NIMH Data Archive - Data

helpcenter.ndastudy.view-cohort

NDA Study - View Cohort

The View Cohort shows the Study cohort characteristics which will includes the name, type, sex and age in months range criteria. Note that age and sex restrict the data that can be added to the cohort. Medical criteria and phenotype are also included. Of particular importance on this page are any comments related to included subjects, which may be different than published results, often attributed to data sharing consent.

Frequently Asked Questions

How do I know the characteristics of the cohort?

The appropriate Medical Criteria, Phenotype, and Sub Type defined by the Study Owner are highlighted. The option trees are automatically expanded so the highlighted options are immediately viewable.

Glossary

Age Range

Age is expressed in months from 0 (birth) to 1200 (100 years old).
Medical Criteria

NDA defines Medical Criteria as a diagnostically based determination of an individual's disease or condition.
Phenotype

NDA defines Phenotype as any physical, morphologic, or biochemical characteristics that are observable in an individual.
Sub Types

NDA defines Sub Type as a subordinate condition or disease that further characterizes an individual.
Cohort Name

A user defined name for the cohort with a 200 character limit.
Cohort Type

Cohort Type options include Baseline, Control, and Test.
Cohort Comments

Comments further characterize the cohort beyond the options provided in the interface to define the cohort.
Cohort Subjects

The Cohort Subjects provides the number of unique subjects for whom data have been associated with the cohort.
Cohort

Summarizes the characteristics of a group of research subjects. The subject count is noted in parentheses.

Contact NDA Help Desk

Study DOI

DOI:
Title:
Description:	Background: Autism spectrum disorder (ASD) is the second-most common neurodevelopmental disorder in childhood. This complex developmental disorder that manifests with restricted interests, repetitive behaviors, and difficulties in communication and social awareness. The inherited and acquired causes of ASD impact many and diverse brain regions, challenging efforts to identify a shared neuroanatomical substrate for this range of symptoms. The striatum and its connections are among the most implicated sites of abnormal structure and/or function in ASD. Striatal projection neurons develop in segregated tissue compartments, the matrix and striosome, that are histochemically, pharmacologically, and functionally distinct. Immunohistochemical assessment of ASD and animal models of autism described abnormal matrix:striosome volume ratios, with an possible shift from striosome to matrix volume. Shifting the matrix:striosome ratio could result from expansion in matrix, reduction in striosome, spatial redistribution of the compartments, or a combination of these changes. Each type of ratio-shifting abnormality may predispose to ASD but yield different combinations of ASD features. Methods: We developed a cohort of 426 children and adults (213 matched ASD-control pairs) and performed connectivity-based parcellation (diffusion tractography) of the striatum. This identified voxels with matrix-like and striosome-like patterns of structural connectivity. Results: Matrix-like volume was increased in ASD, with no evident change in the volume or organization of the striosome-like compartment. The inter-compartment volume difference (matrix minus striosome) within each individual was 31% larger in ASD. Matrix-like volume was increased in both caudate and putamen, and in somatotopic zones throughout the rostral-caudal extent of the striatum. Subjects with moderate elevations in ADOS (Autism Diagnostic Observation Schedule) scores had increased matrix-like volume, but those with highly elevated ADOS scores had 3.7-fold larger increases in matrix-like volume. Conclusions: Matrix and striosome are embedded in distinct structural and functional networks, suggesting that compartment-selective injury or maldevelopment may mediate specific and distinct clinical features. Previously, assessing the striatal compartments in humans required post mortem tissue. Striatal parcellation provides a means to assess neuropsychiatric diseases for compartment-specific abnormalities in vivo. While this ASD cohort had increased matrix-like volume, other mechanisms that shift the matrix:striosome ratio may also increase the chance of developing the diverse social, sensory, and motor phenotypes of ASD.
Publisher:
Publication Date:
Keywords:

Study DOI Status Info

DOI: 10.15154/khn8-jf08
DataCite Status: Findable
NDAR Status: Registered
DOI Registered with DataCite
Public URL Resolves at DOI

Select Subjects

Selected
No records found.

