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To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

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Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities #2803

General
Experiments (2)
Shared Data
Publications (49)
Data Expected (28)
Associated Studies (0)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities
Collection Investigators:	Nim Tottenham
Collection Description:	Children with severe Early Caregiving Adversities (ECAs) are the most vulnerable to psychopathology as a result of prolonged neglect, abuse, and care disruptions that impact neurodevelopment. It is currently estimated that addressing ECAs would lead to a 29.8 percent reduction in worldwide psychiatric illness. Existing research, including findings from the original grant of this renewal, has demonstrated that there is a very strong link between ECA exposures and increased risk for psychopathology and altered neurodevelopment at the population level and yet, given the heterogeneity in ECA populations, there is a critical gap in knowledge regarding how ECAs increase any specific risks to an individual child. The proposed research addresses this significant mental health problem by combining sophisitcated data-analysis methods that use experiential and phenotypic heterogeneity together with longitudinal neuroimaging and behavioral assessments in school-age children. This approach will increase precision when linking ECAs and child outcomes associated with the Research Domain Criteria constructs of Negative Valence and Cognitive Control Systems (NVS/CCS). The overarching goal of the present work is to create an explanatory model for the heterogeneous impact of ECAs on neurodevelopmental trajectories of NVSCCS. This projects premise is that children exposed to ECAs have highly heterogeneous developmental histories as well as heterogeneous outcomes therefore, prediction of ECA outcomes requires cutting-edge, sophisticated data analytic methods. We hypothesize that data-driven approaches will 1) more precisely define NVS/CCS outcomes for school-aged children with ECAs, and 2) provide a more robust explanatory model for links between ECAs and NVS/CCS trajectories. Aim 1A subtypes children with a history of ECAs based on 2.5-year developmental trajectories of NVS/CCS. 300 6-8 year old children (250 sampled from previous institutional and foster care; 50 community comparisons) will provide neuroimaging, behavioral, and self/caregiver reports every 15 months for 2.5 years. Biclustering methods will be applied to the baseline and follow-up data to identify homogeneous NVS/CCS final outcome clusters of children. Aim 1B develops an explanatory model to predict developmental trajectory subtypes for children with ECAs, from early life profiles and brain behavior phenotypes at the time of enrollment. Machine learning methods applied to early life profiles, baseline NVS/CCS profiles, and sex, will predict developmental trajectory subtypes. Aim 2 identifies adverse and protective life events during the 2.5-year assessment period that are predictive of 2.5-year follow-up outcomes for children with ECAs. The inclusion of child-sex and current life-events will identify potential divergence in pathways across middle childhood. This prospective design of children exposed to various ECAs is designed to develop predictive models for ECA trajectory subtypes and outcomes, which can inform our understanding of risk and protective factors in accord with the goals of precision medicine.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	10/31/2017
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$3,823,226.00
Subjects Shared:	327

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH091864-06	Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities	09/01/2017	06/30/2024	325	335	COLUMBIA UNIV NEW YORK MORNINGSIDE	$3,823,226.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
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Collection Description
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Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

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Clinical Trials

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During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
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The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
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In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

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A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
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Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
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The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
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NDA Collection

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ID	Name	Created Date	Status	Type
1200	ECA_1_DTI	01/24/2019	Approved	fMRI
2270	ECA_2_REST	06/13/2023	Approved	fMRI

helpcenter.collection.experiments-tab

Collection - Experiments

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Shared Data:

Title	Type	Number of Subjects
Child Behavior Checklist (CBCL) 6-18	Clinical Assessments	324
Children's Behavior Questionnaire The Very Short Form	Clinical Assessments	323
Pubertal Development Scale	Clinical Assessments	323
Revised Child Anxiety and Depression Scale (RCADS)	Clinical Assessments	324
Services Assessment for Children and Adolescents (SACA)	Clinical Assessments	323

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

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How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
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A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
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The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

