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1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

Collection - Use Existing Experiment
To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.
SelectExperiment IdExperiment NameExperiment Type
Created On
24HI-NGS_R1Omics02/16/2011
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
506PVPREFOmics08/05/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
26ASD_MethylationOmics03/01/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
41ImmunofluorescenceOmics05/11/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
519RestingfMRI11/08/2016
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
145AGRE/FMR1_Illumina.JHUOmics04/14/2014
146AGRE/MECP2_Sanger.JHUOmics04/14/2014
147AGRE/MECP2_Junior.JHUOmics04/14/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
155RestingfMRI07/25/2014
156SpeechfMRI07/25/2014
159EmotionfMRI07/25/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
78MET GenotypesOmics03/18/2013
Collection - Add Experiment
Add Supporting Documentation
Select File

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

[CMS] Attention
[CMS] Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.
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[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
ASD Mathematical Cognition: A Cognitive and Systems Neuroscience Approach
Vinod Menon, Stanford University  
Investigation of math abilities in children with ASD via behavioral tests and brain imaging. Study will investigate cognitive and brain processes as well as brain networks involved in mathematical cognition in ASD populations. First submission will include behavioral (WASI) as well as diagnostic assessments (ADI, ADOS, SCQ).
NIMH Data Archive
01/11/2012
Funding Completed
Close Out
No
$3,920,441.00
86
Loading Chart...
NIH - Extramural None



R01MH084164-01 Mathematical Cognition in Autism: A Cognitive and Systems Neuroscience Approach 06/01/2011 01/31/2022 180 121 STANFORD UNIVERSITY $3,920,441.00

helpcenter.collection.general-tab

NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType
154Math Autism Study - Vinod Menon07/15/2014ApprovedfMRI
515Mathematical Abilities in Children with Autism11/02/2016ApprovedfMRI
helpcenter.collection.experiments-tab

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 40
Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 28
Automated Working Memory Assessment Clinical Assessments 9
Child Behavior Checklist (CBCL) 6-18 Clinical Assessments 47
Image Imaging 46
Research Subject Clinical Assessments 71
Scale for Early Mathematics Anxiety Clinical Assessments 62
Wechsler Abbreviated Scale of Intelligence (WASI) Clinical Assessments 71
Wechsler Individual Achievement Test Second Edition Clinical Assessments 36
Wechsler Individual Achievement Test Third Edition. Part II Clinical Assessments 23
Working Memory Test Battery for Children (WMTB-C) Clinical Assessments 50
helpcenter.collection.shared-data-tab

