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1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

Collection - Use Existing Experiment
To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.
SelectExperiment IdExperiment NameExperiment Type
Created On
24HI-NGS_R1Omics02/16/2011
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
506PVPREFOmics08/05/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
26ASD_MethylationOmics03/01/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
41ImmunofluorescenceOmics05/11/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
519RestingfMRI11/08/2016
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
145AGRE/FMR1_Illumina.JHUOmics04/14/2014
146AGRE/MECP2_Sanger.JHUOmics04/14/2014
147AGRE/MECP2_Junior.JHUOmics04/14/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
154Math Autism Study - Vinod MenonfMRI07/15/2014
155RestingfMRI07/25/2014
156SpeechfMRI07/25/2014
159EmotionfMRI07/25/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
Collection - Add Experiment
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To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Somatosensory Inhibitory Dysfunction in Autism Spectrum Disorder
Richard Edden 
Autism Spectrum Disorder (ASD) is a group of developmental disorders which affects approximately 1% of children, a prevalence rate that is increasing annually. ASD is characterized by social and communicative deficits, but there is increasing recognition of altered sensory processing as an extremely common feature of the disorder. In particular, responses to tactile stimuli are commonly observed, for example, a child with ASD may be unable to tolerate constant low level stimuli such as shirt tags which a typically developing child could habituate to. There is growing evidence that altered responses to sensory stimuli do not just result from altered top down control and emotional processing, but from altered processing of somatosensory information in primary somatosensory cortex due to altered GABAergic inhibition. In this proposal, we propose to use tactile behavioral testing to investigate and characterize differences in primary somatosensory processing, fMRI to directly detect the functional neural signature of this altered processing, and MRS of GABA to probe the neurochemical basis of the dysfunction. These three modes of investigation are unified by the core hypothesis of somatosensory GABAergic dysfunction in ASD. This proposal builds on a strong collaboration between Dr Richard Edden (PI), Dr Stewart Mostofsky (Co-PI) and Dr Mark Tommerdahl (Co-PI), and preliminary behavioral data showing altered patterns of behavioral responses in ASD and reduced GABA concentration in primary somatosensory areas. In Aim 1, we will perform psychophysical measures of tactile discrimination and adaptation in a group of 72 children with ASD between the age of 8 and 12 years with 72 ages, gender, and IQ-matched typically developing children (TDC) as the control group, to investigate whether there are behavioral differences in ASD. In Aim 2, we will compare measurements of GABA concentration and test whether the abnormal tactile processing commonly observed in ASD arises from a GABAergic deficit. In Aim 3, we will perform fMRI measurements during tactile stimulation to observe neural correlates of altered somatosensory processing.
NIMH Data Archive
12/07/2016
Funding Completed
Close Out
No
$2,508,907.00
106
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NIH - Extramural None



R01MH106564-01 Somatosensory Inhibitory Dysfunction in Autism Spectrum Disorder. 01/18/2016 11/30/2022 144 220 JOHNS HOPKINS UNIVERSITY $2,508,907.00

helpcenter.collection.general-tab

NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType
No records found.
helpcenter.collection.experiments-tab

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 10
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 56
Research Subject Clinical Assessments 105
Spectroscopy Form Imaging 53
Vibrotactile Behavioral Battery Clinical Assessments 91
helpcenter.collection.shared-data-tab

