NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Status: The visibility status of an NDA Collection.  Collection Status can be Shared or Private.  Collections in Shared status are visible to all users and can be searched in the NDA Query Tool. Private Collections are not visible to NDA users.  The Status of an NDA Collection only affects the visibility of information about the Collection (metadata) and does not relate to the status of the record-level research data in the NDA Collection.

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.
 

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
     
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
     
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection.  The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
     
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
     
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected. 

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial.  When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
     
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
     
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/about/sharing-regimen.html), the embargo on Data Expected information is released.
     

Funding Source

The organization(s) responsible for providing the funding is listed here. 

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program  Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only. 

Grant Information 

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH. 

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials. 

Frequently Asked Questions

  • When a Collection is created by NDA staff and marked as Shared, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.

  • During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.

  • The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.

  • In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

  • Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.

  • A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users. 

  • Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.

  • The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different.  Collection users with Administrative Privileges are encouraged to edit the Collection Phase.  The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page.  This field is sortable alphabetically in ascending or descending order. Collection Phase options include: 

    • Pre-Enrollment:  A grant/project has started, but has not yet enrolled subjects.
    • Enrolling:  A grant/project has begun enrolling subjects.  Data submission is likely ongoing at this point.
    • Data Analysis:  A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed:  A grant/project has reached the project end date.
  • The Collection State indicates whether the Collection is viewable and searchable.  Collections can be either Private, Shared, or an Ongoing Study.  A Collection that is shared does not necessarily have shared data as the Collection State and state of data are independent of each other.  This field can be edited by Collection users with Administrative Privileges and the Program Officer as listed in eRA (for NIH funded grants). Changes must be saved by clicking the Save button at the bottom of the page.

  • An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.

  • Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.

  • Provides the grant number(s) for the grant(s) associated with the Collection.  The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.

  • A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims. 

  • NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements. 

  • Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.

  • Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.

  • Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.  

  • The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

NDA Help Center

Collection - Shared Data Tab

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

 

Frequently Asked Questions

  • To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection.  Alternatively, you may review an NDA Study Attribution Report available on the General tab.  

  • Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.

  • Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges.  Please contact a program staff member at the appropriate funding institution for more information.

Glossary

  • A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure

  • A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.

  • The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared.  A Shared NDA Collection or NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account.  A Shared Collection or NDA Study does not necessarily mean that data submitted to the Collection or used in the NDA Study have been shared as this is independently determined.  Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions.  Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared, but will only be viewable and accessible if the Collection is Shared.

NDA Help Center

fMRi

fMRI stands for functional magnetic resonance imaging. fMRI tests measure blood flow, providing detailed functional images of the brain or body. 

Acquisition
The Acquisition parameters needed for an experiment include the following:

The name of the experiment is required. Please be concise and specific as possible.
Following experiment name, selection boxes are provided for the Equipment, Software, or other items specific to the experiment type. At least one selection is required for each. If NDAR does not have the appropriate listing, select Add New to add the information provided. Following the selection boxes, provide additional information may be required depending on the experiment type. Any required items are denoted by an asterisk (*).

Block/Event Design
At least one block/event is required. Note that any fields denoted with an asterisk (*) are required. All data must be devoid of personally identifiable data, including the contents of any files attached to the experiment.

Note: To simplify the definition of multiple events, we provide an Import from XML function. This function supports importing data from all three experiment sections (Acquisition, Block/Event Design, and Post Processing), at this time files cannot be uploaded from XML A test format is provided here and our XML Schema Definition (xsd) can be found here.

Post Processing
If you have completed any post-processing on your data, please choose 'Yes' for Has Postprocessing? If not, select 'No'. Depending on this selection the remaining post-processing fields will be enabled (some of which will be required). If you are initially providing data you can select 'No', then return to the experiment to add post-processing steps at a later date when the data are being provided.

Please provide information about post-processing manipulations, i.e. artifact detection algorithms, segmentation used for post data collection, items denoted with an asterisk (*) are required.

Frequently Asked Questions

Glossary

  • This button will add all selections to the Filter Cart. 

  • This button will allow you to copy all of the Experiment details as a template for a new experiment. 

  • Adds all data from the current selections in a Collection or NDA Study to the Filter Cart.

  • This button will allow you to return to the Experiments tab. 

NDA Help Center

Collection - Submissions Tab

Users with permission to access Shared data in the Collection’s assigned Permission Group may use this tab. 

Here, you can:

  • Review your uploads to your Collection, monitor their status, and download them individually to verify their contents.
  • Download individual datasets as a secondary user of the data approved for access.
  • Identify and download datasets containing errors identified by NDA's QA/QC process for review and resolution.
  • Report suspected or discovered Personally Identifiable Information in a submission via the Actions column.

Frequently Asked Questions

Glossary

  • The default view of Datasets within a Collection's Submission tab.

  • A Submission Loading Status on a Collection's Submission Tab that indicates that an issue has prevented the successful loading of the submission.  Users should contact the NDA Help Desk for assistance at NDAHelp@mail.nih.gov.

  • The NDA has two Submission Cycles per year - January 15 and July 15.

  • An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.  

  • The unique and sequentially assigned ID for a submission (e.g. a discrete upload via the Validation and Upload Tool), which may contain any number of datafiles, Data Structures and/or Data Types, regardless of the Submission Loading Status. A single submission may be divided into multiple Datasets, which are based on Data Type.

  • The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

  • The total number of unique subjects for whom data have been submitted, which includes data in both a Private State and a Shared State.

NDA Help Center

Collection - Publications Tab

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab. 

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column. 

 

Frequently Asked Questions

  • Publications are considered relevant to a collection when the data shared is directly related to the project or collection.

  • PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM). 

Glossary

  • A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.

  • Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.

  • A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.

  • PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.

  • The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.  

  • A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

NDA Help Center

EEG

EEG stands for electroencencephalogram and is a test used to measure electrical activity in the brain.

Acquisition
The Acquisition parameters needed for an experiment include the following:

Name of the experiment is required. Please be concise and specific as possible.
Following experiment name, selection boxes are provided for the Equipment, Software, or other items specific to experiment type. At least one selection is required for each. If NDAR does not have the appropriate listing, select Add New to add the information provided. Following the selection boxes, provide additional information may be required depending on experiment type. Any required items are denoted by an asterisk (*).

Block/Event Design
At least one block/event is required. Note that any fields denoted with an asterisk (*) are required. All data must be devoid of personally identifiable data, including the contents of any files attached to the experiment.

Note: To simplify definition of multiple events, we provide an Import from XML function. This function supports importing data from all three experiment sections (Acquisition, Block/Event Design, and Post Processing), at this time files cannot be uploaded from XML A test format is provided here and our XML Schema Definition (xsd) can be found here.

Post Processing
If you have completed any post processing on your data, please choose 'Yes' for Has Postprocessing? If not, select 'No'. Depending on this selection the remaining post processing fields will be enabled (some of which will be required). If you are initially providing data you can select 'No', then return to the experiment to add post processing steps at a later date when the data are being provided.

Please provide information about post-processing manipulations, i.e. artifact detection algorithms, segmentation used for post data collection, items denoted with an asterisk (*) are required.

Frequently Asked Questions

Glossary

  • This button will add all selections to the Filter Cart. 

  • This button will allow you to copy all of the Experiment details as a template for a new experiment. 

  • Adds all data from the current selections in a Collection or NDA Study to the Filter Cart.

  • This button will allow you to return to the Experiments tab. 

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Contributing researchers just getting started on their project will need to define this list by adding all of the items they are collecting under their grant and setting their schedule according to the NDA Data Sharing Regimen. If you fall into this category, you can begin by clicking "add new Data Expected" and selecting which data structures you will be using, saving the page after each change, or requesting new structures by adding and naming a new item, providing any materials NDA Data Dictionary Curators can use to help define your structure. For more information see the tutorial on creating Data Expected.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

 

Frequently Asked Questions

  • An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.

  • The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

  • Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.

  • Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.

  • A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure

  • An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).

  • A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more. 

  • A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database.  Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.

  • Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.

  • Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.

  • Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.

  • An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.

  • The NDA has two Submission Cycles per year - January 15 and July 15.

  • An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.  

NDA Help Center

Collection - Permissions

Collection Owners, Program Officers, and users with Administrator privileges may view this tab.

The available permission groups include:

  • Query: This read-only access is generally for NIH Program Officers
  • Submission: This will grant read access and allow the user to upload data and create experiment definitions. This is for the typical contributing personnel member.
  • Administrator: In addition to the access provided to Query and Submission users, Admins can also edit the Collection itself, create or edit the Data Expected list, and edit user permissions. This access is for the PI, data managers, and anyone they wish to delegate this to.

The PI has a special designation as the Collection Owner in addition to administrator access.

Frequently Asked Questions

  • Collection Owners and Admins may assign Collection Privileges to anyone.

  • Yes, you can assign various Privileges to other users with an NDA account.

  • If you are the Collection Owner or have Admin privileges, you can view and make changes to the list of individuals who have access to the Collection on the Collection's Permissions tab.  Information on users who have access to data Shared in your Collection because they were granted access to a Permission Group is not available.

  • Staff/collaborators who are working submitting data to the Collection, checking the quality of the data, and/or analyzing data should have access for the duration of the project until all data have been submitted, NDA Studies have been created for data used in publications, and/or a collaborative relationship with the user exists.  

  • The individual listed as an Investigator on the General tab of the NDA Collection will generally be able to provide a user access to the NDA Collection.  Additional users may also have this ability if granted Administrator access to an NDA Collection; however, these users are not viewable unless your account has access to the NDA Collection.  Given this, it is best to contact the Investigator to request access to the Collection.

  • Privileges that can be assigned to a user include:
    Submission allows a user to submit data to Collection
    Query allows the user to download data from Collection even when in a Private state
    Admin is both the Submission and Query Privilege + the ability to give privileges to other users.

  • You may have staff who are working on the submission of data or other activities associated with data sharing such as the definition of the Data Expected list or NDA Experiment creation.  Also, many projects have multiple performance sites and wish to share data among the site PIs.  Submitting to the NDA facilitates access by all investigators working on a project even before data have been shared with other users.  You can control who gets access to data while in a Private state.

Glossary

  • A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users. 

  • Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.

NDA Help Center

Eye Tracking

EyeTracking tests follow the movement of the eye. The visual trajectory or focus can help determine predictions and assist in diagnoses. 

Acquisition
The Acquisition parameters needed for an experiment include the following:

The name of the experiment is required. Please be concise and specific as possible.
Following experiment name, selection boxes are provided for the Equipment, Software, or other items specific to the experiment type. At least one selection is required for each. If NDAR does not have the appropriate listing, select Add New to add the information provided. Following the selection boxes, provide additional information may be required depending on the experiment type. Any required items are denoted by an asterisk (*).

Block/Event Design
At least one block/event is required. Note that any fields denoted with an asterisk (*) are required. All data must be devoid of personally identifiable data, including the contents of any files attached to the experiment.

Note: To simplify the definition of multiple events, we provide an Import from XML function. This function supports importing data from all three experiment sections (Acquisition, Block/Event Design, and Post Processing), at this time files cannot be uploaded from XML A test format is provided here and our XML Schema Definition (xsd) can be found here.

Post Processing
If you have completed any post-processing on your data, please choose 'Yes' for Has Postprocessing? If not, select 'No'. Depending on this selection the remaining post-processing fields will be enabled (some of which will be required). If you are initially providing data you can select 'No', then return to the experiment to add post-processing steps at a later date when the data are being provided.

Please provide information about post-processing manipulations, i.e. artifact detection algorithms, segmentation used for post data collection, items denoted with an asterisk (*) are required.

Frequently Asked Questions

Glossary

  • This button will add all selections to the Filter Cart. 

  • This button will allow you to copy all of the Experiment details as a template for a new experiment. 

  • Adds all data from the current selections in a Collection or NDA Study to the Filter Cart.

  • This button will allow you to return to the Experiments tab. 

NDA Help Center

Collection - Experiments Tab

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.  
    2. Associate the experiment to the collection. No modifications can be made to the experiment.

     

Glossary

  • An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.

  • The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

NDA Help Center

Omics

Omics is a collective group of technologies, related to a field of study in Biology such as Genomics or proteomics. 

Experiment Parameters

To define an Omics experiment, provide a meaningful name and select a single molecule. The standard molecules are listed. However, if you are doing proteomic or environmental experiments, simply “Add New” and the new selection will be created. Only one value for molecule is permitted.

Next the technology (box 2) associated with the molecule will be presented along with its application. Again, only one selection is possible. If you wish to see all of NDAR’s options for any one box, Select “Show All”.

Platform

Continue to select the Platform (box 3).

Extraction

Next, the Extraction Protocol (box 4) and Kits (box 5) are presented based upon the Molecule selected and the Processing Protocol (box 6) and Kits (box 7) are presented based upon the Molecule and Technology Application (Box 1 and 2)

Processing

Note that for each of these (boxes 4, 5, 6, and 7) multiple selections are possible.

Additional Information

Lastly, the Software (box 8) and Equipment (box 9) is expected.

 

Once saved, the experiment will be associated with the Collection and by using the returned Experiment_ID, the NDA makes it possible to associate the experiment meta data directly with the data from the experiment.

Frequently Asked Questions

Glossary

  • This button will add all selections to the Filter Cart. 

  • This button will allow you to copy all of the Experiment details as a template for a new experiment. 

  • Adds all data from the current selections in a Collection or NDA Study to the Filter Cart.

  • This button will allow you to return to the Experiments tab. 

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner. 

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data. 

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public. 

Frequently Asked Questions

  • Studies are associated to the Collection automatically when the data is defined in the Study. 

Glossary

  • A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Loading...

National Institute of Mental Health Data Archive (NDA) Sign In
National Institute of Mental Health Data Archive (NDA) Sign In
NDA

Success! An email is on its way!

Please check your email to complete the linking process. The link you receive is only valid for 30 minutes.

Check your spam or junk folder if you do not receive the email in the next few minutes.

Warning Notice This is a U.S. Government computer system, which may be accessed and used only for authorized Government business by authorized personnel. Unauthorized access or use of this computer system may subject violators to criminal, civil, and/or administrative action. All information on this computer system may be intercepted, recorded, read, copied, and disclosed by and to authorized personnel for official purposes, including criminal investigations. Such information includes sensitive data encrypted to comply with confidentiality and privacy requirements. Access or use of this computer system by any person, whether authorized or unauthorized, constitutes consent to these terms. There is no right of privacy in this system.
Create an Account
NIMH Data Archive (NDA) Sign In or Create An Account
Update Password

You have logged in with a temporary password. Please update your password. Passwords must contain 8 or more characters and must contain at least 3 of the following types of characters:

  • Uppercase
  • Lowercase
  • Numbers
  • Special Characters limited to: %,_,!,@,#,$,-,%,&,+,=,),(,*,^,:,;

Subscribe to our mailing list

Mailing List(s)
Email Format

You are now leaving the NIMH Data Archive (NDA) web site to go to:

Click on the address above if the page does not change within 10 seconds.

