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View Cohort

        NDA Help Center

        NDA Study - View Cohort

        The View Cohort shows the Study cohort characteristics which will includes the name, type, sex and age in months range criteria. Note that age and sex restrict the data that can be added to the cohort. Medical criteria and phenotype are also included. Of particular importance on this page are any comments related to included subjects, which may be different than published results, often attributed to data sharing consent.

        Frequently Asked Questions

        • How do I know the characteristics of the cohort?
          The appropriate Medical Criteria, Phenotype, and Sub Type defined by the Study Owner are highlighted. The option trees are automatically expanded so the highlighted options are immediately viewable.


        • Age Range
          Age is expressed in months from 0 (birth) to 1200 (100 years old).
        • Medical Criteria
          NDA defines Medical Criteria as a diagnostically based determination of an individual's disease or condition.
        • Phenotype
          NDA defines Phenotype as any physical, morphologic, or biochemical characteristics that are observable in an individual.
        • Sub Types
          NDA defines Sub Type as a subordinate condition or disease that further characterizes an individual.
        • Cohort Name
          A user defined name for the cohort with a 200 character limit.
        • Cohort Type
          Cohort Type options include Baseline, Control, and Test.
        • Cohort Comments
          Comments further characterize the cohort beyond the options provided in the interface to define the cohort.
        • Cohort Subjects
          The Cohort Subjects provides the number of unique subjects for whom data have been associated with the cohort.
        • Cohort
          Summarizes the characteristics of a group of research subjects. The subject count is noted in parentheses.
        Add URL
        Add File
        Select File
        Study DOI
        Study DOI Status Info
        • DOI: 10.15154/1524418
        • DataCite Status: Findable
        • NDAR Status: Registered
        • DOI Registered with DataCite
        • Public URL Resolves at DOI
        Edit Subjects Dialog
        Select Subjects
        No records found.
        Michael Lombardo ml5893@gmail.com Analysis Shared
        Click for more info Michael Lombardo; Bertelsen, N., Landi, I., Bethlehem, R. A. I., Seidlitz, J., Busuoli, E. M., Mandelli, V., Satta, E., Trakoshis, S., Auyeung, B., Kundu, P., Loth, E., Dumas, G., Baumeister, S., Beckmann, C. F., Bölte, S., Bourgeron, T., Charman, T., Durston, S., Ecker, C., Holt, R. J., Johnson, M. H., Jones, E. J. H., Mason, L., Meyer-Lindenberg, A., Moessnang, C., Oldehinkel, M., Persico, A. M., Tillmann, J., Williams, S. C. R., Spooren, W., Murphy, D. G. M., Buitelaar, J. K., Baron-Cohen, S., the EU-AIMS LEAP Group, Lai, M. C., Lombardo, M. V.
        Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.
        Click for more info Secondary Analysis
        Autism Centers of Excellence (ACE), NIMH Repository & Genomics Resource (NRGR)
        Click for more info
        IDCollectionPermission GroupSubjects
        2288 The Autism Biomarkers Consortium for Clinical Trials NIMH Data Archive235
        2021 Multimodal Developmental Neurogenetics of Females with ASD NIMH Data Archive169
        6 Biological and Information Processing Mechanisms Underlying Autism NIMH Data Archive167
        1 UIC ACE: Translational Studies of Insistence on Sameness in Autism NIMH Data Archive159
        2066 The CHARGE Study: Childhood Autism Risks From Genetics and the Environment NIMH Data Archive120
        2007 Treatment of Autism Symptoms in Children (TASC): Initial RCT with Active Control NIMH Data Archive100
        2179 Neural markers of shared gaze during simulated social interactions in ASD \-Modal Automated Assessment of Behavior during Social Interactions in Children with ASD NIMH Data Archive79
        2030 Electrophysiological Response to Executive Control Training in Autism NIMH Data Archive77
        14 Early Pharmacotherapy Guided by Biomarkers in Autism NIMH Data Archive66
        2026 Biomarkers of Developmental Trajectories and Treatment in ASD NIMH Data Archive60
        2025 Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions NIMH Data Archive57
        2262 Comparing Behavioral Assessments Using Telehealth for Children with Autism NIMH Data Archive55
        2368 Clinical and Immunological Investigations of Subtypes of Autism NIMH Data Archive51
        2845 Attentional, temperamental, and physiological process underlying anxiety in preschoolers with ASD NIMH Data Archive33
