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1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

Collection - Use Existing Experiment
To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.
SelectExperiment IdExperiment NameExperiment Type
Created On
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
154Math Autism Study - Vinod MenonfMRI07/15/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
Collection - Add Experiment
Add Supporting Documentation
Select File

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption
Ami Klin 
The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National Primate Research Center combine methodological and conceptual expertise in child development, behavioral neuroscience, speech science, molecular genetics, and treatment research; all against the backdrop of a city-wide initiative for autism research driven by the largest pediatric healthcare system In the country, Children's Healthcare of Atlanta. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to unravel the developmental complexities of risk and resilience in autism spectrum disorders, so that we may advance the most effective and successful treatments for children. Projects I and II quantify the developmental unfolding of social visual (PI) and social vocal (Pll) engagement, from birth until 24 months of age, to identify profiles for positive outcome as well as risk factors for disability. Project III advances rigorous, randomized-control trials for treatment of ASD into infancy and toddler hood, testing the extent to which developmental trajectories of social engagement (Projects I and II) predict treatment response and outcome. Also starting in infancy. Projects IV and V established for normative social development (PV) and a genetic means to its disruption (PIV) a nonhuman primate model for interrogating the underpinnings of social disability in genes, brain, and behavior. Together, these Projects advance our understanding of the developmental unfolding of autism, and set the stage for changing the course of ASD prior to the point when disability i seven fully manifest. Four Cores provide the resources to support these goals, spanning Assessment, Informatics, Administration, and Training. In its efforts to meet and exceed the aspirational goals for autism set forth by the NIH Interagency Autism Coordinating Committee (lACC), the Emory ACE creates in its wake a new scientific community, focused on the translational social neuroscience of autism spectrum disorders, in the service of children and families.
NIMH Data Archive
Autism Centers of Excellence (ACE)
Funding Completed
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NIH - Extramural None

QA-notification.txt Other Quality Assurance Notification Qualified Researchers

P50MH100029-01 Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption 09/04/2012 05/31/2017 987 528 EMORY UNIVERSITY $8,941,187.00


NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).


  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType
No records found.

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.


  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.
ACE Family Medical History Clinical Assessments 266
ACE Subject Medical History Clinical Assessments 162
ACE Subject Physical Exam Clinical Assessments 89
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 127
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 87
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 1
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Toddler Module Clinical Assessments 150
BSRC Intervention History Form Clinical Assessments 227
CSBS DP Behavior Sample Clinical Assessments 241
CSBS DP Infant-Toddler Checklist Clinical Assessments 230
Child Behavior Checklist (CBCL) 1-5 Clinical Assessments 69
Demographics Clinical Assessments 264
Mullen Scales of Early Learning Clinical Assessments 232
Research Subject Clinical Assessments 266
Sensory Profile Toddler Clinical Assessments 119
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 72
Social Responsiveness Scale (SRS) - Preschool Version Clinical Assessments 69
Vineland-II - Survey Form (2005) Clinical Assessments 220

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.