Disclaimer

NDA is not responsible for the content of this external site and does not monitor other web sites for accuracy.

Accept Terms
Data Access Terms - Decline Terms

Are you sure you want to cancel? This will decline terms and you will not be authorized for access.

Filter Cart
No filters selected
Description
Value Range
Notes
Data Structures with shared data
No filters have been selected
Switch User

1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

SelectExperiment IdExperiment NameExperiment Type
Created On
24HI-NGS_R1Omics02/16/2011
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
506PVPREFOmics08/05/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
26ASD_MethylationOmics03/01/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
41ImmunofluorescenceOmics05/11/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
519RestingfMRI11/08/2016
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
145AGRE/FMR1_Illumina.JHUOmics04/14/2014
146AGRE/MECP2_Sanger.JHUOmics04/14/2014
147AGRE/MECP2_Junior.JHUOmics04/14/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
154Math Autism Study - Vinod MenonfMRI07/15/2014
155RestingfMRI07/25/2014
156SpeechfMRI07/25/2014
159EmotionfMRI07/25/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
Collection - Add Experiment
Add Supporting Documentation
Select File

Please enter the name of the data structure to search or if your definition does not exist, please upload that definition so that it can be appropriately defined for submission. Multiple data structures may be associated with a single Data Expected entry. Please add only one data structure per assessment.

Request Submission Exemption
Characters Remaining:
Not Eligible

The Data Expected list for this Collection shows some raw data as missing. Contact the NDA Help Desk with any questions.

Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

[CMS] Attention
[CMS] Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.
[CMS] Error

[CMS]

Unable to change collection phase where targeted enrollment is less than 90%

Delete Submission Exemption
Are you sure you want to delete this submission exemption?
You have requested to move the sharing dates for the following assessments:
Data Expected Item Original Sharing Date New Sharing Date

Please provide a reason for this change, which will be sent to the Program Officers listed within this collection:

Explanation must be between 20 and 200 characters in length.

Please press Save or Cancel
Add New Email Address - Dialog
New Email Address
Shared
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
UCLA Sigman/Bookheimer ACE and ARRA
Sigman M, Geschwind D, Bookheimer S 
ACE Projects: 1) PI Sigman - Infant Sibs. 2) PI Geschwind - Genetics. 3) PI Dapretto - Mirror neuron and imaging. 4) PI Kasari - Optimizing outcomes for toddlers. 5) PI McCracken - Understanding repetitive behaviors. ARRA: PI Bookheimer - Neural and Phenotypic Correlates of Autism Risk Genes
NIMH Data Archive
04/01/2008
Autism Centers of Excellence (ACE)
Funding Completed
Close Out
Shared
No
$8,207,980.00
452
Loading Chart...
NIH - Extramural None


P50HD055784-01 Determinants of Social, Communicative, and Other Core Deficits in Autism 08/06/2007 07/31/2012 872 533 UNIVERSITY OF CALIFORNIA LOS ANGELES $7,117,866.00
R01HD065280-01 Neural and Phenotypic Correlates of Autism Risk Genes 09/30/2009 08/31/2012 120 20 UNIVERSITY OF CALIFORNIA LOS ANGELES $1,090,114.00

helpcenter.collection.general-tab

NDA Help Center

Collection - General

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Status: The visibility status of an NDA Collection. Collection Status can be Shared or Private. Collections in Shared status are visible to all users and can be searched in the NDA Query Tool. Private Collections are not visible to NDA users. The Status of an NDA Collection only affects the visibility of information about the Collection (metadata) and does not relate to the status of the record-level research data in the NDA Collection.

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/about/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those withAdministrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the optionis also available tolimit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project capturedby the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff and marked as Shared, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Collection State
    The Collection State indicates whether the Collection is viewable and searchable. Collections can be either Private, Shared, or an Ongoing Study. A Collection that is shared does not necessarily have shared data as the Collection State and state of data are independent of each other. This field can be edited by Collection users with Administrative Privileges and the Program Officer as listed in eRA (for NIH funded grants). Changes must be saved by clicking the Save button at the bottom of the page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType
65SNP genotypes Illumina 370k07/30/2012ApprovedOmics
67SNP genotypes Illumina Omni-1: 2010-139, 2010-043, 2011-00508/20/2012ApprovedOmics
68SNP genotypes Illumina OmniExpress: 2011-01508/20/2012ApprovedOmics
helpcenter.collection.experiments-tab

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 286
Autism Diagnostic Observation Schedule (ADOS) - Module 4 Clinical Assessments 4
Autism Diagnostic Observation Schedule (ADOS)- Module 1 Clinical Assessments 3
Autism Diagnostic Observation Schedule (ADOS)- Module 2 Clinical Assessments 37
Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 144
CHARGE Medical History Clinical Assessments 211
CHARGE Physical Exam Clinical Assessments 193
Genomics Sample Genomics 180
Genomics Subject Genomics 180
Image Imaging 161
Karyotype Clinical Assessments 22
Modified CHARGE Family Medical History (2007) Clinical Assessments 161
Modified CHARGE Family Medical History (rev July 2007) Clinical Assessments 1
Mullen Scales of Early Learning Clinical Assessments 101
Stanford-Binet Intelligence Scales, Fifth Edition (SB5) Clinical Assessments 29
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 257
Wechsler Intelligence Scale for Children - IV [part 2] Clinical Assessments 65
helpcenter.collection.shared-data-tab