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
38279628Create StudyBrain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism ResearchSong, Yulu; Hupfeld, Kathleen E; Davies-Jenkins, Christopher W; Zöllner, Helge J; Murali-Manohar, Saipavitra; Mumuni, Abdul Nashirudeen; Crocetti, Deana; Yedavalli, Vivek; Oeltzschner, Georg; Alessi, Natalie; Batschelett, Mitchell A; Puts, Nicolaas A J; Mostofsky, Stewart H; Edden, Richard A EMarch 1, 2024Not Determined
37382829Create StudySex Differences and Behavioral Associations with Typically Developing Pediatric Regional Cerebellar Gray Matter Volume.Cerebellum (London, England)Rice, Laura C; Rochowiak, Rebecca N; Plotkin, Micah R; Rosch, Keri S; Mostofsky, Stewart H; Crocetti, DeanaApril 1, 2024Not Determined
36272043Create StudyCould Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females.Journal of autism and developmental disordersAsaridou, Magdalini; Wodka, Ericka L; Edden, Richard A E; Mostofsky, Stewart H; Puts, Nicolaas A J; He, Jason LJanuary 1, 2024Not Determined
36227445Create StudyExploring the Symptom Profiles of Intolerance of Uncertainty in Autistic Children.Journal of autism and developmental disordersKeefer, Amy; Singh, Vini; Jang, Yeon Sik; Alon, Leigh; Surmacz, Madison; Holingue, Calliope; Mostofsky, Stewart H; Vasa, Roma AJanuary 1, 2024Not Determined
35752413Create StudyHypoxia alters posterior cingulate cortex metabolism during a memory task: A 1H fMRS study.NeuroImageRogan, Matthew; Friend, Alexander T; Rossetti, Gabriella Mk; Edden, Richard; Mikkelsen, Mark; Oliver, Samuel J; Macdonald, Jamie H; Mullins, Paul GOctober 15, 2022Not Determined
35561944Create StudyAccounting for motion in resting-state fMRI: What part of the spectrum are we characterizing in autism spectrum disorder?NeuroImageNebel, Mary Beth; Lidstone, Daniel E; Wang, Liwei; Benkeser, David; Mostofsky, Stewart H; Risk, Benjamin BAugust 15, 2022Not Determined
34654960Create StudyEdited magnetic resonance spectroscopy in the neonatal brain.NeuroradiologySong, Yulu; Lally, Peter J; Yanez Lopez, Maria; Oeltzschner, Georg; Nebel, Mary Beth; Gagoski, Borjan; Kecskemeti, Steven; Hui, Steve C N; Zöllner, Helge J; Shukla, Deepika; Arichi, Tomoki; De Vita, Enrico; Yedavalli, Vivek; Thayyil, Sudhin; Fallin, Daniele; Dean 3rd, Douglas C; Grant, P Ellen; Wisnowski, Jessica L; Edden, Richard A EFebruary 1, 2022Not Determined
34558129Create StudyComparison of linear combination modeling strategies for edited magnetic resonance spectroscopy at 3 T.NMR in biomedicineZöllner, Helge J; Tapper, Sofie; Hui, Steve C N; Barker, Peter B; Edden, Richard A E; Oeltzschner, GeorgJanuary 1, 2022Not Determined
34330613Create StudyMoving Toward Understanding Autism: Visual-Motor Integration, Imitation, and Social Skill Development.Pediatric neurologyLidstone, Daniel E; Mostofsky, Stewart HSeptember 1, 2021Not Determined
34326312Create StudyRegion-specific elevations of glutamate + glutamine correlate with the sensory symptoms of autism spectrum disorders.Translational psychiatryHe, Jason L; Oeltzschner, Georg; Mikkelsen, Mark; Deronda, Alyssa; Harris, Ashley D; Crocetti, Deana; Wodka, Ericka L; Mostofsky, Stewart H; Edden, Richard A E; Puts, Nicolaas A JJuly 29, 2021Not Determined
34303880Create StudyAberrant prefrontal cortical-striatal functional connectivity in children with primary complex motor stereotypies.Cortex; a journal devoted to the study of the nervous system and behaviorAugustine, Farhan; Nebel, Mary B; Mostofsky, Stewart H; Mahone, E Mark; Singer, Harvey SSeptember 1, 2021Not Determined
