deyou; Crowley, Terrence B; Kushan-Wells, Leila; Bearden, Carrie E; Kates, Wendy R; Gothelf, Doron; Schneider, Maude; Eliez, Stephan; Breckpot, Jeroen; Swillen, Ann; Vorstman, Jacob; Zackai, Elaine; Benavides Gonzalez, Felipe; Repetto, Gabriela M; Emanuel, Beverly S; Bassett, Anne S; Vermeesch, Joris R; Marshall, Christian R; Morrow, Bernice E; International Chromosome 22q11.2, International 22q11.2 Brain and Behavior Consortia	April 2018	Not Determined
29331595	Create Study	The interaction between neurocognitive functioning, subthreshold psychotic symptoms and pharmacotherapy in 22q11.2 deletion syndrome: A longitudinal comparative study.	European psychiatry : the journal of the Association of European Psychiatrists	Weinberger, R; Weisman, O; Guri, Y; Harel, T; Weizman, A; Gothelf, D	February 1, 2018	Not Determined
29300829	Create Study	PGA: post-GWAS analysis for disease gene identification.	Bioinformatics (Oxford, England)	Lin, Jhih-Rong; Jaroslawicz, Daniel; Cai, Ying; Zhang, Quanwei; Wang, Zhen; Zhang, Zhengdong D	May 15, 2018	Not Determined
29281626	Create Study	Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies.	PLoS genetics	Lin, Jhih-Rong; Zhang, Quanwei; Cai, Ying; Morrow, Bernice E; Zhang, Zhengdong D	December 2017	Not Determined
29171699	Create Study	Higher adaptive functioning and lower rate of psychotic comorbidity in married versus unmarried individuals with 22q11.2 deletion syndrome.	American journal of medical genetics. Part A	Mosheva, Mariela; Eyal, Stav; Weisman, Omri; Gilad, Reut; Fishman, Yael; Weinberger, Ronnie; Weizman, Abraham; Gothelf, Doron	November 1, 2018	Not Determined
29141125	Create Study	Elevated Proinflammatory Markers in 22q11.2 Deletion Syndrome Are Associated With Psychosis and Cognitive Deficits.	The Journal of clinical psychiatry	Mekori-Domachevsky, Ehud; Taler, Michal; Shoenfeld, Yehuda; Gurevich, Michael; Sonis, Polina; Weisman, Omri; Weizman, Abraham; Gothelf, Doron	November 1, 2017	Not Determined
29048724	Create Study	Longitudinal perspectives on the psychosis spectrum in 22q11.2 deletion syndrome.	American journal of medical genetics. Part A	Tang, Sunny X; Gur, Raquel E	October 1, 2018	Not Determined
28990288	Create Study	Comparing the broad socio-cognitive profile of youth with Williams syndrome and 22q11.2 deletion syndrome.	Journal of intellectual disability research : JIDR	Weisman O, Feldman R, Burg-Malki M, Keren M, Geva R, Diesendruck G, Gothelf D	December 2017	Not Determined
28965848	Create Study	Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.	American journal of human genetics	Demaerel, Wolfram; Hestand, Matthew S; Vergaelen, Elfi; Swillen, Ann; López-Sánchez, Marcos; Pérez-Jurado, Luis A; McDonald-McGinn, Donna M; Zackai, Elaine; Emanuel, Beverly S; Morrow, Bernice E; Breckpot, Jeroen; Devriendt, Koenraad; Vermeesch, Joris R; International 22q11.2 Brain and Behavior Consortium	October 2017	Not Determined
28882829	Create Study	Childhood cognitive development in 22q11.2 deletion syndrome: case-control study.	The British journal of psychiatry : the journal of mental science	Chawner, Samuel J R A; Doherty, Joanne L; Moss, Hayley; Niarchou, Maria; Walters, James T R; Owen, Michael J; van den Bree, Marianne B M	October 2017	Not Determined
