NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Data Structures:

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The Data Expected list for this Collection shows some raw data as missing. Contact the NDA Help Desk with any questions.

Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

You have requested to move the sharing dates for the following assessments:

Data Expected Item	Original Sharing Date	New Sharing Date

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Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP) #2126

General
Experiments (11)
Shared Data
Publications (74)
Data Expected (26)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)
Collection Investigators:	Carol Tamminga
Collection Description:	Psychotic symptoms are present in a significant subset of individuals with Bipolar Disorder (BD) and carry devastating personal and clinical implications. Most biomedical research on BD has ignored the variable presentation of psychosis possibly overlooking biologically significant heterogeneity in BD; such heterogeneity may cause inconsistencies in the literature by treating BD as a homogenous category 7,18. The expression of psychosis in some BD patients (BD-P) and absence in others (BD-NP) may indicate divergent disease processes of critical nosological and clinical relevance. PARDIP leverages a large sample of BD, a comprehensive battery, and sophisticated analytic tools to establish whether BD-P and BD-NP represent a difference in degree or a difference in kind. Long-term goals: This work will critically impact how BD is classified and studied, provide robust targets for effective future etiological studies, and clarify the utility of available biomarkers o major psychiatric disturbance. PARDIP represents a step toward mechanistically based classification of psychiatric disorders. Specific Aims: PARDIP will (i) identify the patterns of bo-cognitive disruptions which mark psychosis (BD-PBD-NP) or mood instability in general (BD healthy comparisons), (ii) explore how these biomarkers relate to one another and to other dimensions of psychopathology present in BD, and (iii) utilize latent class and cluster analyses of the multivariate dataset to verify taxonicity within BD with regard to psychosis and uncover latent psychiatric subgroups of interest for future genotyping and etiological research. Methods: The three-year PARDIP project will recruit 135 psychotic BD, 135 non-psychotic BD, and 135 psychiatrically healthy comparison subjects (all new recruits), administering a comprehensive battery focused on the psychosis and mania domains of psychopathology. We will obtain measures of neurophysiology, (smooth pursuit eye movements, antisaccades, auditory ERPs), cognition (cognitive battery, response inhibition, spatial working memory), neuroanatomy (structural magnetic resonance imaging [MRI]), emotional processing (ERPs to emotional pictures), intrinsic brain state (resting functional MRI connectivity), and circadian function (Actigraphy). We will compare biomarkers between BD-P, BD-NP, and H groups to determine which track with psychosis and which track with affective disturbance. We will identify common sources of variance among measures with joint-ICA and PCA approaches, and examine how biomarkers and biomarker composites relate to other aspects of clinical heterogeneity. Taxometric procedures (MAXCOV- HITMAX and its multivariate extension MAXEIG-HITMAX and k-means clustering) will be carried out with the multivariate dataset to empirically identify distinct subgroups of subjects. PARDIP will be conducted by 4 experienced research groups (across 3 collection sites) with a long history of close and productive collaboration.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	10/24/2014
NIH Research Initiative:	NIMH Repository & Genomics Resource (NRGR)
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$2,444,622.00
Subjects Shared:	310

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01MH096900-01	4/4-Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)	08/01/2013	06/30/2016	Not Reported	Not Reported	UNIVERSITY OF GEORGIA	$222,750.00
R01MH096942-01	4/6 Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)	08/01/2013	06/30/2017	135	115	BETH ISRAEL DEACONESS MEDICAL CENTER	$783,000.00
R01MH096957-01	3/4-Psychosis & Affective Research Domains and Intermediate Phenotypes (PARDIP)	08/01/2013	06/30/2016	135	56	YALE UNIVERSITY	$726,675.00
R01MH096913-01	Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)	08/01/2013	06/30/2016	135	109	UT SOUTHWESTERN MEDICAL CENTER	$712,197.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
476	Resting state (eyes open)	06/10/2016	Approved	fMRI
531	Rest - eyes open	12/02/2016	Approved	EEG
532	ODDBALL	12/02/2016	Approved	EEG
536	GATING	12/12/2016	Approved	EEG
537	IAPS	12/12/2016	Approved	EEG
538	AUDSS	12/12/2016	Approved	EEG
539	VISSS	12/12/2016	Approved	EEG
566	Prosaccade	01/03/2017	Approved	Eye Tracking
569	Antisaccade	01/04/2017	Approved	Eye Tracking
575	Ramp Mask Ramp Task	01/06/2017	Approved	Eye Tracking