34271159Create StudyDeep sr-DDL: Deep structurally regularized dynamic dictionary learning to integrate multimodal and dynamic functional connectomics data for multidimensional clinical characterizations.NeuroImageD'Souza, N S; Nebel, M B; Crocetti, D; Robinson, J; Wymbs, N; Mostofsky, S H; Venkataraman, ANovember 1, 2021Not Determined
34061022Create StudyThe trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies.eLifePorges, Eric C; Jensen, Greg; Foster, Brent; Edden, Richard Ae; Puts, Nicolaas AjJune 1, 2021Not Determined
33677261Create StudyNeuropsychiatric disease classification using functional connectomics - results of the connectomics in neuroimaging transfer learning challenge.Medical image analysisSchirmer, Markus D; Venkataraman, Archana; Rekik, Islem; Kim, Minjeong; Mostofsky, Stewart H; Nebel, Mary Beth; Rosch, Keri; Seymour, Karen; Crocetti, Deana; Irzan, Hassna; Hütel, Michael; Ourselin, Sebastien; Marlow, Neil; Melbourne, Andrew; Levchenko, Egor; Zhou, Shuo; Kunda, Mwiza; Lu, Haiping; Dvornek, Nicha C; Zhuang, Juntang; Pinto, Gideon; Samal, Sandip; Zhang, Jennings; Bernal-Rusiel, Jorge L; Pienaar, Rudolph; Chung, Ai WernMay 1, 2021Not Determined
33530131Create StudyComparison of different linear-combination modeling algorithms for short-TE proton spectra.NMR in biomedicineZöllner, Helge J; Považan, Michal; Hui, Steve C N; Tapper, Sofie; Edden, Richard A E; Oeltzschner, GeorgApril 1, 2021Not Determined
33484109Create StudyA Data Driven Approach Reveals That Anomalous Motor System Connectivity is Associated With the Severity of Core Autism Symptoms.Autism research : official journal of the International Society for Autism ResearchLidstone, Daniel E; Rochowiak, Rebecca; Mostofsky, Stewart H; Nebel, Mary BethJanuary 22, 2021Not Determined
33483581Create StudyDisorder-specific alterations of tactile sensitivity in neurodevelopmental disorders.Communications biologyHe, Jason L; Wodka, Ericka; Tommerdahl, Mark; Edden, Richard A E; Mikkelsen, Mark; Mostofsky, Stewart H; Puts, Nicolaas A JJanuary 22, 2021Not Determined
33461914Create StudyLinks between parent-reported measures of poor sleep and executive function in childhood autism and attention deficit hyperactivity disorder.Sleep healthHolingue, Calliope; Volk, Heather; Crocetti, Deana; Gottlieb, Bridget; Spira, Adam P; Mostofsky, Stewart HJune 1, 2021Not Determined
33229247Create StudyComputerized Assessment of Motor Imitation as a Scalable Method for Distinguishing Children With Autism.Biological psychiatry. Cognitive neuroscience and neuroimagingTunçgenç, Bahar; Pacheco, Carolina; Rochowiak, Rebecca; Nicholas, Rosemary; Rengarajan, Sundararaman; Zou, Erin; Messenger, Brice; Vidal, René; Mostofsky, Stewart HMarch 1, 2021Not Determined
32946145Create StudySpectral editing in 1 H magnetic resonance spectroscopy: Experts'' consensus recommendations.NMR in biomedicineChoi, In-Young; Andronesi, Ovidiu C; Barker, Peter; Bogner, Wolfgang; Edden, Richard A E; Kaiser, Lana G; Lee, Phil; Marjańska, Małgorzata; Terpstra, Melissa; de Graaf, Robin AMay 1, 2021Not Determined
32928500Create StudyAssociations Between Cognitive Function and Levels of Glutamatergic Metabolites and Gamma-Aminobutyric Acid in Antipsychotic-Naïve Patients With Schizophrenia or Psychosis.Biological psychiatryBojesen, Kirsten Borup; Broberg, Brian Villumsen; Fagerlund, Birgitte; Jessen, Kasper; Thomas, Marie Bjerregaard; Sigvard, Anne; Tangmose, Karen; Nielsen, Mette Ødegaard; Andersen, Gitte Saltoft; Larsson, Henrik Bo Wiberg; Edden, Richard A E; Rostrup, Egill; Glenthøj, Birte YdingFebruary 1, 2021Not Determined
