NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

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Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption #2028

General
Experiments (0)
Shared Data
Publications (77)
Data Expected (23)
Associated Studies (3)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption
Collection Investigators:	Ami Klin
Collection Description:	The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National Primate Research Center combine methodological and conceptual expertise in child development, behavioral neuroscience, speech science, molecular genetics, and treatment research; all against the backdrop of a city-wide initiative for autism research driven by the largest pediatric healthcare system In the country, Children's Healthcare of Atlanta. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to unravel the developmental complexities of risk and resilience in autism spectrum disorders, so that we may advance the most effective and successful treatments for children. Projects I and II quantify the developmental unfolding of social visual (PI) and social vocal (Pll) engagement, from birth until 24 months of age, to identify profiles for positive outcome as well as risk factors for disability. Project III advances rigorous, randomized-control trials for treatment of ASD into infancy and toddler hood, testing the extent to which developmental trajectories of social engagement (Projects I and II) predict treatment response and outcome. Also starting in infancy. Projects IV and V established for normative social development (PV) and a genetic means to its disruption (PIV) a nonhuman primate model for interrogating the underpinnings of social disability in genes, brain, and behavior. Together, these Projects advance our understanding of the developmental unfolding of autism, and set the stage for changing the course of ASD prior to the point when disability i seven fully manifest. Four Cores provide the resources to support these goals, spanning Assessment, Informatics, Administration, and Training. In its efforts to meet and exceed the aspirational goals for autism set forth by the NIH Interagency Autism Coordinating Committee (lACC), the Emory ACE creates in its wake a new scientific community, focused on the translational social neuroscience of autism spectrum disorders, in the service of children and families.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	01/04/2013
NIH Research Initiative:	Autism Centers of Excellence (ACE)
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$8,941,187.00
Subjects Shared:	266

{"values":[]}

{"values":[["Autism Spectrum Severely Affected",2],["Not Defined",103],["Typical Control",2],["Autism Spectrum Affected",2]]}

Loading Chart...

Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

File Name	File Type	Description	Audience
QA-notification.txt	Other	Quality Assurance Notification	Qualified Researchers

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
P50MH100029-01	Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption	09/04/2012	05/31/2017	987	528	EMORY UNIVERSITY	$8,941,187.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
ACE Family Medical History	Clinical Assessments	266
ACE Subject Medical History	Clinical Assessments	162
ACE Subject Physical Exam	Clinical Assessments	89
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1	Clinical Assessments	127
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2	Clinical Assessments	87
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3	Clinical Assessments	1
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Toddler Module	Clinical Assessments	150
BSRC Intervention History Form	Clinical Assessments	227
CSBS DP Behavior Sample	Clinical Assessments	241