Investigators: Study Investigators	Waugh, JL; Hassan AAO; Funk AT; Maldjian JA
Abstract:	Background: Autism spectrum disorder (ASD) is the second-most common neurodevelopmental disorder in childhood. This complex developmental disorder that manifests with restricted interests, repetitive behaviors, and difficulties in communication and social awareness. The inherited and acquired causes of ASD impact many and diverse brain regions, challenging efforts to identify a shared neuroanatomical substrate for this range of symptoms. The striatum and its connections are among the most implicated sites of abnormal structure and/or function in ASD. Striatal projection neurons develop in segregated tissue compartments, the matrix and striosome, that are histochemically, pharmacologically, and functionally distinct. Immunohistochemical assessment of ASD and animal models of autism described abnormal matrix:striosome volume ratios, with an possible shift from striosome to matrix volume. Shifting the matrix:striosome ratio could result from expansion in matrix, reduction in striosome, spatial redistribution of the compartments, or a combination of these changes. Each type of ratio-shifting abnormality may predispose to ASD but yield different combinations of ASD features. Methods: We developed a cohort of 426 children and adults (213 matched ASD-control pairs) and performed connectivity-based parcellation (diffusion tractography) of the striatum. This identified voxels with matrix-like and striosome-like patterns of structural connectivity. Results: Matrix-like volume was increased in ASD, with no evident change in the volume or organization of the striosome-like compartment. The inter-compartment volume difference (matrix minus striosome) within each individual was 31% larger in ASD. Matrix-like volume was increased in both caudate and putamen, and in somatotopic zones throughout the rostral-caudal extent of the striatum. Subjects with moderate elevations in ADOS (Autism Diagnostic Observation Schedule) scores had increased matrix-like volume, but those with highly elevated ADOS scores had 3.7-fold larger increases in matrix-like volume. Conclusions: Matrix and striosome are embedded in distinct structural and functional networks, suggesting that compartment-selective injury or maldevelopment may mediate specific and distinct clinical features. Previously, assessing the striatal compartments in humans required post mortem tissue. Striatal parcellation provides a means to assess neuropsychiatric diseases for compartment-specific abnormalities in vivo. While this ASD cohort had increased matrix-like volume, other mechanisms that shift the matrix:striosome ratio may also increase the chance of developing the diverse social, sensory, and motor phenotypes of ASD.
Results:	URL for the published paper
Documents:
DOI:	10.15154/khn8-jf08
Data Usage: Study Data Usage	Secondary Analysis

In this NDA Study, data were analyzed or curated from the following NDA Collection(s):