  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
38403868Create StudyFoundations of Vocal Category Development in Autistic Infants.Journal of autism and developmental disordersSu, Pumpki Lei; Yoo, Hyunjoo; Ramsay, Gordon; Long, Helen L; Bene, Edina R; Klaiman, Cheryl; Pulver, Stormi L; Richardson, Shana; Pileggi, Moira L; Brane, Natalie; Oller, D KimbroughFebruary 25, 2024Not Determined
38227035Create StudyDiagnosis of Autism-Reply.JAMAJones, Warren; Klaiman, Cheryl; Klin, AmiJanuary 16, 2024Not Determined
37595203Create StudyLateralization of major white matter tracts during infancy is time-varying and tract-specific.Cerebral cortex (New York, N.Y. : 1991)Ford, Aiden; Ammar, Zeena; Li, Longchuan; Shultz, SarahSeptember 26, 2023Not Determined
37556592Create StudyEarly Sleep Differences in Young Infants with Autism Spectrum Disorder.Journal of developmental and behavioral pediatrics : JDBPFoster, Miranda; Federico, Alexis; Klaiman, Cheryl; Bradshaw, JessicaOctober 1, 2023Not Determined
36868715Create StudyA Comparison of the Clinical Presentation of Preterm Birth and Autism Spectrum Disorder: Commonalities and Distinctions in Children Under 3.Clinics in perinatologyMendez, Adriana I; Tokish, Hannah; McQueen, Emma; Chawla, Shivaang; Klin, Ami; Maitre, Nathalie L; Klaiman, CherylMarch 1, 2023Not Determined
36820480Create StudyTranslating advances in developmental social neuroscience into greater access to early diagnosis in autism spectrum disorder.MedicinaKlin, AmiMarch 1, 2023Not Determined
36635470Create StudySong preferences predict the quality of vocal learning in zebra finches.Scientific reportsRodríguez-Saltos, Carlos Antonio; Bhise, Aditya; Karur, Prasanna; Khan, Ramsha Nabihah; Lee, Sumin; Ramsay, Gordon; Maney, Donna LJanuary 12, 2023Not Determined
36584126Create StudyPerspectives on the origin of language: Infants vocalize most during independent vocal play but produce their most speech-like vocalizations during turn taking.PloS oneLong, Helen L; Ramsay, Gordon; Griebel, Ulrike; Bene, Edina R; Bowman, Dale D; Burkhardt-Reed, Megan M; Oller, D KimbroughJanuary 1, 2022Not Determined
36527322Create StudyInfant-directed song potentiates infants'' selective attention to adults'' mouths over the first year of life.Developmental scienceAlviar, Camila; Sahoo, Manash; Edwards, Laura A; Jones, Warren; Klin, Ami; Lense, MiriamSeptember 1, 2023Not Determined
36322755Create StudyMusic of infant-directed singing entrains infants'' social visual behavior.Proceedings of the National Academy of Sciences of the United States of AmericaLense, Miriam D; Shultz, Sarah; Astésano, Corine; Jones, WarrenNovember 8, 2022Not Determined
36202237Create StudyThe Pull-to-Sit Task: Examining Infant Postural Development in Autism Spectrum Disorder.The Journal of pediatricsBradshaw, Jessica; Shi, Dexin; Federico, Alexis; Klaiman, Cheryl; Saulnier, CelineFebruary 1, 2023Not Determined
36074577Create StudyRhesus monkeys with damage to amygdala or orbitofrontal cortex perform well on novelty-based memory tasks.Behavioral neuroscienceKrasney, Joshua L; Manns, Joseph R; Kazama, Andrew M; Bachevalier, JocelyneFebruary 1, 2023Not Determined
35307295Create StudyApplications of chemogenetics in non-human primates.Current opinion in pharmacologyRaper, Jessica; Galvan, AdrianaJune 1, 2022Not Determined
35171805Create StudyFrontiers in the research of autism pathogenesis.MedicinaKlin, AmiFebruary 2, 2022Not Determined
35092647Create StudyHeritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study.Autism research : official journal of the International Society for Autism ResearchGunter, Chris; Harris, R Alan; Kovacs-Balint, Zsofia; Raveendran, Muthuswamy; Michopoulos, Vasiliki; Bachevalier, Jocelyne; Raper, Jessica; Sanchez, Mar M; Rogers, JeffreyMarch 1, 2022Not Determined
34974250Create StudyDear reviewers: Responses to common reviewer critiques about infant neuroimaging studies.Developmental cognitive neuroscienceKorom, Marta; Camacho, M Catalina; Filippi, Courtney A; Licandro, Roxane; Moore, Lucille A; Dufford, Alexander; Zöllei, Lilla; Graham, Alice M; Spann, Marisa; Howell, Brittany; FIT’NG; Shultz, Sarah; Scheinost, DustinFebruary 1, 2022Not Determined