CSBS DP Infant-Toddler Checklist	Clinical Assessments	230
Child Behavior Checklist (CBCL) 1-5	Clinical Assessments	69
Demographics	Clinical Assessments	264
Mullen Scales of Early Learning	Clinical Assessments	232
Research Subject	Clinical Assessments	266
Sensory Profile Toddler	Clinical Assessments	119
Social Communication Questionnaire (SCQ) - Current Form	Clinical Assessments	72
Social Responsiveness Scale (SRS) - Preschool Version	Clinical Assessments	69
Vineland-II - Survey Form (2005)	Clinical Assessments	220

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
39071272	Create Study	A Novel Registration Framework for Aligning Longitudinal Infant Brain Tensor Images.	bioRxiv : the preprint server for biology	Duan, Kuaikuai; Li, Longchuan; Calhoun, Vince D; Shultz, Sarah	July 16, 2024	Not Determined
39011552	Create Study	Familial Recurrence of Autism: Updates From the Baby Siblings Research Consortium.	Pediatrics	Ozonoff, Sally; Young, Gregory S; Bradshaw, Jessica; Charman, Tony; Chawarska, Katarzyna; Iverson, Jana M; Klaiman, Cheryl; Landa, Rebecca J; McDonald, Nicole; Messinger, Daniel; Schmidt, Rebecca J; Wilkinson, Carol L; Zwaigenbaum, Lonnie	August 1, 2024	Not Determined
38809807	Create Study	Infant vocal category exploration as a foundation for speech development.	PloS one	Yoo, Hyunjoo; Su, Pumpki Lei; Ramsay, Gordon; Long, Helen L; Bene, Edina R; Oller, D Kimbrough	January 1, 2024	Not Determined
38757642	Create Study	Canonical babbling trajectories across the first year of life in autism and typical development.	Autism : the international journal of research and practice	Long, Helen L; Ramsay, Gordon; Bene, Edina R; Su, Pumpki Lei; Yoo, Hyunjoo; Klaiman, Cheryl; Pulver, Stormi L; Richardson, Shana; Pileggi, Moira L; Brane, Natalie; Oller, D Kimbrough	May 17, 2024	Not Determined
38739568	Create Study	The Development of Socially Directed Attention: An Functional Magnetic Resonance Imaging Study in Infant Monkeys.	Journal of cognitive neuroscience	Kovacs-Balint, Zsofia; Sanchez, Mar M; Wang, Arick; Feczko, Eric; Earl, Eric; Styner, Martin; Fair, Damien; Bachevalier, Jocelyne	May 10, 2024	Not Determined
38403868	Create Study	Foundations of Vocal Category Development in Autistic Infants.	Journal of autism and developmental disorders	Su, Pumpki Lei; Yoo, Hyunjoo; Ramsay, Gordon; Long, Helen L; Bene, Edina R; Klaiman, Cheryl; Pulver, Stormi L; Richardson, Shana; Pileggi, Moira L; Brane, Natalie; Oller, D Kimbrough	February 25, 2024	Not Determined
38227035	Create Study	Diagnosis of Autism-Reply.	JAMA	Jones, Warren; Klaiman, Cheryl; Klin, Ami	January 16, 2024	Not Determined
37595203	Create Study	Lateralization of major white matter tracts during infancy is time-varying and tract-specific.	Cerebral cortex (New York, N.Y. : 1991)	Ford, Aiden; Ammar, Zeena; Li, Longchuan; Shultz, Sarah	September 26, 2023	Not Determined
37556592	Create Study	Early Sleep Differences in Young Infants with Autism Spectrum Disorder.	Journal of developmental and behavioral pediatrics : JDBP	Foster, Miranda; Federico, Alexis; Klaiman, Cheryl; Bradshaw, Jessica	October 1, 2023	Not Determined
36868715	Create Study	A Comparison of the Clinical Presentation of Preterm Birth and Autism Spectrum Disorder: Commonalities and Distinctions in Children Under 3.	Clinics in perinatology	Mendez, Adriana I; Tokish, Hannah; McQueen, Emma; Chawla, Shivaang; Klin, Ami; Maitre, Nathalie L; Klaiman, Cheryl	March 1, 2023	Not Determined
36820480	Create Study	Translating advances in developmental social neuroscience into greater access to early diagnosis in autism spectrum disorder.	Medicina	Klin, Ami	March 1, 2023	Not Determined
36635470	Create Study	Song preferences predict the quality of vocal learning in zebra finches.	Scientific reports	Rodríguez-Saltos, Carlos Antonio; Bhise, Aditya; Karur, Prasanna; Khan, Ramsha Nabihah; Lee, Sumin; Ramsay, Gordon; Maney, Donna L	January 12, 2023	Not Determined