601	Polhemus	01/18/2017	Approved	EEG

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Barratt Impulsivity Scale	Clinical Assessments	297
Brief Assessment of Cognition	Clinical Assessments	276
Child School Information	Clinical Assessments	248
Childhood Trauma Questionnaire	Clinical Assessments	271
Clinical Anxiety Scale	Clinical Assessments	154
Clinical Trials: Inclusion/Exclusion Criteria	Clinical Assessments	308
Demographics Data	Clinical Assessments	308
EEG Subject Files	Imaging	240
EEG Task Questionnaire	Clinical Assessments	262
Emotional ERP Task Evaluation Form	Clinical Assessments	241
Eye Tracking Subject-Experiment	Imaging	233
Fagerstrom Test for Nicotine Dependence	Clinical Assessments	272
Family History Form	Clinical Assessments	260
Hollingshead Socioeconomic Rating Scale	Clinical Assessments	304
Image	Imaging	213
Lifetime Dimensions of Psychosis Scale	Clinical Assessments	161
Medications	Clinical Assessments	275
Menopausal Form	Clinical Assessments	79
Montgomery-Asberg Depression Rating Scale	Clinical Assessments	181
Psychiatric Medical History	Clinical Assessments	303
Psychosocial Interview	Clinical Assessments	258
Research Subject	Clinical Assessments	308
Social Functioning Scale	Clinical Assessments	293
Spatial CAPacity Delayed Response Test (SCAP)	Clinical Assessments	238
Structured Clinical Interview for the Positive and Negative Syndrome Scale	Clinical Assessments	178
Wechsler Memory Scale, Third Edition (WMS-III)	Clinical Assessments	287
Wide Range Achievement Test 4 (WRAT4)	Clinical Assessments	288
Young Mania Rating Scale	Clinical Assessments	181

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38260530	Create Study	Differentiating Biomarker Features and Familial Characteristics of B-SNIP Psychosis Biotypes.	Research square	Parker, David; Trotti, Rebekah; McDowell, Jennifer; Keedy, Sarah; Keshavan, Matcheri; Pearlson, Godfrey; Gershon, Elliot; Ivleva, Elena; Huang, Ling-Yu; Sauer, Kodiak; Hill, Scot; Sweeny, John; Tamminga, Carol; Clementz, Brett	January 5, 2024	Not Determined
37121219	Create Study	Emotional scene processing in biotypes of psychosis.	Psychiatry research	Trotti, R L; Parker, D A; Sabatinelli, D; Keshavan, M S; Keedy, S K; Gershon, E S; Pearlson, G D; Hill, S K; Tamminga, C A; McDowell, J E; Clementz, B A	June 1, 2023	Not Determined
36644018	Create Study	Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features.	Biomarkers in neuropsychiatry	Parker, David A; Trotti, Rebekah L; McDowell, Jennifer E; Keedy, Sarah K; Gershon, Elliot S; Ivleva, Elena I; Pearlson, Godfrey D; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A	December 1, 2020	Not Determined
35260788	Create Study	A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Zhao, Qiannan; Cao, Hengyi; Zhang, Wenjing; Li, Siyi; Xiao, Yuan; Tamminga, Carol A; Keshavan, Matcheri S; Pearlson, Godfrey D; Clementz, Brett A; Gershon, Elliot S; Hill, Scot Kristian; Keedy, Sarah K; Ivleva, Elena I; Lencer, Rebekka; Sweeney, John A; Gong, Qiyong; Lui, Su	November 1, 2022	Not Determined
34887147	Create Study	Real-time facial emotion recognition deficits across the psychosis spectrum: A B-SNIP Study.	Schizophrenia research	Rubin, Leah H; Han, Jiaxu; Coughlin, Jennifer M; Hill, S Kristian; Bishop, Jeffrey R; Tamminga, Carol A; Clementz, Brett A; Pearlson, Godfrey D; Keshavan, Matcheri S; Gershon, Elliot S; Heilman, Keri J; Porges, Stephen W; Sweeney, John A; Keedy, Sarah	May 1, 2022	Not Determined
34409449	Create Study	Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.	Schizophrenia bulletin	Clementz, Brett A; Parker, David A; Trotti, Rebekah L; McDowell, Jennifer E; Keedy, Sarah K; Keshavan, Matcheri S; Pearlson, Godfrey D; Gershon, Elliot S; Ivleva, Elena I; Huang, Ling-Yu; Hill, S Kristian; Sweeney, John A; Thomas, Olivia; Hudgens-Haney, Matthew; Gibbons, Robert D; Tamminga, Carol A	January 21, 2022	Not Determined
34407624	Create Study	Auditory Oddball Responses Across the Schizophrenia-Bipolar Spectrum and Their Relationship to Cognitive and Clinical Features.	The American journal of psychiatry	Parker, David A; Trotti, Rebekah L; McDowell, Jennifer E; Keedy, Sarah K; Hill, S Kristian; Gershon, Elliot S; Ivleva, Elena I; Pearlson, Godfrey D; Keshavan, Matcheri S; Tamminga, Carol A; Clementz, Brett A	October 1, 2021	Not Determined
34322947	Create Study	Improving the predictive potential of diffusion MRI in schizophrenia using normative models-Towards subject-level classification.	Human brain mapping	Elad, Doron; Cetin-Karayumak, Suheyla; Zhang, Fan; Cho, Kang Ik K; Lyall, Amanda E; Seitz-Holland, Johanna; Ben-Ari, Rami; Pearlson, Godfrey D; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A; Schretlen, David J; Viher, Petra Verena; Stegmayer, Katharina; Walther, Sebastian; Lee, Jungsun; Crow, Tim J; James, Anthony; Voineskos, Aristotle N; Buchanan, Robert W; Szeszko, Philip R; Malhotra, Anil K; Keshavan, Matcheri S; Shenton, Martha E; Rathi, Yogesh; Bouix, Sylvain; Sochen, Nir; Kubicki, Marek R; Pasternak, Ofer	October 1, 2021	Not Determined