34786700Create StudyEarly social communication development in infants with autism spectrum disorder.Child developmentBradshaw, Jessica; McCracken, Courtney; Pileggi, Moira; Brane, Natalie; Delehanty, Abigail; Day, Taylor; Federico, Alexis; Klaiman, Cheryl; Saulnier, Celine; Klin, Ami; Wetherby, AmyNovember 1, 2021Not Determined
34713902Create StudyNeonatal neurobehavior in infants with autism spectrum disorder.Developmental medicine and child neurologyBradshaw, Jessica; Shi, Dexin; Hendrix, Cassandra L; Saulnier, Celine; Klaiman, CherylMay 1, 2022Not Determined
34628143Create StudyEarly Vocal Development in Tuberous Sclerosis Complex.Pediatric neurologyGipson, Tanjala T; Ramsay, Gordon; Ellison, Ellen E; Bene, Edina R; Long, Helen L; Oller, D KimbroughDecember 1, 2021Not Determined
34482735Create StudyProtophones, the precursors to speech, dominate the human infant vocal landscape.Philosophical transactions of the Royal Society of London. Series B, Biological sciencesOller, D Kimbrough; Ramsay, Gordon; Bene, Edina; Long, Helen L; Griebel, UlrikeOctober 25, 2021Not Determined
34014933Create StudyValidation of the Social Responsiveness Scale (SRS) to screen for atypical social behaviors in juvenile macaques.PloS oneKovacs Balint, Z; Raper, J; Michopoulos, V; Howell, L H; Gunter, C; Bachevalier, J; Sanchez, M MJanuary 1, 2021Not Determined
33989505Create StudyEarly Observation of Red Flags in 12-Month-Old Infant Siblings Later Diagnosed With Autism Spectrum Disorder.American journal of speech-language pathologyPileggi, Moira L; Brane, Natalie; Bradshaw, Jessica; Delehanty, Abigail; Day, Taylor; McCracken, Courtney; Stapel-Wax, Jennifer; Wetherby, Amy MJuly 14, 2021Not Determined
33730320Create StudyDiagnostic Evaluations of Autism Spectrum Disorder during the COVID-19 Pandemic.Journal of autism and developmental disordersJang, Jina; White, Stormi Pulver; Esler, Amy N; Kim, So Hyun; Klaiman, Cheryl; Megerian, Jonathan T; Morse, Amy; Nadler, Cy; Kanne, Stephen MFebruary 1, 2022Not Determined
33507867Create StudyMulti-Site Infant Brain Segmentation Algorithms: The iSeg-2019 Challenge.IEEE transactions on medical imagingSun, Yue; Gao, Kun; Wu, Zhengwang; Li, Guannan; Zong, Xiaopeng; Lei, Zhihao; Wei, Ying; Ma, Jun; Yang, Xiaoping; Feng, Xue; Zhao, Li; Le Phan, Trung; Shin, Jitae; Zhong, Tao; Zhang, Yu; Yu, Lequan; Li, Caizi; Basnet, Ramesh; Ahmad, M Omair; Swamy, M N S; Ma, Wenao; Dou, Qi; Bui, Toan Duc; Noguera, Camilo Bermudez; Landman, Bennett; Gotlib, Ian H; Humphreys, Kathryn L; Shultz, Sarah; Li, Longchuan; Niu, Sijie; Lin, Weili; Jewells, Valerie; Shen, Dinggang; Li, Gang; Wang, LiMay 1, 2021Not Determined
33465553Create StudyStructural development of cortical lobes during the first 6 months of life in infant macaques.Developmental cognitive neuroscienceKovacs-Balint, Z A; Payne, C; Steele, J; Li, L; Styner, M; Bachevalier, J; Sanchez, M MApril 1, 2021Not Determined
33383575Create StudyA comprehensive atlas of white matter tracts in the chimpanzee.PLoS biologyBryant, Katherine L; Li, Longchuan; Eichert, Nicole; Mars, Rogier BDecember 1, 2020Not Determined
33359631Create StudyIn-vivo diffusion MRI protocol optimization for the chimpanzee brain and examination of aging effects on the primate optic nerve at 3T.Magnetic resonance imagingZhang, Xiaodong; Li, Chun-Xia; Yan, Yumei; Nair, Govind; Rilling, James K; Herndon, James G; Preuss, Todd M; Hu, Xiaoping; Li, LongchuanApril 1, 2021Not Determined
33151499Create StudyPredictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder.Journal of autism and developmental disordersBradshaw, Jessica; Gillespie, Scott; McCracken, Courtney; King, Bryan H; McCracken, James T; Johnson, Cynthia R; Lecavalier, Luc; Smith, Tristram; Swiezy, Naomi; Bearss, Karen; Sikich, Linmarie; Donnelly, Craig; Hollander, Eric; McDougle, Christopher J; Scahill, LawrenceSeptember 1, 2021Not Determined
33009972Create StudyVisual Traces of Language Acquisition in Toddlers with Autism Spectrum Disorder During the Second Year of Life.Journal of autism and developmental disordersHabayeb, Serene; Tsang, Tawny; Saulnier, Celine; Klaiman, Cheryl; Jones, Warren; Klin, Ami; Edwards, Laura AJuly 1, 2021Not Determined