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Collection or NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared Collection or NDA Study does not necessarily mean that data submitted to the Collection or used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared, but will only be viewable and accessible if the Collection is Shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
35678946Create StudyPredictors of Attrition in a Randomized Trial of a Social Communication Intervention for Infant-Toddlers at Risk for Autism.Journal of autism and developmental disordersSterrett, Kyle; Magaña, Maira Tafolla; Gulsrud, Amanda; Paparella, Tanya; Kasari, ConnieJune 9, 2022Not Determined
35437928Create StudySuper responders: Predicting language gains from JASPER among limited language children with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchPanganiban, Jonathan; Kasari, ConnieAugust 1, 2022Not Determined
34882790Create StudyAtypical cerebellar functional connectivity at 9 months of age predicts delayed socio-communicative profiles in infants at high and low risk for autism.Journal of child psychology and psychiatry, and allied disciplinesOkada, Nana J; Liu, Janelle; Tsang, Tawny; Nosco, Erin; McDonald, Nicole M; Cummings, Kaitlin K; Jung, Jiwon; Patterson, Genevieve; Bookheimer, Susan Y; Green, Shulamite A; Jeste, Shafali S; Dapretto, MirellaSeptember 1, 2022Not Determined
34807457Create StudyStudying the early emergence of autism: what is the goal of baby siblings research?Developmental medicine and child neurologyMcDonald, Nicole MMay 1, 2022Not Determined
34797038Create StudyParenting stress in caregiver-mediated interventions for toddlers with autism: An application of quantile regression mixed models.Autism research : official journal of the International Society for Autism ResearchSchlink, Andrew; Williams, Justin; Pizzano, Maria; Gulsrud, Amanda; Kasari, ConnieFebruary 1, 2022Not Determined
34158222Create StudyDrug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.European neuropsychopharmacology : the journal of the European College of NeuropsychopharmacologyMcCracken, James T; Anagnostou, Evdokia; Arango, Celso; Dawson, Geraldine; Farchione, Tiffany; Mantua, Valentina; McPartland, James; Murphy, Declan; Pandina, Gahan; Veenstra-VanderWeele, Jeremy; ISCTM/ECNP ASD Working GroupJuly 1, 2021Not Determined
34109620Create StudyEarly concerns in parents of infants at risk for autism.Developmental medicine and child neurologyTran, Amanda T; Del Rosario, Mithi; Nosco, Erin; Li, Yihao; Senturk, Damla; Mcdonald, Nicole M; Wilson, Rujuta B; Dapretto, Mirella; Jeste, Shafali SDecember 1, 2021Not Determined
34098753Create StudyWhat are the odds? Predicting the likelihood of a negative episode in a sample of toddlers with autism spectrum disorder.Autism : the international journal of research and practiceDimachkie Nunnally, Amanda; Sterrett, Kyle; Gulsrud, Amanda; Kasari, ConnieNovember 1, 2021Not Determined
34050248Create StudyTranscriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes.Scientific reportsMullegama, Sureni V; Klein, Steven D; Williams, Stephen R; Innis, Jeffrey W; Probst, Frank J; Haldeman-Englert, Chad; Martinez-Agosto, Julian A; Yang, Ying; Tian, Yuchen; Elsea, Sarah H; Ezashi, ToshihikoMay 28, 2021Not Determined
33866373Create StudyAltered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991)Nair, Aarti; Jalal, Rhideeta; Liu, Janelle; Tsang, Tawny; McDonald, Nicole M; Jackson, Lisa; Ponting, Carolyn; Jeste, Shafali S; Bookheimer, Susan Y; Dapretto, MirellaJuly 29, 2021Not Determined
33860866Create StudyBeyond Baby Siblings-Expanding the Definition of "High-Risk Infants" in Autism Research.Current psychiatry reportsMcDonald, Nicole M; Jeste, Shafali SApril 16, 2021Not Determined
33587311Create StudyAssociations between physiological and neural measures of sensory reactivity in youth with autism.Journal of child psychology and psychiatry, and allied disciplinesJung, Jiwon; Zbozinek, Tomislav D; Cummings, Kaitlin K; Wilhelm, Frank H; Dapretto, Mirella; Craske, Michelle G; Bookheimer, Susan Y; Green, Shulamite AOctober 1, 2021Not Determined
33436538Create StudySensory over-responsivity is related to GABAergic inhibition in thalamocortical circuits.Translational psychiatryWood, Emily T; Cummings, Kaitlin K; Jung, Jiwon; Patterson, Genevieve; Okada, Nana; Guo, Jia; O'Neill, Joseph; Dapretto, Mirella; Bookheimer, Susan Y; Green, Shulamite AJanuary 12, 2021Not Determined
33389145Create Study5q35 duplication presents with psychiatric and undergrowth phenotypes mediated by NSD1 overexpression and mTOR signaling downregulation.Human geneticsQuintero-Rivera, Fabiola; Eno, Celeste C; Sutanto, Christine; Jones, Kelly L; Nowaczyk, Małgorzata J M; Wong, Derek; Earl, Dawn; Mirzaa, Ghayda; Beck, Anita; Martinez-Agosto, Julian AApril 1, 2021Not Determined
33368921Create StudyLack of neural evidence for implicit language learning in 9-month-old infants at high risk for autism.Developmental scienceLiu, Janelle; Tsang, Tawny; Ponting, Carolyn; Jackson, Lisa; Jeste, Shafali S; Bookheimer, Susan Y; Dapretto, MirellaJuly 1, 2021Not Determined
33043498Create StudyFunctional connectivity during language processing in 3-month-old infants at familial risk for autism spectrum disorder.The European journal of neuroscienceTran, Xuan A; McDonald, Nicole; Dickinson, Abigail; Scheffler, Aaron; Frohlich, Joel; Marin, Andrew; Kure Liu, Christopher; Nosco, Erin; Şentürk, Damla; Dapretto, Mirella; Spurling Jeste, ShafaliMarch 1, 2021Not Determined
32860348Create StudySex Differences in Salience Network Connectivity and its Relationship to Sensory Over-Responsivity in Youth with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism ResearchCummings, Kaitlin K; Lawrence, Katherine E; Hernandez, Leanna M; Wood, Emily T; Bookheimer, Susan Y; Dapretto, Mirella; Green, Shulamite ASeptember 2020Not Determined
32798139Create StudyMultivariate Neural Connectivity Patterns in Early Infancy Predict Later Autism Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimagingDickinson, Abigail; Daniel, Manjari; Marin, Andrew; Gaonkar, Bilwaj; Dapretto, Mirella; McDonald, Nicole M; Jeste, ShafaliJanuary 1, 2021Not Determined
32658762Create StudyEmerging atypicalities in functional connectivity of language-related networks in young infants at high familial risk for ASD.Developmental cognitive neuroscienceLiu, Janelle; Okada, Nana J; Cummings, Kaitlin K; Jung, Jiwon; Patterson, Genevieve; Bookheimer, Susan Y; Jeste, Shafali S; Dapretto, MirellaOctober 1, 2020Not Determined
32634676Create StudyFunctional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease.Current opinion in genetics & developmentWamsley, Brie; Geschwind, Daniel HDecember 1, 2020Not Determined
32215919Create StudyElectrophysiological signatures of visual statistical learning in 3-month-old infants at familial and low risk for autism spectrum disorder.Developmental psychobiologyMarin, Andrew; Hutman, Ted; Ponting, Carolyn; McDonald, Nicole M; Carver, Leslie; Baker, Elizabeth; Daniel, Manjari; Dickinson, Abigail; Dapretto, Mirella; Johnson, Scott P; Jeste, Shafali SSeptember 1, 2020Not Determined
31696785Create StudyPositive social feedback alters emotional ratings and reward valuation of neutral faces.Quarterly journal of experimental psychology (2006)Young, Katherine S; Hasratian, Anni M; Parsons, Christine E; Zinbarg, Richard E; Nusslock, Robin; Bookheimer, Susan Y; Craske, Michelle GJuly 2020Not Determined
31654560Create StudyBehavioral characterization of dup15q syndrome: Toward meaningful endpoints for clinical trials.American journal of medical genetics. Part ADiStefano, Charlotte; Wilson, Rujuta B; Hyde, Carly; Cook, Edwin H; Thibert, Ronald L; Reiter, Lawrence T; Vogel-Farley, Vanessa; Hipp, Joerg; Jeste, ShafaliJanuary 2020Not Determined
31639285Create StudyMutations in the sonic hedgehog pathway cause macrocephaly-associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway.American journal of medical genetics. Part AKlein, Steven D; Nguyen, Dzung C; Bhakta, Viraj; Wong, Derek; Chang, Vivian Y; Davidson, Tom B; Martinez-Agosto, Julian ADecember 2019Not Determined
31589284Create StudyDevelopmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study.JAMA neurologyMcDonald, Nicole M; Senturk, Damla; Scheffler, Aaron; Brian, Jessica A; Carver, Leslie J; Charman, Tony; Chawarska, Katarzyna; Curtin, Suzanne; Hertz-Piccioto, Irva; Jones, Emily J H; Klin, Ami; Landa, Rebecca; Messinger, Daniel S; Ozonoff, Sally; Stone, Wendy L; Tager-Flusberg, Helen; Webb, Sara Jane; Young, Gregory; Zwaigenbaum, Lonnie; Jeste, Shafali SJanuary 2020Not Determined
31585457Create StudyDefining and distinguishing infant behavioral states using acoustic cry analysis: is colic painful?Pediatric researchParga, Joanna J; Lewin, Sharon; Lewis, Juanita; Montoya-Williams, Diana; Alwan, Abeer; Shaul, Brianna; Han, Carol; Bookheimer, Susan Y; Eyer, Sherry; Dapretto, Mirella; Zeltzer, Lonnie; Dunlap, Lauren; Nookala, Usha; Sun, Daniel; Dang, Bianca H; Anderson, Ariana EFebruary 2020Not Determined
31500805Create StudySynaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders.Biological psychiatryForsyth, Jennifer K; Nachun, Daniel; Gandal, Michael J; Geschwind, Daniel H; Anderson, Ariana E; Coppola, Giovanni; Bearden, Carrie EJanuary 2020Not Determined
31462477Create StudyMulticentre, randomised waitlist control trial investigating a parent-assisted social skills group programme for adolescents with brain injuries: protocol for the friends project.BMJ openGilmore, Rose; Sakzewski, Leanne; Ziviani, Jenny; Mcintyre, Sarah; Smithers Sheedy, Hayley; Hilton, Nicola; Williams, Tracey; Quinn, Kirsten; Sarandrea, Anne Marie; Laugeson, Elizabeth; Chatfield, MarkAugust 2019Not Determined
31419043Create StudyEarly patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex.Autism research : official journal of the International Society for Autism ResearchDickinson, Abigail; Varcin, Kandice J; Sahin, Mustafa; Nelson 3rd, Charles A; Jeste, Shafali SDecember 2019Not Determined
31312421Create StudyMechanisms underlying the EEG biomarker in Dup15q syndrome.Molecular autismFrohlich J, Reiter LT, Saravanapandian V, Distefano C, Huberty S, Hyde C, Chamberlain S, Bearden CE, Golshani P, Irimia A, Olsen RW, Hipp JF, Jeste SSJanuary 2019Not Determined
31241851Create StudyDevelopmental screening and early intervention in a childcare setting for young children at risk for autism and other developmental delays: A feasibility trial.Autism research : official journal of the International Society for Autism ResearchGulsrud, Amanda; Carr, Themba; Williams, Justin; Panganiban, Jonathan; Jones, Felica; Kimbrough, Jackie; Shih, Wendy; Kasari, ConnieSeptember 1, 2019Not Determined
31232238Create StudyHotspot Mutations in DICER1 Causing GLOW Syndrome-Associated Macrocephaly via Modulation of Specific microRNA Populations Result in the Activation of PI3K/ATK/mTOR Signaling.MicroRNA (Shariqah, United Arab Emirates)Klein, Steven D; Martinez-Agosto, Julian AJanuary 1, 2020Not Determined
31230465Create StudyDistinct Patterns of Neural Habituation and Generalization in Children and Adolescents With Autism With Low and High Sensory Overresponsivity.The American journal of psychiatryGreen, Shulamite A; Hernandez, Leanna; Lawrence, Katherine E; Liu, Janelle; Tsang, Tawny; Yeargin, Jillian; Cummings, Kaitlin; Laugeson, Elizabeth; Dapretto, Mirella; Bookheimer, Susan YDecember 2019Not Determined
31223334Create StudyEEG Data Collection in Children with ASD: The Role of State in Data Quality and Spectral Power.Research in autism spectrum disordersDiStefano, Charlotte; Dickinson, Abigail; Baker, Elizabeth; Jeste, Shafali SpurlingJanuary 2019Not Determined
31163191Create StudyMethodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies.Biological psychologySabatos-DeVito, Maura; Murias, Michael; Dawson, Geraldine; Howell, Toni; Yuan, Andrew; Marsan, Samuel; Bernier, Raphael A; Brandt, Cynthia A; Chawarska, Katarzyna; Dzuira, James D; Faja, Susan; Jeste, Shafali S; Naples, Adam; Nelson, Charles A; Shic, Frederick; Sugar, Catherine A; Webb, Sara J; McPartland, James C; Autism Biomarkers Consortium for Clinical TrialsSeptember 2019Not Determined
31150625Create StudyHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice.CellSharon, Gil; Cruz, Nikki Jamie; Kang, Dae-Wook; Gandal, Michael J; Wang, Bo; Kim, Young-Mo; Zink, Erika M; Casey, Cameron P; Taylor, Bryn C; Lane, Christianne J; Bramer, Lisa M; Isern, Nancy G; Hoyt, David W; Noecker, Cecilia; Sweredoski, Michael J; Moradian, Annie; Borenstein, Elhanan; Jansson, Janet K; Knight, Rob; Metz, Thomas O; Lois, Carlos; Geschwind, Daniel H; Krajmalnik-Brown, Rosa; Mazmanian, Sarkis KMay 2019Not Determined
31141683Create StudyReduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism.Cell reportsLazaro, Maria T; Taxidis, Jiannis; Shuman, Tristan; Bachmutsky, Iris; Ikrar, Taruna; Santos, Rommel; Marcello, G Mark; Mylavarapu, Apoorva; Chandra, Swasty; Foreman, Allison; Goli, Rachna; Tran, Duy; Sharma, Nikhil; Azhdam, Michelle; Dong, Hongmei; Choe, Katrina Y; Peñagarikano, Olga; Masmanidis, Sotiris C; Rácz, Bence; Xu, Xiangmin; Geschwind, Daniel H; Golshani, PeymanMay 2019Not Determined
30974225Create StudyERP evidence of semantic processing in children with ASD.Developmental cognitive neuroscienceDistefano C, Senturk D, Jeste SSApril 2019Not Determined
30901538Create StudyDefining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders.CellSullivan PF, Geschwind DHMarch 2019Not Determined
30632286Create StudySocial complexity and the early social environment affect visual social attention to faces.Autism research : official journal of the International Society for Autism ResearchTsang, Tawny; Johnson, Scott; Jeste, Shafali; Dapretto, MirellaMarch 2019Not Determined
30628809Create StudyEarly motor abilities in infants at heightened versus low risk for ASD: A Baby Siblings Research Consortium (BSRC) study.Journal of abnormal psychologyIverson, Jana M; Shic, Frederick; Wall, Carla A; Chawarska, Katarzyna; Curtin, Suzanne; Estes, Annette; Gardner, Judith M; Hutman, Ted; Landa, Rebecca J; Levin, April R; Libertus, Klaus; Messinger, Daniel S; Nelson, Charles A; Ozonoff, Sally; Sacrey, Lori-Ann R; Sheperd, Kelly; Stone, Wendy L; Tager-Flusberg, Helen B; Wolff, Jason J; Yirmiya, Nurit; Young, Gregory SJanuary 2019Not Determined
30542259Create StudyImbalance of Functional Connectivity and Temporal Entropy in Resting-State Networks in Autism Spectrum Disorder: A Machine Learning Approach.Frontiers in neuroscienceSmith, Robert X; Jann, Kay; Dapretto, Mirella; Wang, Danny J JJanuary 2018Not Determined
30541423Create StudyWhat's missing in autism spectrum disorder motor assessments?Journal of neurodevelopmental disordersWilson RB, Mccracken JT, Rinehart NJ, Jeste SSDecember 2018Not Determined
30506566Create StudyThe dysregulation profile in preschoolers with and without a family history of autism spectrum disorder.Journal of child psychology and psychiatry, and allied disciplinesMiller, Meghan; Iosif, Ana-Maria; Young, Gregory S; Bell, Laura J; Schwichtenberg, A J; Hutman, Ted; Ozonoff, SallyMay 2019Not Determined
30447054Create StudyMutations in STAG2 cause an X-linked cohesinopathy associated with undergrowth, developmental delay, and dysmorphia: Expanding the phenotype in males.Molecular genetics & genomic medicineMullegama, Sureni V; Klein, Steven D; Signer, Rebecca H; UCLA Clinical Genomics Center; Vilain, Eric; Martinez-Agosto, Julian AFebruary 2019Not Determined
30375176Create StudyAtypical longitudinal development of functional connectivity in adolescents with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchLawrence, Katherine E; Hernandez, Leanna M; Bookheimer, Susan Y; Dapretto, MirellaJanuary 2019Not Determined
30372577Create StudyAltered lateralization of dorsal language tracts in 6-week-old infants at risk for autism.Developmental scienceLiu, Janelle; Tsang, Tawny; Jackson, Lisa; Ponting, Carolyn; Jeste, Shafali S; Bookheimer, Susan Y; Dapretto, MirellaMay 2019Not Determined
30272146Create StudyThe Neuroanatomy of Autism Spectrum Disorder Symptomatology in 22q11.2 Deletion Syndrome.Cerebral cortex (New York, N.Y. : 1991)Gudbrandsen, M; Daly, E; Murphy, C M; Wichers, R H; Stoencheva, V; Perry, E; Andrews, D; Blackmore, C E; Rogdaki, M; Kushan, L; Bearden, C E; Murphy, D G M; Craig, M C; Ecker, CJuly 2019Not Determined