36584126	Create Study	Perspectives on the origin of language: Infants vocalize most during independent vocal play but produce their most speech-like vocalizations during turn taking.	PloS one	Long, Helen L; Ramsay, Gordon; Griebel, Ulrike; Bene, Edina R; Bowman, Dale D; Burkhardt-Reed, Megan M; Oller, D Kimbrough	January 1, 2022	Not Determined
36527322	Create Study	Infant-directed song potentiates infants'' selective attention to adults'' mouths over the first year of life.	Developmental science	Alviar, Camila; Sahoo, Manash; Edwards, Laura A; Jones, Warren; Klin, Ami; Lense, Miriam	September 1, 2023	Not Determined
36322755	Create Study	Music of infant-directed singing entrains infants'' social visual behavior.	Proceedings of the National Academy of Sciences of the United States of America	Lense, Miriam D; Shultz, Sarah; Astésano, Corine; Jones, Warren	November 8, 2022	Not Determined
36202237	Create Study	The Pull-to-Sit Task: Examining Infant Postural Development in Autism Spectrum Disorder.	The Journal of pediatrics	Bradshaw, Jessica; Shi, Dexin; Federico, Alexis; Klaiman, Cheryl; Saulnier, Celine	February 1, 2023	Not Determined
36074577	Create Study	Rhesus monkeys with damage to amygdala or orbitofrontal cortex perform well on novelty-based memory tasks.	Behavioral neuroscience	Krasney, Joshua L; Manns, Joseph R; Kazama, Andrew M; Bachevalier, Jocelyne	February 1, 2023	Not Determined
35307295	Create Study	Applications of chemogenetics in non-human primates.	Current opinion in pharmacology	Raper, Jessica; Galvan, Adriana	June 1, 2022	Not Determined
35171805	Create Study	Frontiers in the research of autism pathogenesis.	Medicina	Klin, Ami	February 2, 2022	Not Determined
35092647	Create Study	Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study.	Autism research : official journal of the International Society for Autism Research	Gunter, Chris; Harris, R Alan; Kovacs-Balint, Zsofia; Raveendran, Muthuswamy; Michopoulos, Vasiliki; Bachevalier, Jocelyne; Raper, Jessica; Sanchez, Mar M; Rogers, Jeffrey	March 1, 2022	Not Determined
34974250	Create Study	Dear reviewers: Responses to common reviewer critiques about infant neuroimaging studies.	Developmental cognitive neuroscience	Korom, Marta; Camacho, M Catalina; Filippi, Courtney A; Licandro, Roxane; Moore, Lucille A; Dufford, Alexander; Zöllei, Lilla; Graham, Alice M; Spann, Marisa; Howell, Brittany; FIT’NG; Shultz, Sarah; Scheinost, Dustin	February 1, 2022	Not Determined
34786700	Create Study	Early social communication development in infants with autism spectrum disorder.	Child development	Bradshaw, Jessica; McCracken, Courtney; Pileggi, Moira; Brane, Natalie; Delehanty, Abigail; Day, Taylor; Federico, Alexis; Klaiman, Cheryl; Saulnier, Celine; Klin, Ami; Wetherby, Amy	November 1, 2021	Not Determined
34713902	Create Study	Neonatal neurobehavior in infants with autism spectrum disorder.	Developmental medicine and child neurology	Bradshaw, Jessica; Shi, Dexin; Hendrix, Cassandra L; Saulnier, Celine; Klaiman, Cheryl	May 1, 2022	Not Determined
34628143	Create Study	Early Vocal Development in Tuberous Sclerosis Complex.	Pediatric neurology	Gipson, Tanjala T; Ramsay, Gordon; Ellison, Ellen E; Bene, Edina R; Long, Helen L; Oller, D Kimbrough	December 1, 2021	Not Determined
34482735	Create Study	Protophones, the precursors to speech, dominate the human infant vocal landscape.	Philosophical transactions of the Royal Society of London. Series B, Biological sciences	Oller, D Kimbrough; Ramsay, Gordon; Bene, Edina; Long, Helen L; Griebel, Ulrike	October 25, 2021	Not Determined