32656879Create StudyCorrecting frequency and phase offsets in MRS data using robust spectral registration.NMR in biomedicineMikkelsen, Mark; Tapper, Sofie; Near, Jamie; Mostofsky, Stewart H; Puts, Nicolaas A J; Edden, Richard A EOctober 2020Not Determined
32297709Create StudyConcentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism ResearchKolodny, Tamar; Schallmo, Michael-Paul; Gerdts, Jennifer; Edden, Richard A E; Bernier, Raphael A; Murray, Scott OJuly 2020Not Determined
31748505Create StudyEffects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy.Translational psychiatryPretzsch, Charlotte M; Voinescu, Bogdan; Lythgoe, David; Horder, Jamie; Mendez, Maria Andreina; Wichers, Robert; Ajram, Laura; Ivin, Glynis; Heasman, Martin; Edden, Richard A E; Williams, Steven; Murphy, Declan G M; Daly, Eileen; McAlonan, Gráinne MNovember 2019Not Determined
31678501Create StudyA joint network optimization framework to predict clinical severity from resting state functional MRI data.NeuroImageD'Souza, N S; Nebel, M B; Wymbs, N; Mostofsky, S H; Venkataraman, AFebruary 1, 2020Not Determined
31631690Create StudyParsing Heterogeneity in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder with Individual Connectome Mapping.Brain connectivityDajani, Dina R; Burrows, Catherine A; Nebel, Mary Beth; Mostofsky, Stewart H; Gates, Kathleen M; Uddin, Lucina QNovember 2019Not Determined
31524118Create StudyTreatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naïve patients with psychosis.Psychological medicineBojesen, Kirsten B; Ebdrup, Bjørn H; Jessen, Kasper; Sigvard, Anne; Tangmose, Karen; Edden, Richard A E; Larsson, Henrik B W; Rostrup, Egill; Broberg, Brian V; Glenthøj, Birte YOctober 1, 2020Not Determined
30758329Create StudyEffects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyPretzsch, Charlotte Marie; Freyberg, Jan; Voinescu, Bogdan; Lythgoe, David; Horder, Jamie; Mendez, Maria Andreina; Wichers, Robert; Ajram, Laura; Ivin, Glynis; Heasman, Martin; Edden, Richard A E; Williams, Steven; Murphy, Declan G M; Daly, Eileen; McAlonan, Gráinne MJuly 2019Not Determined
30390554Create StudyNeurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla.Neurobiology of agingOeltzschner, Georg; Wijtenburg, S Andrea; Mikkelsen, Mark; Edden, Richard A E; Barker, Peter B; Joo, Jin Hui; Leoutsakos, Jeannie-Marie S; Rowland, Laura M; Workman, Clifford I; Smith, Gwenn SJanuary 2019Not Determined
30282724Create StudyOpposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing.The Journal of neuroscience : the official journal of the Society for NeuroscienceKurcyus, Katarzyna; Annac, Efsun; Hanning, Nina M; Harris, Ashley D; Oeltzschner, Georg; Edden, Richard; Riedl, ValentinNovember 2018Not Determined
29752742Create StudyJ-difference-edited MRS measures of γ-aminobutyric acid before and after acute caffeine administration.Magnetic resonance in medicineOeltzschner, Georg; Zöllner, Helge J; Jonuscheit, Marc; Lanzman, Rotem S; Schnitzler, Alfons; Wittsack, Hans-JörgDecember 2018Not Determined
29215137Create StudyFrequency and phase correction for multiplexed edited MRS of GABA and glutathione.Magnetic resonance in medicineMikkelsen M, Saleh MG, Near J, Chan KL, Gong T, Harris AD, Oeltzschner G, Puts NAJ, Cecil KM, Wilkinson ID, Edden RAEDecember 2017Not Determined
29073732Create StudyHadamard editing of glutathione and macromolecule-suppressed GABA.NMR in biomedicineOeltzschner, Georg; Chan, Kimberly L; Saleh, Muhammad G; Mikkelsen, Mark; Puts, Nicolaas A; Edden, Richard A EJanuary 2018Not Determined