30084925Create StudyHybrid principal components analysis for region-referenced longitudinal functional EEG data.Biostatistics (Oxford, England)Scheffler, Aaron; Telesca, Donatello; Li, Qian; Sugar, Catherine A; Distefano, Charlotte; Jeste, Shafali; Şentürk, DamlaJanuary 2020Not Determined
29963691Create StudyOrganized physical activity programs: improving motor and non-motor symptoms in neurodevelopmental disorders.Developmental medicine and child neurologyRinehart, Nicole J; Jeste, Shafali; Wilson, Rujuta BSeptember 1, 2018Not Determined
29961422Create StudyRecurrence quantification analysis of resting state EEG signals in autism spectrum disorder - a systematic methodological exploration of technical and demographic confounders in the search for biomarkers.BMC medicineHeunis T, Aldrich C, Peters JM, Jeste SS, Sahin M, Scheffer C, De Vries PJJuly 2018Not Determined
29689375Create StudyInterhemispheric alpha-band hypoconnectivity in children with autism spectrum disorder.Behavioural brain researchDickinson, Abigail; DiStefano, Charlotte; Lin, Yin-Ying; Scheffler, Aaron Wolfe; Senturk, Damla; Jeste, Shafali SpurlingAugust 2018Not Determined
29540864Create StudyA randomized, placebo-controlled trial of extended-release guanfacine in children with autism spectrum disorder and ADHD symptoms: an analysis of secondary outcome measures.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyPolitte LC, Scahill L, Figueroa J, Mccracken JT, King B, Mcdougle CJJuly 2018Not Determined
29493557Create StudyMotor development and delay: advances in assessment of motor skills in autism spectrum disorders.Current opinion in neurologyWilson, Rujuta B; Enticott, Peter G; Rinehart, Nicole JApril 1, 2018Not Determined
29461424Create StudyDevelopmental disorders special issue: biomarkers and targeted therapeutics.Current opinion in neurologyJeste SSApril 2018Not Determined
28900778Create StudyEarly Gesture and Vocabulary Development in Infant Siblings of Children with Autism Spectrum Disorder.Journal of autism and developmental disordersIverson, Jana M; Northrup, Jessie B; Leezenbaum, Nina B; Parladé, Meaghan V; Koterba, Erin A; West, Kelsey LJanuary 2018Not Determined
28700096Create StudyPeak alpha frequency is a neural marker of cognitive function across the autism spectrum.The European journal of neuroscienceDickinson, Abigail; DiStefano, Charlotte; Senturk, Damla; Jeste, Shafali SpurlingMarch 1, 2018Relevant
28367513Create StudyCategorical versus dimensional approaches to autism-associated intermediate phenotypes in 22q11.2 microdeletion syndrome.Biological psychiatry. Cognitive neuroscience and neuroimagingJalbrzikowski, Maria; Ahmed, Khwaja Hamzah; Patel, Arati; Jonas, Rachel; Kushan, Leila; Chow, Carolyn; Bearden, Carrie EJanuary 2017Not Determined
28296084Create StudyDe novo loss-of-function variants in STAG2 are associated with developmental delay, microcephaly, and congenital anomalies.American journal of medical genetics. Part AMullegama, Sureni V; Klein, Steven D; Mulatinho, Milene V; Senaratne, Tharanga Niroshini; Singh, Kathryn; UCLA Clinical Genomics Center; Nguyen, Dzung C; Gallant, Natalie M; Strom, Samuel P; Ghahremani, Shahnaz; Rao, Nagesh P; Martinez-Agosto, Julian AMay 2017Not Determined
28291247Create StudyEnhancing studies of the connectome in autism using the autism brain imaging data exchange II.Scientific dataDi Martino, Adriana; O'Connor, David; Chen, Bosi; Alaerts, Kaat; Anderson, Jeffrey S; Assaf, Michal; Balsters, Joshua H; Baxter, Leslie; Beggiato, Anita; Bernaerts, Sylvie; Blanken, Laura M E; Bookheimer, Susan Y; Braden, B Blair; Byrge, Lisa; Castellanos, F Xavier; Dapretto, Mirella; Delorme, Richard; Fair, Damien A; Fishman, Inna; Fitzgerald, Jacqueline; Gallagher, Louise; Keehn, R Joanne Jao; Kennedy, Daniel P; Lainhart, Janet E; Luna, Beatriz; Mostofsky, Stewart H; Müller, Ralph-Axel; Nebel, Mary Beth; Nigg, Joel T; O'Hearn, Kirsten; Solomon, Marjorie; Toro, Roberto; Vaidya, Chandan J; Wenderoth, Nicole; White, Tonya; Craddock, R Cameron; Lord, Catherine; Leventhal, Bennett; Milham, Michael PMarch 2017Not Relevant
28284787Create StudySensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues.Developmental cognitive neuroscienceGreen, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C; Bookheimer, Susan Y; Dapretto, MirellaJanuary 2018Not Determined
28132692Create StudyA Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.American journal of human geneticsSchoch, Kelly; Meng, Linyan; Szelinger, Szabolcs; Bearden, David R; Stray-Pedersen, Asbjorg; Busk, Oyvind L; Stong, Nicholas; Liston, Eriskay; Cohn, Ronald D; Scaglia, Fernando; Rosenfeld, Jill A; Tarpinian, Jennifer; Skraban, Cara M; Deardorff, Matthew A; Friedman, Jeremy N; Akdemir, Zeynep Coban; Walley, Nicole; Mikati, Mohamad A; Kranz, Peter G; Jasien, Joan; McConkie-Rosell, Allyn; McDonald, Marie; Wechsler, Stephanie Burns; Freemark, Michael; Kansagra, Sujay; Freedman, Sharon; Bali, Deeksha; Millan, Francisca; Bale, Sherri; Nelson, Stanley F; Lee, Hane; Dorrani, Naghmeh; UCLA Clinical Genomics Center; Undiagnosed Diseases Network; Goldstein, David B; Xiao, Rui; Yang, Yaping; Posey, Jennifer E; Martinez-Agosto, Julian A; Lupski, James R; Wangler, Michael F; Shashi, VandanaFebruary 2017Not Relevant
28009726Create StudyThe emergence of autism spectrum disorder: insights gained from studies of brain and behaviour in high-risk infants.Current opinion in psychiatryVarcin, Kandice J; Jeste, Shafali SMarch 2017Not Relevant
27940149Create StudyClose genetic relationships between a spousal pair with autism-affected children and high minor allele content in cases in autism-associated SNPs.GenomicsZhu Z, Lu X, Yuan D, Huang SJanuary 2017Not Determined
27896947Create StudyReduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD.Autism research : official journal of the International Society for Autism ResearchGreen, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y; Dapretto, MirellaMay 2017Not Determined
27860216Create StudySomatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies.American journal of medical genetics. Part C, Seminars in medical geneticsKeppler-Noreuil, Kim M; Parker, Victoria E R; Darling, Thomas N; Martinez-Agosto, Julian ADecember 2016Not Determined
27843152Create StudyAdditive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism.Molecular psychiatryHernandez, L M; Krasileva, K; Green, S A; Sherman, L E; Ponting, C; McCarron, R; Lowe, J K; Geschwind, D H; Bookheimer, S Y; Dapretto, MAugust 2017Not Determined
27814521Create StudyThe Central Nervous System and the Gut Microbiome.CellSharon, Gil; Sampson, Timothy R; Geschwind, Daniel H; Mazmanian, Sarkis KNovember 2016Not Determined
27601973Create StudyNoise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables.Frontiers in neuroscienceJann, Kay; Smith, Robert X; Rios Piedra, Edgar A; Dapretto, Mirella; Wang, Danny J JJanuary 2016Not Determined
27422356Create StudyTruncating mutations in APP cause a distinct neurological phenotype.Annals of neurologyKlein S, Goldman A, Lee H, Ghahremani S, Bhakta V, Nelson SF, Martinez-Agosto JASeptember 2016Not Determined
27417857Create StudyNon-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study.Autism research : official journal of the International Society for Autism ResearchCharman, Tony; Young, Gregory S; Brian, Jessica; Carter, Alice; Carver, Leslie J; Chawarska, Katarzyna; Curtin, Suzanne; Dobkins, Karen; Elsabbagh, Mayada; Georgiades, Stelios; Hertz-Picciotto, Irva; Hutman, Ted; Iverson, Jana M; Jones, Emily J; Landa, Rebecca; Macari, Suzanne; Messinger, Daniel S; Nelson, Charles A; Ozonoff, Sally; Saulnier, Celine; Stone, Wendy L; Tager-Flusberg, Helen; Webb, Sara Jane; Yirmiya, Nurit; Zwaigenbaum, LonnieJanuary 2017Not Determined
27358719Create StudyCommentary: sex difference differences? A reply to Constantino.Molecular autismMessinger, Daniel S; Young, Gregory S; Webb, Sara Jane; Ozonoff, Sally; Bryson, Susan E; Carter, Alice; Carver, Leslie; Charman, Tony; Chawarska, Katarzyna; Curtin, Suzanne; Dobkins, Karen; Hertz-Picciotto, Irva; Hutman, Ted; Iverson, Jana M; Landa, Rebecca; Nelson, Charles A; Stone, Wendy L; Tager-Flusberg, Helen; Zwaigenbaum, Lonnie2016Not Relevant
27343889Create StudySalience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity.Journal of the American Academy of Child and Adolescent PsychiatryGreen, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y; Dapretto, MirellaJuly 2016Not Determined
27158270Create StudyIdentification of a distinct developmental and behavioral profile in children with Dup15q syndrome.Journal of neurodevelopmental disordersDistefano C, Gulsrud A, Huberty S, Kasari C, Cook E, Reiter LT, Thibert R, Jeste SSJanuary 2016Not Relevant
26881074Create StudyTheory of Mind Indexes the Broader Autism Phenotype in Siblings of Children with Autism at School Age.Autism research and treatmentTsang T, Gillespie-Lynch K, Hutman TJanuary 2016Not Determined
26808343Create StudyIntact recognition, but attenuated adaptation, for biological motion in youth with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchVan Boxtel JJ, Dapretto M, Lu HOctober 2016Not Determined
26797940Create StudyIncreasing Responsive Parent-Child Interactions and Joint Engagement: Comparing the Influence of Parent-Mediated Intervention and Parent Psychoeducation.Journal of autism and developmental disordersShire, Stephanie Y; Gulsrud, Amanda; Kasari, ConnieMay 2016Not Determined
26687839Create StudyCytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes.NeuronLee, Ji-Ann; Damianov, Andrey; Lin, Chia-Ho; Fontes, Mariana; Parikshak, Neelroop N; Anderson, Erik S; Geschwind, Daniel H; Black, Douglas L; Martin, Kelsey CJanuary 6, 2016Not Relevant
26627310Create StudyJAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.NeuronBerg, Jamee M; Lee, Changhoon; Chen, Leslie; Galvan, Laurie; Cepeda, Carlos; Chen, Jane Y; Peñagarikano, Olga; Stein, Jason L; Li, Alvin; Oguro-Ando, Asami; Miller, Jeremy A; Vashisht, Ajay A; Starks, Mary E; Kite, Elyse P; Tam, Eric; Gdalyahu, Amos; Al-Sharif, Noor B; Burkett, Zachary D; White, Stephanie A; Fears, Scott C; Levine, Michael S; Wohlschlegel, James A; Geschwind, Daniel HDecember 16, 2015Not Determined
26527311Create StudyJoint engagement modulates object discrimination in toddlers: a pilot electrophysiological investigation.Social neuroscienceHutman, Ted; Harrop, Clare; Baker, Elizabeth; Elder, Lauren; Abood, Kimberly; Soares, Annabelle; Jeste, Shafali SpurlingOctober 1, 2016Not Determined
26525461Create StudyIsolating active ingredients in a parent-mediated social communication intervention for toddlers with autism spectrum disorder.Journal of child psychology and psychiatry, and allied disciplinesGulsrud, Amanda C; Hellemann, Gerhard; Shire, Stephanie; Kasari, ConnieMay 2016Not Determined
26509118Create StudyNeural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.NeuroImage. ClinicalMontojo, C A; Congdon, E; Hwang, L; Jalbrzikowski, M; Kushan, L; Vesagas, T K; Jonas, R K; Ventura, J; Bilder, R M; Bearden, C E2015Not Determined
26451968Create StudySchool-age outcomes of infants at risk for autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchMiller, Meghan; Iosif, Ana-Maria; Young, Gregory S; Hill, Monique; Phelps Hanzel, Elise; Hutman, Ted; Johnson, Scott; Ozonoff, SallyJune 1, 2016Not Determined
26445698Create StudyAltered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.Brain and behaviorJann K, Hernandez LM, Beck-Pancer D, McCarron R, Smith RX, Dapretto M, Wang DJSeptember 2015Not Determined
26408631Create StudyPreconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders.Autism : the international journal of research and practiceVirk, Jasveer; Liew, Zeyan; Olsen, Jørn; Nohr, Ellen A; Catov, Janet M; Ritz, BeateAugust 1, 2016Not Determined
26374786Create StudyAutism Spectrum Disorder and Epilepsy: Two Sides of the Same Coin?Journal of child neurologyJeste, Shafali Spurling; Tuchman, RobertoDecember 2015Not Determined
26201030Create StudyTranscriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder.PloS oneJalbrzikowski, Maria; Lazaro, Maria T; Gao, Fuying; Huang, Alden; Chow, Carolyn; Geschwind, Daniel H; Coppola, Giovanni; Bearden, Carrie E2015Not Relevant
26164418Create StudyInfants'' behavioral styles in joint attention situations and parents'' socio-economic status.Infant behavior & developmentAbels, Monika; Hutman, TedAugust 2015Not Determined
26106930Create StudyCharacterizing Resting-State Brain Function Using Arterial Spin Labeling.Brain connectivityChen, J Jean; Jann, Kay; Wang, Danny J JNovember 2015Not Relevant
26096080Create StudyWavelet-based regularity analysis reveals recurrent spatiotemporal behavior in resting-state fMRI.Human brain mappingSmith, Robert X; Jann, Kay; Ances, Beau; Wang, Danny J JSeptember 2015Not Determined
26061819Create StudyNeurobiology of Sensory Overresponsivity in Youth With Autism Spectrum Disorders.JAMA psychiatryGreen, Shulamite A; Hernandez, Leanna; Tottenham, Nim; Krasileva, Kate; Bookheimer, Susan Y; Dapretto, MirellaAugust 2015Not Determined
26045943Create StudyEarly sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study.Molecular autismMessinger, Daniel S; Young, Gregory S; Webb, Sara Jane; Ozonoff, Sally; Bryson, Susan E; Carter, Alice; Carver, Leslie; Charman, Tony; Chawarska, Katarzyna; Curtin, Suzanne; Dobkins, Karen; Hertz-Picciotto, Irva; Hutman, Ted; Iverson, Jana M; Landa, Rebecca; Nelson, Charles A; Stone, Wendy L; Tager-Flusberg, Helen; Zwaigenbaum, LonnieJanuary 2015Not Determined
26018425Create StudyVoICE: A semi-automated pipeline for standardizing vocal analysis across models.Scientific reportsBurkett, Zachary D; Day, Nancy F; Peñagarikano, Olga; Geschwind, Daniel H; White, Stephanie A2015Not Relevant
25973164Create StudyRecurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins.Molecular autismWerling DM, Geschwind DH2015Not Determined
25948600Create StudyCharacterizing caregiver responses to restricted and repetitive behaviors in toddlers with autism spectrum disorder.Autism : the international journal of research and practiceHarrop C, Gulsrud A, Shih W, Hovsepyan L, Kasari CApril 2016Not Determined
25891009Create StudyGene hunting in autism spectrum disorder: on the path to precision medicine.The Lancet. NeurologyGeschwind, Daniel H; State, Matthew WNovember 2015Not Determined
25891007Create StudyNeuroimaging in autism spectrum disorder: brain structure and function across the lifespan.The Lancet. NeurologyEcker, Christine; Bookheimer, Susan Y; Murphy, Declan G MNovember 2015Not Determined
25822242Create StudyRandomized comparative efficacy study of parent-mediated interventions for toddlers with autism.Journal of consulting and clinical psychologyKasari, Connie; Gulsrud, Amanda; Paparella, Tanya; Hellemann, Gerhard; Berry, KathleenJune 2015Not Determined
25727539Create StudySocial responsiveness, an autism endophenotype: genomewide significant linkage to two regions on chromosome 8.The American journal of psychiatryLowe JK, Werling DM, Constantino JN, Cantor RM, Geschwind DHMarch 1, 2015Not Relevant
25715178Create StudyCognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome.JAMA psychiatryVorstman, Jacob A S; Breetvelt, Elemi J; Duijff, Sasja N; Eliez, Stephan; Schneider, Maude; Jalbrzikowski, Maria; Armando, Marco; Vicari, Stefano; Shashi, Vandana; Hooper, Stephen R; Chow, Eva W C; Fung, Wai Lun Alan; Butcher, Nancy J; Young, Donald A; McDonald-McGinn, Donna M; Vogels, Annick; van Amelsvoort, Therese; Gothelf, Doron; Weinberger, Ronnie; Weizman, Abraham; Klaassen, Petra W J; Koops, Sanne; Kates, Wendy R; Antshel, Kevin M; Simon, Tony J; Ousley, Opal Y; Swillen, Ann; Gur, Raquel E; Bearden, Carrie E; Kahn, René S; Bassett, Anne S; International Consortium on Brain and Behavior in 22q11.2 Deletion SyndromeApril 2015Not Relevant
25695138Create StudyDevelopmental disorders.Current opinion in neurologyJeste SS, Geschwind DHApril 2015Not Relevant
25609168Create StudyExogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.Science translational medicinePeñagarikano, Olga; Lázaro, María T; Lu, Xiao-Hong; Gordon, Aaron; Dong, Hongmei; Lam, Hoa A; Peles, Elior; Maidment, Nigel T; Murphy, Niall P; Yang, X William; Golshani, Peyman; Geschwind, Daniel HJanuary 21, 2015Not Relevant
25463468Create StudyFunctional connectivity in BOLD and CBF data: similarity and reliability of resting brain networks.NeuroImageJann K, Gee DG, Kilroy E, Schwab S, Smith RX, Cannon TD, Wang DJFebruary 1, 2015Not Relevant