34014933	Create Study	Validation of the Social Responsiveness Scale (SRS) to screen for atypical social behaviors in juvenile macaques.	PloS one	Kovacs Balint, Z; Raper, J; Michopoulos, V; Howell, L H; Gunter, C; Bachevalier, J; Sanchez, M M	January 1, 2021	Not Determined
33989505	Create Study	Early Observation of Red Flags in 12-Month-Old Infant Siblings Later Diagnosed With Autism Spectrum Disorder.	American journal of speech-language pathology	Pileggi, Moira L; Brane, Natalie; Bradshaw, Jessica; Delehanty, Abigail; Day, Taylor; McCracken, Courtney; Stapel-Wax, Jennifer; Wetherby, Amy M	July 14, 2021	Not Determined
33730320	Create Study	Diagnostic Evaluations of Autism Spectrum Disorder during the COVID-19 Pandemic.	Journal of autism and developmental disorders	Jang, Jina; White, Stormi Pulver; Esler, Amy N; Kim, So Hyun; Klaiman, Cheryl; Megerian, Jonathan T; Morse, Amy; Nadler, Cy; Kanne, Stephen M	February 1, 2022	Not Determined
33507867	Create Study	Multi-Site Infant Brain Segmentation Algorithms: The iSeg-2019 Challenge.	IEEE transactions on medical imaging	Sun, Yue; Gao, Kun; Wu, Zhengwang; Li, Guannan; Zong, Xiaopeng; Lei, Zhihao; Wei, Ying; Ma, Jun; Yang, Xiaoping; Feng, Xue; Zhao, Li; Le Phan, Trung; Shin, Jitae; Zhong, Tao; Zhang, Yu; Yu, Lequan; Li, Caizi; Basnet, Ramesh; Ahmad, M Omair; Swamy, M N S; Ma, Wenao; Dou, Qi; Bui, Toan Duc; Noguera, Camilo Bermudez; Landman, Bennett; Gotlib, Ian H; Humphreys, Kathryn L; Shultz, Sarah; Li, Longchuan; Niu, Sijie; Lin, Weili; Jewells, Valerie; Shen, Dinggang; Li, Gang; Wang, Li	May 1, 2021	Not Determined
33465553	Create Study	Structural development of cortical lobes during the first 6 months of life in infant macaques.	Developmental cognitive neuroscience	Kovacs-Balint, Z A; Payne, C; Steele, J; Li, L; Styner, M; Bachevalier, J; Sanchez, M M	April 1, 2021	Not Determined
33383575	Create Study	A comprehensive atlas of white matter tracts in the chimpanzee.	PLoS biology	Bryant, Katherine L; Li, Longchuan; Eichert, Nicole; Mars, Rogier B	December 1, 2020	Not Determined
33359631	Create Study	In-vivo diffusion MRI protocol optimization for the chimpanzee brain and examination of aging effects on the primate optic nerve at 3T.	Magnetic resonance imaging	Zhang, Xiaodong; Li, Chun-Xia; Yan, Yumei; Nair, Govind; Rilling, James K; Herndon, James G; Preuss, Todd M; Hu, Xiaoping; Li, Longchuan	April 1, 2021	Not Determined
33151499	Create Study	Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder.	Journal of autism and developmental disorders	Bradshaw, Jessica; Gillespie, Scott; McCracken, Courtney; King, Bryan H; McCracken, James T; Johnson, Cynthia R; Lecavalier, Luc; Smith, Tristram; Swiezy, Naomi; Bearss, Karen; Sikich, Linmarie; Donnelly, Craig; Hollander, Eric; McDougle, Christopher J; Scahill, Lawrence	September 1, 2021	Not Determined
33009972	Create Study	Visual Traces of Language Acquisition in Toddlers with Autism Spectrum Disorder During the Second Year of Life.	Journal of autism and developmental disorders	Habayeb, Serene; Tsang, Tawny; Saulnier, Celine; Klaiman, Cheryl; Jones, Warren; Klin, Ami; Edwards, Laura A	July 1, 2021	Not Determined
32938507	Create Study	Affording autism an early brain development re-definition.	Development and psychopathology	Klin, Ami; Micheletti, Megan; Klaiman, Cheryl; Shultz, Sarah; Constantino, John N; Jones, Warren	October 1, 2020	Not Determined
32594763	Create Study	Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder.	Autism : the international journal of research and practice	Bradshaw, Jessica; Trumbull, Ashley; Stapel-Wax, Jennifer; Gillespie, Scott; George, Nisha; Saulnier, Celine; Klaiman, Cheryl; Woods, Juliann; Call, Nathan; Klin, Ami; Wetherby, Amy	October 1, 2020	Not Determined