33693875	Create Study	Neural Processing of Repeated Emotional Scenes in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder.	Schizophrenia bulletin	Trotti, Rebekah L; Abdelmageed, Sunny; Parker, David A; Sabatinelli, Dean; Tamminga, Carol A; Gershon, Elliot S; Keedy, Sarah K; Keshavan, Matcheri S; Pearlson, Godfrey D; Sweeney, John A; McDowell, Jennifer E; Clementz, Brett A	August 21, 2021	Not Determined
33676821	Create Study	Mapping relationships among schizophrenia, bipolar and schizoaffective disorders: A deep classification and clustering framework using fMRI time series.	Schizophrenia research	Yan, Weizheng; Zhao, Min; Fu, Zening; Pearlson, Godfrey D; Sui, Jing; Calhoun, Vince D	July 1, 2022	Not Determined
33550654	Create Study	Reduced white matter microstructure in bipolar disorder with and without psychosis.	Bipolar disorders	Brown, Jennifer A; Jackson, Brooke S; Burton, Courtney R; Hoy, Jennifer E; Sweeney, John A; Pearlson, Godfrey D; Keshavan, Matcheri S; Keedy, Sarah S; Gershon, Elliot S; Tamminga, Carol A; Clementz, Brett A; McDowell, Jennifer E	December 1, 2021	Not Determined
33044802	Create Study	Greater male than female variability in regional brain structure across the lifespan.	Human brain mapping	Wierenga, Lara M; Doucet, Gaelle E; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andreassen, Ole A; Anticevic, Alan; Asherson, Philip; Banaschewski, Tobias; Bargallo, Nuria; Baumeister, Sarah; Baur-Streubel, Ramona; Bertolino, Alessandro; Bonvino, Aurora; Boomsma, Dorret I; Borgwardt, Stefan; Bourque, Josiane; den Braber, Anouk; Brandeis, Daniel; Breier, Alan; Brodaty, Henry; Brouwer, Rachel M; Buitelaar, Jan K; Busatto, Geraldo F; Calhoun, Vince D; Canales-Rodríguez, Erick J; Cannon, Dara M; Caseras, Xavier; Castellanos, Francisco X; Chaim-Avancini, Tiffany M; Ching, Christopher Rk; Clark, Vincent P; Conrod, Patricia J; Conzelmann, Annette; Crivello, Fabrice; Davey, Christopher G; Dickie, Erin W; Ehrlich, Stefan; Van't Ent, Dennis; Fisher, Simon E; Fouche, Jean-Paul; Franke, Barbara; Fuentes-Claramonte, Paola; de Geus, Eco Jc; Di Giorgio, Annabella; Glahn, David C; Gotlib, Ian H; Grabe, Hans J; Gruber, Oliver; Gruner, Patricia; Gur, Raquel E; Gur, Ruben C; Gurholt, Tiril P; de Haan, Lieuwe; Haatveit, Beathe; Harrison, Ben J; Hartman, Catharina A; Hatton, Sean N; Heslenfeld, Dirk J; van den Heuvel, Odile A; Hickie, Ian B; Hoekstra, Pieter J; Hohmann, Sarah; Holmes, Avram J; Hoogman, Martine; Hosten, Norbert; Howells, Fleur M; Hulshoff Pol, Hilleke E; Huyser, Chaim; Jahanshad, Neda; James, Anthony C; Jiang, Jiyang; Jönsson, Erik G; Joska, John A; Kalnin, Andrew J; Karolinska Schizophrenia Project (KaSP) Consortium; Klein, Marieke; Koenders, Laura; Kolskår, Knut K; Krämer, Bernd; Kuntsi, Jonna; Lagopoulos, Jim; Lazaro, Luisa; Lebedeva, Irina S; Lee, Phil H; Lochner, Christine; Machielsen, Marise Wj; Maingault, Sophie; Martin, Nicholas G; Martínez-Zalacaín, Ignacio; Mataix-Cols, David; Mazoyer, Bernard; McDonald, Brenna C; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie L; McPhilemy, Genevieve; van der Meer, Dennis; Menchón, José M; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J; Radua, Joaquim; Reif, Andreas; Richard, Geneviève; Roffman, Joshua L; Rosa, Pedro Gp; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Sarró, Salvador; Satterthwaite, Theodore D; Saykin, Andrew J; Serpa, Mauricio H; Sim, Kang; Simmons, Andrew; Smoller, Jordan W; Sommer, Iris E; Soriano-Mas, Carles; Stein, Dan J; Strike, Lachlan T; Szeszko, Philip R; Temmingh, Henk S; Thomopoulos, Sophia I; Tomyshev, Alexander S; Trollor, Julian N; Uhlmann, Anne; Veer, Ilya M; Veltman, Dick J; Voineskos, Aristotle; Völzke, Henry; Walter, Henrik; Wang, Lei; Wang, Yang; Weber, Bernd; Wen, Wei; West, John D; Westlye, Lars T; Whalley, Heather C; Williams, Steven Cr; Wittfeld, Katharina; Wolf, Daniel H; Wright, Margaret J; Yoncheva, Yuliya N; Zanetti, Marcus V; Ziegler, Georg C; de Zubicaray, Greig I; Thompson, Paul M; Crone, Eveline A; Frangou, Sophia; Tamnes, Christian K	January 1, 2022	Not Determined
32979849	Create Study	Biotyping in psychosis: using multiple computational approaches with one data set.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Tamminga, Carol A; Clementz, Brett A; Pearlson, Godfrey; Keshavan, Macheri; Gershon, Elliot S; Ivleva, Elena I; McDowell, Jennifer; Meda, Shashwath A; Keedy, Sarah; Calhoun, Vince D; Lizano, Paulo; Bishop, Jeffrey R; Hudgens-Haney, Matthew; Alliey-Rodriguez, Ney; Asif, Huma; Gibbons, Robert	January 1, 2021	Not Determined