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Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38664866	Create Study	Probing the content of affective semantic memory following caregiving-related early adversity.	Developmental science	Vannucci, Anna; Fields, Andrea; Bloom, Paul A; Camacho, Nicolas L; Choy, Tricia; Durazi, Amaesha; Hadis, Syntia; Harmon, Chelsea; Heleniak, Charlotte; VanTieghem, Michelle; Dozier, Mary; Milham, Michael P; Ghetti, Simona; Tottenham, Nim	November 1, 2024	Not Determined
38549194	Create Study	The effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study.	Developmental science	Abramson, Lior; Callaghan, Bridget L; Silvers, Jennifer A; Choy, Tricia; VanTieghem, Michelle; Vannucci, Anna; Fields, Andrea; Tottenham, Nim	November 1, 2024	Not Determined
37883086	Create Study	Parent-Perceived Benefits and Harms Associated With Internet Use by Adolescent Offspring.	JAMA network open	Kimball, Harry Graff; Fernandez, Francesca; Moskowitz, Kathleen Anne; Kang, Minji; Alexander, Lindsay M; Conway, Kevin P; Merikangas, Kathleen Ries; Salum, Giovanni Abrahão; Milham, Michael Peter	October 2, 2023	Not Determined
37524685	Create Study	Developmental deviation in delay discounting as a transdiagnostic indicator of risk for child psychopathology.	Journal of child psychology and psychiatry, and allied disciplines	DeRosa, Jacob; Rosch, Keri S; Mostofsky, Stewart H; Nikolaidis, Aki	February 1, 2024	Not Determined
37385583	Create Study	A Randomized Controlled Trial of a Parenting Intervention During Infancy Alters Amygdala-Prefrontal Circuitry in Middle Childhood.	Journal of the American Academy of Child and Adolescent Psychiatry	Valadez, Emilio A; Tottenham, Nim; Korom, Marta; Tabachnick, Alexandra R; Pine, Daniel S; Dozier, Mary	January 1, 2024	Not Determined
37338905	Create Study	Parental Preferences for Mental Health Screening of Youths From a Multinational Survey.	JAMA network open	Kass, Mirelle; Alexander, Lindsay; Moskowitz, Kathleen; James, Najé; Salum, Giovanni Abrahão; Leventhal, Bennett; Merikangas, Kathleen; Milham, Michael Peter	June 1, 2023	Not Determined
37210754	Create Study	Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.	Developmental cognitive neuroscience	Brieant, Alexis; Vannucci, Anna; Nakua, Hajer; Harris, Jenny; Lovell, Jack; Brundavanam, Divya; Tottenham, Nim; Gee, Dylan G	June 1, 2023	Not Determined
37141961	Create Study	Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.	Neuroscience and biobehavioral reviews	Vannucci, Anna; Fields, Andrea; Hansen, Eleanor; Katz, Ariel; Kerwin, John; Tachida, Ayumi; Martin, Nathan; Tottenham, Nim	July 1, 2023	Not Determined
36824818	Create Study	Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.	bioRxiv : the preprint server for biology	Vannucci, Anna; Fields, Andrea; Hansen, Eleanor; Katz, Ariel; Kerwin, John; Tachida, Ayumi; Martin, Nathan; Tottenham, Nim	February 18, 2023	Not Determined
36798244	Create Study	Robust Parental Preferences in Mental Health Screening in Youth From a Multinational Online Survey.	medRxiv : the preprint server for health sciences	Kass, Mirelle; Alexander, Lindsay; Moskowitz, Kathleen; James, Najé; Salum, Giovanni Abrahão; Leventhal, Bennett; Merikangas, Kathleen; Milham, Michael Peter	February 10, 2023	Not Determined
36468788	Create Study	Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes - CORRIGENDUM.	Development and psychopathology	Nikolaidis, Aki; Heleniak, Charlotte; Fields, Andrea; Bloom, Paul A; VanTieghem, Michelle; Vannucci, Anna; Camacho, Nicolas L; Choy, Tricia; Gibson, Lisa; Harmon, Chelsea; Hadis, Syntia S; Douglas, Ian J; Milham, Michael P; Tottenham, Nim	August 1, 2023	Not Determined