25457930Create Study18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryChawarska, Katarzyna; Shic, Frederick; Macari, Suzanne; Campbell, Daniel J; Brian, Jessica; Landa, Rebecca; Hutman, Ted; Nelson, Charles A; Ozonoff, Sally; Tager-Flusberg, Helen; Young, Gregory S; Zwaigenbaum, Lonnie; Cohen, Ira L; Charman, Tony; Messinger, Daniel S; Klin, Ami; Johnson, Scott; Bryson, SusanDecember 2014Not Relevant
25418720Create StudyMaternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells.Stem cell reportsLe Belle, Janel E; Sperry, Jantzen; Ngo, Amy; Ghochani, Yasmin; Laks, Dan R; López-Aranda, Manuel; Silva, Alcino J; Kornblum, Harley INovember 11, 2014Not Relevant
25409314Create StudyProtein interaction networks reveal novel autism risk genes within GWAS statistical noise.PloS oneCorreia, Catarina; Oliveira, Guiomar; Vicente, Astrid M2014Not Determined
25315782Create StudyEarly pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder?Journal of child psychology and psychiatry, and allied disciplinesMiller, Meghan; Young, Gregory S; Hutman, Ted; Johnson, Scott; Schwichtenberg, A J; Ozonoff, SallyJuly 2015Not Determined
25245349Create StudyEarly head growth in infants at risk of autism: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryZwaigenbaum, Lonnie; Young, Gregory S; Stone, Wendy L; Dobkins, Karen; Ozonoff, Sally; Brian, Jessica; Bryson, Susan E; Carver, Leslie J; Hutman, Ted; Iverson, Jana M; Landa, Rebecca J; Messinger, DanielOctober 2014Not Determined
25078724Create StudyTime reproduction performance is associated with age and working memory in high-functioning youth with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchBrenner LA, Shih VH, Colich NL, Sugar CA, Bearden CE, Dapretto MFebruary 2015Not Relevant
25038753Create StudyMost genetic risk for autism resides with common variation.Nature geneticsGaugler, Trent; Klei, Lambertus; Sanders, Stephan J; Bodea, Corneliu A; Goldberg, Arthur P; Lee, Ann B; Mahajan, Milind; Manaa, Dina; Pawitan, Yudi; Reichert, Jennifer; Ripke, Stephan; Sandin, Sven; Sklar, Pamela; Svantesson, Oscar; Reichenberg, Abraham; Hultman, Christina M; Devlin, Bernie; Roeder, Kathryn; Buxbaum, Joseph DAugust 2014Not Determined
25011468Create StudyNeural signatures of autism spectrum disorders: insights into brain network dynamics.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyHernandez, Leanna M; Rudie, Jeffrey D; Green, Shulamite A; Bookheimer, Susan; Dapretto, MirellaJanuary 2015Not Relevant
24577245Create StudyPsychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome.The American journal of psychiatrySchneider, Maude; Debbané, Martin; Bassett, Anne S; Chow, Eva W C; Fung, Wai Lun Alan; van den Bree, Marianne; Owen, Michael; Murphy, Kieran C; Niarchou, Maria; Kates, Wendy R; Antshel, Kevin M; Fremont, Wanda; McDonald-McGinn, Donna M; Gur, Raquel E; Zackai, Elaine H; Vorstman, Jacob; Duijff, Sasja N; Klaassen, Petra W J; Swillen, Ann; Gothelf, Doron; Green, Tamar; Weizman, Abraham; Van Amelsvoort, Therese; Evers, Laurens; Boot, Erik; Shashi, Vandana; Hooper, Stephen R; Bearden, Carrie E; Jalbrzikowski, Maria; Armando, Marco; Vicari, Stefano; Murphy, Declan G; Ousley, Opal; Campbell, Linda E; Simon, Tony J; Eliez, Stephan; International Consortium on Brain and Behavior in 22q11.2 Deletion SyndromeJune 2014Not Relevant
24497750Create StudyAtypical Neural Processing of Ironic and Sincere Remarks in Children and Adolescents with Autism Spectrum Disorders.Metaphor and symbolColich, Natalie L; Wang, Audrey-Ting; Rudie, Jeffrey D; Hernandez, Leanna M; Bookheimer, Susan Y; Dapretto, Mirella2012Not Relevant
24353275Create StudyIs early joint attention associated with school-age pragmatic language?Autism : the international journal of research and practiceGillespie-Lynch, Kristen; Khalulyan, Allie; Del Rosario, Mithi; McCarthy, Brigid; Gomez, Lovella; Sigman, Marian; Hutman, TedFebruary 2015Not Determined
24273724Create StudyStructural abnormalities in cortical volume, thickness, and surface area in 22q11.2 microdeletion syndrome: Relationship with psychotic symptoms.NeuroImage. ClinicalJalbrzikowski, Maria; Jonas, Rachel; Senturk, Damla; Patel, Arati; Chow, Carolyn; Green, Michael F; Bearden, Carrie E2013Not Relevant
24183016Create StudyCortical evolution: judge the brain by its cover.NeuronGeschwind, Daniel H; Rakic, PaskoOctober 30, 2013Not Relevant
24179761Create StudyAltered functional and structural brain network organization in autism.NeuroImage. ClinicalRudie JD, Brown JA, Beck-Pancer D, Hernandez LM, Dennis EL, Thompson PM, Bookheimer SY, Dapretto MJanuary 2012Not Determined
24177988Create StudyNeural substrates of inhibitory control deficits in 22q11.2 deletion syndrome.Cerebral cortex (New York, N.Y. : 1991)Montojo CA, Jalbrzikowski M, Congdon E, Domicoli S, Chow C, Dawson C, Karlsgodt KH, Bilder RM, Bearden CEApril 2015Not Relevant
24157390Create StudyOverreactive brain responses to sensory stimuli in youth with autism spectrum disorders.Journal of the American Academy of Child and Adolescent PsychiatryGreen SA, Rudie JD, Colich NL, Wood JJ, Shirinyan D, Hernandez L, Tottenham N, Dapretto M, Bookheimer SYNovember 2013Not Relevant
24104518Create StudyThe association between parental interaction style and children's joint engagement in families with toddlers with autism.Autism : the international journal of research and practicePatterson SY, Elder L, Gulsrud A, Kasari CJuly 2014Not Relevant
24099842Create StudyDynamic and static contributions of the cerebrovasculature to the resting-state BOLD signal.NeuroImageTak, Sungho; Wang, Danny J J; Polimeni, Jonathan R; Yan, Lirong; Chen, J JeanJanuary 1, 2014Not Relevant
24078018Create StudyUnderconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism.Social cognitive and affective neuroscienceAlaerts K, Woolley DG, Steyaert J, Di Martino A, Swinnen SP, Wenderoth NOctober 2014Not Determined
23992925Create StudyThe 22q11.2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan.Biological psychiatryJonas, Rachel K; Montojo, Caroline A; Bearden, Carrie EMarch 1, 2014Not Relevant
23912681Create StudyDefault mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome.Social cognitive and affective neuroscienceSchreiner MJ, Karlsgodt KH, Uddin LQ, Chow C, Congdon E, Jalbrzikowski M, Bearden CESeptember 2014Not Determined
23820765Create StudyParent-reported temperament trajectories among infant siblings of children with autism.Journal of autism and developmental disordersDel Rosario, Mithi; Gillespie-Lynch, Kristen; Johnson, Scott; Sigman, Marian; Hutman, TedFebruary 2014Not Relevant
23774715Create StudyThe autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism.Molecular psychiatryDi Martino, A; Yan, C-G; Li, Q; Denio, E; Castellanos, F X; Alaerts, K; Anderson, J S; Assaf, M; Bookheimer, S Y; Dapretto, M; Deen, B; Delmonte, S; Dinstein, I; Ertl-Wagner, B; Fair, D A; Gallagher, L; Kennedy, D P; Keown, C L; Keysers, C; Lainhart, J E; Lord, C; Luna, B; Menon, V; Minshew, N J; Monk, C S; Mueller, S; Müller, R-A; Nebel, M B; Nigg, J T; O'Hearn, K; Pelphrey, K A; Peltier, S J; Rudie, J D; Sunaert, S; Thioux, M; Tyszka, J M; Uddin, L Q; Verhoeven, J S; Wenderoth, N; Wiggins, J L; Mostofsky, S H; Milham, M PJune 2014Not Relevant
23619947Create StudyAtypical gaze following in autism: a comparison of three potential mechanisms.Journal of autism and developmental disordersGillespie-Lynch, K; Elias, R; Escudero, P; Hutman, T; Johnson, S PDecember 2013Not Determined
23452686Create StudyBeyond autism: a baby siblings research consortium study of high-risk children at three years of age.Journal of the American Academy of Child and Adolescent PsychiatryMessinger, Daniel; Young, Gregory S; Ozonoff, Sally; Dobkins, Karen; Carter, Alice; Zwaigenbaum, Lonnie; Landa, Rebecca J; Charman, Tony; Stone, Wendy L; Constantino, John N; Hutman, Ted; Carver, Leslie J; Bryson, Susan; Iverson, Jana M; Strauss, Mark S; Rogers, Sally J; Sigman, MarianMarch 2013Not Determined
23352155Create StudyRare inherited variation in autism: beginning to see the forest and a few trees.NeuronStein JL, Parikshak NN, Geschwind DHJanuary 23, 2013Not Relevant
23298182Create StudyDecreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology.ASN neuroMullen, Brian R; Khialeeva, Elvira; Hoffman, Daniel B; Ghiani, Cristina A; Carpenter, Ellen M2013Not Relevant
23284270Create StudyEye-tracking as a Measure of Responsiveness to Joint Attention in Infants at Risk for Autism.Infancy : the official journal of the International Society on Infant StudiesJuly 1, 2012Not Determined
23139906Create StudyAltered integration of speech and gesture in children with autism spectrum disorders.Brain and behaviorHubbard AL, Mcnealy K, Scott-Van Zeeland AA, Callan DE, Bookheimer SY, Dapretto MSeptember 2012Not Determined
23122739Create StudySocial cognition in 22q11.2 microdeletion syndrome: relevance to psychosis?Schizophrenia researchJalbrzikowski, Maria; Carter, Chelsea; Senturk, Damla; Chow, Carolyn; Hopkins, Jessica M; Green, Michael F; Galván, Adriana; Cannon, Tyrone D; Bearden, Carrie EDecember 2012Not Relevant
22965298Create StudyPreschool based JASPER intervention in minimally verbal children with autism: pilot RCT.Journal of autism and developmental disordersGoods KS, Ishijima E, Chang YC, Kasari CMay 2013Not Determined
22962003Create StudyDeficits in mental state attributions in individuals with 22q11.2 deletion syndrome (velo-cardio-facial syndrome).Autism research : official journal of the International Society for Autism ResearchHo JS, Radoeva PD, Jalbrzikowski M, Chow C, Hopkins J, Tran WC, Mehta A, Enrique N, Gilbert C, Antshel KM, Fremont W, Kates WR, Bearden CEDecember 2012Not Determined
22958829Create StudyAutism-associated promoter variant in MET impacts functional and structural brain networks.NeuronRudie, Jeffrey D; Hernandez, Leanna M; Brown, Jesse A; Beck-Pancer, Devora; Colich, Natalie L; Gorrindo, Philip; Thompson, Paul M; Geschwind, Daniel H; Bookheimer, Susan Y; Levitt, Pat; Dapretto, MirellaSeptember 6, 2012Not Determined
22912605Create StudyInsights into multimodal imaging classification of ADHD.Frontiers in systems neuroscienceColby, John B; Rudie, Jeffrey D; Brown, Jesse A; Douglas, Pamela K; Cohen, Mark S; Shehzad, ZarrarJanuary 2012Not Relevant
22849751Create StudyAutism genetics: searching for specificity and convergence.Genome biologyBerg, Jamee M; Geschwind, Daniel H2012Not Determined
22843504Create StudyIndividual common variants exert weak effects on the risk for autism spectrum disorders.Human molecular geneticsAnney, Richard; Klei, Lambertus; Pinto, Dalila; Almeida, Joana; Bacchelli, Elena; Baird, Gillian; Bolshakova, Nadia; Bölte, Sven; Bolton, Patrick F; Bourgeron, Thomas; Brennan, Sean; Brian, Jessica; Casey, Jillian; Conroy, Judith; Correia, Catarina; Corsello, Christina; Crawford, Emily L; de Jonge, Maretha; Delorme, Richard; Duketis, Eftichia; Duque, Frederico; Estes, Annette; Farrar, Penny; Fernandez, Bridget A; Folstein, Susan E; Fombonne, Eric; Gilbert, John; Gillberg, Christopher; Glessner, Joseph T; Green, Andrew; Green, Jonathan; Guter, Stephen J; Heron, Elizabeth A; Holt, Richard; Howe, Jennifer L; Hughes, Gillian; Hus, Vanessa; Igliozzi, Roberta; Jacob, Suma; Kenny, Graham P; Kim, Cecilia; Kolevzon, Alexander; Kustanovich, Vlad; Lajonchere, Clara M; Lamb, Janine A; Law-Smith, Miriam; Leboyer, Marion; Le Couteur, Ann; Leventhal, Bennett L; Liu, Xiao-Qing; Lombard, Frances; Lord, Catherine; Lotspeich, Linda; Lund, Sabata C; Magalhaes, Tiago R; Mantoulan, Carine; McDougle, Christopher J; Melhem, Nadine M; Merikangas, Alison; Minshew, Nancy J; Mirza, Ghazala K; Munson, Jeff; Noakes, Carolyn; Nygren, Gudrun; Papanikolaou, Katerina; Pagnamenta, Alistair T; Parrini, Barbara; Paton, Tara; Pickles, Andrew; Posey, David J; Poustka, Fritz; Ragoussis, Jiannis; Regan, Regina; Roberts, Wendy; Roeder, Kathryn; Roge, Bernadette; Rutter, Michael L; Schlitt, Sabine; Shah, Naisha; Sheffield, Val C; Soorya, Latha; Sousa, Inês; Stoppioni, Vera; Sykes, Nuala; Tancredi, Raffaella; Thompson, Ann P; Thomson, Susanne; Tryfon, Ana; Tsiantis, John; Van Engeland, Herman; Vincent, John B; Volkmar, Fred; Vorstman, J A S; Wallace, Simon; Wing, Kirsty; Wittemeyer, Kerstin; Wood, Shawn; Zurawiecki, Danielle; Zwaigenbaum, Lonnie; Bailey, Anthony J; Battaglia, Agatino; Cantor, Rita M; Coon, Hilary; Cuccaro, Michael L; Dawson, Geraldine; Ennis, Sean; Freitag, Christine M; Geschwind, Daniel H; Haines, Jonathan L; Klauck, Sabine M; McMahon, William M; Maestrini, Elena; Miller, Judith; Monaco, Anthony P; Nelson, Stanley F; Nurnberger Jr, John I; Oliveira, Guiomar; Parr, Jeremy R; Pericak-Vance, Margaret A; Piven, Joseph; Schellenberg, Gerard D; Scherer, Stephen W; Vicente, Astrid M; Wassink, Thomas H; Wijsman, Ellen M; Betancur, Catalina; Buxbaum, Joseph D; Cook, Edwin H; Gallagher, Louise; Gill, Michael; Hallmayer, Joachim; Paterson, Andrew D; Sutcliffe, James S; Szatmari, Peter; Vieland, Veronica J; Hakonarson, Hakon; Devlin, BernieNovember 1, 2012Not Determined
22760337Create StudyNeural and behavioral responses during self-evaluative processes differ in youth with and without autism.Journal of autism and developmental disordersPfeifer, Jennifer H; Merchant, Junaid S; Colich, Natalie L; Hernandez, Leanna M; Rudie, Jeff D; Dapretto, MirellaFebruary 2013Not Relevant
22728336Create StudyInfants' pre-empathic behaviors are associated with language skills.Infant behavior & developmentHutman T, Rozga A, DeLaurentis A, Sigman M, Dapretto MJune 2012Not Determined
22525955Create StudyLongitudinal follow-up of children with autism receiving targeted interventions on joint attention and play.Journal of the American Academy of Child and Adolescent PsychiatryKasari C, Gulsrud A, Freeman S, Paparella T, Hellemann GMay 2012Not Determined
22500773Create StudyAltered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2.Brain connectivityDennis EL, Jahanshad N, Rudie JD, Brown JA, Johnson K, Mcmahon KL, De Zubicaray GI, Montgomery G, Martin NG, Wright MJ, Bookheimer SY, Dapretto M, Toga AW, Thompson PMJanuary 2011Not Determined
22365836Create StudyWhat does CNTNAP2 reveal about autism spectrum disorder?Trends in molecular medicinePeñagarikano O, Geschwind DHMarch 2012Not Relevant
22318914Create StudyAn fMRI investigation of responses to peer rejection in adolescents with autism spectrum disorders.Developmental cognitive neuroscienceMasten, Carrie L; Colich, Natalie L; Rudie, Jeffrey D; Bookheimer, Susan Y; Eisenberger, Naomi I; Dapretto, MirellaJuly 2011Not Relevant
22187107Create StudyBrief report: longitudinal improvements in the quality of joint attention in preschool children with autism.Journal of autism and developmental disordersLawton K, Kasari CFebruary 2012Not Relevant
21996756Create StudyA novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.Human geneticsCasey, Jillian P; Magalhaes, Tiago; Conroy, Judith M; Regan, Regina; Shah, Naisha; Anney, Richard; Shields, Denis C; Abrahams, Brett S; Almeida, Joana; Bacchelli, Elena; Bailey, Anthony J; Baird, Gillian; Battaglia, Agatino; Berney, Tom; Bolshakova, Nadia; Bolton, Patrick F; Bourgeron, Thomas; Brennan, Sean; Cali, Phil; Correia, Catarina; Corsello, Christina; Coutanche, Marc; Dawson, Geraldine; de Jonge, Maretha; Delorme, Richard; Duketis, Eftichia; Duque, Frederico; Estes, Annette; Farrar, Penny; Fernandez, Bridget A; Folstein, Susan E; Foley, Suzanne; Fombonne, Eric; Freitag, Christine M; Gilbert, John; Gillberg, Christopher; Glessner, Joseph T; Green, Jonathan; Guter, Stephen J; Hakonarson, Hakon; Holt, Richard; Hughes, Gillian; Hus, Vanessa; Igliozzi, Roberta; Kim, Cecilia; Klauck, Sabine M; Kolevzon, Alexander; Lamb, Janine A; Leboyer, Marion; Le Couteur, Ann; Leventhal, Bennett L; Lord, Catherine; Lund, Sabata C; Maestrini, Elena; Mantoulan, Carine; Marshall, Christian R; McConachie, Helen; McDougle, Christopher J; McGrath, Jane; McMahon, William M; Merikangas, Alison; Miller, Judith; Minopoli, Fiorella; Mirza, Ghazala K; Munson, Jeff; Nelson, Stanley F; Nygren, Gudrun; Oliveira, Guiomar; Pagnamenta, Alistair T; Papanikolaou, Katerina; Parr, Jeremy R; Parrini, Barbara; Pickles, Andrew; Pinto, Dalila; Piven, Joseph; Posey, David J; Poustka, Annemarie; Poustka, Fritz; Ragoussis, Jiannis; Roge, Bernadette; Rutter, Michael L; Sequeira, Ana F; Soorya, Latha; Sousa, Inês; Sykes, Nuala; Stoppioni, Vera; Tancredi, Raffaella; Tauber, Maïté; Thompson, Ann P; Thomson, Susanne; Tsiantis, John; Van Engeland, Herman; Vincent, John B; Volkmar, Fred; Vorstman, Jacob A S; Wallace, Simon; Wang, Kai; Wassink, Thomas H; White, Kathy; Wing, Kirsty; Wittemeyer, Kerstin; Yaspan, Brian L; Zwaigenbaum, Lonnie; Betancur, Catalina; Buxbaum, Joseph D; Cantor, Rita M; Cook, Edwin H; Coon, Hilary; Cuccaro, Michael L; Geschwind, Daniel H; Haines, Jonathan L; Hallmayer, Joachim; Monaco, Anthony P; Nurnberger Jr, John I; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Scherer, Stephen W; Sutcliffe, James S; Szatmari, Peter; Vieland, Veronica J; Wijsman, Ellen M; Green, Andrew; Gill, Michael; Gallagher, Louise; Vicente, Astrid; Ennis, SeanApril 2012Not Determined