ID	Collection	DOI	Permission Group	Subjects
2021	Multimodal Developmental Neurogenetics of Females with ASD	10.15154/4dat-5683	NIMH Data Archive	1,042
2026	Biomarkers of Developmental Trajectories and Treatment in ASD	10.15154/39tn-yj66	NIMH Data Archive	628
2358	Neural networks for attention to internal and external sensory cues in ASD	10.15154/pc6x-rp60	NIMH Data Archive	297
1906	Atypical Late Neurodevelopment in Autism	10.15154/bx96-q537	NIMH Data Archive	174
2804	Multimodal Developmental Neurogenetics of Females with ASD	10.15154/kr38-n898	NIMH Data Archive	135
2075	Mapping Thalamocortical Networks Across Development in ASD	10.15154/49n6-qn82	NIMH Data Archive	100
2129	Biological Determinants of Brain Variation in Autism	10.15154/vz1e-k126	NIMH Data Archive	79
2400	Atypical Late Neurodevelopment in Autism: A Longitudinal Clinical Phenotype and Multimodal Brain Imaging Study	10.15154/44zw-jc80	NIMH Data Archive	77
3005	Parsing ASD Heterogeneity: Neuroendophenotypes of Social Attention and Sensory Responsivity	10.15154/f5s5-t470	NIMH Data Archive	75
2179	Neural markers of shared gaze during simulated social interactions in ASD \-Modal Automated Assessment of Behavior during Social Interactions in Children with ASD	10.15154/tabd-sm79	NIMH Data Archive	36
2130	Recurrent de novo mutations implicate novel genes underlying simplex autism risk	10.15154/h0s3-bn42	NIMH Data Archive	22
2042	SSC total recall project	10.15154/wtpt-qn32	NIMH Data Archive	20
10	UCLA Sigman/Bookheimer ACE and ARRA	10.15154/mks4-e786	NIMH Data Archive	16
1971	Rapid Phenotyping for Rare Variant Discovery in Autism	10.15154/z8cr-tx40	NIMH Data Archive	6
1936	Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection (SSC)	10.15154/9sc9-de27	NIMH Data Archive	5
2203	Change-sensitive Measurement of Emotion Dysregulation in ASD	10.15154/vxbc-wq93	NIMH Data Archive	5
2030	Electrophysiological Response to Executive Control Training in Autism	10.15154/832m-tq21	NIMH Data Archive	5
2101	Phenotypic Characterization of Gene Disrupting Mutations in ASD	10.15154/g2cd-kb44	NIMH Data Archive	5
3906	The Influence of Social, Educational, and Work Experiences on Psychological Health for Transition-Aged Youth with Autism Spectrum Disorders	10.15154/36k2-cg92	NIMH Data Archive	4
2312	Multimodel Assessment of Social Process Systems across Neurodevelopmental Disorders	10.15154/danj-a358	NIMH Data Archive	4
2035	Autism Genetics, Phase II: Increasing Representation of Human Diversity	10.15154/c8p8-vx52	NIMH Data Archive	3
2254	The neurobiological basis of heterogeneous social and motor deficits in ASD	10.15154/rw82-na31	NIMH Data Archive	3
3957	Chromatin regulation during brain development and in ASD	10.15154/wh5x-yn58	NIMH Data Archive	3
3670	The Autism Biomarkers Consortium for Clinical Trials	10.15154/kjye-gg81	NIMH Data Archive	3
2683	Examining Stress and Arousal Across Pubertal Development in ASD	10.15154/th9d-5273	NIMH Data Archive	3
2424	Neurobiology of Autism With Macrocephaly	10.15154/y2eh-hf59	NIMH Data Archive	3
2288	The Autism Biomarkers Consortium for Clinical Trials	10.15154/3y3w-8z64	NIMH Data Archive	3
1650	SFARI - DNA Methylation Analysis Cohort	10.15154/gkaw-vz58	NIMH Data Archive	3
2004	1/3, 2/3, and 3/3: Sequencing Autism Spectrum Disorder Extended Pedigrees	10.15154/04r0-ka50	NIMH Data Archive	2
2929	Social-communicative deficits in Autism Spectrum Disorder as measured by mGluR5 positron emission tomography	10.15154/skb0-3w31	NIMH Data Archive	2
2292	Molecular Mechanisms of Atypical Habituation in Autism Spectrum Disorders	10.15154/vs5g-4k54	NIMH Data Archive	2
3275	Testing a computational model of neural responses in autism	10.15154/qzkh-3v06	NIMH Data Archive	2
2525	Neural Mechanisms for Social Interactions and Eye Contact in ASD	10.15154/82yh-9828	NIMH Data Archive	2
1999	NIMH Genetics	10.15154/0hqy-6p91	NIMH Data Archive	2
4218	A Longitudinal Study of Employment and Educational Instability for Young Adults with Autism Spectrum Disorder	10.15154/39nk-af12	NIMH Data Archive	1
2650	Trajectories of Brain Maturation among Youth at Risk for Anxiety	10.15154/h879-qb33	NIMH Data Archive	1
3850	Neural mechanisms of sensory reactivity and regulation in autism across development	10.15154/c3y6-5381	NIMH Data Archive	1
2007	Treatment of Autism Symptoms in Children (TASC): Initial RCT with Active Control	10.15154/57s7-jz46	NIMH Data Archive	1
2821	Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism	10.15154/77j6-7y28	NIMH Data Archive	1
1854	Studies to Advance Autism Research and Treatment (STAART).	10.15154/m0m2-gq48	NIMH Data Archive	1
2022	The Social Brain in Schizophrenia and Autism Spectrum Disorders	10.15154/g4mp-bq05	NIMH Data Archive	1
1850	CBT for anxiety in adolescents with autism	10.15154/g338-jc55	NIMH Data Archive	1
2076	1/3 to 3/3 Treatment of anxiety in autism spectrum disorder	10.15154/qfqr-6q70	NIMH Data Archive	1
1654	UW ACE Extended Family Study	10.15154/yqmk-gc77	NIMH Data Archive	1
2328	Simons Simplex Collection (SSC) Genome Studies	10.15154/6nft-5w58	NIMH Data Archive	1
2009	Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors (SOARS-B)	10.15154/gx26-h668	NIMH Data Archive	1
3458	1/5, 2/5, 3/5, 4/5, 5/5 CAPR: Computerized assessment of psychosis risk	10.15154/gcth-2d46	NIMH Data Archive	1
2266	Inhibitory dysfunction in autism	10.15154/xn3k-2181	NIMH Data Archive	1
2070	Eyeblink conditioning in school-aged children with ASD	10.15154/pn22-x635	NIMH Data Archive	1
2017	Wireless EEG System for Training Attention and Eye Movement in ASD	10.15154/wqc2-px14	NIMH Data Archive	1
1880	Computer Adaptive Testing of Adaptive Behavior of Children and Youth with Autism	10.15154/20qm-mf27	NIMH Data Archive	1