36278283	Create Study	Anxiety in children and youth with autism spectrum disorder and the association with amygdala subnuclei structure.	Autism : the international journal of research and practice	Hennessy, Abagail; Seguin, Diane; Correa, Susana; Wang, Jianan; Martinez-Trujillo, Julio C; Nicolson, Rob; Duerden, Emma G	May 1, 2023	Not Determined
35393752	Create Study	Age-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.	Human brain mapping	Bloom, Paul Alexander; VanTieghem, Michelle; Gabard-Durnam, Laurel; Gee, Dylan G; Flannery, Jessica; Caldera, Christina; Goff, Bonnie; Telzer, Eva H; Humphreys, Kathryn L; Fareri, Dominic S; Shapiro, Mor; Algharazi, Sameah; Bolger, Niall; Aly, Mariam; Tottenham, Nim	July 1, 2022	Not Determined
35314012	Create Study	Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes.	Development and psychopathology	Nikolaidis, Aki; Heleniak, Charlotte; Fields, Andrea; Bloom, Paul A; VanTieghem, Michelle; Vannucci, Anna; Camacho, Nicolas L; Choy, Tricia; Gibson, Lisa; Harmon, Chelsea; Hadis, Syntia S; Douglas, Ian J; Milham, Michael P; Tottenham, Nim	May 1, 2022	Not Determined
35080089	Create Study	Experimental evidence for a child-to-adolescent switch in human amygdala-prefrontal cortex communication: A cross-sectional pilot study.	Developmental science	Gee, Dylan G; Hanson, Catherine; Caglar, Leyla Roksan; Fareri, Dominic S; Gabard-Durnam, Laurel J; Mills-Finnerty, Colleen; Goff, Bonnie; Caldera, Christina J; Lumian, Daniel S; Flannery, Jessica; Hanson, Stephen José; Tottenham, Nim	July 1, 2022	Not Determined
34689856	Create Study	Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving.	Development and psychopathology	Stevens, Jennifer S; van Rooij, Sanne J H; Stenson, Anais F; Ely, Timothy D; Powers, Abigail; Clifford, Aimee; Kim, Ye Ji; Hinrichs, Rebecca; Tottenham, Nim; Jovanovic, Tanja	August 1, 2023	Not Determined
34649041	Create Study	Predicting multiscan MRI outcomes in children with neurodevelopmental conditions following MRI simulator training.	Developmental cognitive neuroscience	Simhal, Anish K; Filho, José O A; Segura, Patricia; Cloud, Jessica; Petkova, Eva; Gallagher, Richard; Castellanos, F Xavier; Colcombe, Stan; Milham, Michael P; Di Martino, Adriana	December 1, 2021	Not Determined
34549545	Create Study	Early adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder.	Autism research : official journal of the International Society for Autism Research	Kuenzel, Elizabeth; Seguin, Diane; Nicolson, Robert; Duerden, Emma G	December 1, 2021	Not Determined
34385508	Create Study	Peer victimization and the association with hippocampal development and working memory in children with ADHD and typically-developing children.	Scientific reports	Papadopoulos, Alissa; Seguin, Diane; Correa, Susana; Duerden, Emma G	August 12, 2021	Not Determined
34080760	Create Study	Adaptation in the face of adversity: Decrements and enhancements in children''s cognitive control behavior following early caregiving instability.	Developmental science	Fields, Andrea; Bloom, Paul A; VanTieghem, Michelle; Harmon, Chelsea; Choy, Tricia; Camacho, Nicolas L; Gibson, Lisa; Umbach, Rebecca; Heleniak, Charlotte; Tottenham, Nim	November 1, 2021	Not Determined
33948944	Create Study	Using gastrointestinal distress reports to predict youth anxiety risk: Implications for mental health literacy and community care.	Developmental psychobiology	Bloom, Paul Alexander; Douglas, Ian; VanTieghem, Michelle; Tottenham, Nim; Callaghan, Bridget	September 1, 2021	Not Determined
33517107	Create Study	Longitudinal changes in amygdala, hippocampus and cortisol development following early caregiving adversity.	Developmental cognitive neuroscience	VanTieghem, Michelle; Korom, Marta; Flannery, Jessica; Choy, Tricia; Caldera, Christina; Humphreys, Kathryn L; Gabard-Durnam, Laurel; Goff, Bonnie; Gee, Dylan G; Telzer, Eva H; Shapiro, Mor; Louie, Jennifer Y; Fareri, Dominic S; Bolger, Niall; Tottenham, Nim	April 1, 2021	Not Determined