32510341	Create Study	Early developmental changes in visual social engagement in infant rhesus monkeys.	Developmental cognitive neuroscience	Wang, Arick; Payne, Christa; Moss, Shannon; Jones, Warren R; Bachevalier, Jocelyne	June 1, 2020	Not Determined
32428468	Create Study	Infant boys are more vocal than infant girls.	Current biology : CB	Oller, D Kimbrough; Griebel, Ulrike; Bowman, Dale D; Bene, Edina; Long, Helen L; Yoo, Hyunjoo; Ramsay, Gordon	May 18, 2020	Not Determined
32427957	Create Study	Blink Rate Patterns Provide a Reliable Measure of Individual Engagement with Scene Content.	Scientific reports	Ranti, Carolyn; Jones, Warren; Klin, Ami; Shultz, Sarah	May 2020	Not Determined
32239147	Create Study	Rhesus Macaque Brain Developmental Trajectory: A Longitudinal Analysis Using Tensor-Based Structural Morphometry and Diffusion Tensor Imaging.	Cerebral cortex (New York, N.Y. : 1991)	Kim, Jeongchul; Jung, Youngkyoo; Barcus, Richard; Bachevalier, Jocelyne H; Sanchez, Mar M; Nader, Michael A; Whitlow, Christopher T	June 2020	Not Determined
32202497	Create Study	Cross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe.	eLife	Eichert, Nicole; Robinson, Emma C; Bryant, Katherine L; Jbabdi, Saad; Jenkinson, Mark; Li, Longchuan; Krug, Kristine; Watkins, Kate E; Mars, Rogier B	March 2020	Not Determined
31975908	Create Study	Biomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health.	Focus (American Psychiatric Publishing)	Klin, Ami	April 1, 2018	Not Determined
31724729	Create Study	Evolutionary modifications in human brain connectivity associated with schizophrenia.	Brain : a journal of neurology	van den Heuvel, Martijn P; Scholtens, Lianne H; de Lange, Siemon C; Pijnenburg, Rory; Cahn, Wiepke; van Haren, Neeltje E M; Sommer, Iris E; Bozzali, Marco; Koch, Kathrin; Boks, Marco P; Repple, Jonathan; Pievani, Michela; Li, Longchuan; Preuss, Todd M; Rilling, James K	December 2019	Not Determined
31649260	Create Study	Genetic mapping and evolutionary analysis of human-expanded cognitive networks.	Nature communications	Wei, Yongbin; de Lange, Siemon C; Scholtens, Lianne H; Watanabe, Kyoko; Ardesch, Dirk Jan; Jansen, Philip R; Savage, Jeanne E; Li, Longchuan; Preuss, Todd M; Rilling, James K; Posthuma, Danielle; van den Heuvel, Martijn P	October 24, 2019	Not Determined
31589284	Create Study	Developmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study.	JAMA neurology	McDonald, Nicole M; Senturk, Damla; Scheffler, Aaron; Brian, Jessica A; Carver, Leslie J; Charman, Tony; Chawarska, Katarzyna; Curtin, Suzanne; Hertz-Piccioto, Irva; Jones, Emily J H; Klin, Ami; Landa, Rebecca; Messinger, Daniel S; Ozonoff, Sally; Stone, Wendy L; Tager-Flusberg, Helen; Webb, Sara Jane; Young, Gregory; Zwaigenbaum, Lonnie; Jeste, Shafali S	January 2020	Not Determined
31541000	Create Study	Chemogenetic Inhibition of the Amygdala Modulates Emotional Behavior Expression in Infant Rhesus Monkeys.	eNeuro	Raper, Jessica; Murphy, Lauren; Richardson, Rebecca; Romm, Zoe; Kovacs-Balint, Zsofia; Payne, Christa; Galvan, Adriana	January 1, 2019	Not Determined
31256875	Create Study	Public Discussion Affects Question Asking at Academic Conferences.	American journal of human genetics	Telis, Natalie; Glassberg, Emily C; Pritchard, Jonathan K; Gunter, Chris	July 2019	Not Determined
31072758	Create Study	Interindividual Variability of Functional Connectivity in Awake and Anesthetized Rhesus Macaque Monkeys.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Xu, Ting; Sturgeon, Darrick; Ramirez, Julian S B; Froudist-Walsh, Seán; Margulies, Daniel S; Schroeder, Charles E; Fair, Damien A; Milham, Michael P	June 2019	Not Determined
31032937	Create Study	Research Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis.	Journal of child psychology and psychiatry, and allied disciplines	Micheletti, Megan; McCracken, Courtney; Constantino, John N; Mandell, David; Jones, Warren; Klin, Ami	January 2020	Not Determined