Study Type:	Analysis
Cohorts:	Test - ASD and Control subjects (2166) Age: 0 to 1,440 months Sex: Both
Measures:	Primary Measures: (99) Secondary Measures: (0)
Data Analysis:

helpcenter.ndastudy.summary-tab

NDA Study - Summary Tab

An NDA Study describes an analysis, pipeline result, or curated data release - including the cohorts, measures, and methods - referencing the underlying source data in the NDA. Once the data is referenced and the study is shared, the underlying data will not change. It will be immutable allowing others to access those data without change into near perpetuity. Only the assessments (i.e. typically rows in a database) and outcome measures (i.e. columns in a database) included in the study are shared. By sharing data this way (e.g. specific outcome measures by subject/timepoint) an ongoing project's other unpublished data - typically other research aims - will remain embargoed according to a project's established data sharing schedule (see collection).

When a study is created, a Digital Object Identifier (DOI) is reserved by the NDA, but will not be active. Once the study is shared, the DOI will then be issued and if associated with a publication, the NDA DOI will be linked to the publication's DOI.

Frequently Asked Questions

How can I get access to an NDA Study if I am involved in creating/modifying the NDA Study?

The individual listed as an Investigator on the General tab of the NDA Collection and any individuals defined as administrators can be provided this privilege. When the study is shared, all of those that have approved access to the data are given read-only access.

Glossary

Abstract

The Abstract of the publication or other public disclosure of analysis results. The publication abstract is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
Documents

Provides links to additional documentation to help explain the NDA Study.
Cohort

Summarizes the characteristics of a group of research subjects. The subject count is noted in parentheses.
Data Analysis

Summarizes the Data Analysis methods used.
Data Usage

Identifies the NDA Study as a Primary Analysis or Secondary Analysis.
Digital Object Identifier (DOI)

A persistent and unique identifier that is issued for each NDA Study that may increase the visibility of a researcher's work. Authors are expected to reference the location of data in the publication using the DOI.
Download Button

Adds all data from the current Collection or NDA Study to the Filter Cart.
Investigators