28960581Create StudyInhibitory motor dysfunction in parkinson's disease subtypes.Journal of magnetic resonance imaging : JMRIGong T, Xiang Y, Saleh MG, Gao F, Chen W, Edden RAE, Wang GSeptember 2017Not Determined
28898569Create StudyAltered task-related modulation of long-range connectivity in children with autism.Autism research : official journal of the International Society for Autism ResearchPillai, Ajay S; McAuliffe, Danielle; Lakshmanan, Balaji M; Mostofsky, Stewart H; Crone, Nathan E; Ewen, Joshua BFebruary 2018Not Determined
28745021Create StudyThe impact of T1 versus EPI spatial normalization templates for fMRI data analyses.Human brain mappingCalhoun VD, Wager TD, Krishnan A, Rosch KS, Seymour KE, Nebel MB, Mostofsky SH, Nyalakanai P, Kiehl KJuly 2017Not Relevant
28734060Create StudyEffects of eddy currents on selective spectral editing experiments at 3T.Journal of magnetic resonance imaging : JMRIOeltzschner, Georg; Snoussi, Karim; Puts, Nicolaas A; Mikkelsen, Mark; Harris, Ashley D; Pradhan, Subechhya; Tsapkini, Kyrana; Schär, Michael; Barker, Peter B; Edden, Richard A EMarch 2018Not Determined
28089657Create StudyAutism spectrum disorder in the scope of tactile processing.Developmental cognitive neuroscienceMikkelsen, Mark; Wodka, Ericka L; Mostofsky, Stewart H; Puts, Nicolaas A JJanuary 2018Not Relevant
27751663Create StudyAnomalous Putamen Volume in Children With Complex Motor Stereotypies.Pediatric neurologyMahone EM, Crocetti D, Tochen L, Kline T, Mostofsky SH, Singer HSDecember 2016Not Determined
27685800Create StudyAltered neurotransmitter metabolism in adolescents with high-functioning autism.Psychiatry researchDrenthen GS, Barendse EM, Aldenkamp AP, Van Veenendaal TM, Puts NA, Edden RA, Zinger S, Thoonen G, Hendriks MP, Kessels RP, Jansen JFOctober 2016Not Determined
27653620Create StudyDyspraxia in ASD: Impaired coordination of movement elements.Autism research : official journal of the International Society for Autism ResearchMcauliffe D, Pillai AS, Tiedemann A, Mostofsky SH, Ewen JBApril 2017Not Determined
27611990Create StudyReduced GABA and altered somatosensory function in children with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchPuts, Nicolaas A J; Wodka, Ericka L; Harris, Ashley D; Crocetti, Deana; Tommerdahl, Mark; Mostofsky, Stewart H; Edden, Richard A EApril 2017Not Determined
27534734Create StudySimultaneous edited MRS of GABA and glutathione.NeuroImageSaleh MG, Oeltzschner G, Chan KL, Puts NA, Mikkelsen M, Schär M, Harris AD, Edden RAAugust 2016Not Relevant
27239903Create StudyProspective frequency correction for macromolecule-suppressed GABA editing at 3T.Journal of magnetic resonance imaging : JMRIEdden, Richard A E; Oeltzschner, Georg; Harris, Ashley D; Puts, Nicolaas A J; Chan, Kimberly L; Boer, Vincent O; Schär, Michael; Barker, Peter BDecember 2016Not Relevant
helpcenter.collection.publications-tab

NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
14407/15/2017
105
Approved
To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.
Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADOS info icon
14407/15/2017
56
Approved
ADI-R info icon
14407/15/2017
10
Approved
Spectroscopy info icon
14407/15/2017
53
Approved
Vibrotactile Behavioral Battery info icon
14407/15/2017
91
Approved
Structure not yet defined
No Status history for this Data Expected has been recorded yet
helpcenter.collection.data-expected-tab

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitrySocial-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.9/1708Secondary AnalysisShared
* Data not on individual level
helpcenter.collection.associated-studies-tab

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.
Edit