28761081	Create Study	A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11.2 Deletion Syndrome Brain Behavior Consortium.	Molecular psychiatry	Gur, R E; Bassett, A S; McDonald-McGinn, D M; Bearden, C E; Chow, E; Emanuel, B S; Owen, M; Swillen, A; Van den Bree, M; Vermeesch, J; Vorstman, J A S; Warren, S; Lehner, T; Morrow, B	December 2017	Not Determined
28750581	Create Study	Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome.	The American journal of psychiatry	Bassett, Anne S; Lowther, Chelsea; Merico, Daniele; Costain, Gregory; Chow, Eva W C; van Amelsvoort, Therese; McDonald-McGinn, Donna; Gur, Raquel E; Swillen, Ann; Van den Bree, Marianne; Murphy, Kieran; Gothelf, Doron; Bearden, Carrie E; Eliez, Stephan; Kates, Wendy; Philip, Nicole; Sashi, Vandana; Campbell, Linda; Vorstman, Jacob; Cubells, Joseph; Repetto, Gabriela M; Simon, Tony; Boot, Erik; Heung, Tracy; Evers, Rens; Vingerhoets, Claudia; van Duin, Esther; Zackai, Elaine; Vergaelen, Elfi; Devriendt, Koen; Vermeesch, Joris R; Owen, Michael; Murphy, Clodagh; Michaelovosky, Elena; Kushan, Leila; Schneider, Maude; Fremont, Wanda; Busa, Tiffany; Hooper, Stephen; McCabe, Kathryn; Duijff, Sasja; Isaev, Karin; Pellecchia, Giovanna; Wei, John; Gazzellone, Matthew J; Scherer, Stephen W; Emanuel, Beverly S; Guo, Tingwei; Morrow, Bernice E; Marshall, Christian R; International 22q11.2DS Brain and Behavior Consortium	November 2017	Not Determined
28627787	Create Study	Psychiatric and cognitive characteristics of individuals with Danon disease (LAMP2 gene mutation).	American journal of medical genetics. Part A	Yardeni, Maya; Weisman, Omri; Mandel, Hanna; Weinberger, Ronnie; Quarta, Giovanni; Salazar-Mendiguchía, Joel; Garcia-Pavia, Pablo; Lobato-Rodríguez, Maria José; Simon, Lourdes Fajardo; Dov, Freimark; Arad, Michael; Gothelf, Doron	September 2017	Not Determined
28367513	Create Study	Categorical versus dimensional approaches to autism-associated intermediate phenotypes in 22q11.2 microdeletion syndrome.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Jalbrzikowski, Maria; Ahmed, Khwaja Hamzah; Patel, Arati; Jonas, Rachel; Kushan, Leila; Chow, Carolyn; Bearden, Carrie E	January 2017	Not Determined
28328118	Create Study	22q11.2 deletion syndrome in diverse populations.	American journal of medical genetics. Part A	Kruszka, Paul; Addissie, Yonit A; McGinn, Daniel E; Porras, Antonio R; Biggs, Elijah; Share, Matthew; Crowley, T Blaine; Chung, Brian H Y; Mok, Gary T K; Mak, Christopher C Y; Muthukumarasamy, Premala; Thong, Meow-Keong; Sirisena, Nirmala D; Dissanayake, Vajira H W; Paththinige, C Sampath; Prabodha, L B Lahiru; Mishra, Rupesh; Shotelersuk, Vorasuk; Ekure, Ekanem Nsikak; Sokunbi, Ogochukwu Jidechukwu; Kalu, Nnenna; Ferreira, Carlos R; Duncan, Jordann-Mishael; Patil, Siddaramappa Jagdish; Jones, Kelly L; Kaplan, Julie D; Abdul-Rahman, Omar A; Uwineza, Annette; Mutesa, Leon; Moresco, Angélica; Obregon, María Gabriela; Richieri-Costa, Antonio; Gil-da-Silva-Lopes, Vera L; Adeyemo, Adebowale A; Summar, Marshall; Zackai, Elaine H; McDonald-McGinn, Donna M; Linguraru, Marius George; Muenke, Maximilian	April 2017	Not Determined
