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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Collection - Use Existing Experiment
To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.
SelectExperiment IdExperiment NameExperiment Type
Created On
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
154Math Autism Study - Vinod MenonfMRI07/15/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
Collection - Add Experiment
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To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities
Nim Tottenham 
Children with severe Early Caregiving Adversities (ECAs) are the most vulnerable to psychopathology as a result of prolonged neglect, abuse, and care disruptions that impact neurodevelopment. It is currently estimated that addressing ECAs would lead to a 29.8 percent reduction in worldwide psychiatric illness. Existing research, including findings from the original grant of this renewal, has demonstrated that there is a very strong link between ECA exposures and increased risk for psychopathology and altered neurodevelopment at the population level and yet, given the heterogeneity in ECA populations, there is a critical gap in knowledge regarding how ECAs increase any specific risks to an individual child. The proposed research addresses this significant mental health problem by combining sophisitcated data-analysis methods that use experiential and phenotypic heterogeneity together with longitudinal neuroimaging and behavioral assessments in school-age children. This approach will increase precision when linking ECAs and child outcomes associated with the Research Domain Criteria constructs of Negative Valence and Cognitive Control Systems (NVS/CCS). The overarching goal of the present work is to create an explanatory model for the heterogeneous impact of ECAs on neurodevelopmental trajectories of NVSCCS. This projects premise is that children exposed to ECAs have highly heterogeneous developmental histories as well as heterogeneous outcomes therefore, prediction of ECA outcomes requires cutting-edge, sophisticated data analytic methods. We hypothesize that data-driven approaches will 1) more precisely define NVS/CCS outcomes for school-aged children with ECAs, and 2) provide a more robust explanatory model for links between ECAs and NVS/CCS trajectories. Aim 1A subtypes children with a history of ECAs based on 2.5-year developmental trajectories of NVS/CCS. 300 6-8 year old children (250 sampled from previous institutional and foster care; 50 community comparisons) will provide neuroimaging, behavioral, and self/caregiver reports every 15 months for 2.5 years. Biclustering methods will be applied to the baseline and follow-up data to identify homogeneous NVS/CCS final outcome clusters of children. Aim 1B develops an explanatory model to predict developmental trajectory subtypes for children with ECAs, from early life profiles and brain behavior phenotypes at the time of enrollment. Machine learning methods applied to early life profiles, baseline NVS/CCS profiles, and sex, will predict developmental trajectory subtypes. Aim 2 identifies adverse and protective life events during the 2.5-year assessment period that are predictive of 2.5-year follow-up outcomes for children with ECAs. The inclusion of child-sex and current life-events will identify potential divergence in pathways across middle childhood. This prospective design of children exposed to various ECAs is designed to develop predictive models for ECA trajectory subtypes and outcomes, which can inform our understanding of risk and protective factors in accord with the goals of precision medicine.
NIMH Data Archive
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NIH - Extramural None

R01MH091864-06 Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities 09/01/2017 06/30/2024 325 335 COLUMBIA UNIV NEW YORK MORNINGSIDE $3,823,226.00


NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).


  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.


  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.
Child Behavior Checklist (CBCL) 6-18 Clinical Assessments 324
Children's Behavior Questionnaire The Very Short Form Clinical Assessments 323
Pubertal Development Scale Clinical Assessments 323
Revised Child Anxiety and Depression Scale (RCADS) Clinical Assessments 324
Services Assessment for Children and Adolescents (SACA) Clinical Assessments 323

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.