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
38695515Create StudyShort-term number sense training recapitulates long-term neurodevelopmental changes from childhood to adolescence.Developmental sciencePark, Yunji; Zhang, Yuan; Chang, Hyesang; Menon, VinodMay 2, 2024Not Determined
38645139Create StudyIntegrated number sense tutoring remediates aberrant neural representations in children with mathematical disabilities.bioRxiv : the preprint server for biologyPark, Yunji; Zhang, Yuan; Schwartz, Flora; Iuculano, Teresa; Chang, Hyesang; Menon, VinodApril 12, 2024Not Determined
38596747Create StudyShort-term cognitive training recapitulates hippocampal functional changes associated with one year of longitudinal skill development.Trends in neuroscience and educationRosenberg-Lee, Miriam; Iuculano, Teresa; Bae, Se Ri; Richardson, Jennifer; Qin, Shaozheng; Jolles, Dietsje; Menon, VinodMarch 1, 2018Not Determined
38421061Create StudyLong-term abacus training gains in children are predicted by medial temporal lobe anatomy and circuitry.Developmental scienceXie, Ye; Chang, Hyesang; Zhang, Yi; Wang, Chunjie; Zhang, Yuan; Chen, Lang; Geng, Fengji; Ku, Yixuan; Menon, Vinod; Chen, FeiyanJuly 1, 2024Not Determined
38377194Create StudyDeep learning models reveal replicable, generalizable, and behaviorally relevant sex differences in human functional brain organization.Proceedings of the National Academy of Sciences of the United States of AmericaRyali, Srikanth; Zhang, Yuan; de Los Angeles, Carlo; Supekar, Kaustubh; Menon, VinodFebruary 27, 2024Not Determined
38263761Create StudyAtypical pattern separation memory and its association with restricted interests and repetitive behaviors in autistic children.Autism : the international journal of research and practiceChen, Lang; Liu, Jin; Kang, Julia Boram; Rosenberg-Lee, Miriam; Abrams, Daniel A; Menon, VinodJune 1, 2024Not Determined
37534879Create StudyAtypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism.eLifeLiu, Jin; Chang, Hyesang; Abrams, Daniel A; Kang, Julia Boram; Chen, Lang; Rosenberg-Lee, Miriam; Menon, VinodAugust 3, 2023Not Determined
37491674Create StudyBayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyCai, Weidong; Mizuno, Yoshifumi; Tomoda, Akemi; Menon, VinodOctober 1, 2023Not Determined
37196984Create StudyReplicable Patterns of Memory Impairments in Children With Autism and Their Links to Hyperconnected Brain Circuits.Biological psychiatry. Cognitive neuroscience and neuroimagingLiu, Jin; Chen, Lang; Chang, Hyesang; Rudoler, Jeremy; Al-Zughoul, Ahmad Belal; Kang, Julia Boram; Abrams, Daniel A; Menon, VinodNovember 1, 2023Not Determined
36747659Create StudyAtypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism.bioRxiv : the preprint server for biologyLiu, Jin; Chang, Hyesang; Abrams, Daniel A; Kang, Julia Boram; Chen, Lang; Rosenberg-Lee, Miriam; Menon, VinodJanuary 26, 2023Not Determined
36635147Create StudyAberrant Emotional Prosody Circuitry Predicts Social Communication Impairments in Children With Autism.Biological psychiatry. Cognitive neuroscience and neuroimagingLeipold, Simon; Abrams, Daniel A; Karraker, Shelby; Phillips, Jennifer M; Menon, VinodMay 1, 2023Not Determined
35640787Create StudyMethylphenidate remediates aberrant brain network dynamics in children with attention-deficit/hyperactivity disorder: A randomized controlled trial.NeuroImageMizuno, Yoshifumi; Cai, Weidong; Supekar, Kaustubh; Makita, Kai; Takiguchi, Shinichiro; Tomoda, Akemi; Menon, VinodAugust 15, 2022Not Determined
35483917Create StudyA Neurodevelopmental Shift in Reward Circuitry from Mother''s to Nonfamilial Voices in Adolescence.The Journal of neuroscience : the official journal of the Society for NeuroscienceAbrams, Daniel A; Mistry, Percy K; Baker, Amanda E; Padmanabhan, Aarthi; Menon, VinodMay 18, 2022Not Determined
35410879Create StudyFoundational Number Sense Training Gains Are Predicted by Hippocampal-Parietal Circuits.The Journal of neuroscience : the official journal of the Society for NeuroscienceChang, Hyesang; Chen, Lang; Zhang, Yuan; Xie, Ye; de Los Angeles, Carlo; Adair, Emma; Zanitti, Gaston; Wassermann, Demian; Rosenberg-Lee, Miriam; Menon, VinodMay 11, 2022Not Determined
35382930Create StudyRobust, Generalizable, and Interpretable Artificial Intelligence-Derived Brain Fingerprints of Autism and Social Communication Symptom Severity.Biological psychiatrySupekar, Kaustubh; Ryali, Srikanth; Yuan, Rui; Kumar, Devinder; de Los Angeles, Carlo; Menon, VinodOctober 15, 2022Not Determined
35164888Create StudyDeep learning identifies robust gender differences in functional brain organization and their dissociable links to clinical symptoms in autism.The British journal of psychiatry : the journal of mental scienceSupekar, Kaustubh; de Los Angeles, Carlo; Ryali, Srikanth; Cao, Kaidi; Ma, Tengyu; Menon, VinodFebruary 15, 2022Not Determined
