NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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The Data Expected list for this Collection shows some raw data as missing. Contact the NDA Help Desk with any questions.

Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

[CMS] Error

[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

You have requested to move the sharing dates for the following assessments:

Data Expected Item	Original Sharing Date	New Sharing Date

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Treatment of Bipolar Mania in Older Adults (GERI-BD) #2550

General
Experiments (0)
Shared Data
Publications (22)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Treatment of Bipolar Mania in Older Adults (GERI-BD)
Collection Investigators:	Robert Young, John Beyer, Laszlo Gyulai, Benoit Mulsant, Martha Sajatovic, Lauren Marangell
Collection Description:	This is the first controlled acute treatment study of bipolar disorder in adults 60 years or older with current DSM-IV manic, mixed, or hypomanic episodes. The number of older adults with severe and disabling bipolar disorder is increasing, and information to guide the management of the treatment of the disease is lacking in this population. Guidelines for treatment of younger people with bipolar disorder cannot be used for older people, and there are no safety and efficacy data upon which to base initial treatment decisions for older patients with bipolar mania. Mood stabilizers lithium and divalproex are the first-line treatment for bipolar disorder. However, in aged patients physiological changes and comorbid diseases may increase vulnerability to side effects and limit the benefits of the medications. This double-blind study will compare the benefits and side-effects of 9 weeks of treatment with lithium and divalproex in people with bipolar mania. Participants, who may be treated during inpatient hospitalization or as outpatients, will be randomly assigned to receive either lithium or divalproex. During the first 3 weeks of treatment careful titration of lithium and divalproex will be done to reach dose ranges. All other psychotropic medications will be discontinued. Behavioral interventions and or lorazepam may be added, if necessary. After the first 3 weeks, if symptoms do not improve, risperidone will be added to be taken every day with the study medication.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	11/09/2016
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$7,958,741.00
Subjects Shared:	224

{"values":[]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

File Name	File Type	Description	Audience
GERIBD_to_NDA_Structure_Mapping.xlsx	Other	Structure Mapping	Qualified Researchers
GERI-BD Clinical Trial Overview.pdf	Objectives	GERI-BD Clinical Trial Overview	Qualified Researchers
GERI_BD Protocol.pdf	Methods	GERI-BD Protocol	Qualified Researchers
GERI-BD Schedule of Procedures.pdf	Other	GERI-BD Schedule of Procedures	Qualified Researchers

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
U01MH068846-01	Acute Pharmacotherapy of Late-Life Mania	08/01/2005	07/31/2011	43	53	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	$1,152,278.00
U01MH068848-01	Acute and Continuation Treatment in Late Life Mania	08/01/2005	07/31/2011	43	32	DUKE UNIVERSITY	$1,063,635.00
U01MH074091-01	Acute Pharmacotherapy of Late-Life Mania	08/01/2005	07/31/2011	43	41	CASE WESTERN RESERVE UNIVERSITY	$1,206,191.00
U01MH074511-01	Acute Pharmacotherapy of Late-Life Mania-Study Coordinaating Center	08/01/2005	07/31/2011	Not Reported	Not Reported	WEILL MEDICAL COLL OF CORNELL UNIV	$1,255,381.00
U01MH070948-01	Acute Pharmacotherapy of Late-Life Mania	08/01/2005	07/31/2011	43	39	BAYLOR COLLEGE OF MEDICINE	$895,581.00
U01MH068844-01	Acute Pharmacotherapy of Late-Life Mania	08/01/2005	07/31/2012	43	26	UNIVERSITY OF PENNSYLVANIA	$1,735,624.00
U01MH068847-01	Acute Pharmacotherapy of Late-Life Mania	08/01/2005	07/31/2012	43	32	WEILL MEDICAL COLL OF CORNELL UNIV	$650,051.00

Clinical Trials:

Brief Summary	Status	Clinical Trial ID	Study ID	Principal Investigator	Start Date	End Date
This study will compare the benefits and side effects of lithium and divalproex in the treatment of older adults with bipolar mania.	Completed	NCT00254488	U01MH068847	Robert Young, MD	November 2005	August 2011