        2293 Components of Emotional Processing in Toddlers with ASD NIMH Data Archive33
        2557 Environmental Influence on Infant Microbiome Development and ASD Symptoms NIMH Data Archive30
        2072 Intrinsic Brain Architecture of Young Children with Autism While Awake and Asleep NIMH Data Archive29
        2197 The role of vasopressin in the social deficits of autism NIMH Data Archive29
        1946 Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers NIMH Data Archive26
        2020 Adaptive Interventions for Minimally Verbal Children with ASD in the Community NIMH Data Archive24
        2316 Quantitative Measurements of Cortical Excitability in Neurodevelopmental Disorder NIMH Data Archive24
        1889 ASD Mathematical Cognition: A Cognitive and Systems Neuroscience Approach NIMH Data Archive23
        2285 Integrity and Dynamic Processing Efficiency of Networks in ASD NIMH Data Archive18
        2108 Neural Phenotypes of Females with Autism Spectrum Disorder NIMH Data Archive17
        2828 Sensory consequences of action in children with autism spectrum disorders NIMH Data Archive15
        2266 Inhibitory dysfunction in autism NIMH Data Archive15
        2761 Charting the trajectory of executive control in autism in order to optimize delivery of intervention NIMH Data Archive14
        10 UCLA Sigman/Bookheimer ACE and ARRA NIMH Data Archive14
        2282 Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder NIMH Data Archive13
        2566 Direct Examination of Imitation-Based Learning in Autism NIMH Data Archive11
        2181 Sex Differences in the Neural Mechanisms of Treatment Response NIMH Data Archive9
        2561 Somatosensory Inhibitory Dysfunction in Autism Spectrum Disorder NIMH Data Archive9
        2027 A Longitudinal MRI Study of Infants at Risk for Autism (ACE 2) NIMH Data Archive8
        1358 Biological Signatures of Autism NIMH Data Archive8
        2292 Molecular Mechanisms of Atypical Habituation in Autism Spectrum Disorders NIMH Data Archive8
        3088 Brainstem Contributions to Sensorimotor and Core Symptoms in Children with Autism Spectrum Disorder NIMH Data Archive8
        19 Longitudinal MRI Study of Infants at Risk for Autism NIMH Data Archive7
        2821 Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism NIMH Data Archive7
        2777 Center for the Development of Phenotype-Based Treatments of Autism Spectrum Disorder NIMH Data Archive6
        2424 Neurobiology of Autism With Macrocephaly NIMH Data Archive4
        2559 Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum Disorder NIMH Data Archive4
        2075 Mapping Thalamocortical Networks Across Development in ASD NIMH Data Archive4
        2198 Pivotal Response Treatment Package for Young Children with Autism NIMH Data Archive4
        3022 Electrophysiological Markers for Interventions in Phelan-McDermid Syndrome and Idiopathic Autism NIMH Data Archive3
        8 Yale Autism Center of Excellence: Mechanisms of Social Engagement in the Autism Spectrum Disorders NIMH Data Archive2
        1854 Studies to Advance Autism Research and Treatment (STAART). NIMH Data Archive2
        1923 Components of Limited Activity Monitoring in Toddlers with ASD NIMH Data Archive2
        2129 Biological Determinants of Brain Variation in Autism NIMH Data Archive2
        2799 A Novel Framework for Impaired Imitation in ASD NIMH Data Archive1
        1654 UW ACE Extended Family Study NIMH Data Archive1
        1850 CBT for anxiety in adolescents with autism NIMH Data Archive1
        1866 1/2 Development of a Screening Interview for Research Studies of ASD NIMH Data Archive1
        1886 PDN Screening Data NIMH Data Archive1
        2060 Dysfunction of Sensory Inhibition in Autism NIMH Data Archive1
        2022 The Social Brain in Schizophrenia and Autism Spectrum Disorders NIMH Data Archive1
        Age: 0 to 1,260 months
        Sex: Both

        NDA Help Center

        NDA Study - Summary Tab

        An NDA Study describes an analysis, pipeline result, or curated data release - including the cohorts, measures, and methods - referencing the underlying source data in the NDA. Once the data is referenced and the study is shared, the underlying data will not change. It will be immutable allowing others to access those data without change into near perpetuity. Only the assessments (i.e. typically rows in a database) and outcome measures (i.e. columns in a database) included in the study are shared. By sharing data this way (e.g. specific outcome measures by subject/timepoint) an ongoing project's other unpublished data - typically other research aims - will remain embargoed according to a project's established data sharing schedule (see collection).