31012398	Create Study	Development of attention from birth to 5 months in infants at risk for autism spectrum disorder.	Development and psychopathology	Bradshaw, Jessica; Klin, Ami; Evans, Lindsey; Klaiman, Cheryl; Saulnier, Celine; McCracken, Courtney	May 2020	Not Determined
30886094	Create Study	Evolutionary expansion of connectivity between multimodal association areas in the human brain compared with chimpanzees.	Proceedings of the National Academy of Sciences of the United States of America	Ardesch DJ, Scholtens LH, Li L, Preuss TM, Rilling JK, Van Den Heuvel MP	April 2019	Not Determined
30525959	Create Study	Early emergence of discrepancy in adaptive behavior and cognitive skills in toddlers with autism spectrum disorder.	Autism : the international journal of research and practice	Bradshaw, Jessica; Gillespie, Scott; Klaiman, Cheryl; Klin, Ami; Saulnier, Celine	August 2019	Not Determined
30272135	Create Study	Early Developmental Trajectories of Functional Connectivity Along the Visual Pathways in Rhesus Monkeys.	Cerebral cortex (New York, N.Y. : 1991)	Kovacs-Balint, Z; Feczko, E; Pincus, M; Earl, E; Miranda-Dominguez, O; Howell, B; Morin, E; Maltbie, E; Li, L; Steele, J; Styner, M; Bachevalier, J; Fair, D; Sanchez, M	July 22, 2019	Not Determined
30271278	Create Study	Walking Ability is Associated with Social Communication Skills in Infants at High Risk for Autism Spectrum Disorder.	Infancy : the official journal of the International Society on Infant Studies	Bradshaw, Jessica; Klaiman, Cheryl; Gillespie, Scott; Brane, Natalie; Lewis, Moira; Saulnier, Celine	January 2018	Not Determined
30170273	Create Study	Optimization of macaque brain DMRI connectome by neuron tracing and myelin stain data.	Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society	Zhang, Tuo; Kong, Jun; Jing, Ke; Chen, Hanbo; Jiang, Xi; Li, Longchuan; Guo, Lei; Lu, Jianfeng; Hu, Xiaoping; Liu, Tianming	November 2018	Not Determined
30148064	Create Study	White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors.	NeuroImage. Clinical	Na, Sabrina; Li, Longchuan; Crosson, Bruce; Dotson, Vonetta; MacDonald, Tobey J; Mao, Hui; King, Tricia Z	January 2018	Not Determined
30059417	Create Study	Screening for Autism Spectrum Disorder: Profiles of Children Who Are Missed.	Journal of developmental and behavioral pediatrics : JDBP	Beacham, Chloe; Reid, Morganne; Bradshaw, Jessica; Lambha, Meena; Evans, Lindsey; Gillespie, Scott; Klaiman, Cheryl; Richardson, Shana S	December 1, 2018	Not Determined
29884173	Create Study	Study protocol for The Emory 3q29 Project: evaluation of neurodevelopmental, psychiatric, and medical symptoms in 3q29 deletion syndrome.	BMC psychiatry	Murphy, Melissa M; Lindsey Burrell, T; Cubells, Joseph F; España, Roberto Antonio; Gambello, Michael J; Goines, Katrina C B; Klaiman, Cheryl; Li, Longchuan; Novacek, Derek M; Papetti, Ava; Sanchez Russo, Rossana Lucia; Saulnier, Celine A; Shultz, Sarah; Walker, Elaine; Mulle, Jennifer Gladys	June 2018	Not Determined
29642002	Create Study	Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo.	Cell reports	Xu, Ting; Falchier, Arnaud; Sullivan, Elinor L; Linn, Gary; Ramirez, Julian S B; Ross, Deborah; Feczko, Eric; Opitz, Alexander; Bagley, Jennifer; Sturgeon, Darrick; Earl, Eric; Miranda-Domínguez, Oscar; Perrone, Anders; Craddock, R Cameron; Schroeder, Charles E; Colcombe, Stan; Fair, Damien A; Milham, Michael P	April 2018	Not Determined
29633852	Create Study	Implementing systems-based innovations to improve access to early screening, diagnosis, and treatment services for children with autism spectrum disorder: An Autism Spectrum Disorder Pediatric, Early Detection, Engagement, and Services network study.	Autism : the international journal of research and practice	Broder Fingert, Sarabeth; Carter, Alice; Pierce, Karen; Stone, Wendy L; Wetherby, Amy; Scheldrick, Chris; Smith, Christopher; Bacon, Elizabeth; James, Stephen N; Ibañez, Lisa; Feinberg, Emily	April 2019	Not Determined