The authors of the publication or other public disclosure of analysis results. The publication's authors are automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable and uses a last name, first name format with multiple names separated by semicolons.
Primary Analysis

Primary Analysis is one of the Data Use types NDA recognizes for NDA Studies. It indicates that the NDA Study's creator was involved in the collection of the data (in whole or in part) used in the NDA Study. In other words, at least some and potentially all of the data used was originally collected by the creator of the NDA Study. A Primary Analysis Study.
NDA Study Owner

The NDA user, who does not necessarily have to be one of the Investigators listed in the NDA Study, primarily involved in creating the NDA Study who is serving as the point of contact. The NDA user who creates the NDA Study is automatically assigned as the Study Owner.
Private

The term 'Private' generally means not available to others; however, there are some slightly different meanings based on what is Private. The default state for an NDA Collection, NDA Study, Supporting Documentation, and data is Private and, therefore, accessible only to those users with appropriate Privileges so it will not be viewable and searchable publicly. A Collection may be Shared while the data and Supporting Documentation remain Private.
Results

Provides a link to the publication or other public disclosure of analysis results defined in the NDA Study.
Secondary Analysis

Secondary Analysis is one of the Data Use types NDA recognizes for NDA Studies. It indicates that the NDA Study's creator was not involved in the collection of the data (in whole or in part) used in the NDA Study, but was involved in the analysis of those data. In other words, none of the data used was originally collected by the creator of the NDA Study. A Secondary Analysis Study will provide an Attribution Report listing the Collections and the researchers responsible for collecting and depositing the original data.
Study Type

The NDA Study Type can be either Analysis (i.e. often associated with a computational pipeline), Clinical Trial, Finding (i.e. a result associated with a publication, or Release (i.e. a dataset release, often annually) to indicate the type of work defined in the NDA Study. Studies, once shared do not change.
Analysis Study Type

The Analysis Study Type is primarily used to share a pipeline; however, it could be used to share a statistical analysis or method.
Release Study Type

A static, curated data set.
Finding Study Type

The Finding Study Type associates data to a publication or some type of result.
Clinical Trial Study Type

A Clinical Trial Study is a finding specific to a clinical trial.
Study ID Number

The Study ID number is a unique three digit number routinely expressed as S### that is assigned by the NDA.
Study State

The Study State indicates whether the Study is viewable, searchable, and if the associated data can be accessed by users with appropriate data access Permissions. The default Study State is Private, which means that only the Collection Owner and users with Read Only Privileges. Only the Study Owner can Share the Study.
Study Title

The Study Title is generally the title of the publication or other public disclosure of analysis results. The publication title is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
Edit Button

The Edit Button allows a user to modify or add information once authenticated and if the user has appropriate permissions.
Return Button (Study)

The Return Button brings the user back to the Data from Papers page.
Sex

Sex is defined at birth and can only be Male or Female. In some places in the NDA, we incorrectly used the data_element name of Gender. Users are encouraged to review definitions and not make assumptions based upon a data element name.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.

Contact NDA Help Desk

IDFilter by ID	TypeFilter by Type	NameFilter by Name	SexFilter by Sex	Age FromFilter by Age From	Age ToFilter by Age To	CommentsFilter by Comments	SubjectsFilter by Subjects	Actions
3880	Test	ASD and Control subjects	Both	0	1,440		2,166

helpcenter.ndastudy.cohorts-tab

NDA Study - Cohorts Tab

The Cohort Tab allows users to view the cohorts for the NDA Study that were defined by the Study Owner. Cohorts identify general cohort characteristics (such as sex, age in months, and phenotype by medical criteria, phenotype, and subtype). Once a cohort is defined by the collection owner, subject data are then added through the NDA filter cart, but only subjects that meet the cohort's criteria (e.g. age restrictions and sex). Note too that a subject/age can exist only in one cohort.

Frequently Asked Questions

What should I do if all data can not be included in an analysis?