32725849	Create Study	What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.	Human brain mapping	Ching, Christopher R K; Hibar, Derrek P; Gurholt, Tiril P; Nunes, Abraham; Thomopoulos, Sophia I; Abé, Christoph; Agartz, Ingrid; Brouwer, Rachel M; Cannon, Dara M; de Zwarte, Sonja M C; Eyler, Lisa T; Favre, Pauline; Hajek, Tomas; Haukvik, Unn K; Houenou, Josselin; Landén, Mikael; Lett, Tristram A; McDonald, Colm; Nabulsi, Leila; Patel, Yash; Pauling, Melissa E; Paus, Tomas; Radua, Joaquim; Soeiro-de-Souza, Marcio G; Tronchin, Giulia; van Haren, Neeltje E M; Vieta, Eduard; Walter, Henrik; Zeng, Ling-Li; Alda, Martin; Almeida, Jorge; Alnaes, Dag; Alonso-Lana, Silvia; Altimus, Cara; Bauer, Michael; Baune, Bernhard T; Bearden, Carrie E; Bellani, Marcella; Benedetti, Francesco; Berk, Michael; Bilderbeck, Amy C; Blumberg, Hilary P; Bøen, Erlend; Bollettini, Irene; Del Mar Bonnin, Caterina; Brambilla, Paolo; Canales-Rodríguez, Erick J; Caseras, Xavier; Dandash, Orwa; Dannlowski, Udo; Delvecchio, Giuseppe; Díaz-Zuluaga, Ana M; Dima, Danai; Duchesnay, Édouard; Elvsåshagen, Torbjørn; Fears, Scott C; Frangou, Sophia; Fullerton, Janice M; Glahn, David C; Goikolea, Jose M; Green, Melissa J; Grotegerd, Dominik; Gruber, Oliver; Haarman, Bartholomeus C M; Henry, Chantal; Howells, Fleur M; Ives-Deliperi, Victoria; Jansen, Andreas; Kircher, Tilo T J; Knöchel, Christian; Kramer, Bernd; Lafer, Beny; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; MacIntosh, Bradley J; Melloni, Elisa M T; Mitchell, Philip B; Nenadic, Igor; Nery, Fabiano; Nugent, Allison C; Oertel, Viola; Ophoff, Roel A; Ota, Miho; Overs, Bronwyn J; Pham, Daniel L; Phillips, Mary L; Pineda-Zapata, Julian A; Poletti, Sara; Polosan, Mircea; Pomarol-Clotet, Edith; Pouchon, Arnaud; Quidé, Yann; Rive, Maria M; Roberts, Gloria; Ruhe, Henricus G; Salvador, Raymond; Sarró, Salvador; Satterthwaite, Theodore D; Schene, Aart H; Sim, Kang; Soares, Jair C; Stäblein, Michael; Stein, Dan J; Tamnes, Christian K; Thomaidis, Georgios V; Upegui, Cristian Vargas; Veltman, Dick J; Wessa, Michèle; Westlye, Lars T; Whalley, Heather C; Wolf, Daniel H; Wu, Mon-Ju; Yatham, Lakshmi N; Zarate, Carlos A; Thompson, Paul M; Andreassen, Ole A; ENIGMA Bipolar Disorder Working Group	January 1, 2022	Not Determined
32674921	Create Study	Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.	Schizophrenia research	Gotra, Milena Y; Hill, Scot K; Gershon, Elliot S; Tamminga, Carol A; Ivleva, Elena I; Pearlson, Godfrey D; Keshavan, Matcheri S; Clementz, Brett A; McDowell, Jennifer E; Buckley, Peter F; Sweeney, John A; Keedy, Sarah K	September 1, 2020	Not Determined
32600898	Create Study	Testing Psychosis Phenotypes From Bipolar-Schizophrenia Network for Intermediate Phenotypes for Clinical Application: Biotype Characteristics and Targets.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Clementz, Brett A; Trotti, Rebekah L; Pearlson, Godfrey D; Keshavan, Matcheri S; Gershon, Elliot S; Keedy, Sarah K; Ivleva, Elena I; McDowell, Jennifer E; Tamminga, Carol A	August 1, 2020	Not Determined
32583570	Create Study	Altered cerebral perfusion in bipolar disorder: A pCASL MRI study.	Bipolar disorders	Zeng, Victor; Lizano, Paulo; Bolo, Nicolas R; Lutz, Olivia; Brady Jr, Roscoe; Ivleva, Elena I; Dai, Weiying; Clementz, Brett; Tamminga, Carol; Pearlson, Godfrey; Keshavan, Matcheri	March 2021	Not Determined
31759574	Create Study	Neuroimaging in Schizophrenia.	Neuroimaging clinics of North America	Keshavan, Matcheri S; Collin, Guusje; Guimond, Synthia; Kelly, Sinead; Prasad, Konasale M; Lizano, Paulo	February 1, 2020	Not Determined
31759570	Create Study	Imaging-Based Subtyping for Psychiatric Syndromes.	Neuroimaging clinics of North America	Ivleva, Elena I; Turkozer, Halide B; Sweeney, John A	February 2020	Not Determined
31721386	Create Study	Smooth pursuit eye movement deficits as a biomarker for psychotic features in bipolar disorder-Findings from the PARDIP study.	Bipolar disorders	Brakemeier, Svenja; Sprenger, Andreas; Meyhöfer, Inga; McDowell, Jennifer E; Rubin, Leah H; Hill, S Kristian; Keshavan, Matcheri S; Pearlson, Godfrey D; Tamminga, Carol A; Gershon, Elliot S; Keedy, Sarah S; Sweeney, John A; Clementz, Brett A; Lencer, Rebekka	September 2020	Not Determined
31634753	Create Study	Electrophysiological correlates of emotional scene processing in bipolar disorder.	Journal of psychiatric research	Trotti, Rebekah L; Parker, David A; Sabatinelli, Dean; Tamminga, Carol A; Gershon, Elliot S; Keedy, Sarah K; Keshavan, Matcheri S; Pearlson, Godfrey D; Sweeney, John A; McDowell, Jennifer E; Clementz, Brett A	January 1, 2020	Not Determined
31630476	Create Study	Abnormal perfusion fluctuation and perfusion connectivity in bipolar disorder measured by dynamic arterial spin labeling.	Bipolar disorders	Dai, Weiying; Chen, Mingzhao; Duan, Wenna; Zhao, Li; Bolo, Nicolas R; Tamminga, Carol; Clementz, Brett A; Pearlson, Godfrey D; Alsop, David C; Keshavan, Matcheri	June 2020	Not Determined
31080153	Create Study	Auditory steady-state EEG response across the schizo-bipolar spectrum.	Schizophrenia research	Parker DA, Hamm JP, Mcdowell JE, Keedy SK, Gershon ES, Ivleva EI, Pearlson GD, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA	July 2019	Not Determined
29759822	Create Study	Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Rodrigue, Amanda L; McDowell, Jennifer E; Tandon, Neeraj; Keshavan, Matcheri S; Tamminga, Carol A; Pearlson, Godfrey D; Sweeney, John A; Gibbons, Robert D; Clementz, Brett A	December 2018	Not Determined