33487578	Create Study	Depression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Tottenham, Nim; Weissman, Myrna M; Wang, Zhishun; Warner, Virginia; Gameroff, Marc J; Semanek, David P; Hao, Xuejun; Gingrich, Jay A; Peterson, Bradley S; Posner, Jonathan; Talati, Ardesheer	March 1, 2021	Not Determined
33427163	Create Study	Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving.	Development and psychopathology	Tottenham, Nim	December 1, 2020	Not Determined
33248256	Create Study	Is it time to switch your T1W sequence? Assessing the impact of prospective motion correction on the reliability and quality of structural imaging.	NeuroImage	Ai, Lei; Craddock, R Cameron; Tottenham, Nim; Dyke, Jonathan P; Lim, Ryan; Colcombe, Stanley; Milham, Michael; Franco, Alexandre R	February 1, 2021	Not Determined
33103280	Create Study	An exploration of amygdala-prefrontal mechanisms in the intergenerational transmission of learned fear.	Developmental science	Silvers, Jennifer A; Callaghan, Bridget L; VanTieghem, Michelle; Choy, Tricia; O'Sullivan, Kaitlin; Tottenham, Nim	May 1, 2021	Not Determined
32731812	Create Study	Early Parenting Intervention Effects on Brain Responses to Maternal Cues Among High-Risk Children.	The American journal of psychiatry	Valadez, Emilio A; Tottenham, Nim; Tabachnick, Alexandra R; Dozier, Mary	September 1, 2020	Not Determined
32671835	Create Study	Parent''s anxiety links household stress and young children''s behavioral dysregulation.	Developmental psychobiology	Fields, Andrea; Harmon, Chelsea; Lee, Zoe; Louie, Jennifer Y; Tottenham, Nim	January 1, 2021	Not Determined
32654667	Create Study	Callous-unemotional traits and reduced default mode network connectivity within a community sample of children.	Development and psychopathology	Umbach, Rebecca H; Tottenham, Nim	October 1, 2021	Not Determined
32572148	Create Study	Diagnostic Associations of Processing Speed in a Transdiagnostic, Pediatric Sample.	Scientific reports	Kramer, Eliza; Koo, Bonhwang; Restrepo, Anita; Koyama, Maki; Neuhaus, Rebecca; Pugh, Kenneth; Andreotti, Charissa; Milham, Michael	June 22, 2020	Not Determined
32456610	Create Study	Problematic internet use in children and adolescents: associations with psychiatric disorders and impairment.	BMC psychiatry	Restrepo, Anita; Scheininger, Tohar; Clucas, Jon; Alexander, Lindsay; Salum, Giovanni A; Georgiades, Kathy; Paksarian, Diana; Merikangas, Kathleen R; Milham, Michael P	May 27, 2020	Not Determined
32119986	Create Study	Bagging improves reproducibility of functional parcellation of the human brain.	NeuroImage	Nikolaidis, Aki; Solon Heinsfeld, Anibal; Xu, Ting; Bellec, Pierre; Vogelstein, Joshua; Milham, Michael	July 1, 2020	Not Determined
32111822	Create Study	Adverse caregiving in infancy blunts neural processing of the mother.	Nature communications	Opendak, Maya; Theisen, Emma; Blomkvist, Anna; Hollis, Kaitlin; Lind, Teresa; Sarro, Emma; Lundström, Johan N; Tottenham, Nim; Dozier, Mary; Wilson, Donald A; Sullivan, Regina M	February 28, 2020	Not Determined
31951308	Create Study	Increased activation of the fear neurocircuitry in children exposed to violence.	Depression and anxiety	van Rooij, Sanne J H; Smith, Ryan D; Stenson, Anaïs F; Ely, Timothy D; Yang, Xinyi; Tottenham, Nim; Stevens, Jennifer S; Jovanovic, Tanja	April 1, 2020	Not Determined
31595961	Create Study	Evaluating fMRI-Based Estimation of Eye Gaze During Naturalistic Viewing.	Cerebral cortex (New York, N.Y. : 1991)	Son, Jake; Ai, Lei; Lim, Ryan; Xu, Ting; Colcombe, Stanley; Franco, Alexandre Rosa; Cloud, Jessica; LaConte, Stephen; Lisinski, Jonathan; Klein, Arno; Craddock, R Cameron; Milham, Michael	March 14, 2020	Not Determined
31476430	Create Study	Brain age prediction: Cortical and subcortical shape covariation in the developing human brain.	NeuroImage	Zhao, Yihong; Klein, Arno; Castellanos, F Xavier; Milham, Michael P	November 15, 2019	Not Determined