Some subjects may not have consented for data sharing so it is not necessarily true that all data from all subjects is available through the NDA Study. If some data or subjects are missing, note this in the Comments section of the cohort definition. Additionally, the NDA provides subjects that are excluded from the analysis for whatever reason (e.g. different aim, dropped out of the study, etc.). The reason for exclusion of subjects should be made in the comments section.

Glossary

Age Range

Age is expressed in months from 0 (birth) to 1200 (100 years old).
Download Button

Adds all data from the current Collection or NDA Study to the Filter Cart.
Owner Email

The email address of the Study Owner, which may be used to contact the Investigators involved in the NDA Study and/or the associated publication.
Private

The term 'Private' generally means not available to others; however, there are some slightly different meanings based on what is Private. The default state for an NDA Collection, NDA Study, Supporting Documentation, and data is Private and, therefore, accessible only to those users with appropriate Privileges so it will not be viewable and searchable publicly. A Collection may be Shared while the data and Supporting Documentation remain Private.
Analysis Study Type

The Analysis Study Type is primarily used to share a pipeline; however, it could be used to share a statistical analysis or method.
Clinical Trial Study Type

A Clinical Trial Study is a finding specific to a clinical trial.
Finding Study Type

The Finding Study Type associates data to a publication or some type of result.
Release Study Type

A static, curated data set.
Edit Button

The Edit Button allows a user to modify or add information once authenticated and if the user has appropriate permissions.
Return Button (Study)

The Return Button brings the user back to the Data from Papers page.
Study Title

The Study Title is generally the title of the publication or other public disclosure of analysis results. The publication title is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
Sex

Sex is defined at birth and can only be Male or Female. In some places in the NDA, we incorrectly used the data_element name of Gender. Users are encouraged to review definitions and not make assumptions based upon a data element name.
Cohort Comments

Comments further characterize the cohort beyond the options provided in the interface to define the cohort.
Cohort Name

A user defined name for the cohort with a 200 character limit.
Cohort Subjects

The Cohort Subjects provides the number of unique subjects for whom data have been associated with the cohort.
Cohort Type

Cohort Type options include Baseline, Control, and Test.
Cohort

Summarizes the characteristics of a group of research subjects. The subject count is noted in parentheses.