29609895	Create Study	Neonatal Transitions in Social Behavior and Their Implications for Autism.	Trends in cognitive sciences	Shultz, Sarah; Klin, Ami; Jones, Warren	May 2018	Not Determined
29516447	Create Study	An agenda for 21st century neurodevelopmental medicine: lessons from autism.	Revista de neurologia	Klin, A; Jones, W	March 2018	Not Determined
29410484	Create Study	A Longitudinal Investigation of Preferential Attention to Biological Motion in 2- to 24-Month-Old Infants.	Scientific reports	Sifre, Robin; Olson, Lindsay; Gillespie, Scott; Klin, Ami; Jones, Warren; Shultz, Sarah	February 2018	Not Determined
29238311	Create Study	Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder.	Frontiers in psychiatry	Okuda, Paola Matiko Martins; Klaiman, Cheryl; Bradshaw, Jessica; Reid, Morganne; Cogo-Moreira, Hugo	January 2017	Not Determined
28700580	Create Study	Infant viewing of social scenes is under genetic control and is atypical in autism.	Nature	Constantino, John N; Kennon-McGill, Stefanie; Weichselbaum, Claire; Marrus, Natasha; Haider, Alyzeh; Glowinski, Anne L; Gillespie, Scott; Klaiman, Cheryl; Klin, Ami; Jones, Warren	July 2017	Relevant
27855484	Create Study	Mechanisms of Diminished Attention to Eyes in Autism.	The American journal of psychiatry	Moriuchi JM, Klin A, Jones W	January 2017	Not Determined
26113807	Create Study	Robust estimation of group-wise cortical correspondence with an application to macaque and human neuroimaging studies.	Frontiers in neuroscience	Lyu, Ilwoo; Kim, Sun H; Seong, Joon-Kyung; Yoo, Sang W; Evans, Alan; Shi, Yundi; Sanchez, Mar; Niethammer, Marc; Styner, Martin A	2015	Not Determined
26089584	Create Study	Automatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases.	Proceedings of SPIE--the International Society for Optical Engineering	Cherel, Marie; Budin, Francois; Prastawa, Marcel; Gerig, Guido; Lee, Kevin; Buss, Claudia; Lyall, Amanda; Consing, Kirsten Zaldarriaga; Styner, Martin	February 21, 2015	Not Determined
26028802	Create Study	LOGISMOS-B for Primates: Primate Cortical Surface Reconstruction and Thickness Measurement.	Proceedings of SPIE--the International Society for Optical Engineering	Oguz, Ipek; Styner, Martin; Sanchez, Mar; Shi, Yundi; Sonka, Milan	2015	Not Determined
25745376	Create Study	Toward innovative, cost-effective, and systemic solutions to improve outcomes and well-being of military families affected by autism spectrum disorder.	The Yale journal of biology and medicine	Klin, Ami; Wetherby, Amy M; Woods, Juliann; Saulnier, Celine; Stapel-Wax, Jennifer; Klaiman, Cheryl; Jones, Warren; Rubin, Emily; Scahill, Lawrence; Call, Nathan; Bearss, Karen; Gunter, Chris; Courtemanche, Charles J; Lemieux, Anthony; Cox, James C; Mandell, David S; Van Decar, James P; Miller, Ronald A; Shireman, Cherri L	March 2015	Not Relevant
25726820	Create Study	Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge.	Revista de neurologia	Klin, Ami; Klaiman, Cheryl; Jones, Warren	February 25, 2015	Not Determined
25457930	Create Study	18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.	Journal of the American Academy of Child and Adolescent Psychiatry	Chawarska, Katarzyna; Shic, Frederick; Macari, Suzanne; Campbell, Daniel J; Brian, Jessica; Landa, Rebecca; Hutman, Ted; Nelson, Charles A; Ozonoff, Sally; Tager-Flusberg, Helen; Young, Gregory S; Zwaigenbaum, Lonnie; Cohen, Ira L; Charman, Tony; Messinger, Daniel S; Klin, Ami; Johnson, Scott; Bryson, Susan	December 2014	Not Determined