32938507Create StudyAffording autism an early brain development re-definition.Development and psychopathologyKlin, Ami; Micheletti, Megan; Klaiman, Cheryl; Shultz, Sarah; Constantino, John N; Jones, WarrenOctober 1, 2020Not Determined
32594763Create StudyFactors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder.Autism : the international journal of research and practiceBradshaw, Jessica; Trumbull, Ashley; Stapel-Wax, Jennifer; Gillespie, Scott; George, Nisha; Saulnier, Celine; Klaiman, Cheryl; Woods, Juliann; Call, Nathan; Klin, Ami; Wetherby, AmyOctober 1, 2020Not Determined
32510341Create StudyEarly developmental changes in visual social engagement in infant rhesus monkeys.Developmental cognitive neuroscienceWang, Arick; Payne, Christa; Moss, Shannon; Jones, Warren R; Bachevalier, JocelyneJune 1, 2020Not Determined
32428468Create StudyInfant boys are more vocal than infant girls.Current biology : CBOller, D Kimbrough; Griebel, Ulrike; Bowman, Dale D; Bene, Edina; Long, Helen L; Yoo, Hyunjoo; Ramsay, GordonMay 18, 2020Not Determined
32427957Create StudyBlink Rate Patterns Provide a Reliable Measure of Individual Engagement with Scene Content.Scientific reportsRanti, Carolyn; Jones, Warren; Klin, Ami; Shultz, SarahMay 2020Not Determined
32239147Create StudyRhesus Macaque Brain Developmental Trajectory: A Longitudinal Analysis Using Tensor-Based Structural Morphometry and Diffusion Tensor Imaging.Cerebral cortex (New York, N.Y. : 1991)Kim, Jeongchul; Jung, Youngkyoo; Barcus, Richard; Bachevalier, Jocelyne H; Sanchez, Mar M; Nader, Michael A; Whitlow, Christopher TJune 2020Not Determined
32202497Create StudyCross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe.eLifeEichert, Nicole; Robinson, Emma C; Bryant, Katherine L; Jbabdi, Saad; Jenkinson, Mark; Li, Longchuan; Krug, Kristine; Watkins, Kate E; Mars, Rogier BMarch 2020Not Determined
31975908Create StudyBiomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health.Focus (American Psychiatric Publishing)Klin, AmiApril 1, 2018Not Determined
31724729Create StudyEvolutionary modifications in human brain connectivity associated with schizophrenia.Brain : a journal of neurologyvan den Heuvel, Martijn P; Scholtens, Lianne H; de Lange, Siemon C; Pijnenburg, Rory; Cahn, Wiepke; van Haren, Neeltje E M; Sommer, Iris E; Bozzali, Marco; Koch, Kathrin; Boks, Marco P; Repple, Jonathan; Pievani, Michela; Li, Longchuan; Preuss, Todd M; Rilling, James KDecember 2019Not Determined
31589284Create StudyDevelopmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study.JAMA neurologyMcDonald, Nicole M; Senturk, Damla; Scheffler, Aaron; Brian, Jessica A; Carver, Leslie J; Charman, Tony; Chawarska, Katarzyna; Curtin, Suzanne; Hertz-Piccioto, Irva; Jones, Emily J H; Klin, Ami; Landa, Rebecca; Messinger, Daniel S; Ozonoff, Sally; Stone, Wendy L; Tager-Flusberg, Helen; Webb, Sara Jane; Young, Gregory; Zwaigenbaum, Lonnie; Jeste, Shafali SJanuary 2020Not Determined
31541000Create StudyChemogenetic Inhibition of the Amygdala Modulates Emotional Behavior Expression in Infant Rhesus Monkeys.eNeuroRaper, Jessica; Murphy, Lauren; Richardson, Rebecca; Romm, Zoe; Kovacs-Balint, Zsofia; Payne, Christa; Galvan, AdrianaJanuary 1, 2019Not Determined
31256875Create StudyPublic Discussion Affects Question Asking at Academic Conferences.American journal of human geneticsTelis, Natalie; Glassberg, Emily C; Pritchard, Jonathan K; Gunter, ChrisJuly 2019Not Determined
31072758Create StudyInterindividual Variability of Functional Connectivity in Awake and Anesthetized Rhesus Macaque Monkeys.Biological psychiatry. Cognitive neuroscience and neuroimagingXu, Ting; Sturgeon, Darrick; Ramirez, Julian S B; Froudist-Walsh, Seán; Margulies, Daniel S; Schroeder, Charles E; Fair, Damien A; Milham, Michael PJune 2019Not Determined
31032937Create StudyResearch Review: Outcomes of 24- to 36-month-old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplinesMicheletti, Megan; McCracken, Courtney; Constantino, John N; Mandell, David; Jones, Warren; Klin, AmiJanuary 2020Not Determined