21962519Create StudyAbsence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.CellPeñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DHSeptember 30, 2011Not Relevant
21855394Create StudyGenetics of autism spectrum disorders.Trends in cognitive sciencesGeschwind, Daniel HSeptember 2011Not Relevant
21784971Create StudyReduced functional integration and segregation of distributed neural systems underlying social and emotional information processing in autism spectrum disorders.Cerebral cortex (New York, N.Y. : 1991)Rudie, Jeffrey D; Shehzad, Zarrar; Hernandez, Leanna M; Colich, Natalie L; Bookheimer, Susan Y; Iacoboni, Marco; Dapretto, MirellaMay 2012Not Relevant
21522181Create StudyGene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.European journal of human genetics : EJHGAnney, Richard J L; Kenny, Elaine M; O'Dushlaine, Colm; Yaspan, Brian L; Parkhomenka, Elena; Buxbaum, Joseph D; Sutcliffe, James; Gill, Michael; Gallagher, Louise; Autism Genome Project; Buxbaum, Joseph D; Sutcliffe, James; Gill, Michael; Gallagher, LouiseOctober 2011Not Determined
21519953Create StudySelective visual attention at twelve months: signs of autism in early social interactions.Journal of autism and developmental disordersHutman T, Chela MK, Gillespie-Lynch K, Sigman MApril 2012Not Relevant
21484201Create StudyNovel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism.Journal of neurodevelopmental disordersVieland, Veronica J; Hallmayer, Joachim; Huang, Yungui; Pagnamenta, Alistair T; Pinto, Dalila; Khan, Hameed; Monaco, Anthony P; Paterson, Andrew D; Scherer, Stephen W; Sutcliffe, James S; Szatmari, Peter; Autism Genome Project (AGP)June 2011Not Determined
21358544Create StudyNeurodevelopmental disorders: hope for a new beginning.Current opinion in neurologyGeschwind, Daniel HApril 2011Not Relevant
21334443Create StudyAtypical neural networks for social orienting in autism spectrum disorders.NeuroImageGreene, Deanna J; Colich, Natalie; Iacoboni, Marco; Zaidel, Eran; Bookheimer, Susan Y; Dapretto, MirellaMay 1, 2011Not Relevant
21211782Create StudyProliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.Cell stem cellLe Belle, Janel E; Orozco, Nicolas M; Paucar, Andres A; Saxe, Jonathan P; Mottahedeh, Jack; Pyle, April D; Wu, Hong; Kornblum, Harley IJanuary 7, 2011Not Relevant
21048216Create StudyAltered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2.Science translational medicineScott-Van Zeeland, Ashley A; Abrahams, Brett S; Alvarez-Retuerto, Ana I; Sonnenblick, Lisa I; Rudie, Jeffrey D; Ghahremani, Dara; Mumford, Jeanette A; Poldrack, Russell A; Dapretto, Mirella; Geschwind, Daniel H; Bookheimer, Susan YNovember 3, 2010Not Determined
20663923Create StudyA genome-wide scan for common alleles affecting risk for autism.Human molecular geneticsAnney, Richard; Klei, Lambertus; Pinto, Dalila; Regan, Regina; Conroy, Judith; Magalhaes, Tiago R; Correia, Catarina; Abrahams, Brett S; Sykes, Nuala; Pagnamenta, Alistair T; Almeida, Joana; Bacchelli, Elena; Bailey, Anthony J; Baird, Gillian; Battaglia, Agatino; Berney, Tom; Bolshakova, Nadia; Bölte, Sven; Bolton, Patrick F; Bourgeron, Thomas; Brennan, Sean; Brian, Jessica; Carson, Andrew R; Casallo, Guillermo; Casey, Jillian; Chu, Su H; Cochrane, Lynne; Corsello, Christina; Crawford, Emily L; Crossett, Andrew; Dawson, Geraldine; de Jonge, Maretha; Delorme, Richard; Drmic, Irene; Duketis, Eftichia; Duque, Frederico; Estes, Annette; Farrar, Penny; Fernandez, Bridget A; Folstein, Susan E; Fombonne, Eric; Freitag, Christine M; Gilbert, John; Gillberg, Christopher; Glessner, Joseph T; Goldberg, Jeremy; Green, Jonathan; Guter, Stephen J; Hakonarson, Hakon; Heron, Elizabeth A; Hill, Matthew; Holt, Richard; Howe, Jennifer L; Hughes, Gillian; Hus, Vanessa; Igliozzi, Roberta; Kim, Cecilia; Klauck, Sabine M; Kolevzon, Alexander; Korvatska, Olena; Kustanovich, Vlad; Lajonchere, Clara M; Lamb, Janine A; Laskawiec, Magdalena; Leboyer, Marion; Le Couteur, Ann; Leventhal, Bennett L; Lionel, Anath C; Liu, Xiao-Qing; Lord, Catherine; Lotspeich, Linda; Lund, Sabata C; Maestrini, Elena; Mahoney, William; Mantoulan, Carine; Marshall, Christian R; McConachie, Helen; McDougle, Christopher J; McGrath, Jane; McMahon, William M; Melhem, Nadine M; Merikangas, Alison; Migita, Ohsuke; Minshew, Nancy J; Mirza, Ghazala K; Munson, Jeff; Nelson, Stanley F; Noakes, Carolyn; Noor, Abdul; Nygren, Gudrun; Oliveira, Guiomar; Papanikolaou, Katerina; Parr, Jeremy R; Parrini, Barbara; Paton, Tara; Pickles, Andrew; Piven, Joseph; Posey, David J; Poustka, Annemarie; Poustka, Fritz; Prasad, Aparna; Ragoussis, Jiannis; Renshaw, Katy; Rickaby, Jessica; Roberts, Wendy; Roeder, Kathryn; Roge, Bernadette; Rutter, Michael L; Bierut, Laura J; Rice, John P; Salt, Jeff; Sansom, Katherine; Sato, Daisuke; Segurado, Ricardo; Senman, Lili; Shah, Naisha; Sheffield, Val C; Soorya, Latha; Sousa, Inês; Stoppioni, Vera; Strawbridge, Christina; Tancredi, Raffaella; Tansey, Katherine; Thiruvahindrapduram, Bhooma; Thompson, Ann P; Thomson, Susanne; Tryfon, Ana; Tsiantis, John; Van Engeland, Herman; Vincent, John B; Volkmar, Fred; Wallace, Simon; Wang, Kai; Wang, Zhouzhi; Wassink, Thomas H; Wing, Kirsty; Wittemeyer, Kerstin; Wood, Shawn; Yaspan, Brian L; Zurawiecki, Danielle; Zwaigenbaum, Lonnie; Betancur, Catalina; Buxbaum, Joseph D; Cantor, Rita M; Cook, Edwin H; Coon, Hilary; Cuccaro, Michael L; Gallagher, Louise; Geschwind, Daniel H; Gill, Michael; Haines, Jonathan L; Miller, Judith; Monaco, Anthony P; Nurnberger Jr, John I; Paterson, Andrew D; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Scherer, Stephen W; Sutcliffe, James S; Szatmari, Peter; Vicente, Astrid M; Vieland, Veronica J; Wijsman, Ellen M; Devlin, Bernie; Ennis, Sean; Hallmayer, JoachimOctober 15, 2010Not Determined
20552678Create StudyAccuracy of phenotyping of autistic children based on Internet implemented parent report.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsLee, Hane; Marvin, Alison R; Watson, Tamara; Piggot, Judith; Law, J Kiely; Law, Paul A; Constantino, John N; Nelson, Stanley FSeptember 2010Not Relevant
20546081Create StudyResponse to distress in infants at risk for autism: a prospective longitudinal study.Journal of child psychology and psychiatry, and allied disciplinesHutman, Ted; Rozga, Agata; DeLaurentis, Angeline D; Barnwell, Jenna M; Sugar, Catherine A; Sigman, MarianSeptember 2010Not Determined
20531469Create StudyFunctional impact of global rare copy number variation in autism spectrum disorders.NaturePinto, Dalila; Pagnamenta, Alistair T; Klei, Lambertus; Anney, Richard; Merico, Daniele; Regan, Regina; Conroy, Judith; Magalhaes, Tiago R; Correia, Catarina; Abrahams, Brett S; Almeida, Joana; Bacchelli, Elena; Bader, Gary D; Bailey, Anthony J; Baird, Gillian; Battaglia, Agatino; Berney, Tom; Bolshakova, Nadia; Bölte, Sven; Bolton, Patrick F; Bourgeron, Thomas; Brennan, Sean; Brian, Jessica; Bryson, Susan E; Carson, Andrew R; Casallo, Guillermo; Casey, Jillian; Chung, Brian H Y; Cochrane, Lynne; Corsello, Christina; Crawford, Emily L; Crossett, Andrew; Cytrynbaum, Cheryl; Dawson, Geraldine; de Jonge, Maretha; Delorme, Richard; Drmic, Irene; Duketis, Eftichia; Duque, Frederico; Estes, Annette; Farrar, Penny; Fernandez, Bridget A; Folstein, Susan E; Fombonne, Eric; Freitag, Christine M; Gilbert, John; Gillberg, Christopher; Glessner, Joseph T; Goldberg, Jeremy; Green, Andrew; Green, Jonathan; Guter, Stephen J; Hakonarson, Hakon; Heron, Elizabeth A; Hill, Matthew; Holt, Richard; Howe, Jennifer L; Hughes, Gillian; Hus, Vanessa; Igliozzi, Roberta; Kim, Cecilia; Klauck, Sabine M; Kolevzon, Alexander; Korvatska, Olena; Kustanovich, Vlad; Lajonchere, Clara M; Lamb, Janine A; Laskawiec, Magdalena; Leboyer, Marion; Le Couteur, Ann; Leventhal, Bennett L; Lionel, Anath C; Liu, Xiao-Qing; Lord, Catherine; Lotspeich, Linda; Lund, Sabata C; Maestrini, Elena; Mahoney, William; Mantoulan, Carine; Marshall, Christian R; McConachie, Helen; McDougle, Christopher J; McGrath, Jane; McMahon, William M; Merikangas, Alison; Migita, Ohsuke; Minshew, Nancy J; Mirza, Ghazala K; Munson, Jeff; Nelson, Stanley F; Noakes, Carolyn; Noor, Abdul; Nygren, Gudrun; Oliveira, Guiomar; Papanikolaou, Katerina; Parr, Jeremy R; Parrini, Barbara; Paton, Tara; Pickles, Andrew; Pilorge, Marion; Piven, Joseph; Ponting, Chris P; Posey, David J; Poustka, Annemarie; Poustka, Fritz; Prasad, Aparna; Ragoussis, Jiannis; Renshaw, Katy; Rickaby, Jessica; Roberts, Wendy; Roeder, Kathryn; Roge, Bernadette; Rutter, Michael L; Bierut, Laura J; Rice, John P; Salt, Jeff; Sansom, Katherine; Sato, Daisuke; Segurado, Ricardo; Sequeira, Ana F; Senman, Lili; Shah, Naisha; Sheffield, Val C; Soorya, Latha; Sousa, Inês; Stein, Olaf; Sykes, Nuala; Stoppioni, Vera; Strawbridge, Christina; Tancredi, Raffaella; Tansey, Katherine; Thiruvahindrapduram, Bhooma; Thompson, Ann P; Thomson, Susanne; Tryfon, Ana; Tsiantis, John; Van Engeland, Herman; Vincent, John B; Volkmar, Fred; Wallace, Simon; Wang, Kai; Wang, Zhouzhi; Wassink, Thomas H; Webber, Caleb; Weksberg, Rosanna; Wing, Kirsty; Wittemeyer, Kerstin; Wood, Shawn; Wu, Jing; Yaspan, Brian L; Zurawiecki, Danielle; Zwaigenbaum, Lonnie; Buxbaum, Joseph D; Cantor, Rita M; Cook, Edwin H; Coon, Hilary; Cuccaro, Michael L; Devlin, Bernie; Ennis, Sean; Gallagher, Louise; Geschwind, Daniel H; Gill, Michael; Haines, Jonathan L; Hallmayer, Joachim; Miller, Judith; Monaco, Anthony P; Nurnberger Jr, John I; Paterson, Andrew D; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Szatmari, Peter; Vicente, Astrid M; Vieland, Veronica J; Wijsman, Ellen M; Scherer, Stephen W; Sutcliffe, James S; Betancur, CatalinaJuly 15, 2010Not Determined
20437601Create StudyReward processing in autism.Autism research : official journal of the International Society for Autism ResearchScott-Van Zeeland, Ashley A; Dapretto, Mirella; Ghahremani, Dara G; Poldrack, Russell A; Bookheimer, Susan YApril 2010Not Relevant
20394055Create StudyLanguage-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds.The Journal of comparative neurologyPanaitof, S Carmen; Abrahams, Brett S; Dong, Hongmei; Geschwind, Daniel H; White, Stephanie AJune 1, 2010Not Relevant
20385903Create StudyConnecting genes to brain in the autism spectrum disorders.Archives of neurologyAbrahams, Brett S; Geschwind, Daniel HApril 2010Not Relevant
20303070Create StudyNo neural evidence of statistical learning during exposure to artificial languages in children with autism spectrum disorders.Biological psychiatryScott-Van Zeeland, Ashley A; McNealy, Kristin; Wang, A Ting; Sigman, Marian; Bookheimer, Susan Y; Dapretto, MirellaAugust 15, 2010Not Relevant
20302390Create StudyFactors predicting language lateralization in patients with perisylvian vascular malformations. Clinical article.Journal of neurosurgeryLee, Darrin J; Pouratian, Nader; Bookheimer, Susan Y; Martin, Neil AOctober 2010Not Determined
20121438Create StudyThe reliability of neuroanatomy as a predictor of eloquence: a review.Neurosurgical focusPouratian N, Bookheimer SYFebruary 2010Not Relevant
19874940Create StudyAutism: the ups and downs of neuroligin.Biological psychiatryGeschwind DHNovember 15, 2009Not Relevant
19630577Create StudyAdvances in autism.Annual review of medicineGeschwind DH2009Not Relevant
19557195Create StudyGenome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.PLoS geneticsBucan, Maja; Abrahams, Brett S; Wang, Kai; Glessner, Joseph T; Herman, Edward I; Sonnenblick, Lisa I; Alvarez Retuerto, Ana I; Imielinski, Marcin; Hadley, Dexter; Bradfield, Jonathan P; Kim, Cecilia; Gidaya, Nicole B; Lindquist, Ingrid; Hutman, Ted; Sigman, Marian; Kustanovich, Vlad; Lajonchere, Clara M; Singleton, Andrew; Kim, Junhyong; Wassink, Thomas H; McMahon, William M; Owley, Thomas; Sweeney, John A; Coon, Hilary; Nurnberger, John I; Li, Mingyao; Cantor, Rita M; Minshew, Nancy J; Sutcliffe, James S; Cook, Edwin H; Dawson, Geraldine; Buxbaum, Joseph D; Grant, Struan F A; Schellenberg, Gerard D; Geschwind, Daniel H; Hakonarson, HakonJune 2009Not Determined
19477629Create StudyGenetic advances in autism: heterogeneity and convergence on shared pathways.Current opinion in genetics & developmentBill, Brent R; Geschwind, Daniel HJune 2009Not Relevant
19404256Create StudyCommon genetic variants on 5p14.1 associate with autism spectrum disorders.NatureWang, Kai; Zhang, Haitao; Ma, Deqiong; Bucan, Maja; Glessner, Joseph T; Abrahams, Brett S; Salyakina, Daria; Imielinski, Marcin; Bradfield, Jonathan P; Sleiman, Patrick M A; Kim, Cecilia E; Hou, Cuiping; Frackelton, Edward; Chiavacci, Rosetta; Takahashi, Nagahide; Sakurai, Takeshi; Rappaport, Eric; Lajonchere, Clara M; Munson, Jeffrey; Estes, Annette; Korvatska, Olena; Piven, Joseph; Sonnenblick, Lisa I; Alvarez Retuerto, Ana I; Herman, Edward I; Dong, Hongmei; Hutman, Ted; Sigman, Marian; Ozonoff, Sally; Klin, Ami; Owley, Thomas; Sweeney, John A; Brune, Camille W; Cantor, Rita M; Bernier, Raphael; Gilbert, John R; Cuccaro, Michael L; McMahon, William M; Miller, Judith; State, Matthew W; Wassink, Thomas H; Coon, Hilary; Levy, Susan E; Schultz, Robert T; Nurnberger, John I; Haines, Jonathan L; Sutcliffe, James S; Cook, Edwin H; Minshew, Nancy J; Buxbaum, Joseph D; Dawson, Geraldine; Grant, Struan F A; Geschwind, Daniel H; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Hakonarson, HakonMay 28, 2009Not Determined
19155745Create StudyYour brain on Google: patterns of cerebral activation during internet searching.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric PsychiatrySmall GW, Moody TD, Siddarth P, Bookheimer SYFebruary 2009Not Determined
19125863Create StudyMethyl-CpG-binding protein 2 polymorphisms and vulnerability to autism.Genes, brain, and behaviorLoat, C S; Curran, S; Lewis, C M; Duvall, J; Geschwind, D; Bolton, P; Craig, I WOctober 2008Not Determined
18999331Create StudyModeling longitudinal change in the language abilities of children with autism: parent behaviors and child characteristics as predictors of change.Developmental psychologySiller M, Sigman MNovember 2008Not Determined
18987363Create StudyA functional genetic link between distinct developmental language disorders.The New England journal of medicineVernes, Sonja C; Newbury, Dianne F; Abrahams, Brett S; Winchester, Laura; Nicod, Jérôme; Groszer, Matthias; Alarcón, Maricela; Oliver, Peter L; Davies, Kay E; Geschwind, Daniel H; Monaco, Anthony P; Fisher, Simon ENovember 27, 2008Not Relevant
18984147Create StudyAutism: many genes, common pathways?CellGeschwind, Daniel HOctober 31, 2008Not Relevant
18954473Create StudyFrontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing.Journal of the International Neuropsychological Society : JINSBookheimer SY, Wang AT, Scott A, Sigman M, Dapretto MNovember 2008Not Relevant
18704077Create StudyAutism: Family connections.NatureGeschwind, Daniel HAugust 14, 2008Not Relevant
18414403Create StudyAdvances in autism genetics: on the threshold of a new neurobiology.Nature reviews. GeneticsAbrahams, Brett S; Geschwind, Daniel HMay 2008Not Relevant
17347882Create StudyOffering to share: how to put heads together in autism neuroimaging.Journal of autism and developmental disordersBelmonte, Matthew K; Mazziotta, John C; Minshew, Nancy J; Evans, Alan C; Courchesne, Eric; Dager, Stephen R; Bookheimer, Susan Y; Aylward, Elizabeth H; Amaral, David G; Cantor, Rita M; Chugani, Diane C; Dale, Anders M; Davatzikos, Christos; Gerig, Guido; Herbert, Martha R; Lainhart, Janet E; Murphy, Declan G; Piven, Joseph; Reiss, Allan L; Schultz, Robert T; Zeffiro, Thomas A; Levi-Pearl, Susan; Lajonchere, Clara; Colamarino, Sophia AJanuary 2008Not Determined
helpcenter.collection.publications-tab

NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
28700096Create StudyPeak alpha frequency is a neural marker of cognitive function across the autism spectrum.The European journal of neuroscienceDickinson, Abigail; DiStefano, Charlotte; Senturk, Damla; Jeste, Shafali SpurlingMarch 1, 2018
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
18605/13/2015
180
Approved

You can use "Add New Data Expected" to add exsiting structures and create your project's list. However, this is also the method you can use to request new structures be created for your project. When adding the Data Expected item, if the structure already exists you can locate it and specify your dates and enrollment. To add a new structure and request it be defined in the Data Dictionary, select Upload Definition and attach the definition or material needed to create it, including manual, codebooks, forms, etc. If you have multiple files, please upload a zipped archive containing them all.

Expected dates should be selected based on the standard Data Sharing Regimen and are restricted to within date ranges based on the project start and end dates.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Mullen Scales of Early Learning info icon
10907/15/2008
101
Approved
Genomics/omics info icon
55107/15/2008
180
Approved
ABC Community info icon
3607/31/2012
0
Approved
Reynell Developmental Language Scales info icon
7107/15/2008
0
Approved
ADOS info icon
41107/15/2008
187
Approved
Simpson-Angus Rating Scale (SAS) info icon
3607/31/2012
0
Approved
ADI-R info icon
30307/15/2008
286
Approved
Childrens Yale-Brown OC Scale (CY-BOCS) info icon
15307/15/2008
0
Approved
Medical History info icon
16707/15/2008
216
Approved
Social Responsiveness Scale (SRS) info icon
67507/15/2008
0
Approved
Wechsler Abbreviated Scale of Intelligence (WASI) info icon
11607/15/2008
0
Approved
Genetic Test info icon
55107/15/2008
22
Approved
Interpersonal Reactivity Index info icon
13707/15/2008
0
Approved
Child and Adolescent Symptom Inventory (CASI) info icon
3607/31/2012
0
Approved
Social Communication Questionnaire (SCQ) info icon
13607/15/2008
0
Approved
Demographics info icon
12507/15/2008
0
Approved
Child Behavior Checklist (CBCL) info icon
17407/31/2012
0
Approved
M-CHAT info icon
18407/15/2014
0
Approved
Parenting Stress Index (PSI) info icon
7107/15/2008
0
Approved
Abnormal Involuntary Movement Scale (AIMS) info icon
3607/31/2012
0
Approved
Clinical Global Impression (CGI) info icon
3607/31/2012
0
Approved
Early Social Communication Scales (ESCS) info icon
7207/15/2008
0
Approved
Structured Play Assessment info icon
7207/31/2012
0
Approved
Screen for Childhood Anxiety Related Emotional Disorders (SCARED) info icon
1107/31/2012
0
Approved
Interpersonal Competence Scale (ICS) info icon
11407/31/2012
0
Approved
Wechsler Intelligence Scale for Children info icon
10807/15/2008
65
Approved
DAS-II: Differential Ability Scales info icon
7107/31/2012
0
Approved
MacArthur Bates Communicative Development Inventory info icon
9707/15/2008
0
Approved
Peabody Picture Vocabulary Test, Fourth Edition info icon
15807/15/2008
0
Approved
Wechsler Adult Intelligence Scale info icon
307/15/2008
0
Approved
Repetitive Behavior Scale - Revised (RBS-R) info icon
27007/15/2008
0
Approved
Intervention History info icon
12507/15/2008
0
Approved
Wechsler Preschool Primary Scale Intelligence (WPPSI) info icon
1707/15/2008
0
Approved
Stanford Binet info icon
1107/15/2008
29
Approved
Physical Exam info icon
17207/15/2008
193
Approved
Sensory Profile info icon
6507/31/2012
0
Approved
Behavior Rating Inventory of Executive Function (BRIEF) info icon
13007/15/2008
0
Approved
Clinical Evaluation of Language Fundamentals (CELF) info icon
17407/15/2008
0
Approved
Vineland (Parent and Caregiver) info icon
42107/15/2008
257
Approved
Imaging (Structural, fMRI, DTI, PET, microscopy) info icon
17207/15/2008
161
Approved
Parenting Daily Hassles info icon
7207/31/2012
0
Approved
EEG info icon
7207/15/2014
0
Approved
Structure not yet defined
No Status history for this Data Expected has been recorded yet
helpcenter.collection.data-expected-tab