28223510	Create Study	PEMapper and PECaller provide a simplified approach to whole-genome sequencing.	Proceedings of the National Academy of Sciences of the United States of America	Johnston, H Richard; Chopra, Pankaj; Wingo, Thomas S; Patel, Viren; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome; Epstein, Michael P; Mulle, Jennifer G; Warren, Stephen T; Zwick, Michael E; Cutler, David J	March 2017	Not Determined
28204757	Create Study	Subthreshold Psychosis in 22q11.2 Deletion Syndrome: Multisite Naturalistic Study.	Schizophrenia bulletin	Weisman, Omri; Guri, Yael; Gur, Raquel E; McDonald-McGinn, Donna M; Calkins, Monica E; Tang, Sunny X; Emanuel, Beverly; Zackai, Elaine H; Eliez, Stephan; Schneider, Maude; Schaer, Marie; Kates, Wendy R; Antshel, Kevin M; Fremont, Wanda; Shashi, Vandana; Hooper, Stephen R; Armando, Marco; Vicari, Stefano; Pontillo, Maria; Kushan, Leila; Jalbrzikowski, Maria; Bearden, Carrie E; Cubells, Joseph F; Ousley, Opal Y; Walker, Elaine F; Simon, Tony J; Stoddard, Joel; Niendam, Tara A; van den Bree, Marianne B M; Gothelf, Doron; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	September 1, 2017	Not Determined
28119035	Create Study	Autism Spectrum and psychosis risk in the 22q11.2 deletion syndrome. Findings from a prospective longitudinal study.	Schizophrenia research	Fiksinski, A M; Breetvelt, E J; Duijff, S N; Bassett, A S; Kahn, R S; Vorstman, J A S	October 2017	Not Determined
28041919	Create Study	Negative subthreshold psychotic symptoms distinguish 22q11.2 deletion syndrome from other neurodevelopmental disorders: A two-site study.	Schizophrenia research	Mekori-Domachevsky E, Guri Y, Yi J, Weisman O, Calkins ME, Tang SX, Gross R, Mcdonald-Mcginn DM, Emanuel BS, Zackai EH, Zalsman G, Weizman A, Gur RC, Gur RE, Gothelf D	October 2017	Not Determined
27754856	Create Study	Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia.	Genetics	Lin, Jhih-Rong; Cai, Ying; Zhang, Quanwei; Zhang, Wen; Nogales-Cadenas, Rubén; Zhang, Zhengdong D	December 2016	Not Determined
27718271	Create Study	Neuropsychiatric aspects of 22q11.2 deletion syndrome: considerations in the prenatal setting.	Prenatal diagnosis	Bassett AS, Costain G, Marshall CR	January 2017	Not Determined
27717277	Create Study	Ultra high risk status and transition to psychosis in 22q11.2 deletion syndrome.	World psychiatry : official journal of the World Psychiatric Association (WPA)	Schneider, Maude; Armando, Marco; Pontillo, Maria; Vicari, Stefano; Debbané, Martin; Schultze-Lutter, Frauke; Eliez, Stephan	October 2016	Not Determined
27619075	Create Study	IQ and hemizygosity for the Val158 Met functional polymorphism of COMT in 22q11DS.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Franconi, Colleen P; McDonald-McGinn, Donna; Zackai, Elaine H; McNamara, Meghan A; Salmons 4th, Harold; Moss, Edward; Gur, Raquel E; Devoto, Marcella; Emanuel, Beverly S	December 1, 2016	Not Determined
27537705	Create Study	Obesity in adults with 22q11.2 deletion syndrome.	Genetics in medicine : official journal of the American College of Medical Genetics	Voll, Sarah L; Boot, Erik; Butcher, Nancy J; Cooper, Samantha; Heung, Tracy; Chow, Eva W C; Silversides, Candice K; Bassett, Anne S	February 2017	Not Determined