31012398Create StudyDevelopment of attention from birth to 5 months in infants at risk for autism spectrum disorder.Development and psychopathologyBradshaw, Jessica; Klin, Ami; Evans, Lindsey; Klaiman, Cheryl; Saulnier, Celine; McCracken, CourtneyMay 2020Not Determined
30886094Create StudyEvolutionary expansion of connectivity between multimodal association areas in the human brain compared with chimpanzees.Proceedings of the National Academy of Sciences of the United States of AmericaArdesch DJ, Scholtens LH, Li L, Preuss TM, Rilling JK, Van Den Heuvel MPApril 2019Not Determined
30525959Create StudyEarly emergence of discrepancy in adaptive behavior and cognitive skills in toddlers with autism spectrum disorder.Autism : the international journal of research and practiceBradshaw, Jessica; Gillespie, Scott; Klaiman, Cheryl; Klin, Ami; Saulnier, CelineAugust 2019Not Determined
30272135Create StudyEarly Developmental Trajectories of Functional Connectivity Along the Visual Pathways in Rhesus Monkeys.Cerebral cortex (New York, N.Y. : 1991)Kovacs-Balint, Z; Feczko, E; Pincus, M; Earl, E; Miranda-Dominguez, O; Howell, B; Morin, E; Maltbie, E; Li, L; Steele, J; Styner, M; Bachevalier, J; Fair, D; Sanchez, MJuly 22, 2019Not Determined
30271278Create StudyWalking Ability is Associated with Social Communication Skills in Infants at High Risk for Autism Spectrum Disorder.Infancy : the official journal of the International Society on Infant StudiesBradshaw, Jessica; Klaiman, Cheryl; Gillespie, Scott; Brane, Natalie; Lewis, Moira; Saulnier, CelineJanuary 2018Not Determined
30170273Create StudyOptimization of macaque brain DMRI connectome by neuron tracing and myelin stain data.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging SocietyZhang, Tuo; Kong, Jun; Jing, Ke; Chen, Hanbo; Jiang, Xi; Li, Longchuan; Guo, Lei; Lu, Jianfeng; Hu, Xiaoping; Liu, TianmingNovember 2018Not Determined
30148064Create StudyWhite matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors.NeuroImage. ClinicalNa, Sabrina; Li, Longchuan; Crosson, Bruce; Dotson, Vonetta; MacDonald, Tobey J; Mao, Hui; King, Tricia ZJanuary 2018Not Determined
30059417Create StudyScreening for Autism Spectrum Disorder: Profiles of Children Who Are Missed.Journal of developmental and behavioral pediatrics : JDBPBeacham, Chloe; Reid, Morganne; Bradshaw, Jessica; Lambha, Meena; Evans, Lindsey; Gillespie, Scott; Klaiman, Cheryl; Richardson, Shana SDecember 1, 2018Not Determined
29884173Create StudyStudy protocol for The Emory 3q29 Project: evaluation of neurodevelopmental, psychiatric, and medical symptoms in 3q29 deletion syndrome.BMC psychiatryMurphy, Melissa M; Lindsey Burrell, T; Cubells, Joseph F; España, Roberto Antonio; Gambello, Michael J; Goines, Katrina C B; Klaiman, Cheryl; Li, Longchuan; Novacek, Derek M; Papetti, Ava; Sanchez Russo, Rossana Lucia; Saulnier, Celine A; Shultz, Sarah; Walker, Elaine; Mulle, Jennifer GladysJune 2018Not Determined
29642002Create StudyDelineating the Macroscale Areal Organization of the Macaque Cortex In Vivo.Cell reportsXu, Ting; Falchier, Arnaud; Sullivan, Elinor L; Linn, Gary; Ramirez, Julian S B; Ross, Deborah; Feczko, Eric; Opitz, Alexander; Bagley, Jennifer; Sturgeon, Darrick; Earl, Eric; Miranda-Domínguez, Oscar; Perrone, Anders; Craddock, R Cameron; Schroeder, Charles E; Colcombe, Stan; Fair, Damien A; Milham, Michael PApril 2018Not Determined
29633852Create StudyImplementing systems-based innovations to improve access to early screening, diagnosis, and treatment services for children with autism spectrum disorder: An Autism Spectrum Disorder Pediatric, Early Detection, Engagement, and Services network study.Autism : the international journal of research and practiceBroder Fingert, Sarabeth; Carter, Alice; Pierce, Karen; Stone, Wendy L; Wetherby, Amy; Scheldrick, Chris; Smith, Christopher; Bacon, Elizabeth; James, Stephen N; Ibañez, Lisa; Feinberg, EmilyApril 2019Not Determined
29609895Create StudyNeonatal Transitions in Social Behavior and Their Implications for Autism.Trends in cognitive sciencesShultz, Sarah; Klin, Ami; Jones, WarrenMay 2018Not Determined
29516447Create StudyAn agenda for 21st century neurodevelopmental medicine: lessons from autism.Revista de neurologiaKlin, A; Jones, WMarch 2018Not Determined