31423596	Create Study	Measuring strengths and weaknesses in dimensional psychiatry.	Journal of child psychology and psychiatry, and allied disciplines	Alexander, Lindsay M; Salum, Giovanni A; Swanson, James M; Milham, Michael P	January 1, 2020	Not Determined
31399257	Create Study	Early Adversity and the Neotenous Human Brain.	Biological psychiatry	Tottenham, Nim	February 15, 2020	Not Determined
31332302	Create Study	Parental presence switches avoidance to attraction learning in children.	Nature human behaviour	Tottenham, Nim; Shapiro, Mor; Flannery, Jessica; Caldera, Christina; Sullivan, Regina M	October 1, 2019	Not Determined
31038094	Create Study	Working memory moderates the association between early institutional care and separation anxiety symptoms in late childhood and adolescence.	Development and psychopathology	Alba, Laura Alicia; Flannery, Jessica; Shapiro, Mor; Tottenham, Nim	August 1, 2019	Not Determined
31030002	Create Study	Mechanisms linking childhood adversity with psychopathology: Learning as an intervention target.	Behaviour research and therapy	McLaughlin, Katie A; DeCross, Stephanie N; Jovanovic, Tanja; Tottenham, Nim	July 1, 2019	Not Determined
30952600	Create Study	Decreased Amygdala Reactivity to Parent Cues Protects Against Anxiety Following Early Adversity: An Examination Across 3 Years.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Callaghan, Bridget L; Gee, Dylan G; Gabard-Durnam, Laurel; Telzer, Eva H; Humphreys, Kathryn L; Goff, Bonnie; Shapiro, Mor; Flannery, Jessica; Lumian, Daniel S; Fareri, Dominic S; Caldera, Christina; Tottenham, Nim	July 1, 2019	Not Determined
30919798	Create Study	Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity.	Development and psychopathology	Callaghan, Bridget L; Fields, Andrea; Gee, Dylan G; Gabard-Durnam, Laurel; Caldera, Christina; Humphreys, Kathryn L; Goff, Bonnie; Flannery, Jessica; Telzer, Eva H; Shapiro, Mor; Tottenham, Nim	February 1, 2020	Not Determined
30786246	Create Study	Using a Developmental Ecology Framework to Align Fear Neurobiology Across Species.	Annual review of clinical psychology	Callaghan, Bridget; Meyer, Heidi; Opendak, Maya; Van Tieghem, Michelle; Harmon, Chelsea; Li, Anfei; Lee, Francis S; Sullivan, Regina M; Tottenham, Nim	May 7, 2019	Not Determined
30588896	Create Study	Friendship and social functioning following early institutional rearing: The role of ADHD symptoms.	Development and psychopathology	Humphreys, Kathryn L; Gabard-Durnam, Laurel; Goff, Bonnie; Telzer, Eva H; Flannery, Jessica; Gee, Dylan G; Park, Valentina; Lee, Steve S; Tottenham, Nim	October 1, 2019	Not Determined
29162189	Create Study	Altered ventral striatal-medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care.	Development and psychopathology	Fareri, Dominic S; Gabard-Durnam, Laurel; Goff, Bonnie; Flannery, Jessica; Gee, Dylan G; Lumian, Daniel S; Caldera, Christina; Tottenham, Nim	December 2017	Not Relevant
28993819	Create Study	Vigilance, the Amygdala, and Anxiety in Youths with a History of Institutional Care.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Silvers, Jennifer A; Goff, Bonnie; Gabard-Durnam, Laurel J; Gee, Dylan G; Fareri, Dominic S; Caldera, Christina; Tottenham, Nim	September 2017	Not Relevant
28950973	Create Study	The developing amygdala: a student of the world and a teacher of the cortex.	Current opinion in psychology	Tottenham, Nim; Gabard-Durnam, Laurel J	October 2017	Not Relevant
28439771	Create Study	Neurobiological Programming of Early Life Stress: Functional Development of Amygdala-Prefrontal Circuitry and Vulnerability for Stress-Related Psychopathology.	Current topics in behavioral neurosciences	VanTieghem, Michelle R; Tottenham, Nim	January 2018	Not Relevant