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Client Satisfaction Questionnaire	Clinical Assessments	224
Clinical Global Impression (CGI)	Clinical Assessments	224
Clinical Lab Tests	Clinical Assessments	224
Color Reading Interference (Stroop)	Clinical Assessments	217
Concomitant Medications	Clinical Assessments	224
Cumulative Illness Rating Scale	Clinical Assessments	224
Demographic Form	Clinical Assessments	224
Duke Social Support Index	Clinical Assessments	224
ECG Results	Clinical Assessments	224
Early Termination Form	Clinical Assessments	224
Framingham Stroke Risk Profile	Clinical Assessments	224
Guess of Treatment Condition	Clinical Assessments	224
Hamilton Rating Scale for Depression	Clinical Assessments	224
Hopkins Verbal Learning Test - Revised	Clinical Assessments	224
Mattis Dementia Rating Scale	Clinical Assessments	224
Medical History	Clinical Assessments	224
Medical Outcomes Survey SF-12	Clinical Assessments	224
Medication Adherance Form	Clinical Assessments	224
Medication Logs by Phase	Clinical Assessments	224
Mini Mental State Exam	Clinical Assessments	224
Montgomery-Asberg Depression Rating Scale	Clinical Assessments	224
Physical Examination	Clinical Assessments	224
Structured Clinical Interview for DSM-IV	Clinical Assessments	224
The Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale	Clinical Assessments	224
Trail Making Test, Child and Adult	Clinical Assessments	224
Vital Signs	Clinical Assessments	224
WHO Disability Assessment Schedule	Clinical Assessments	224
Young Mania Rating Scale	Clinical Assessments	224

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
34279542	Create Study	Low-Density Lipoprotein Cholesterol Trajectories and Prevalence of High Low-Density Lipoprotein Cholesterol Consistent With Heterozygous Familial Hypercholesterolemia in US Children.	JAMA pediatrics	Zhang, Yiyi; Woo, Jessica G; Urbina, Elaine M; Jacobs Jr, David R; Moran, Andrew E; de Ferranti, Sarah D	October 1, 2021	Not Determined
32015723	Create Study	GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.	Focus (American Psychiatric Publishing)	Young, Robert C; Mulsant, Benoit H; Sajatovic, Martha; Gildengers, Ariel G; Gyulai, Laszlo; Al Jurdi, Rayan K; Beyer, John; Evans, Jovier; Banerjee, Samprit; Greenberg, Rebecca; Marino, Patricia; Kunik, Mark E; Chen, Peijun; Barrett, Marna; Schulberg, Herbert C; Bruce, Martha L; Reynolds, Charles F; Alexopoulos, George S; GERI-BD Study Group	July 1, 2019	Not Determined
31097301	Study (812)	Understanding Aging in Bipolar Disorder by Integrating Archival Clinical Research Datasets.	The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry	Eyler, Lisa T; Aebi, Michelle E; Daly, Rebecca E; Hansen, Kristen; Tatsuoka, Curtis; Young, Robert C; Sajatovic, Martha	October 2019	Not Determined
29088928	Create Study	GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.	The American journal of psychiatry	Young, Robert C; Mulsant, Benoit H; Sajatovic, Martha; Gildengers, Ariel G; Gyulai, Laszlo; Al Jurdi, Rayan K; Beyer, John; Evans, Jovier; Banerjee, Samprit; Greenberg, Rebecca; Marino, Patricia; Kunik, Mark E; Chen, Peijun; Barrett, Marna; Schulberg, Herbert C; Bruce, Martha L; Reynolds 3rd, Charles F; Alexopoulos, George S; GERI-BD Study Group	November 2017	Not Determined
28543407	Create Study	Assessing bipolar disorder in the older adult: the GERI-BD toolbox.	International journal of geriatric psychiatry	Marino P, Schulberg HC, Gildengers AG, Mulsant BH, Sajatovic M, Gyulai L, Aljurdi RK, Evans LD, Banerjee S, Gur RC, Young RC,	January 2018	Not Determined
24664811	Create Study	Social support in late life mania: GERI-BD.	International journal of geriatric psychiatry	Beyer JL, Greenberg RL, Marino P, Bruce ML, Al Jurdi RK, Sajatovic M, Gyulai L, Mulsant BH, Gildengers A, Young RC	October 2014	Not Relevant
24006234	Create Study	Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age.	International journal of geriatric psychiatry	Rej S, Butters MA, Aizenstein HJ, Begley A, Tsay J, Reynolds CF, Mulsant BH, Gildengers A	April 2014	Not Determined
22859933	Create Study	Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.	PloS one	Teh, Cheryl Ann; Lee, Tih-Shih; Kuchibhatla, Margaratha; Ashley-Koch, Allison; Macfall, James; Krishnan, Ranga; Beyer, John	January 2012	Not Determined
22846332	Create Study	Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression?	Psychological medicine	Gildengers, A G; Chisholm, D; Butters, M A; Anderson, S J; Begley, A; Holm, M; Rogers, J C; Reynolds 3rd, C F; Mulsant, B H	April 2013	Not Relevant
22467848	Create Study	Characteristics associated with inpatient versus outpatient status in older adults with bipolar disorder.	Journal of geriatric psychiatry and neurology	Al Jurdi RK, Schulberg HC, Greenberg RL, Kunik ME, Gildengers A, Sajatovic M, Mulsant BH, Young RC,	March 2012	Not Determined
22420595	Create Study	Cognition in older adults with bipolar disorder versus major depressive disorder.	Bipolar disorders	Gildengers AG, Butters MA, Chisholm D, Anderson SJ, Begley A, Holm M, Rogers JC, Reynolds CF, Mulsant BH	March 2012	Not Determined
21360754	Create Study	Depression symptom ratings in geriatric patients with bipolar mania.	International journal of geriatric psychiatry	Sajatovic, Martha; Al Jurdi, Rayan; Gildengers, Ariel; Greenberg, Rebecca L; Tenhave, Thomas; Bruce, Martha L; Mulsant, Benoit; Young, Robert C	November 2011	Not Determined
21176032	Create Study	The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults.	Bipolar disorders	Gildengers AG, Mulsant BH, Al Jurdi RK, Beyer JL, Greenberg RL, Gyulai L, Moberg PJ, Sajatovic M, Ten Have T, Young RC,	December 2010	Not Determined
20891020	Create Study	Risk factors for dementia in patients over 65 with diabetes.	International journal of geriatric psychiatry	Parikh NM, Morgan RO, Kunik ME, Chen H, Aparasu RR, Yadav RK, Schulz PE, Johnson ML	July 2011	Not Determined
20148867	Create Study	Conceptual and methodological issues in designing a randomized, controlled treatment trial for geriatric bipolar disorder: GERI-BD.	Bipolar disorders	Young RC, Schulberg HC, Gildengers AG, Sajatovic M, Mulsant BH, Gyulai L, Beyer J, Marangell L, Kunik M, Ten Have T, Bruce ML, Gur R, Marino P, Evans JD, Reynolds CF, Alexopoulos GS	February 2010	Not Relevant
19452498	Create Study	Gray and white matter brain volumes in older adults with bipolar disorder.	International journal of geriatric psychiatry	Beyer JL, Kuchibhatla M, Payne ME, Macfall J, Cassidy F, Krishnan KR	December 2009	Not Determined
18837859	Create Study	New research perspectives in the treatment of bipolar disorder in older adults.	Bipolar disorders	Gyulai, Laszlo; Young, Robert C	September 2008	Not Determined
18760843	Create Study	Web-based training and interrater reliability testing for scoring the Hamilton Depression Rating Scale.	Psychiatry research	Rosen, Jules; Mulsant, Benoit H; Marino, Patricia; Groening, Christopher; Young, Robert C; Fox, Debra	October 2008	Not Determined
18515695	Create Study	Executive dysfunction in elderly bipolar manic patients.	The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry	Gunning-Dixon, Faith M; Murphy, Christopher F; Alexopoulos, George S; Majcher-Tascio, Magdalena; Young, Robert C	June 2008	Not Determined
18456339	Create Study	Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence.	Journal of affective disorders	Andreescu C, Mulsant BH, Emanuel JE	September 2008	Not Relevant
17430306	Create Study	Age and ratings of manic psychopathology.	Bipolar disorders	Young, Robert C; Kiosses, Dimitris; Heo, Moonseong; Schulberg, Herbert C; Murphy, C; Klimstra, Sibel; Deasis, Jose M; Alexopoulos, George S	May 2007	Not Determined
16325732	Create Study	Evidence-based pharmacological treatment of geriatric bipolar disorder.	The Psychiatric clinics of North America	Young, Robert C	December 2005	Not Relevant