  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
38664866Create StudyProbing the content of affective semantic memory following caregiving-related early adversity.Developmental scienceVannucci, Anna; Fields, Andrea; Bloom, Paul A; Camacho, Nicolas L; Choy, Tricia; Durazi, Amaesha; Hadis, Syntia; Harmon, Chelsea; Heleniak, Charlotte; VanTieghem, Michelle; Dozier, Mary; Milham, Michael P; Ghetti, Simona; Tottenham, NimApril 25, 2024Not Determined
38549194Create StudyThe effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study.Developmental scienceAbramson, Lior; Callaghan, Bridget L; Silvers, Jennifer A; Choy, Tricia; VanTieghem, Michelle; Vannucci, Anna; Fields, Andrea; Tottenham, NimMarch 28, 2024Not Determined
37883086Create StudyParent-Perceived Benefits and Harms Associated With Internet Use by Adolescent Offspring.JAMA network openKimball, Harry Graff; Fernandez, Francesca; Moskowitz, Kathleen Anne; Kang, Minji; Alexander, Lindsay M; Conway, Kevin P; Merikangas, Kathleen Ries; Salum, Giovanni Abrahão; Milham, Michael PeterOctober 2, 2023Not Determined
37524685Create StudyDevelopmental deviation in delay discounting as a transdiagnostic indicator of risk for child psychopathology.Journal of child psychology and psychiatry, and allied disciplinesDeRosa, Jacob; Rosch, Keri S; Mostofsky, Stewart H; Nikolaidis, AkiFebruary 1, 2024Not Determined
37385583Create StudyA Randomized Controlled Trial of a Parenting Intervention During Infancy Alters Amygdala-Prefrontal Circuitry in Middle Childhood.Journal of the American Academy of Child and Adolescent PsychiatryValadez, Emilio A; Tottenham, Nim; Korom, Marta; Tabachnick, Alexandra R; Pine, Daniel S; Dozier, MaryJanuary 1, 2024Not Determined
37338905Create StudyParental Preferences for Mental Health Screening of Youths From a Multinational Survey.JAMA network openKass, Mirelle; Alexander, Lindsay; Moskowitz, Kathleen; James, Najé; Salum, Giovanni Abrahão; Leventhal, Bennett; Merikangas, Kathleen; Milham, Michael PeterJune 1, 2023Not Determined
37210754Create StudyCharacterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.Developmental cognitive neuroscienceBrieant, Alexis; Vannucci, Anna; Nakua, Hajer; Harris, Jenny; Lovell, Jack; Brundavanam, Divya; Tottenham, Nim; Gee, Dylan GJune 1, 2023Not Determined
37141961Create StudyInterpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.Neuroscience and biobehavioral reviewsVannucci, Anna; Fields, Andrea; Hansen, Eleanor; Katz, Ariel; Kerwin, John; Tachida, Ayumi; Martin, Nathan; Tottenham, NimJuly 1, 2023Not Determined
36798244Create StudyRobust Parental Preferences in Mental Health Screening in Youth From a Multinational Online Survey.medRxiv : the preprint server for health sciencesKass, Mirelle; Alexander, Lindsay; Moskowitz, Kathleen; James, Najé; Salum, Giovanni Abrahão; Leventhal, Bennett; Merikangas, Kathleen; Milham, Michael PeterFebruary 10, 2023Not Determined
36468788Create StudyHeterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes - CORRIGENDUM.Development and psychopathologyNikolaidis, Aki; Heleniak, Charlotte; Fields, Andrea; Bloom, Paul A; VanTieghem, Michelle; Vannucci, Anna; Camacho, Nicolas L; Choy, Tricia; Gibson, Lisa; Harmon, Chelsea; Hadis, Syntia S; Douglas, Ian J; Milham, Michael P; Tottenham, NimAugust 1, 2023Not Determined
36278283Create StudyAnxiety in children and youth with autism spectrum disorder and the association with amygdala subnuclei structure.Autism : the international journal of research and practiceHennessy, Abagail; Seguin, Diane; Correa, Susana; Wang, Jianan; Martinez-Trujillo, Julio C; Nicolson, Rob; Duerden, Emma GMay 1, 2023Not Determined
35393752Create StudyAge-related change in task-evoked amygdala-prefrontal circuitry: A multiverse approach with an accelerated longitudinal cohort aged 4-22 years.Human brain mappingBloom, Paul Alexander; VanTieghem, Michelle; Gabard-Durnam, Laurel; Gee, Dylan G; Flannery, Jessica; Caldera, Christina; Goff, Bonnie; Telzer, Eva H; Humphreys, Kathryn L; Fareri, Dominic S; Shapiro, Mor; Algharazi, Sameah; Bolger, Niall; Aly, Mariam; Tottenham, NimJuly 1, 2022Not Determined
35314012Create StudyHeterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes.Development and psychopathologyNikolaidis, Aki; Heleniak, Charlotte; Fields, Andrea; Bloom, Paul A; VanTieghem, Michelle; Vannucci, Anna; Camacho, Nicolas L; Choy, Tricia; Gibson, Lisa; Harmon, Chelsea; Hadis, Syntia S; Douglas, Ian J; Milham, Michael P; Tottenham, NimMay 1, 2022Not Determined