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	1	01/15/2019	329	07/15/2019	0	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Services Assessment for Children and Adolescents (SACA)	1	01/15/2019	330	07/15/2019	323	Approved
Child Anxiety and Depression Scale - Revised (RCADS)	300	07/15/2021	328	01/15/2022	324	Approved
Wechsler Abbreviated Scale of Intelligence (WASI)	1	01/15/2019	330	07/15/2019	0	Approved
Child Behavior Checklist (CBCL)	300	07/15/2021	329	01/15/2022	324	Approved
Conners	300	01/15/2024	307	07/15/2024	0	Approved
Pubertal Development Scale (PDS)	300	01/15/2019	333	07/15/2019	323	Approved
Childrens Behavior Questionnaire (CBQ)	100	01/15/2019	323	07/15/2019	323	Approved
Kiddie-Sads (K-SADS)	300	06/30/2024	328	06/30/2025	0	Approved
Behavior Rating Inventory of Executive Function (BRIEF)	1	01/15/2019	327	07/15/2019	0	Approved
Beck Depression Inventory	300	06/30/2024	327	06/30/2025	0	Approved
Affective Reactivity Index	300	01/15/2019	333	07/15/2019	0	Approved
State-Trait Anxiety Inventory for Adults	300	06/30/2024	324	06/30/2025	0	Approved
Traumatic Events Screening Inventory	300	01/15/2019	324	07/15/2019	0	Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)	1	06/30/2023	1	06/30/2024	0	Approved
Dimensional Change Card Sort Test	300	07/14/2022	322	07/14/2023	0	Approved
Alabama Parenting Questionnaire	300	01/15/2024	328	07/15/2024	0	Approved
Flanker Task	300	07/14/2022	322	07/14/2023	0	Approved
Physical and Neurological Examination for Subtle Signs (PANESS)	300	01/15/2019	324	07/15/2019	0	Approved
NIH Toolbox Fear Anxiety Surveys	300	06/30/2023	331	11/15/2023	0	Approved
Sadness Survey	300	01/15/2024	322	07/15/2024	0	Approved
Income-to-Needs Ratio	300	06/30/2024	326	06/30/2025	0	Approved
Psychotropic Medication Checklist	300	06/30/2024	325	06/20/2025	0	Approved
Security Scale	300	07/15/2024	327	10/31/2024	0	Approved
Space Treasure	300	06/30/2024	171	10/31/2024	0	Approved
Reactive Attachment Disorder Symptom Checklist	300	07/15/2024	282	10/31/2024	0	Approved
Social Aptitude Scale	300	07/15/2024	283	10/31/2024	0	Approved
Friendship Questionnaire	300	07/15/2024	281	10/31/2024	0	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
No records found.

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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