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Verbal Learning Harmonization	Motivation: Auditory verbal learning tasks (AVLTs) are a core component of neuropsychological assessment, but the variety of AVLTs in common use makes it difficult to compare scores across instruments. This limits integration of research findings. The objective of this study was to derive and disseminate crosswalks that directly equate raw scores across common AVLTs. Methods: A large, international repository of raw AVLT data was compiled, and a multisite mega study analysis was conducted. Empirical Bayes harmonization was used to isolate and remove site effects, followed by linear models which adjusted for covariates, including age, sex, education, and race/ethnicity. After corrections, a continuous item response theory (IRT) model was then used to estimate each individual subject’s latent verbal learning ability while accounting for different item difficulties. Results: We aggregated raw data from studies of clinical samples and healthy controls from around the world that measured at least one verbal learning task. After applying exclusion criteria, the final sample was comprised of N = 10,505 individuals with and without history of traumatic brain injury from 53 studies above the age of 16 years who were tested on the California Verbal Learning Test (CVLT), Rey Auditory Verbal Learning Test (RAVLT), or the Hopkins Verbal Learning Test-Revised (HVLT). Harmonization significantly reduced inter-site variance by 37% while preserving covariate effects for further study. The effects of age, sex, and education on scores were reported and were found to be consistent across all AVLTs. Crosswalks were created by linking scores of individuals with the same verbal learning ability across AVLTs. The derived conversions agreed with held-out data of dually-administered tests. Conclusion: This study reports the co-calibration and validation of methods to harmonize raw scores across three common verbal learning instruments. Moreover, we developed a free online tool for cross-assessment raw score conversion. These methods address longstanding data compatibility issues for AVLTs, and offer perspectives on how large-scale data harmonization initiatives can increase the robustness and reproducibility of research and findings across the behavioral sciences.	224/3745	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

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Glossary