28844436	Create Study	Psychosis subgroups differ in intrinsic neural activity but not task-specific processing.	Schizophrenia research	Hudgens-Haney, Matthew E; Ethridge, Lauren E; McDowell, Jennifer E; Keedy, Sarah K; Pearlson, Godfrey D; Tamminga, Carol A; Keshavan, Matcheri S; Sweeney, John A; Clementz, Brett A	May 2018	Not Determined
28467520	Create Study	Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.	JAMA psychiatry	Sheffield, Julia M; Kandala, Sridhar; Tamminga, Carol A; Pearlson, Godfrey D; Keshavan, Matcheri S; Sweeney, John A; Clementz, Brett A; Lerman-Sinkoff, Dov B; Hill, S Kristian; Barch, Deanna M	June 2017	Not Determined
28419491	Create Study	Intrinsic neural activity differences among psychotic illnesses.	Psychophysiology	Hudgens-Haney, Matthew E; Ethridge, Lauren E; Knight, Justin B; McDowell, Jennifer E; Keedy, Sarah K; Pearlson, Godfrey D; Tamminga, Carol A; Keshavan, Matcheri S; Sweeney, John A; Clementz, Brett A	August 2017	Not Determined
28390849	Create Study	Cognitive burden of anticholinergic medications in psychotic disorders.	Schizophrenia research	Eum, Seenae; Hill, S Kristian; Rubin, Leah H; Carnahan, Ryan M; Reilly, James L; Ivleva, Elena I; Keedy, Sarah K; Tamminga, Carol A; Pearlson, Godfrey D; Clementz, Brett A; Gershon, Elliot S; Keshavan, Matcheri S; Keefe, Richard S E; Sweeney, John A; Bishop, Jeffrey R	December 2017	Not Determined
28294459	Create Study	Identifying dynamic functional connectivity biomarkers using GIG-ICA: Application to schizophrenia, schizoaffective disorder, and psychotic bipolar disorder.	Human brain mapping	Du, Yuhui; Pearlson, Godfrey D; Lin, Dongdong; Sui, Jing; Chen, Jiayu; Salman, Mustafa; Tamminga, Carol A; Ivleva, Elena I; Sweeney, John A; Keshavan, Matcheri S; Clementz, Brett A; Bustillo, Juan; Calhoun, Vince D	May 2017	Not Determined
27872267	Create Study	Endophenotypes, Epigenetics, Polygenicity and More: Irv Gottesman''s Dynamic Legacy.	Schizophrenia bulletin	Braff, David L; Tamminga, Carol A	January 2017	Not Determined
27870395	Create Study	Sex differences in associations of arginine vasopressin and oxytocin with resting-state functional brain connectivity.	Journal of neuroscience research	Rubin, Leah H; Yao, Li; Keedy, Sarah K; Reilly, James L; Bishop, Jeffrey R; Carter, C Sue; Pournajafi-Nazarloo, Hossein; Drogos, Lauren L; Tamminga, Carol A; Pearlson, Godfrey D; Keshavan, Matcheri S; Clementz, Brett A; Hill, Scot K; Liao, Wei; Ji, Gong-Jun; Lui, Su; Sweeney, John A	January 2017	Not Determined
27791098	Create Study	Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.	Proceedings of the National Academy of Sciences of the United States of America	Lepack, Ashley E; Bagot, Rosemary C; Peña, Catherine J; Loh, Yong-Hwee E; Farrelly, Lorna A; Lu, Yang; Powell, Samuel K; Lorsch, Zachary S; Issler, Orna; Cates, Hannah M; Tamminga, Carol A; Molina, Henrik; Shen, Li; Nestler, Eric J; Allis, C David; Maze, Ian	November 2016	Not Determined
27306316	Create Study	Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder.	Schizophrenia bulletin	Reilly, James L; Hill, S Kristian; Gold, James M; Keefe, Richard S E; Clementz, Brett A; Gershon, Elliot; Keshavan, Matcheri S; Pearlson, Godfrey; Tamminga, Carol A; Sweeney, John A	March 2017	Not Determined
27216897	Create Study	Does Biology Transcend the Symptom-based Boundaries of Psychosis?	The Psychiatric clinics of North America	Pearlson, Godfrey D; Clementz, Brett A; Sweeney, John A; Keshavan, Matcheri S; Tamminga, Carol A	June 2016	Not Relevant
27033329	Create Study	Cognitive Function in Individuals With Psychosis: Moderation by Adolescent Cannabis Use.	Schizophrenia bulletin	Hanna, Rebecca C; Shalvoy, Alexandra; Cullum, C Munro; Ivleva, Elena I; Keshavan, Matcheri; Pearlson, Godfrey; Hill, S Kristian; Sweeney, John A; Tamminga, Carol A; Ghose, Subroto	November 2016	Not Determined
27021555	Create Study	COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.	Schizophrenia research	Shukla, Abhay A; Jha, Manish; Birchfield, Thomas; Mukherjee, Shibani; Gleason, Kelly; Abdisalaam, Salim; Asaithamby, Aroumougame; Adams-Huet, Beverley; Tamminga, Carol A; Ghose, Subroto	May 2016	Not Determined
26977453	Create Study	Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Rubin, Leah H; Connelly, Jessica J; Reilly, James L; Carter, C Sue; Drogos, Lauren L; Pournajafi-Nazarloo, Hossein; Ruocco, Anthony C; Keedy, Sarah K; Matthew, Ian; Tandon, Neeraj; Pearlson, Godfrey D; Clementz, Brett A; Tamminga, Carol A; Gershon, Elliot S; Keshavan, Matcheri S; Bishop, Jeffrey R; Sweeney, John A	March 2016	Not Determined
26954565	Create Study	Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes.	Biological psychiatry	Francis, Alan N; Mothi, Suraj S; Mathew, Ian T; Tandon, Neeraj; Clementz, Brett; Pearlson, Godfrey D; Sweeney, John A; Tamminga, Carol A; Keshavan, Matcheri S	October 2016	Not Determined
26891710	Create Study	Brain imaging demonstrates a reduced neural impact of eating in obesity.	Obesity (Silver Spring, Md.)	Puzziferri, Nancy; Zigman, Jeffrey M; Thomas, Binu P; Mihalakos, Perry; Gallagher, Ryan; Lutter, Michael; Carmody, Thomas; Lu, Hanzhang; Tamminga, Carol A	April 2016	Not Determined
