Though early intervention and treatment is linked to improved long-term health, few tools currently exist to
identify people who are at early risk of developing schizophrenia or to predict who will go on to develop
psychosis. The Accelerating Medicines Partnership (AMP®) SCZ program aims to generate tools that will
fast-track the development of effective, early-stage treatments for people who are at risk for
schizophrenia. For more information about the AMP SCZ Study, including protocols, please visit the AMP SCZ Study website.
The June 2024 AMP-SCZ Release 2.0 includes fully quality-controlled data from screening through month 2 for
1,048 unique subjects. This includes clinical and behavioral measures, with baseline data from 647 to 934
subjects, month 1 from 486 to 520 subjects, and month 2 from 529 to 552 subjects, depending on the measure.
Unprocessed Electroencephalography (EEG) data includes 640 subjects at baseline and 301 at month 2, and
unprocessed magnetic resonance imaging (MRI, dMRI, and rs-fMRI) covers 425 subjects.
Redacted open interview transcripts include transcripts of language samples collected at baseline for 532
subjects and month 2 for 275 subjects using the Open-ended language sample protocol and language samples
collected using the PSYCHS clinical interview at screening for 132 subjects, baseline for 181 subjects,
month 1 for 225 subjects, and month 2 for 214 subjects.
Raw actigraphy watch data is available for 258 subjects, smartphone surveys for 174 subjects, and smartphone
data (including screen use, accelerometry, and geolocation) for 110 subjects. Fluid biomarkers are available
at baseline for 772 to 887 subjects and at month 2 for 445 to 507 subjects. Please refer to the spreadsheet
“ampscz-release-2.0-record.csv”
for data availability for each measure per subject.
The behavioral data package includes demographic, physical health, clinical assessments, and cognitive and
behavioral data for participants at baseline, month 1, and month 2. The AMP SCZ 2.0 Data Release Reference
Manual describes the overall contents of various instruments used in the AMP SCZ project. We recommend
downloading the behavioral package to understand what is available before downloading other packages.
The unprocessed 64 channels EEG data for baseline and month 2, from 5 different paradigm types (Combined Visual Oddball (VOD) with
Mismatch Negativity (MMN), Auditory Oddball (AOD), Auditory Steady-State Response (ASSR), Resting-State w/
Eyes Open, Resting-State w/ Eyes Closed) are included in the EEG data package. Sessions compliant with
standard operating procedures (SOPs) with high-quality control ratings are included in this release.
The unprocessed MRI data from the following modalities are included in this release: structural T1- and
T2-weighted (T1w and T2w), diffusion MRI (dMRI), and resting state functional scans (rs-fMRI).
Language samples were collected at baseline and month 2 using open-ended interviews and monthly using the
PSYCHS clinical interview. The fully redacted transcripts are available in the Transcripts data package.
The raw accelerometer data obtained from the actigraphy watch and smartphone data acquired from short daily
self-report surveys and passive data (accelerometer and screen state) are available in the Actigraphy &
Phone Data package.
The raw smartphone geolocation data is available in the Phone Geolocation Data package.
Note that accessing the geolocation data requires additional IRB approval.
Downloading Data
Select one or more available datasets in the nested dropdowns below to add subsets of the data to your
Workspace and Filter Cart. Click on the nested dropdowns to explore all the datasets and on the “i” icons
for descriptions. When Creating a Data Package, select "include associated files" to include imaging files
in download packages.
Note: Some datasets are larger than the monthly NDA download limit of 20 Terabytes. To
download datasets over 20TB without delays, end users can request a temporary Download Threshold extension
from the NDA Help Desk at NDAHelp@mail.nih.gov. In your request,
name the data you need to download (e.g., AMP SCZ 2.0 resting state functional scans (rs-fMRI) data) and the
data package size. See NDA's User Download
Threshold page for more information.
The "Tips" box on the right provides further instructions and details the remaining steps to select and
download data.