        When a study is created, a Digital Object Identifier (DOI) is reserved by the NDA, but will not be active. Once the study is shared, the DOI will then be issued and if associated with a publication, the NDA DOI will be linked to the publication's DOI.

        Frequently Asked Questions

        • How can I get access to an NDA Study if I am involved in creating/modifying the NDA Study?
          The individual listed as an Investigator on the General tab of the NDA Collection and any individuals defined as administrators can be provided this privilege. When the study is shared, all of those that have approved access to the data are given read-only access.


        • Abstract
          The Abstract of the publication or other public disclosure of analysis results. The publication abstract is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
        • Documents
          Provides links to additional documentation to help explain the NDA Study.
        • Cohort
          Summarizes the characteristics of a group of research subjects. The subject count is noted in parentheses.
        • Data Analysis
          Summarizes the Data Analysis methods used.
        • Data Usage
          Identifies the NDA Study as a Primary Analysis or Secondary Analysis.
        • Digital Object Identifier (DOI)
          A persistent and unique identifier that is issued for each NDA Study that may increase the visibility of a researcher's work. Authors are expected to reference the location of data in the publication using the DOI.
        • Download Button
          Adds all data from the current Collection or NDA Study to the Filter Cart.
        • Investigators
          The authors of the publication or other public disclosure of analysis results. The publication's authors are automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable and uses a last name, first name format with multiple names separated by semicolons.
        • Primary Analysis
          Primary Analysis is one of the Data Use types NDA recognizes for NDA Studies. It indicates that the NDA Study's creator was involved in the collection of the data (in whole or in part) used in the NDA Study. In other words, at least some and potentially all of the data used was originally collected by the creator of the NDA Study. A Primary Analysis Study.
        • NDA Study Owner
          The NDA user, who does not necessarily have to be one of the Investigators listed in the NDA Study, primarily involved in creating the NDA Study who is serving as the point of contact. The NDA user who creates the NDA Study is automatically assigned as the Study Owner.
        • Private
          The term 'Private' generally means not available to others; however, there are some slightly different meanings based on what is Private. The default state for an NDA Collection, NDA Study, Supporting Documentation, and data is Private and, therefore, accessible only to those users with appropriate Privileges so it will not be viewable and searchable publicly. A Collection may be Shared while the data and Supporting Documentation remain Private.
        • Results
          Provides a link to the publication or other public disclosure of analysis results defined in the NDA Study.
        • Secondary Analysis
          Secondary Analysis is one of the Data Use types NDA recognizes for NDA Studies. It indicates that the NDA Study's creator was not involved in the collection of the data (in whole or in part) used in the NDA Study, but was involved in the analysis of those data. In other words, none of the data used was originally collected by the creator of the NDA Study. A Secondary Analysis Study will provide an Attribution Report listing the Collections and the researchers responsible for collecting and depositing the original data.
        • Study Type
          The NDA Study Type can be either Analysis (i.e. often associated with a computational pipeline), Clinical Trial, Finding (i.e. a result associated with a publication, or Release (i.e. a dataset release, often annually) to indicate the type of work defined in the NDA Study. Studies, once shared do not change.
        • Analysis Study Type
          The Analysis Study Type is primarily used to share a pipeline; however, it could be used to share a statistical analysis or method.
        • Release Study Type
          A static, curated data set.
        • Finding Study Type
          The Finding Study Type associates data to a publication or some type of result.
        • Clinical Trial Study Type
          A Clinical Trial Study is a finding specific to a clinical trial.
        • Study ID Number
          The Study ID number is a unique three digit number routinely expressed as S### that is assigned by the NDA.
        • Study State
          The Study State indicates whether the Study is viewable, searchable, and if the associated data can be accessed by users with appropriate data access Permissions. The default Study State is Private, which means that only the Collection Owner and users with Read Only Privileges. Only the Study Owner can Share the Study.
        • Study Title
          The Study Title is generally the title of the publication or other public disclosure of analysis results. The publication title is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
        • Edit Button
          The Edit Button allows a user to modify or add information once authenticated and if the user has appropriate permissions.
        • Return Button (Study)
          The Return Button brings the user back to the Data from Papers page.
        • Sex
          Sex is defined at birth and can only be Male or Female. In some places in the NDA, we incorrectly used the data_element name of Gender. Users are encouraged to review definitions and not make assumptions based upon a data element name.
        • Data Use Limitations
          Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
        • Permission Group
          Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.