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Contributing researchers just getting started on their project will need to define this list by adding all of the items they are collecting under their grant and setting their schedule according to the NDA Data Sharing Regimen. If you fall into this category, you can begin by clicking "Add New Data Expected" and selecting which data structures you will be using, saving the page after each change, or requesting new structures by adding and naming a new item, providing any materials NDA Data Dictionary Curators can use to help define your structure. For more information see the tutorial on creating Data Expected.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save"" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Examining the validity of the use of ratio IQs in psychological assessments IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.166/17423Secondary AnalysisShared
Controls for SCCRIPTo establish a well characterized cohort for pediatric patients living with sickle cell disease90/11185Secondary AnalysisPrivate
Characterizing Auditory Hyperreactivity in AutismObjective: To answer the following research questions: 1) What is the prevalence of auditory hyper-reactivity in ASD? 2) Does auditory hyper-reactivity severity change with age? and 3) What are the most common auditory stimuli reported to be bothersome? Research Design: Primarily descriptive secondary data analysis. Methods: Type of data: Questionnaire items regarding auditory hyper-reactivity will be filtered from: Autism Diagnostic Interview-Revised, Sensory Profile (all forms), Sensory Over-Responsivity Scale, and Sensory Experiences Questionnaire in addition to demographics (i.e., age, race, ethnicity, diagnoses). Analysis Plan: Descriptive statistics, tables and figures will be used to summarize the prevalence and severity of auditory hyper-reactivity by age. Linear regression modeling will be used to evaluate changes in auditory hyper-reactivity by age. If data is available for control subjects, statistical analyses will be conducted for means comparison (ASD vs. non-ASD). 286/7001Secondary AnalysisPrivate
The evolution and population diversity of human-specific segmental duplicationsSegmental duplications contribute to human evolution, adaptation and genomic instability but are often poorly characterized. We investigate the evolution, genetic variation and coding potential of human-specific segmental duplications (HSDs). We identify 218 HSDs based on analysis of 322 deeply sequenced archaic and contemporary hominid genomes. We sequence 550 human and nonhuman primate genomic clones to reconstruct the evolution of the largest, most complex regions with protein-coding potential (n=80 genes/33 gene families). We show that HSDs are non-randomly organized, associate preferentially with ancestral ape duplications termed “core duplicons”, and evolved primarily in an interspersed inverted orientation. In addition to Homo sapiens-specific gene expansions (e.g., TCAF1/2), we highlight ten gene families (e.g., ARHGAP11B and SRGAP2C) where copy number never returns to the ancestral state, there is evidence of mRNA splicing, and no common gene-disruptive mutations are observed in the general population. Such duplicates are candidates for the evolution of human-specific adaptive traits. 1/6360Primary AnalysisShared
The effect of compensatory mechanisms during and after pregnancy on a child's developmentEarly childhood involves rapid processes of human growth leading to different trajectories in physical, cognitive, social, and emotional development (Graignic-Philippe et al., 2014). These processes are influenced by a wide variety of factors such as maternal health, environmental stressors, and early childhood experiences. Current literature has shown how exposure to both acute and chronic stress during pregnancy have a pathogenetic effect throughout childhood (Kim & Leventhal, 2015; Rice, et al, 2010), leading to neurotypical or atypical development. Studies have shown how these stressors are linked neurodevelopmental disorders such Autism Spectrum Disorders (Zerbo et al., 2015; Atladóttir et al., 2012) or Attention Deficit Hyperactivity Disorder (Rosenqvist et al., 2019). In recent years, there has been a shift from traditional diagnostic research models to synthesis of different scientific fields to map lifecourse development in order for rapid translation into healthcare practices (Halfon et al., 2014). Whilst there are studies showing links between stress and atypical developmental outcomes, there is still very limited literature on compensatory mechanisms found pre- and post-pregnancy, which illustrate development of protective factors (such as presence of self-regulation, high verbal intelligence, sociability, adept social communication) against atypical developmental outcomes. This study aims to identify and measure the presence of these protective factors that appear to guard against or mitigate the emergence of neurodevelopmental disorders. Therefore, nationwide and longitudinal data are needed in order to accurately create risk models in order to map developmental trajectories. 3/5717Secondary AnalysisPrivate
Unravelling the Collective Diagnostic Power Behind the Features in the Autism Diagnostic Observation ScheduleBackground: Autism is a group of heterogeneous disorders defined by deficits in social interaction and communication. Typically, diagnosis depends on the results of a behavioural examination called the Autism Diagnostic Observation Schedule (ADOS). Unfortunately, administration of the ADOS exam is time-consuming and requires a significant amount of expert intervention, leading to delays in diagnosis and access to early intervention programs. The diagnostic power of each feature in the ADOS exam is currently unknown. Our hypothesis is that certain features could be removed from the exam without a significant reduction in diagnostic accuracy, sensitivity or specificity. Objective: Determine the smallest subset of predictive features in ADOS module-1 (an exam variant for patients with minimal verbal skills). Methodology: ADOS module-1 datasets were acquired from the Autism Genetic Resource Exchange and the National Database for Autism Research. The datasets contained 2572 samples with the following labels: autism (1763), autism spectrum (513), and non-autism (296). The datasets were used as input to 4 different cost-sensitive classifiers in Weka (functional trees, LADTree, logistic model trees, and PART). For each classifier, a 10-fold cross validation was preformed and the number of predictive features, accuracy, sensitivity, and specificity was recorded. Results & Conclusion: Each classifier resulted in a reduction of the number of ADOS features required for autism diagnosis. The LADtree classifier was able to obtain the largest reduction, utilizing only 10 of 29 ADOS module-1 features (96.8% accuracy, 96.9% sensitivity, and 95.9% specificity). Overall, these results are a step towards a more efficient behavioural exam for autism diagnosis. 3/1832Secondary AnalysisShared
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitrySocial-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.14/1708Secondary AnalysisShared
Development of a Short Form of the SRS: An Application of IRTBackground: Research and practice in autism spectrum disorder (ASD) rely on quantitative measures, such as the Social Responsiveness Scale (SRS), for characterization and diagnosis. Like many ASD diagnostic measures, SRS scores are influenced by factors unrelated to ASD core features. This study further interrogates the psychometric properties of the SRS using item response theory (IRT), and demonstrates a strategy to enhance measure specificity by applying IRT results. Methods: SRS analyses were conducted on a large sample (N=21,426) of youth from four ASD databases. Items were subjected to item factor analyses and evaluation of item bias by gender, age, and expressive language level. Results: Item selection based on dimensionality and DIF analyses produced a reduced item SRS subscale that was unidimensional in structure, highly reliable (α=.96), and free of gender, age, expressive language, and non-verbal IQ influence. The subscale also showed strong relationships with established measures of autism symptom severity (ADOS, ADI-R, Vineland). Degree of association between all measures varied as a function of expressive language. Conclusions: Results identified specific SRS items that are more vulnerable to non-ASD-related traits. The resultant 16-item SRS subscale may possess superior psychometric properties compared to the original scale and emerge as a more precise measure of ASD core symptom severity, facilitating research and practice. Future research using IRT is needed to further refine existing measures of autism symptomatology. 12/1478Secondary AnalysisPrivate
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using C-PAC pipeline and ANTsAn automated pipeline was developed to reference Neuroimages hosted by the National Database for Autism Research (NDAR) and derive volumes for distinct brain structures using Advanced Normalization Tools (ANTs) and the Configurable-Pipeline for the Analysis of Connectomes (C-PAC) platform. This pipeline utilized the ANTs cortical thickness methodology discuessed in "Large-Scale Evaluation of ANTs and Freesurfer Cortical Tchickness Measurements" [http://www.ncbi.nlm.nih.gov/pubmed/24879923] to extract a cortical thickness volume from T1-weighted anatomical MRI data gathered from the NDAR database. This volume was then registered to an stereotaxic-space anatomical template (OASIS-30 Atropos Template) which was acquired from the Mindboggle Project webpage [http://mindboggle.info/data.html]. After registration, the mean cortical thickness was calculated at 31 ROIs on each hemisphere of the cortex and using the Desikan-Killiany-Tourville (DKT-31) cortical labelling protocol [http://mindboggle.info/faq/labels.html] over the OASIS-30 template. **NOTE: This study is ongoing; additional data my be available in the future.** As a result, each subject that was processed has a cortical thickness volume image and a text file with the mean thickness ROIs (in mm) stored in Amazon Web Services (AWS) Simple Storage Service (S3). Additionally, these results were tabulated in an AWS-hosted database (through NDAR) to enable simple, efficient querying and data access. All of the code used to perform this analysis is publicly available on Github [https://github.com/FCP-INDI/ndar-dev]. Additionally, as a computing platform, we developed an Amazon Machine Image (AMI) that comes fully equipped to run this pipeline on any dataset. Using AWS Elastic Cloud Computing (EC2), users can launch our publicly available AMI ("C-PAC with benchmark", AMI ID: "ami-fee34296", N. Virginia region) and run the ANTs cortical thickness pipeline. The AMI is fully compatible with Sun Grid Engine as well; this enables users to perform many pipeline runs in parallel over a cluster-computing framework.107/1428Secondary AnalysisShared
A Gyrification Analysis Approach Based on Laplace Beltrami Eigenfunction Level-SetsAn accurate measure of the complexity of patterns of cortical folding or gyrification is necessary for understanding normal brain development and neurodevelopmental disorders. Conventional gyrification indices (GIs) are calculated based on surface curvature (curvature-based GI) or an outer hull surface of the cortex (outer surface-based GI). The latter is dependent on the definition of the outer hull surface and a correspondence function between surfaces. In the present study, we propose the Laplace Beltrami-based gyrification index (LB-GI), a new curvature-based local GI computed using the first three Laplace Beltrami eigenfunction level-sets, which addresses shortcomings of the existing methods. The LB-GI was applied to investigate the cortical maturation profile of the human brain from preschool to early adulthood using the PING database. The results showed both positive and negative associations of cortical folding with age and revealed more details in patterns of cortical folding than conventional curvature based methods. It is anticipated that the LB-GI will prove advantageous in large clinical neuroimaging studies. 107/1054Secondary AnalysisPrivate
Personalized Autism Symptom Assessment with the Youth Top Problems Scale: Observational and Parent-Report Formats for Clinical Trials ApplicationsTo date, few measures of comorbid psychiatric symptoms in the context of autism spectrum disorder (ASD) have been established as both psychometrically robust and sensitive to the effects of treatment. Therefore, I propose to conduct an item response theory (IRT) analysis for this study using the Child and Adolescent Symptom Inventory (CASI) data from the National Database for Autism Research. Item parameters will be obtained through an IRT calibration of CASI items using flexMIRT.3 (Cai, 2016). In order to conduct IRT, the CASI calibration sample will include both these NDAR participants and a sample of 68 children with diagnoses of ASD and IQ>70 (ages 6-13 years) who participated in our recent NIMH-funded clinical trial of cognitive behavioral therapy, which will create a sample large enough for the IRT analysis. I plan to publish this data as part of a broader psychometric study of children with autism.3/746Secondary AnalysisPrivate
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using LONI WorkflowsLONI utilized de-identified data from NDAR's cloud and a LONI Pipeline (pipeline.loni.usc.edu) processing workflow to perform a secondary structural MRI examination. The workflow used in this study pulls data from and provided by NDAR to an instance on the LONI compute cluster, aligns data to a standard orientation using FSLreorient2stsd, and undergoes further image processing to eventually identify, extract, and analyze cortical and sub-cortical structures in different MRI brain volumes. Two methods were used for this image processing: the first uses Freesurfer Recon_All to extract brain cortical parcellation and surfaces, align the data to an atlas, and identify, and analyze regions of interest; the second uses FSL to extract the brain (BET), align the data to an atlas, and extract ROIs including sub-cortical regions using FSL FIRST. The second method also uses Freesurfer (mri_segstats) to perform statistical analysis of these ROIs. Lastly, the LONI Pipeline workflow updates and returns the data processed and extracted by Freesurfer and FSL as a miNDAR back to NDAR's cloud storage instance. These results can be used to assess quality control or be used to perform post-hoc comparisons of cortical and sub-cortical brain architecture between subject types. See also, Torgerson et al. (2015) Brain Imaging and Behavior, for additional details on using LONI Pipeline to access and process NDAR data.106/740Secondary AnalysisShared
Gender differences in restricted and repetitive behaviors and interests in autismBackground: The female autism phenotype has been defined by differences in core autism spectrum disorder (ASD) symptomology related to reciprocal social communication and restricted and repetitive behaviors and interests (RRBI). Previous research on RRBI in ASD has found that affected boys have increased stereotyped and restricted behaviors compared to girls with ASD (Hiller, Young, & Weber, 2014; Mandy et al., 2012). Other domains of RRBI (i.e., self-injurious, compulsive, and insistence on sameness behaviors), which contribute to DSM-5 diagnosis, are less studied and have not been examined across gender. To date, no studies have examined gender differences using a comprehensive RRBI measure, which spans stereotyped, self-injurious, compulsive, insistence on sameness, and restricted behavior domains. Objectives: To investigate whether symptoms of RRBI (i.e., stereotyped, self-injurious, ritualistic, compulsive, insistence on sameness, and restricted behavior), as measured by item-level data on the Repetitive Behavior Scale-Revised (RBS-R), can classify males versus females with ASD. Methods: Participants included 615 youth with ASD (507 males; 82.4%), between 3 and 18 years of age (M=10.26, SD=4.20), who agreed to share data with the National Database for Autism Research (NDAR). A stepwise discriminant function analysis (DFA) was used to predict the degree RBS-R data could correctly classify gender in a large sample of individuals with ASD. Standardized canonical function coefficients (SCFC) from the DFA represent the contribution of each variable to the discrimination between groups, with greater SCFC indicating greater discrimination. Results: DFA results suggest that RBS-R items significantly differentiate girls versus boys with ASD, Wilks’ λ=0.89, χ2=70.79, p<0.001. Of note, gender was classified based on a set of 8 items (see table 1). Interestingly, the items that differentiated boys from girls did not solely consist of higher stereotyped and restricted behavior in boys (as indicated by negative SCFC scores). Half of the items that differentiated gender were higher in females with ASD (as indicated by positive SCFC scores) and from the self-injurious, compulsive, and insistence on sameness domains. This set of RBS-R items had greater success in correctly classifying boys with ASD (67.90%) than in correctly classifying affected girls (61.00%). Conclusions: This study extends findings of gender differences in RRBI for ASD, demonstrating that girls with ASD may demonstrate higher self-injurious, compulsive, and insistence on sameness behavior than affected boys. It is important for future research to disentangle whether these elevated rates of RRBI in girls with ASD are central to the female autism phenotype or an epiphenomenon of the high rates of co-occurring disorders (e.g., anxiety) noted in affected girls. 1/612Secondary AnalysisPrivate
Derivation of Quality Measures for Structural Images by Neuroimaging PipelinesUsing the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Structural QA was performed according to Haselgrove, et al (http://journal.frontiersin.org/Journal/10.3389/fninf.2014.00052/abstract) to provide values for Signal to Noise (SNR) and Contrast to Noise (CNR) Ratios that can be compared between subjects within NDAR and between other public data releases.108/423Secondary AnalysisShared
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using NITRC-CEA draft publication is in progress. GitHub repository with code for working with NDAR Data is available here: https://github.com/chaselgrove/ndar **Note this study is ongoing; additional may be added.**107/356Secondary AnalysisShared
Derivation of Quality Measures for Time-Series Images by Neuroimaging PipelinesUsing the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Time series QA was performed according to Friedman, et al. (http://www.ncbi.nlm.nih.gov/pubmed/16952468) providing values for Signal to Noise Ratio that can be compared to other subjects.107/356Secondary AnalysisShared
Cortico-Basal Ganglia Brain Structure and Links to Restricted, Repetitive Behavior in Autism Spectrum DisorderRestricted repetitive behavior (RRB) is one of two criteria domains required for the diagnosis of autism spectrum disorder (ASD). Neuroimaging is widely used to study brain alterations associated with ASD and the domain of social and communication deficits, but there has been less work regarding alterations associated with RRB. In this study we utilized neuroimaging data available from the National Database for Autism Research to assess volume in the basal ganglia and cerebellum, as well as microstructure in basal ganglia and cerebellar white matter tracts in ASD. We also investigated whether these measures differed between males and females with ASD, and how these factors correlated with clinical measures of RRB from the same individuals. We found that individuals with ASD had significant differences in free-water corrected fractional anisotropy (FAT) and free-water in cortico-basal ganglia white matter tracts, but that these measures did not differ between males versus females with ASD. Moreover, both FAT and free-water in these tracts were significantly correlated with measures of RRB. Despite no differences in volumetric measures in basal ganglia and cerebellum, these findings suggest the links between RRB and brain structure are within specific cortico-basal ganglia white matter tracts.2/192Secondary AnalysisPrivate
Neural Correlates of Restricted Repetitive Behavior in Autism Spectrum DisorderThe objective of this study is to investigate relationships between restricted, repetitive behavior and neural circuitry alterations in autism spectrum disorder (ASD). The neural circuitry mediating restricted, repetitive behaviors is largely unknown, and consequently effective treatments are lacking. In order to perform these investigations we will use the National Database for Autism Research (NDAR) to access questionnaires and assessments related to repetitive behavior as well as MRI, fMRI, and DTI scans from subjects with autism spectrum disorder (ASD) and typically developing controls. We will perform between-group morphological comparisons, as well as assessments of brain connectivity (e.g. diffusion tractography). For subjects with ASD, we will also correlate neuroimaging data to repetitive behavior scores. This study will help to better understand the link between restricted, repetitive behavior and specific brain alterations 2/192Secondary AnalysisPrivate
* Data not on individual level
helpcenter.collection.associated-studies-tab

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.
Edit