27524298	Create Study	Neurocognitive profile in psychotic versus nonpsychotic individuals with 22q11.2 deletion syndrome.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology	Weinberger R, Yi J, Calkins M, Guri Y, Mcdonald-Mcginn DM, Emanuel BS, Zackai EH, Ruparel K, Carmel M, Michaelovsky E, Weizman A, Gur RC, Gur RE, Gothelf D	October 2016	Not Determined
27517838	Create Study	Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome.	Journal of neural transmission (Vienna, Austria : 1996)	Midbari Kufert Y, Nachmani A, Nativ E, Weizman A, Gothelf D	December 2016	Not Determined
27336054	Create Study	Early interventions in risk groups for schizophrenia: what are we waiting for?	NPJ schizophrenia	Sommer, Iris E; Bearden, Carrie E; van Dellen, Edwin; Breetvelt, Elemi J; Duijff, Sasja N; Maijer, Kim; van Amelsvoort, Therese; de Haan, Lieuwe; Gur, Raquel E; Arango, Celso; Díaz-Caneja, Covadonga M; Vinkers, Christiaan H; Vorstman, Jacob As	January 1, 2016	Not Determined
27334937	Create Study	Mental disorders of known aetiology and precision medicine in psychiatry: a promising but neglected alliance.	Psychological medicine	Fraguas, D; Díaz-Caneja, C M; State, M W; O'Donovan, M C; Gur, R E; Arango, C	January 2017	Not Determined
27274857	Create Study	A catalog of hemizygous variation in 127 22q11 deletion patients.	Human genome variation	Hestand MS, Nowakowska BA, Vergaelen E, Van Houdt J, Dehaspe L, Suhl JA, Del-Favero J, Mortier G, Zackai E, Swillen A, Devriendt K, Gur RE, Mcdonald-Mcginn DM, Warren ST, Emanuel BS, Vermeesch JR	January 2016	Not Determined
27200494	Create Study	Performance on a computerized neurocognitive battery in 22q11.2 deletion syndrome: A comparison between US and Israeli cohorts.	Brain and cognition	Yi JJ, Weinberger R, Moore TM, Calkins ME, Guri Y, Mcdonald-Mcginn DM, Zackai EH, Emanuel BS, Gur RE, Gothelf D, Gur RC	July 2016	Not Determined
27189754	Create Study	22q11.2 deletion syndrome.	Nature reviews. Disease primers	McDonald-McGinn, Donna M; Sullivan, Kathleen E; Marino, Bruno; Philip, Nicole; Swillen, Ann; Vorstman, Jacob A S; Zackai, Elaine H; Emanuel, Beverly S; Vermeesch, Joris R; Morrow, Bernice E; Scambler, Peter J; Bassett, Anne S	November 19, 2015	Not Determined
26921528	Create Study	The use of two different MLPA kits in 22q11.2 deletion syndrome.	European journal of medical genetics	Evers LJ, Engelen JJ, Houben LM, Curfs LM, Van Amelsvoort TA	April 2016	Not Determined
26855683	Create Study	Atypical functional connectivity in resting-state networks of individuals with 22q11.2 deletion syndrome: associations with neurocognitive and psychiatric functioning.	Journal of neurodevelopmental disorders	Mattiaccio LM, Coman IL, Schreiner MJ, Antshel KM, Fremont WP, Bearden CE, Kates WR	January 2016	Not Determined
26779858	Create Study	The importance of understanding cognitive trajectories: the case of 22q11.2 deletion syndrome.	Current opinion in psychiatry	Swillen A	March 2016	Not Determined
26528648	Create Study	Impact of psychiatric comorbidity and cognitive deficit on function in 22q11.2 deletion syndrome.	The Journal of clinical psychiatry	Yi JJ, Calkins ME, Tang SX, Kohler CG, Mcdonald-Mcginn DM, Zackai EH, Savitt AP, Bilker WB, Whinna DA, Souders MC, Emanuel BS, Gur RC, Gur RE	October 2015	Not Determined
26509118	Create Study	Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.	NeuroImage. Clinical	Montojo, C A; Congdon, E; Hwang, L; Jalbrzikowski, M; Kushan, L; Vesagas, T K; Jonas, R K; Ventura, J; Bilder, R M; Bearden, C E	January 2015	Not Determined