29410484Create StudyA Longitudinal Investigation of Preferential Attention to Biological Motion in 2- to 24-Month-Old Infants.Scientific reportsSifre, Robin; Olson, Lindsay; Gillespie, Scott; Klin, Ami; Jones, Warren; Shultz, SarahFebruary 2018Not Determined
29238311Create StudyAssessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder.Frontiers in psychiatryOkuda, Paola Matiko Martins; Klaiman, Cheryl; Bradshaw, Jessica; Reid, Morganne; Cogo-Moreira, HugoJanuary 2017Not Determined
28700580Create StudyInfant viewing of social scenes is under genetic control and is atypical in autism.NatureConstantino, John N; Kennon-McGill, Stefanie; Weichselbaum, Claire; Marrus, Natasha; Haider, Alyzeh; Glowinski, Anne L; Gillespie, Scott; Klaiman, Cheryl; Klin, Ami; Jones, WarrenJuly 2017Relevant
27855484Create StudyMechanisms of Diminished Attention to Eyes in Autism.The American journal of psychiatryMoriuchi JM, Klin A, Jones WJanuary 2017Not Determined
26113807Create StudyRobust estimation of group-wise cortical correspondence with an application to macaque and human neuroimaging studies.Frontiers in neuroscienceLyu, Ilwoo; Kim, Sun H; Seong, Joon-Kyung; Yoo, Sang W; Evans, Alan; Shi, Yundi; Sanchez, Mar; Niethammer, Marc; Styner, Martin A2015Not Determined
26089584Create StudyAutomatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases.Proceedings of SPIE--the International Society for Optical EngineeringCherel, Marie; Budin, Francois; Prastawa, Marcel; Gerig, Guido; Lee, Kevin; Buss, Claudia; Lyall, Amanda; Consing, Kirsten Zaldarriaga; Styner, MartinFebruary 21, 2015Not Determined
26028802Create StudyLOGISMOS-B for Primates: Primate Cortical Surface Reconstruction and Thickness Measurement.Proceedings of SPIE--the International Society for Optical EngineeringOguz, Ipek; Styner, Martin; Sanchez, Mar; Shi, Yundi; Sonka, Milan2015Not Determined
25745376Create StudyToward innovative, cost-effective, and systemic solutions to improve outcomes and well-being of military families affected by autism spectrum disorder.The Yale journal of biology and medicineKlin, Ami; Wetherby, Amy M; Woods, Juliann; Saulnier, Celine; Stapel-Wax, Jennifer; Klaiman, Cheryl; Jones, Warren; Rubin, Emily; Scahill, Lawrence; Call, Nathan; Bearss, Karen; Gunter, Chris; Courtemanche, Charles J; Lemieux, Anthony; Cox, James C; Mandell, David S; Van Decar, James P; Miller, Ronald A; Shireman, Cherri LMarch 2015Not Relevant
25726820Create StudyReducing age of autism diagnosis: developmental social neuroscience meets public health challenge.Revista de neurologiaKlin, Ami; Klaiman, Cheryl; Jones, WarrenFebruary 25, 2015Not Determined
25457930Create Study18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryChawarska, Katarzyna; Shic, Frederick; Macari, Suzanne; Campbell, Daniel J; Brian, Jessica; Landa, Rebecca; Hutman, Ted; Nelson, Charles A; Ozonoff, Sally; Tager-Flusberg, Helen; Young, Gregory S; Zwaigenbaum, Lonnie; Cohen, Ira L; Charman, Tony; Messinger, Daniel S; Klin, Ami; Johnson, Scott; Bryson, SusanDecember 2014Not Determined
25445180Create StudySocial visual engagement in infants and toddlers with autism: early developmental transitions and a model of pathogenesis.Neuroscience and biobehavioral reviewsKlin, Ami; Shultz, Sarah; Jones, WarrenMarch 2015Not Relevant
24683983Create StudyGroup-wise cortical correspondence via sulcal curve-constrained entropy minimization.Information processing in medical imaging : proceedings of the ... conferenceLyu, Ilwoo; Kim, Sun Hyung; Seong, Joon-Kyung; Yoo, Sang Wook; Evans, Alan C; Shi, Yundi; Sanchez, Mar; Niethammer, Marc; Styner, Martin A2013Not Determined
24327553Create StudyPCLR: phase-constrained low-rank model for compressive diffusion-weighted MRI.Magnetic resonance in medicineGao H, Li L, Zhang K, Zhou W, Hu XNovember 2014Not Determined
24196715Create StudyAttention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism.NatureJones W, Klin ADecember 19, 2013Not Determined
23603286Create StudyMapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography.NeuroImageLi L, Hu X, Preuss TM, Glasser MF, Damen FW, Qiu Y, Rilling JOctober 15, 2013Not Determined

NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).


  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.
Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Mullen Scales of Early Learning info icon
ADOS info icon
Medical History info icon
Eye Tracking info icon
Social Responsiveness Scale (SRS) info icon
Early Screening of Autistic Traits Questionnaire (ESAT) info icon
Social Communication Questionnaire (SCQ) info icon
Demographics info icon
Child Behavior Checklist (CBCL) info icon
Parenting Stress Index (PSI) info icon
Communication and Symbolic Behavior Scales (CSBS) info icon
Intervention History info icon
Physical Exam info icon
Sensory Profile info icon
Vineland (Parent and Caregiver) info icon
Patient Health Questionnaire info icon
Edinburgh Postnatal Depression Scale info icon
Developmental Profiling of Spoken Language Development info icon
Goldman-Fristoe Test of Articulation info icon
LENA - Frequency of Speech info icon
Systematic Observation of Red Flags for ASD in Young Children (SORF) info icon
Measures of Active Engagement and Transactional Support (MAETS) info icon
Structure not yet defined
No Status history for this Data Expected has been recorded yet

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.


  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Examining the validity of the use of ratio IQs in psychological assessments IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.231/17423Secondary AnalysisShared
The importance of low IQ to early diagnosis of autismSome individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood. 229/6323Secondary AnalysisShared
Investigating autism etiology and heterogeneity by decision tree algorithmAutism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism. 33/3382Secondary AnalysisShared
* Data not on individual level

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.


  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.