25445180	Create Study	Social visual engagement in infants and toddlers with autism: early developmental transitions and a model of pathogenesis.	Neuroscience and biobehavioral reviews	Klin, Ami; Shultz, Sarah; Jones, Warren	March 2015	Not Relevant
24683983	Create Study	Group-wise cortical correspondence via sulcal curve-constrained entropy minimization.	Information processing in medical imaging : proceedings of the ... conference	Lyu, Ilwoo; Kim, Sun Hyung; Seong, Joon-Kyung; Yoo, Sang Wook; Evans, Alan C; Shi, Yundi; Sanchez, Mar; Niethammer, Marc; Styner, Martin A	2013	Not Determined
24327553	Create Study	PCLR: phase-constrained low-rank model for compressive diffusion-weighted MRI.	Magnetic resonance in medicine	Gao H, Li L, Zhang K, Zhou W, Hu X	November 2014	Not Determined
24196715	Create Study	Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism.	Nature	Jones W, Klin A	December 19, 2013	Not Determined
23603286	Create Study	Mapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography.	NeuroImage	Li L, Hu X, Preuss TM, Glasser MF, Damen FW, Qiu Y, Rilling J	October 15, 2013	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	330	07/15/2013	266	11/15/2013	266	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Mullen Scales of Early Learning	330	07/15/2013	232	11/15/2013	232	Approved
ADOS	230	07/15/2013	189	11/15/2013	189	Approved
Medical History	330	07/15/2013	266	11/15/2013	266	Approved
Eye Tracking	330	11/27/2017	0	09/28/2018	0	Approved
Social Responsiveness Scale (SRS)	235	07/15/2013	69	11/15/2013	69	Approved
Early Screening of Autistic Traits Questionnaire (ESAT)	330	11/27/2017	0	09/28/2018	0	Approved
Social Communication Questionnaire (SCQ)	330	07/15/2013	72	11/15/2013	72	Approved
Demographics	330	07/15/2013	264	11/15/2013	264	Approved
Child Behavior Checklist (CBCL)	330	07/15/2013	69	11/15/2013	69	Approved
Parenting Stress Index (PSI)	135	11/27/2017	0	09/28/2018	0	Approved
Communication and Symbolic Behavior Scales (CSBS)	92	11/27/2017	242	09/28/2018	242	Approved
Intervention History	330	07/15/2013	227	11/15/2013	227	Approved
Physical Exam	230	07/15/2013	89	11/15/2013	89	Approved
Sensory Profile	330	07/15/2013	119	11/15/2013	119	Approved
Vineland (Parent and Caregiver)	330	07/15/2013	220	11/15/2013	220	Approved
Patient Health Questionnaire	133	11/27/2017	0	09/28/2018	0	Approved
Edinburgh Postnatal Depression Scale	153	11/27/2017	0	09/28/2018	0	Approved
Developmental Profiling of Spoken Language Development	330	11/27/2017	0	09/28/2018	0	Requested New
Goldman-Fristoe Test of Articulation	330	07/15/2013	0	11/15/2013	0	Approved
LENA - Frequency of Speech	330	11/27/2017	0	09/28/2018	0	Approved
Systematic Observation of Red Flags for ASD in Young Children (SORF)	330	11/27/2017	0	09/28/2018	0	Approved
Measures of Active Engagement and Transactional Support (MAETS)	92	11/27/2017	0	09/28/2018	0	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Examining the validity of the use of ratio IQs in psychological assessments	IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.	231/17423	Secondary Analysis	Shared
The importance of low IQ to early diagnosis of autism	Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood.	229/6323	Secondary Analysis	Shared
Investigating autism etiology and heterogeneity by decision tree algorithm	Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism.	33/3382	Secondary Analysis	Shared

* Data not on individual level

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Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

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Studies are associated to the Collection automatically when the data is defined in the Study.

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Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

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