26400629	Create Study	The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Niarchou, Maria; Martin, Joanna; Thapar, Anita; Owen, Michael J; van den Bree, Marianne B M	December 2015	Not Determined
26384369	Create Study	Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome.	G3 (Bethesda, Md.)	Merico, Daniele; Zarrei, Mehdi; Costain, Gregory; Ogura, Lucas; Alipanahi, Babak; Gazzellone, Matthew J; Butcher, Nancy J; Thiruvahindrapuram, Bhooma; Nalpathamkalam, Thomas; Chow, Eva W C; Andrade, Danielle M; Frey, Brendan J; Marshall, Christian R; Scherer, Stephen W; Bassett, Anne S	September 16, 2015	Not Determined
25989227	Create Study	Developmental trajectories in 22q11.2 deletion.	American journal of medical genetics. Part C, Seminars in medical genetics	Swillen A, Mcdonald-Mcginn D	June 2015	Not Determined
25892112	Create Study	Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome.	American journal of human genetics	Mlynarski, Elisabeth E; Sheridan, Molly B; Xie, Michael; Guo, Tingwei; Racedo, Silvia E; McDonald-McGinn, Donna M; Gai, Xiaowu; Chow, Eva W C; Vorstman, Jacob; Swillen, Ann; Devriendt, Koen; Breckpot, Jeroen; Digilio, Maria Cristina; Marino, Bruno; Dallapiccola, Bruno; Philip, Nicole; Simon, Tony J; Roberts, Amy E; Piotrowicz, Małgorzata; Bearden, Carrie E; Eliez, Stephan; Gothelf, Doron; Coleman, Karlene; Kates, Wendy R; Devoto, Marcella; Zackai, Elaine; Heine-Suñer, Damian; Shaikh, Tamim H; Bassett, Anne S; Goldmuntz, Elizabeth; Morrow, Bernice E; Emanuel, Beverly S; International Chromosome 22q11.2 Consortium	May 2015	Not Determined
25840117	Create Study	The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth.	NeuroImage	Satterthwaite, Theodore D; Connolly, John J; Ruparel, Kosha; Calkins, Monica E; Jackson, Chad; Elliott, Mark A; Roalf, David R; Hopson, Ryan; Prabhakaran, Karthik; Behr, Meckenzie; Qiu, Haijun; Mentch, Frank D; Chiavacci, Rosetta; Sleiman, Patrick M A; Gur, Ruben C; Hakonarson, Hakon; Gur, Raquel E	January 2016	Not Determined
25715178	Create Study	Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome.	JAMA psychiatry	Vorstman, Jacob A S; Breetvelt, Elemi J; Duijff, Sasja N; Eliez, Stephan; Schneider, Maude; Jalbrzikowski, Maria; Armando, Marco; Vicari, Stefano; Shashi, Vandana; Hooper, Stephen R; Chow, Eva W C; Fung, Wai Lun Alan; Butcher, Nancy J; Young, Donald A; McDonald-McGinn, Donna M; Vogels, Annick; van Amelsvoort, Therese; Gothelf, Doron; Weinberger, Ronnie; Weizman, Abraham; Klaassen, Petra W J; Koops, Sanne; Kates, Wendy R; Antshel, Kevin M; Simon, Tony J; Ousley, Opal Y; Swillen, Ann; Gur, Raquel E; Bearden, Carrie E; Kahn, René S; Bassett, Anne S; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	April 2015	Not Determined
25640419	Create Study	Population genetics identifies challenges in analyzing rare variants.	Genetic epidemiology	Johnston HR, Hu Y, Cutler DJ	March 2015	Not Determined
25569435	Create Study	Practical guidelines for managing adults with 22q11.2 deletion syndrome.	Genetics in medicine : official journal of the American College of Medical Genetics	Fung, Wai Lun Alan; Butcher, Nancy J; Costain, Gregory; Andrade, Danielle M; Boot, Erik; Chow, Eva W C; Chung, Brian; Cytrynbaum, Cheryl; Faghfoury, Hanna; Fishman, Leona; García-Miñaúr, Sixto; George, Susan; Lang, Anthony E; Repetto, Gabriela; Shugar, Andrea; Silversides, Candice; Swillen, Ann; van Amelsvoort, Therese; McDonald-McGinn, Donna M; Bassett, Anne S	August 1, 2015	Not Determined