35046478Create StudyMothers adapt their voice during children''s adolescent development.Scientific reportsLeipold, Simon; Abrams, Daniel A; Menon, VinodJanuary 19, 2022Not Determined
34667149Create StudymTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity.Nature communicationsPagani, Marco; Barsotti, Noemi; Bertero, Alice; Trakoshis, Stavros; Ulysse, Laura; Locarno, Andrea; Miseviciute, Ieva; De Felice, Alessia; Canella, Carola; Supekar, Kaustubh; Galbusera, Alberto; Menon, Vinod; Tonini, Raffaella; Deco, Gustavo; Lombardo, Michael V; Pasqualetti, Massimo; Gozzi, AlessandroOctober 19, 2021Not Determined
34329664Create StudyLinear and nonlinear profiles of weak behavioral and neural differentiation between numerical operations in children with math learning difficulties.NeuropsychologiaChen, Lang; Iuculano, Teresa; Mistry, Percy; Nicholas, Jonathan; Zhang, Yuan; Menon, VinodSeptember 17, 2021Not Determined
34112791Create StudyAberrant dynamics of cognitive control and motor circuits predict distinct restricted and repetitive behaviors in children with autism.Nature communicationsSupekar, Kaustubh; Ryali, Srikanth; Mistry, Percy; Menon, VinodJune 10, 2021Not Determined
34108794Create StudyEmerging neurodevelopmental perspectives on mathematical learning.Developmental review : DRMenon, Vinod; Chang, HyesangJune 1, 2021Not Determined
34060183Create StudyNeural representational similarity between symbolic and non-symbolic quantities predicts arithmetic skills in childhood but not adolescence.Developmental scienceSchwartz, Flora; Zhang, Yuan; Chang, Hyesang; Karraker, Shelby; Kang, Julia Boram; Menon, VinodNovember 1, 2021Not Determined
32496190Create StudyMicrostructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control.eLifeMenon, Vinod; Gallardo, Guillermo; Pinsk, Mark A; Nguyen, Van-Dang; Li, Jing-Rebecca; Cai, Weidong; Wassermann, DemianJune 4, 2020Not Determined
32452464Create StudyNeural correlates of cognitive variability in childhood autism and relation to heterogeneity in decision-making dynamics.Developmental cognitive neuroscienceIuculano, T; Padmanabhan, A; Chen, L; Nicholas, J; Mitsven, S; de Los Angeles, C; Menon, VApril 1, 2020Not Determined
31710975Create StudyFaster learners transfer their knowledge better: Behavioral, mnemonic, and neural mechanisms of individual differences in children's learning.Developmental cognitive neuroscienceChang H, Rosenberg-Lee M, Qin S, Menon VDecember 2019Not Determined
31032147Create StudyQuantitative analysis of heterogeneity in academic achievement of children with autism.Clinical psychological science : a journal of the Association for Psychological ScienceChen, Lang; Abrams, Daniel A; Rosenberg-Lee, Miriam; Iuculano, Teresa; Wakeman, Holly N; Prathap, Sandhya; Chen, Tianwen; Menon, VinodMarch 2019Not Determined
30806350Create StudyImpaired voice processing in reward and salience circuits predicts social communication in children with autism.eLifeAbrams, Daniel Arthur; Padmanabhan, Aarthi; Chen, Tianwen; Odriozola, Paola; Baker, Amanda E; Kochalka, John; Phillips, Jennifer M; Menon, VinodFebruary 2019Not Determined
30071947Create StudyThe Triple Network Model, Insight, and Large-Scale Brain Organization in Autism.Biological psychiatryMenon, VinodAugust 2018Not Determined
30016410Create StudyDeficits in mesolimbic reward pathway underlie social interaction impairments in children with autism.Brain : a journal of neurologySupekar K, Kochalka J, Schaer M, Wakeman H, Qin S, Padmanabhan A, Menon VSeptember 2018Not Determined
29920856Create StudyNeural signatures of co-occurring reading and mathematical difficulties.Developmental scienceSkeide, Michael A; Evans, Tanya M; Mei, Edward Z; Abrams, Daniel A; Menon, VinodNovember 2018Not Determined
29703592Create StudyPersonalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder.Biological psychiatryDickie, Erin W; Ameis, Stephanie H; Shahab, Saba; Calarco, Navona; Smith, Dawn E; Miranda, Dayton; Viviano, Joseph D; Voineskos, Aristotle NAugust 2018Not Determined
29034353Create StudyThe Default Mode Network in Autism.Biological psychiatry. Cognitive neuroscience and neuroimagingPadmanabhan, Aarthi; Lynch, Charles J; Schaer, Marie; Menon, VinodSeptember 2017Not Relevant
27185915Create StudyNeural circuits underlying mother''s voice perception predict social communication abilities in children.Proceedings of the National Academy of Sciences of the United States of AmericaAbrams, Daniel A; Chen, Tianwen; Odriozola, Paola; Cheng, Katherine M; Baker, Amanda E; Padmanabhan, Aarthi; Ryali, Srikanth; Kochalka, John; Feinstein, Carl; Menon, VinodMay 2016Not Determined
26972835Create StudyThe Empathizing-Systemizing Theory, Social Abilities, and Mathematical Achievement in Children.Scientific reportsEscovar E, Rosenberg-Lee M, Uddin LQ, Menon V2016Not Determined