26795203	Create Study	Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic Mice.	PloS one	Yun, Sanghee; Donovan, Michael H; Ross, Michele N; Richardson, Devon R; Reister, Robin; Farnbauch, Laure A; Fischer, Stephanie J; Riethmacher, Dieter; Gershenfeld, Howard K; Lagace, Diane C; Eisch, Amelia J	January 2016	Not Determined
26732139	Create Study	Large-Scale Fusion of Gray Matter and Resting-State Functional MRI Reveals Common and Distinct Biological Markers across the Psychosis Spectrum in the B-SNIP Cohort.	Frontiers in psychiatry	Wang, Zheng; Meda, Shashwath A; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A; Schretlen, David J; Calhoun, Vince D; Lui, Su; Pearlson, Godfrey D	January 2015	Not Determined
26651391	Create Study	Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.	The American journal of psychiatry	Clementz, Brett A; Sweeney, John A; Hamm, Jordan P; Ivleva, Elena I; Ethridge, Lauren E; Pearlson, Godfrey D; Keshavan, Matcheri S; Tamminga, Carol A	April 2016	Not Determined
26617533	Create Study	Joint Coupling of Awake EEG Frequency Activity and MRI Gray Matter Volumes in the Psychosis Dimension: A BSNIP Study.	Frontiers in psychiatry	Soh, Pauline; Narayanan, Balaji; Khadka, Sabin; Calhoun, Vince D; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A; Pearlson, Godfrey D	January 2015	Not Determined
26481615	Create Study	Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.	Schizophrenia research	Lencer, Rebekka; Sprenger, Andreas; Reilly, James L; McDowell, Jennifer E; Rubin, Leah H; Badner, Judith A; Keshavan, Matcheri S; Pearlson, Godfrey D; Tamminga, Carol A; Gershon, Elliot S; Clementz, Brett A; Sweeney, John A	December 2015	Not Determined
26462502	Create Study	Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study.	Schizophrenia bulletin	Mokhtari, Mohammadreza; Narayanan, Balaji; Hamm, Jordan P; Soh, Pauline; Calhoun, Vince D; Ruaño, Gualberto; Kocherla, Mohan; Windemuth, Andreas; Clementz, Brett A; Tamminga, Carol A; Sweeney, John A; Keshavan, Matcheri S; Pearlson, Godfrey D	May 2016	Not Determined
26442095	Create Study	An introductory review of parallel independent component analysis (p-ICA) and a guide to applying p-ICA to genetic data and imaging phenotypes to identify disease-associated biological pathways and systems in common complex disorders.	Frontiers in genetics	Pearlson, Godfrey D; Liu, Jingyu; Calhoun, Vince D	January 1, 2015	Not Determined
26418130	Create Study	Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells.	Stem cells (Dayton, Ohio)	Petrik, David; Latchney, Sarah E; Masiulis, Irene; Yun, Sanghee; Zhang, Zilai; Wu, Jiang I; Eisch, Amelia J	December 2015	Not Determined
26139371	Create Study	Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.	Neuron	Maze, Ian; Wenderski, Wendy; Noh, Kyung-Min; Bagot, Rosemary C; Tzavaras, Nikos; Purushothaman, Immanuel; Elsässer, Simon J; Guo, Yin; Ionete, Carolina; Hurd, Yasmin L; Tamminga, Carol A; Halene, Tobias; Farrelly, Lorna; Soshnev, Alexey A; Wen, Duancheng; Rafii, Shahin; Birtwistle, Marc R; Akbarian, Schahram; Buchholz, Bruce A; Blitzer, Robert D; Nestler, Eric J; Yuan, Zuo-Fei; Garcia, Benjamin A; Shen, Li; Molina, Henrik; Allis, C David	July 2015	Not Determined
26123450	Create Study	Alterations in hippocampal connectivity across the psychosis dimension.	Psychiatry research	Samudra, Niyatee; Ivleva, Elena I; Hubbard, Nicholas A; Rypma, Bart; Sweeney, John A; Clementz, Brett A; Keshavan, Matcheri S; Pearlson, Godfrey D; Tamminga, Carol A	August 2015	Not Determined
26012519	Create Study	Frequency-Specific Neural Signatures of Spontaneous Low-Frequency Resting State Fluctuations in Psychosis: Evidence From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium.	Schizophrenia bulletin	Meda, Shashwath A; Wang, Zheng; Ivleva, Elena I; Poudyal, Gaurav; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A; Schretlen, David J; Calhoun, Vincent D; Lui, Su; Damaraju, Eswar; Pearlson, Godfrey D	November 2015	Not Determined
26008884	Create Study	Working memory impairment in probands with schizoaffective disorder and first degree relatives of schizophrenia probands extend beyond deficits predicted by generalized neuropsychological impairment.	Schizophrenia research	Kristian Hill, S; Buchholz, Alison; Amsbaugh, Hayley; Reilly, James L; Rubin, Leah H; Gold, James M; Keefe, Richard S E; Pearlson, Godfrey D; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A	August 2015	Not Determined
25888923	Create Study	Neuroimaging data sharing on the neuroinformatics database platform.	NeuroImage	Book, Gregory A; Stevens, Michael C; Assaf, Michal; Glahn, David C; Pearlson, Godfrey D	January 1, 2016	Not Relevant
25883891	Create Study	Neuroimaging Biomarkers for Psychosis.	Current behavioral neuroscience reports	Hager, Brandon M; Keshavan, Matcheri S	March 6, 2015	Not Relevant