35080089Create StudyExperimental evidence for a child-to-adolescent switch in human amygdala-prefrontal cortex communication: A cross-sectional pilot study.Developmental scienceGee, Dylan G; Hanson, Catherine; Caglar, Leyla Roksan; Fareri, Dominic S; Gabard-Durnam, Laurel J; Mills-Finnerty, Colleen; Goff, Bonnie; Caldera, Christina J; Lumian, Daniel S; Flannery, Jessica; Hanson, Stephen José; Tottenham, NimJuly 1, 2022Not Determined
34689856Create StudyAmygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving.Development and psychopathologyStevens, Jennifer S; van Rooij, Sanne J H; Stenson, Anais F; Ely, Timothy D; Powers, Abigail; Clifford, Aimee; Kim, Ye Ji; Hinrichs, Rebecca; Tottenham, Nim; Jovanovic, TanjaAugust 1, 2023Not Determined
34649041Create StudyPredicting multiscan MRI outcomes in children with neurodevelopmental conditions following MRI simulator training.Developmental cognitive neuroscienceSimhal, Anish K; Filho, José O A; Segura, Patricia; Cloud, Jessica; Petkova, Eva; Gallagher, Richard; Castellanos, F Xavier; Colcombe, Stan; Milham, Michael P; Di Martino, AdrianaDecember 1, 2021Not Determined
34549545Create StudyEarly adversity and positive parenting: Association with cognitive outcomes in children with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchKuenzel, Elizabeth; Seguin, Diane; Nicolson, Robert; Duerden, Emma GDecember 1, 2021Not Determined
34385508Create StudyPeer victimization and the association with hippocampal development and working memory in children with ADHD and typically-developing children.Scientific reportsPapadopoulos, Alissa; Seguin, Diane; Correa, Susana; Duerden, Emma GAugust 12, 2021Not Determined
34080760Create StudyAdaptation in the face of adversity: Decrements and enhancements in children''s cognitive control behavior following early caregiving instability.Developmental scienceFields, Andrea; Bloom, Paul A; VanTieghem, Michelle; Harmon, Chelsea; Choy, Tricia; Camacho, Nicolas L; Gibson, Lisa; Umbach, Rebecca; Heleniak, Charlotte; Tottenham, NimNovember 1, 2021Not Determined
33948944Create StudyUsing gastrointestinal distress reports to predict youth anxiety risk: Implications for mental health literacy and community care.Developmental psychobiologyBloom, Paul Alexander; Douglas, Ian; VanTieghem, Michelle; Tottenham, Nim; Callaghan, BridgetSeptember 1, 2021Not Determined
33517107Create StudyLongitudinal changes in amygdala, hippocampus and cortisol development following early caregiving adversity.Developmental cognitive neuroscienceVanTieghem, Michelle; Korom, Marta; Flannery, Jessica; Choy, Tricia; Caldera, Christina; Humphreys, Kathryn L; Gabard-Durnam, Laurel; Goff, Bonnie; Gee, Dylan G; Telzer, Eva H; Shapiro, Mor; Louie, Jennifer Y; Fareri, Dominic S; Bolger, Niall; Tottenham, NimApril 1, 2021Not Determined
33487578Create StudyDepression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.Biological psychiatry. Cognitive neuroscience and neuroimagingTottenham, Nim; Weissman, Myrna M; Wang, Zhishun; Warner, Virginia; Gameroff, Marc J; Semanek, David P; Hao, Xuejun; Gingrich, Jay A; Peterson, Bradley S; Posner, Jonathan; Talati, ArdesheerMarch 1, 2021Not Determined
33427163Create StudyNeural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving.Development and psychopathologyTottenham, NimDecember 1, 2020Not Determined
33248256Create StudyIs it time to switch your T1W sequence? Assessing the impact of prospective motion correction on the reliability and quality of structural imaging.NeuroImageAi, Lei; Craddock, R Cameron; Tottenham, Nim; Dyke, Jonathan P; Lim, Ryan; Colcombe, Stanley; Milham, Michael; Franco, Alexandre RFebruary 1, 2021Not Determined
33103280Create StudyAn exploration of amygdala-prefrontal mechanisms in the intergenerational transmission of learned fear.Developmental scienceSilvers, Jennifer A; Callaghan, Bridget L; VanTieghem, Michelle; Choy, Tricia; O'Sullivan, Kaitlin; Tottenham, NimMay 1, 2021Not Determined
32731812Create StudyEarly Parenting Intervention Effects on Brain Responses to Maternal Cues Among High-Risk Children.The American journal of psychiatryValadez, Emilio A; Tottenham, Nim; Tabachnick, Alexandra R; Dozier, MarySeptember 1, 2020Not Determined