25151417	Create Study	Measuring prodromal symptoms in youth with developmental disabilities: a lesson from 22q11 deletion syndrome.	Journal of the American Academy of Child and Adolescent Psychiatry	Gothelf D	September 2014	Not Determined
25059276	Create Study	A tale worth telling: the impact of the diagnosis experience on disclosure of genetic disorders.	Journal of intellectual disability research : JIDR	Goodwin, J; Schoch, K; Shashi, V; Hooper, S R; Morad, O; Zalevsky, M; Gothelf, D; Campbell, L E	May 2015	Not Determined
24577245	Create Study	Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome.	The American journal of psychiatry	Schneider, Maude; Debbané, Martin; Bassett, Anne S; Chow, Eva W C; Fung, Wai Lun Alan; van den Bree, Marianne; Owen, Michael; Murphy, Kieran C; Niarchou, Maria; Kates, Wendy R; Antshel, Kevin M; Fremont, Wanda; McDonald-McGinn, Donna M; Gur, Raquel E; Zackai, Elaine H; Vorstman, Jacob; Duijff, Sasja N; Klaassen, Petra W J; Swillen, Ann; Gothelf, Doron; Green, Tamar; Weizman, Abraham; Van Amelsvoort, Therese; Evers, Laurens; Boot, Erik; Shashi, Vandana; Hooper, Stephen R; Bearden, Carrie E; Jalbrzikowski, Maria; Armando, Marco; Vicari, Stefano; Murphy, Declan G; Ousley, Opal; Campbell, Linda E; Simon, Tony J; Eliez, Stephan; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome	June 2014	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	1,789	08/03/2020	1,300	01/04/2021	0	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Genomics/omics	1,489	10/01/2020	1,129	01/04/2021	1,058	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 Deletion Syndrome	The 22q11.2 deletion syndrome (22q11DS) is associated with a 20 – 25% risk for schizophrenia. In a cohort of 962 individuals with 22q11DS we examined the shared genetic basis between schizophrenia and schizophrenia-related early trajectory phenotypes: subthreshold symptoms of psychosis, low baseline intellectual functioning, and cognitive decline. We studied the association of these phenotypes with two polygenic scores, derived for schizophrenia and intelligence, and evaluated their use for individual risk prediction in 22q11DS. Polygenic scores were not only associated with schizophrenia and baseline IQ, respectively, but schizophrenia polygenic score was also significantly associated with cognitive (verbal IQ) decline and nominally associated with subthreshold psychosis. Further, comparing the tail-end deciles of the schizophrenia and IQ polygenic score distributions, 33% versus 9% of 22q11DS subjects had schizophrenia, and 63% versus 24% had intellectual disability. Collectively, these data show both a shared genetic basis for schizophrenia and schizophrenia-related phenotypes, and highlight the future potential of polygenic scores for risk stratification among individuals with highly, but incompletely, penetrant genetic variants.	1300/1300	Primary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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