25615564	Create Study	Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study.	The American journal of psychiatry	Narayanan, Balaji; Ethridge, Lauren E; O'Neil, Kasey; Dunn, Sabra; Mathew, Ian; Tandon, Neeraj; Calhoun, Vince D; Ruaño, Gualberto; Kocherla, Mohan; Windemuth, Andreas; Clementz, Brett A; Tamminga, Carol A; Sweeney, John A; Keshavan, Matcheri S; Pearlson, Godfrey D	May 2015	Not Determined
25585032	Create Study	Synaptic proteins in the hippocampus indicative of increased neuronal activity in CA3 in schizophrenia.	The American journal of psychiatry	Li, Wei; Ghose, Subroto; Gleason, Kelly; Begovic, Anita; Perez, Jessica; Bartko, John; Russo, Scott; Wagner, Anthony D; Selemon, Lynn; Tamminga, Carol A	April 2015	Not Determined
25581236	Create Study	Etiologic, phenomenologic, and endophenotypic overlap of schizophrenia and bipolar disorder.	Annual review of clinical psychology	Pearlson GD	2015	Not Relevant
25261042	Create Study	Behavioral response inhibition in psychotic disorders: diagnostic specificity, familiality and relation to generalized cognitive deficit.	Schizophrenia research	Ethridge, Lauren E; Soilleux, Melanie; Nakonezny, Paul A; Reilly, James L; Hill, S Kristian; Keefe, Richard S E; Gershon, Elliot S; Pearlson, Godfrey D; Tamminga, Carol A; Keshavan, Matcheri S; Sweeney, John A	November 2014	Not Determined
25194139	Create Study	Regressing to Prior Response Preference After Set Switching Implicates Striatal Dysfunction Across Psychotic Disorders: Findings From the B-SNIP Study.	Schizophrenia bulletin	Hill, S Kristian; Reilly, James L; Ragozzino, Michael E; Rubin, Leah H; Bishop, Jeffrey R; Gur, Ruben C; Gershon, Elliot S; Tamminga, Carol A; Pearlson, Godfrey D; Keshavan, Matcheri S; Keefe, Richard S E; Sweeney, John A	July 2015	Not Determined
25156338	Create Study	Detecting reliable cognitive change in individual patients with the MATRICS Consensus Cognitive Battery.	Schizophrenia research	Gray, Bradley E; McMahon, Robert P; Green, Michael F; Seidman, Larry J; Mesholam-Gately, Raquelle I; Kern, Robert S; Nuechterlein, Keith H; Keefe, Richard S; Gold, James M	October 2014	Not Relevant
25052782	Create Study	Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study.	Schizophrenia research	Ruocco, Anthony C; Reilly, James L; Rubin, Leah H; Daros, Alex R; Gershon, Elliot S; Tamminga, Carol A; Pearlson, Godfrey D; Hill, S Kristian; Keshavan, Matcheri S; Gur, Ruben C; Sweeney, John A	September 2014	Not Determined
24923619	Create Study	Event-related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder.	Biological psychiatry	Ethridge, Lauren E; Hamm, Jordan P; Pearlson, Godfrey D; Tamminga, Carol A; Sweeney, John A; Keshavan, Matcheri S; Clementz, Brett A	January 2015	Not Determined
24907239	Create Study	Correlations between brain structure and symptom dimensions of psychosis in schizophrenia, schizoaffective, and psychotic bipolar I disorders.	Schizophrenia bulletin	Padmanabhan, Jaya L; Tandon, Neeraj; Haller, Chiara S; Mathew, Ian T; Eack, Shaun M; Clementz, Brett A; Pearlson, Godfrey D; Sweeney, John A; Tamminga, Carol A; Keshavan, Matcheri S	January 2015	Not Determined
24778245	Create Study	Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.	Proceedings of the National Academy of Sciences of the United States of America	Meda, Shashwath A; Ruaño, Gualberto; Windemuth, Andreas; O'Neil, Kasey; Berwise, Clifton; Dunn, Sabra M; Boccaccio, Leah E; Narayanan, Balaji; Kocherla, Mohan; Sprooten, Emma; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A; Calhoun, Vince D; Pearlson, Godfrey D	May 2014	Not Determined
24660885	Create Study	Diagnostic specificity and familiality of early versus late evoked potentials to auditory paired stimuli across the schizophrenia-bipolar psychosis spectrum.	Psychophysiology	Hamm, Jordan P; Ethridge, Lauren E; Boutros, Nashaat N; Keshavan, Matcheri S; Sweeney, John A; Pearlson, Godfrey D; Tamminga, Carol A; Clementz, Brett A	April 2014	Not Determined
24619535	Create Study	Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders.	Schizophrenia bulletin	Rubin, Leah H; Carter, C Sue; Bishop, Jeffrey R; Pournajafi-Nazarloo, Hossein; Drogos, Lauren L; Hill, S Kristian; Ruocco, Anthony C; Keedy, Sarah K; Reilly, James L; Keshavan, Matcheri S; Pearlson, Godfrey D; Tamminga, Carol A; Gershon, Elliot S; Sweeney, John A	November 2014	Not Determined
24562492	Create Study	Bipolar and schizophrenia network for intermediate phenotypes: outcomes across the psychosis continuum.	Schizophrenia bulletin	Tamminga CA, Pearlson G, Keshavan M, Sweeney J, Clementz B, Thaker G	March 2014	Not Determined
24557771	Create Study	Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer).	Schizophrenia bulletin	Arnold, Sara J M; Ivleva, Elena I; Gopal, Tejas A; Reddy, Anil P; Jeon-Slaughter, Haekyung; Sacco, Carolyn B; Francis, Alan N; Tandon, Neeraj; Bidesi, Anup S; Witte, Bradley; Poudyal, Gaurav; Pearlson, Godfrey D; Sweeney, John A; Clementz, Brett A; Keshavan, Matcheri S; Tamminga, Carol A	January 2015	Not Determined