32671835Create StudyParent''s anxiety links household stress and young children''s behavioral dysregulation.Developmental psychobiologyFields, Andrea; Harmon, Chelsea; Lee, Zoe; Louie, Jennifer Y; Tottenham, NimJanuary 1, 2021Not Determined
32654667Create StudyCallous-unemotional traits and reduced default mode network connectivity within a community sample of children.Development and psychopathologyUmbach, Rebecca H; Tottenham, NimOctober 1, 2021Not Determined
32572148Create StudyDiagnostic Associations of Processing Speed in a Transdiagnostic, Pediatric Sample.Scientific reportsKramer, Eliza; Koo, Bonhwang; Restrepo, Anita; Koyama, Maki; Neuhaus, Rebecca; Pugh, Kenneth; Andreotti, Charissa; Milham, MichaelJune 22, 2020Not Determined
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32111822Create StudyAdverse caregiving in infancy blunts neural processing of the mother.Nature communicationsOpendak, Maya; Theisen, Emma; Blomkvist, Anna; Hollis, Kaitlin; Lind, Teresa; Sarro, Emma; Lundström, Johan N; Tottenham, Nim; Dozier, Mary; Wilson, Donald A; Sullivan, Regina MFebruary 28, 2020Not Determined
31951308Create StudyIncreased activation of the fear neurocircuitry in children exposed to violence.Depression and anxietyvan Rooij, Sanne J H; Smith, Ryan D; Stenson, Anaïs F; Ely, Timothy D; Yang, Xinyi; Tottenham, Nim; Stevens, Jennifer S; Jovanovic, TanjaApril 1, 2020Not Determined
31595961Create StudyEvaluating fMRI-Based Estimation of Eye Gaze During Naturalistic Viewing.Cerebral cortex (New York, N.Y. : 1991)Son, Jake; Ai, Lei; Lim, Ryan; Xu, Ting; Colcombe, Stanley; Franco, Alexandre Rosa; Cloud, Jessica; LaConte, Stephen; Lisinski, Jonathan; Klein, Arno; Craddock, R Cameron; Milham, MichaelMarch 14, 2020Not Determined
31476430Create StudyBrain age prediction: Cortical and subcortical shape covariation in the developing human brain.NeuroImageZhao, Yihong; Klein, Arno; Castellanos, F Xavier; Milham, Michael PNovember 15, 2019Not Determined
31423596Create StudyMeasuring strengths and weaknesses in dimensional psychiatry.Journal of child psychology and psychiatry, and allied disciplinesAlexander, Lindsay M; Salum, Giovanni A; Swanson, James M; Milham, Michael PJanuary 1, 2020Not Determined
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31332302Create StudyParental presence switches avoidance to attraction learning in children.Nature human behaviourTottenham, Nim; Shapiro, Mor; Flannery, Jessica; Caldera, Christina; Sullivan, Regina MOctober 1, 2019Not Determined
31038094Create StudyWorking memory moderates the association between early institutional care and separation anxiety symptoms in late childhood and adolescence.Development and psychopathologyAlba, Laura Alicia; Flannery, Jessica; Shapiro, Mor; Tottenham, NimAugust 1, 2019Not Determined
31030002Create StudyMechanisms linking childhood adversity with psychopathology: Learning as an intervention target.Behaviour research and therapyMcLaughlin, Katie A; DeCross, Stephanie N; Jovanovic, Tanja; Tottenham, NimJuly 1, 2019Not Determined
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30919798Create StudyMind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity.Development and psychopathologyCallaghan, Bridget L; Fields, Andrea; Gee, Dylan G; Gabard-Durnam, Laurel; Caldera, Christina; Humphreys, Kathryn L; Goff, Bonnie; Flannery, Jessica; Telzer, Eva H; Shapiro, Mor; Tottenham, NimFebruary 1, 2020Not Determined
30786246Create StudyUsing a Developmental Ecology Framework to Align Fear Neurobiology Across Species.Annual review of clinical psychologyCallaghan, Bridget; Meyer, Heidi; Opendak, Maya; Van Tieghem, Michelle; Harmon, Chelsea; Li, Anfei; Lee, Francis S; Sullivan, Regina M; Tottenham, NimMay 7, 2019Not Determined
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29162189Create StudyAltered ventral striatal-medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care.Development and psychopathologyFareri, Dominic S; Gabard-Durnam, Laurel; Goff, Bonnie; Flannery, Jessica; Gee, Dylan G; Lumian, Daniel S; Caldera, Christina; Tottenham, NimDecember 2017Not Relevant
28993819Create StudyVigilance, the Amygdala, and Anxiety in Youths with a History of Institutional Care.Biological psychiatry. Cognitive neuroscience and neuroimagingSilvers, Jennifer A; Goff, Bonnie; Gabard-Durnam, Laurel J; Gee, Dylan G; Fareri, Dominic S; Caldera, Christina; Tottenham, NimSeptember 2017Not Relevant
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NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).


