Though early intervention and treatment is linked to improved long-term health, few tools currently exist to
identify people who are at early risk of developing schizophrenia or to predict who will go on to develop
psychosis. The Accelerating Medicines Partnership (AMP®) SCZ program aims to generate tools that will
fast-track the development of effective, early-stage treatments for people who are at risk for
schizophrenia. For more information about the AMP SCZ Study, including protocols, please visit the AMP SCZ Study website.
The November 2023 AMP SCZ Release 1.0 contains fully quality-controlled screening and baseline data from 430
unique subjects ages 12-30. This includes 273-428 behavioral and clinical measures (depending on the
measure), 260 unprocessed Electroencephalography (EEG), 162 unprocessed magnetic resonance imaging (MRI,
dMRI, and rs-fMRI), 138 redacted open interview transcripts, 105 raw actigraphy watch and phone data (70
smartphone surveys, 56 smartphone screen use, 56 smartphone accelerometry), and 53 smartphone geolocations.
Please refer to the spreadsheet “ampscz-release-1.0-record.csv” for data availability for each measure per
subject.
The behavioral data package includes demographic, physical health, clinical assessments, and cognitive and
behavioral data for participants at baseline. The AMP SCZ 1.0 Data Release Reference Manual describes the
overall contents of various instruments used in the AMP SCZ project. We recommend downloading the behavioral
package to understand what is available before downloading other packages.
The unprocessed 64 channels EEG data from 5 different paradigm types (Combined Visual Oddball (VOD) with
Mismatch Negativity (MMN), Auditory Oddball (AOD), Auditory Steady-State Response (ASSR), Resting-State w/
Eyes Open, Resting-State w/ Eyes Closed) are included in the EEG data package. Sessions compliant with
standard operating procedures (SOPs) with high-quality control ratings are included in this release.
The unprocessed MRI data from the following modalities are included in this release: structural T1- and
T2-weighted (T1w and T2w), diffusion MRI (dMRI), and resting state functional scans (rs-fMRI).
The fully redacted transcripts of the interviews collected at baseline using the Open-ended language sample
protocol are available in the redacted Open Interview Transcripts data package.
The raw accelerometer data obtained from the actigraphy watch and smartphone data acquired from short daily
self-report surveys and passive data (accelerometer and screen state) are available in the Actigraphy &
Phone Data package.
The raw smartphone geolocation data is available in the Phone Geolocation Data package.
Note that accessing the geolocation data requires additional IRB approval.
Downloading Data
Select one or more available datasets in the nested dropdowns below to add subsets of the data to your
Workspace and Filter Cart. Click on the nested dropdowns to explore all the datasets and on the “i” icons
for descriptions. When Creating a Data Package, select "include associated files" to include imaging files
in download packages.
Note: Some datasets are larger than the monthly NDA download limit of 20 Terabytes. To
download datasets over 20TB without delays, end users can request a temporary Download Threshold extension
from the NDA Help Desk at NDAHelp@mail.nih.gov. In your request,
name the data you need to download (e.g., AMP SCZ 1.0 resting state functional scans (rs-fMRI) data) and the
data package size. See NDA's User Download
Threshold page for more information.
The "Tips" box on the right provides further instructions and details the remaining steps to select and
download data.