24439302	Create Study	Resting state electroencephalogram oscillatory abnormalities in schizophrenia and psychotic bipolar patients and their relatives from the bipolar and schizophrenia network on intermediate phenotypes study.	Biological psychiatry	Narayanan, Balaji; O'Neil, Kasey; Berwise, Clifton; Stevens, Michael C; Calhoun, Vince D; Clementz, Brett A; Tamminga, Carol A; Sweeney, John A; Keshavan, Matcheri S; Pearlson, Godfrey D	September 2014	Not Determined
24369266	Create Study	Local gyrification index in probands with psychotic disorders and their first-degree relatives.	Biological psychiatry	Nanda, Pranav; Tandon, Neeraj; Mathew, Ian T; Giakoumatos, Christoforos I; Abhishekh, Hulegar A; Clementz, Brett A; Pearlson, Godfrey D; Sweeney, John; Tamminga, Carol A; Keshavan, Matcheri S	September 2014	Not Determined
24080895	Create Study	Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories.	Schizophrenia bulletin	Reilly, James L; Frankovich, Kyle; Hill, Scot; Gershon, Elliot S; Keefe, Richard S E; Keshavan, Matcheri S; Pearlson, Godfrey D; Tamminga, Carol A; Sweeney, John A	September 2014	Not Determined
23975275	Create Study	Prolonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder.	Brain imaging and behavior	Rosenfeld, Ethan S; Pearlson, Godfrey D; Sweeney, John A; Tamminga, Carol A; Keshavan, Matcheri S; Nonterah, Camilla; Stevens, Michael C	March 2014	Not Determined
23941660	Create Study	Family history of psychosis moderates early auditory cortical response abnormalities in non-psychotic bipolar disorder.	Bipolar disorders	Hamm JP, Ethridge LE, Shapiro JR, Pearlson GD, Tamminga CA, Sweeney JA, Keshavan MS, Thaker GK, Clementz BA	November 2013	Not Relevant
23778975	Create Study	Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction.	Schizophrenia bulletin	Unschuld, Paul G; Buchholz, Alison S; Varvaris, Mark; van Zijl, Peter C M; Ross, Christopher A; Pekar, James J; Hock, Christoph; Sweeney, John A; Tamminga, Carol A; Keshavan, Matcheri S; Pearlson, Godfrey D; Thaker, Gunvant K; Schretlen, David J	May 2014	Not Determined
23599252	Create Study	Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension.	Schizophrenia bulletin	Ivleva, Elena I; Moates, Amanda F; Hamm, Jordan P; Bernstein, Ira H; O'Neill, Hugh B; Cole, Darwynn; Clementz, Brett A; Thaker, Gunvant K; Tamminga, Carol A	May 2014	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	405	01/15/2017	308	06/01/2019	308	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Mania Rating Scale	405	01/15/2017	181	06/01/2019	181	Approved
Childhood Trauma Questionnaire	405	01/15/2016	271	06/01/2019	271	Approved
Medical History	405	01/15/2017	303	06/01/2019	303	Approved
EEG Task Questionnaire	270	01/31/2017	262	06/01/2019	262	Approved
Eye Tracking	270	01/31/2017	233	06/01/2019	233	Approved
Demographics	405	01/15/2017	308	05/15/2017	308	Approved
Positive and Negative Syndrome Scale (PANSS)	405	01/15/2017	178	06/01/2019	178	Approved
Social Functioning Scale (SFS)	405	01/15/2017	293	06/01/2019	293	Approved
Wechsler Memory Scale, Third Edition (WMS-III)	405	01/15/2017	287	06/01/2019	287	Approved
Medications	405	01/15/2017	275	06/01/2019	275	Approved
Brief Assessment of Cognition	405	01/15/2017	276	06/01/2019	276	Approved
Wide Range Achievement Test	405	01/15/2017	288	06/01/2019	288	Approved
Fagerstrom Test for Nicotine Dependence	405	01/15/2017	272	06/01/2019	272	Approved
Clinical Trials: Inclusion/Exclusion Criteria	405	01/15/2017	308	05/15/2017	308	Approved
Child School Information	405	01/15/2017	248	06/01/2019	248	Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)	405	01/31/2017	213	06/01/2019	213	Approved
Family History Form	405	01/15/2017	260	06/01/2019	260	Approved
Lifetime Dimensions of Psychosis Scale	405	01/15/2017	161	06/01/2019	161	Approved
Emotional ERP Task Evaluation Form	270	01/15/2017	241	06/01/2019	241	Approved
Spatial CAPacity Delayed Response Test (SCAP)	405	01/15/2017	238	06/01/2019	238	Approved
Barratt Impulsivity Scale	405	01/15/2017	297	06/01/2019	297	Approved
Psychosocial Interview	405	01/15/2017	258	06/01/2019	258	Approved
EEG	405	01/31/2017	240	06/01/2019	240	Approved
Montgomery-Asberg Depression Rating Scale	405	01/15/2017	181	06/01/2019	181	Approved
Clinical Anxiety Scale	270	01/15/2017	154	06/01/2019	154	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
The Frequency of Symptom-Based Phenotypes of Mental Disorders is Long-Tailed	The heterogeneity of symptoms among individuals diagnosed with the same mental disorder has been blamed to hinder research in mental health and the development of effective treatments. Although widely acknowledged as problematic, the characteristics of this heterogeneity are largely unknown. We assessed the frequency of symptom phenotypes across a variety of clinical and non-clinical populations and found a consistent, long-tailed distribution. This distribution represents a mixture of a few very commonly expressed phenotypes and the sum of many, each only rarely displayed ones. As a consequence, the non-normality of this distribution induces a systematic bias, affecting all research and treatments relying on a symptom-based definition of mental disorders.	178/5743	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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Glossary