26659551Create StudyDistinctive Role of Symbolic Number Sense in Mediating the Mathematical Abilities of Children with Autism.Journal of autism and developmental disordersHiniker A, Rosenberg-Lee M, Menon VApril 2016Not Determined
26655682Create StudyHeterogeneous and nonlinear development of human posterior parietal cortex function.NeuroImageChang TT, Metcalfe AW, Padmanabhan A, Chen T, Menon VFebruary 1, 2016Not Determined
26454817Create StudyInsula response and connectivity during social and non-social attention in children with autism.Social cognitive and affective neuroscienceOdriozola P, Uddin LQ, Lynch CJ, Kochalka J, Chen T, Menon VMarch 2016Not Determined
26146534Create StudySex differences in cortical volume and gyrification in autism.Molecular autismSchaer M, Kochalka J, Padmanabhan A, Supekar K, Menon VJanuary 2015Not Determined
25073720Create StudyBrain State Differentiation and Behavioral Inflexibility in Autism†.Cerebral cortex (New York, N.Y. : 1991)Uddin LQ, Supekar K, Lynch CJ, Cheng KM, Odriozola P, Barth ME, Phillips J, Feinstein C, Abrams DA, Menon VDecember 2015Not Determined
24268662Create StudyAmygdala subregional structure and intrinsic functional connectivity predicts individual differences in anxiety during early childhood.Biological psychiatryQin S, Young CB, Duan X, Chen T, Supekar K, Menon VJune 1, 2014Not Determined
24210821Create StudyBrain hyperconnectivity in children with autism and its links to social deficits.Cell reportsSupekar K, Uddin LQ, Khouzam A, Phillips J, Gaillard WD, Kenworthy LE, Yerys BE, Vaidya CJ, Menon VNovember 14, 2013Not Determined
23966925Create StudyReconceptualizing functional brain connectivity in autism from a developmental perspective.Frontiers in human neuroscienceUddin, Lucina Q; Supekar, Kaustubh; Menon, Vinod2013Not Determined
23954299Create StudyBrain organization underlying superior mathematical abilities in children with autism.Biological psychiatryIuculano, Teresa; Rosenberg-Lee, Miriam; Supekar, Kaustubh; Lynch, Charles J; Khouzam, Amirah; Phillips, Jennifer; Uddin, Lucina Q; Menon, VinodFebruary 1, 2014Not Determined
23803651Create StudySalience network-based classification and prediction of symptom severity in children with autism.JAMA psychiatryUddin LQ, Supekar K, Lynch CJ, Khouzam A, Phillips J, Feinstein C, Ryali S, Menon VAugust 2013Not Determined
23776244Create StudyUnderconnectivity between voice-selective cortex and reward circuitry in children with autism.Proceedings of the National Academy of Sciences of the United States of AmericaAbrams, Daniel A; Lynch, Charles J; Cheng, Katherine M; Phillips, Jennifer; Supekar, Kaustubh; Ryali, Srikanth; Uddin, Lucina Q; Menon, VinodJuly 16, 2013Not Determined
23774715Create StudyThe autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism.Molecular psychiatryDi Martino, A; Yan, C-G; Li, Q; Denio, E; Castellanos, F X; Alaerts, K; Anderson, J S; Assaf, M; Bookheimer, S Y; Dapretto, M; Deen, B; Delmonte, S; Dinstein, I; Ertl-Wagner, B; Fair, D A; Gallagher, L; Kennedy, D P; Keown, C L; Keysers, C; Lainhart, J E; Lord, C; Luna, B; Menon, V; Minshew, N J; Monk, C S; Mueller, S; Müller, R-A; Nebel, M B; Nigg, J T; O'Hearn, K; Pelphrey, K A; Peltier, S J; Rudie, J D; Sunaert, S; Thioux, M; Tyszka, J M; Uddin, L Q; Verhoeven, J S; Wenderoth, N; Wiggins, J L; Mostofsky, S H; Milham, M PJune 2014Not Determined
23375976Create StudyDefault mode network in childhood autism: posteromedial cortex heterogeneity and relationship with social deficits.Biological psychiatryLynch CJ, Uddin LQ, Supekar K, Khouzam A, Phillips J, Menon VAugust 1, 2013Not Determined
22682904Create StudyWeak task-related modulation and stimulus representations during arithmetic problem solving in children with developmental dyscalculia.Developmental cognitive neuroscienceAshkenazi S, Rosenberg-Lee M, Tenison C, Menon VFebruary 15, 2012Not Determined
22171056Create StudyDynamic reconfiguration of structural and functional connectivity across core neurocognitive brain networks with development.The Journal of neuroscience : the official journal of the Society for NeuroscienceUddin, Lucina Q; Supekar, Kaustubh S; Ryali, Srikanth; Menon, VinodDecember 14, 2011Not Determined
21890111Create StudyMultivariate searchlight classification of structural magnetic resonance imaging in children and adolescents with autism.Biological psychiatryUddin, Lucina Q; Menon, Vinod; Young, Christina B; Ryali, Srikanth; Chen, Tianwen; Khouzam, Amirah; Minshew, Nancy J; Hardan, Antonio YNovember 1, 2011Not Determined
21620984Create StudyWhat difference does a year of schooling make? Maturation of brain response and connectivity between 2nd and 3rd grades during arithmetic problem solving.NeuroImageRosenberg-Lee M, Barth M, Menon VAugust 1, 2011Not Determined
helpcenter.collection.publications-tab

NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
507/15/2012
71
Approved
To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.
Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADOS info icon
507/15/2012
28
Approved
ADI-R info icon
507/15/2012
40
Approved
Wechsler Abbreviated Scale of Intelligence (WASI) info icon
507/15/2012
71
Approved
Child Behavior Checklist (CBCL) info icon
507/15/2012
47
Approved
Working Memory Test Battery for Children (WMTB-C) info icon
508/31/2013
50
Approved
Wechsler Individual Achievement Test info icon
507/15/2012
58
Approved
Automated Working Memory Assessment (AWMA) info icon
508/31/2013
9
Approved
Scale for Early Mathematics Anxiety (SEMA) info icon
508/31/2013
62
Approved
Imaging (Structural, fMRI, DTI, PET, microscopy) info icon
507/15/2014
46
Approved
Structure not yet defined
No Status history for this Data Expected has been recorded yet
helpcenter.collection.data-expected-tab

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitrySocial-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.23/1708Secondary AnalysisShared
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using C-PAC pipeline and ANTsAn automated pipeline was developed to reference Neuroimages hosted by the National Database for Autism Research (NDAR) and derive volumes for distinct brain structures using Advanced Normalization Tools (ANTs) and the Configurable-Pipeline for the Analysis of Connectomes (C-PAC) platform. This pipeline utilized the ANTs cortical thickness methodology discuessed in "Large-Scale Evaluation of ANTs and Freesurfer Cortical Tchickness Measurements" [http://www.ncbi.nlm.nih.gov/pubmed/24879923] to extract a cortical thickness volume from T1-weighted anatomical MRI data gathered from the NDAR database. This volume was then registered to an stereotaxic-space anatomical template (OASIS-30 Atropos Template) which was acquired from the Mindboggle Project webpage [http://mindboggle.info/data.html]. After registration, the mean cortical thickness was calculated at 31 ROIs on each hemisphere of the cortex and using the Desikan-Killiany-Tourville (DKT-31) cortical labelling protocol [http://mindboggle.info/faq/labels.html] over the OASIS-30 template. **NOTE: This study is ongoing; additional data my be available in the future.** As a result, each subject that was processed has a cortical thickness volume image and a text file with the mean thickness ROIs (in mm) stored in Amazon Web Services (AWS) Simple Storage Service (S3). Additionally, these results were tabulated in an AWS-hosted database (through NDAR) to enable simple, efficient querying and data access. All of the code used to perform this analysis is publicly available on Github [https://github.com/FCP-INDI/ndar-dev]. Additionally, as a computing platform, we developed an Amazon Machine Image (AMI) that comes fully equipped to run this pipeline on any dataset. Using AWS Elastic Cloud Computing (EC2), users can launch our publicly available AMI ("C-PAC with benchmark", AMI ID: "ami-fee34296", N. Virginia region) and run the ANTs cortical thickness pipeline. The AMI is fully compatible with Sun Grid Engine as well; this enables users to perform many pipeline runs in parallel over a cluster-computing framework.5/1428Secondary AnalysisShared
Derivation of Quality Measures for Structural Images by Neuroimaging PipelinesUsing the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Structural QA was performed according to Haselgrove, et al (http://journal.frontiersin.org/Journal/10.3389/fninf.2014.00052/abstract) to provide values for Signal to Noise (SNR) and Contrast to Noise (CNR) Ratios that can be compared between subjects within NDAR and between other public data releases.5/423Secondary AnalysisShared
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using NITRC-CEA draft publication is in progress. GitHub repository with code for working with NDAR Data is available here: https://github.com/chaselgrove/ndar **Note this study is ongoing; additional may be added.**5/356Secondary AnalysisShared
Derivation of Quality Measures for Time-Series Images by Neuroimaging PipelinesUsing the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Time series QA was performed according to Friedman, et al. (http://www.ncbi.nlm.nih.gov/pubmed/16952468) providing values for Signal to Noise Ratio that can be compared to other subjects.2/356Secondary AnalysisShared
* Data not on individual level
helpcenter.collection.associated-studies-tab

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.
Edit