  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.
Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Services Assessment for Children and Adolescents (SACA) info icon
Child Anxiety and Depression Scale - Revised (RCADS) info icon
Wechsler Abbreviated Scale of Intelligence (WASI) info icon
Child Behavior Checklist (CBCL) info icon
Conners info icon
Pubertal Development Scale (PDS) info icon
Childrens Behavior Questionnaire (CBQ) info icon
Behavior Rating Inventory of Executive Function (BRIEF) info icon
Affective Reactivity Index info icon
Traumatic Events Screening Inventory info icon
Imaging (Structural, fMRI, DTI, PET, microscopy) info icon
Dimensional Change Card Sort Test info icon
Alabama Parenting Questionnaire info icon
Flanker Task info icon
Physical and Neurological Examination for Subtle Signs (PANESS) info icon
NIH Toolbox Fear Anxiety Surveys info icon
Sadness Survey info icon
Religiosity Form info icon
NIH Toolbox Anger info icon
Security Scale info icon
Space Treasure info icon
Reactive Attachment Disorder Symptom Checklist info icon
Perceived Racism Scale info icon
Social Aptitude Scale info icon
Friendship Questionnaire info icon
Presence of Mentor Scale info icon
Structure not yet defined
No Status history for this Data Expected has been recorded yet

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.


  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
No records found.

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.


  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.