Contact NDA Help Desk

MeasureFilter by Measure	Type of Outcome	Subjects
ACE Family Medical History - Version 01	Primary	418
ACE Subject Medical History - Version 01	Primary	431
ACE Subject Physical Exam - Version 01	Primary	75
Aberrant Behavior Checklist (ABC) - Community - Version 02	Primary	178
Anthropometric Information - Version 01	Primary	159
Autism Diagnostic Interview - Cumulative - Version 02	Primary	90
Autism Diagnostic Interview, Revised (ADI-R) - Version 04	Primary	332
Autism Diagnostic Observation Schedule (ADOS) - Module 4 - Version 02		69
Autism Diagnostic Observation Schedule (ADOS) - Module 4 - Version 02	Primary
subjectkey	Primary
src_subject_id	Primary
interview_age	Primary
gender	Primary
Autism Diagnostic Observation Schedule (ADOS)- Module 1 - Version 02		12
Autism Diagnostic Observation Schedule (ADOS)- Module 1 - Version 02	Primary
subjectkey	Primary
interview_date	Primary
interview_age	Primary
gender	Primary
Autism Diagnostic Observation Schedule (ADOS)- Module 2 - Version 02	Primary	19
Autism Diagnostic Observation Schedule (ADOS)- Module 3 - Version 02	Primary	84
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 - Version 01	Primary	258
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 4 - Version 01	Primary	113
Autism Spectrum Quotient (AQ) - Version 01	Primary	65
BRIEF-Parent - Version 01	Primary	545
Beck Depression Inventory - Version 01	Primary	96
Broad Autism Phenotype Questionnaire (BAPQ) - Version 01	Primary	462
Bruininks-Oseretsky Test of Motor Proficiency Second Edition - Version 01	Primary	76
CADS-P - Version 01	Primary	151
CELF Preschool - Version 01	Primary	21
CELF-3 Clinical Eval of Lang Fundamentals, 3th ed - Version 01	Primary	152
CELF-4 Clinical Eval of Lang Fundamentals, 4th ed - Version 02	Primary	510
Child Behavior Checklist (CBCL) 6-18 - Version 01	Primary	513
Child Symptom Inventory Parent/Teacher Checklist - Version 01	Primary	77
Child/Adolescent Symptom Inventory - Version 01	Primary	406
Children's Communication Checklist - 2 - Version 01	Primary	11
Clinical Global Impression (CGI) - Version 01	Primary	47
Communication Checklist - Adult - Version 01	Primary	22
Comprehensive Test of Phonological Processing (CTOPP) - Version 01	Primary	159
DAS-II: Differential Ability Scales 2nd Ed. School Age - Version 04	Primary	573
DAS-II:Differential Ability Scales 2nd Ed. Early Years - Version 03	Primary	19
Demographics - Version 02	Primary	424
Developmental Behavior Checklist - Version 01	Primary	141
EEG Subject Files - Version 01	Primary	618
Early Adolescent Temperament Questionnaire - Version 01	Primary	117
Edinburgh Handedness Inventory - Version 01	Primary	258
Empathy Quotient - Version 01	Primary	55
Expressive Vocabulary Test - Version 01	Primary	149
Eye Tracking Subject-Experiment - Version 01	Primary	205
Finger Tapping Test - Version 02	Primary	106
Genomics Genetic Test - Version 01	Primary	254
Genomics Sample - Version 03	Primary	553
Genomics Subject - Version 02	Primary	553
Grooved Pegboard Test - Version 02	Primary	143
Halstead-Reitan Grip Strength - Version 01	Primary	156
Heartbeat Distractor Task - Version 01	Primary	50
Hooper Visual Organization Test (VOT) - Version 01	Primary	138
Image - Version 03		808
Image - Version 03	Primary
bvecfile	Primary
bvalfile	Primary
Imaging Work Flow - Version 01	Primary	24
Interpersonal Competence Scale - Version 01	Primary	78
Interpersonal Reactivity Index (IRI) - Version 01	Primary	78
Mullen Scales of Early Learning - Version 03	Primary	181
Peabody Picture Vocabulary Test, Fourth Edition-Form A - Version 02	Primary	76
Peabody Picture Vocabulary Test, Third Edition (Form A) - Version 01	Primary	146
Pubertal Development Scale - Version 01	Primary	595
Repetitive Behavior Scale - Revised (RBS-R) - Version 02	Primary	205
Repetitive Behavior Scales - Early Childhood Supplement - Version 01	Primary	476
Research Subject - Version 01	Primary	1,803
SRS-2. Adult, Preschool and School Age - Version 01	Primary	800
Screen for Child Anxiety Related Disorders (SCARED), Parent/Child - Version 01	Primary	261
Sensory Experiences Questionnaire - Version 01	Primary	119
Sensory Profile Adult - Version 01	Primary	405
Sensory Profile Caregiver - Version 01	Primary	274
Sensory Profile Caregiver 2 - Version 01	Primary	126
Sensory Profile Short - Version 01	Primary	76
Social Communication Questionnaire (SCQ) - Current Form - Version 04	Primary	204
Social Communication Questionnaire (SCQ) - Lifetime - Version 04	Primary	533
Social Responsiveness Scale (SRS) - Version 02	Primary	453
Social Responsiveness Scale (SRS) - Adult/Self Version - Version 03	Primary	519
Somatosensory Contact Ability - Version 01	Primary	202
Systemising Quotient - Version 01	Primary	43
Temperament in Middle Childhood Questionnaire - Version 01	Primary	50
Test of Memory and Learning (TOMAL) - Version 01	Primary	110
Thermal Detection Ability - Version 01	Primary	193
Tool Use Task - Version 01	Primary	118
Toronto Alexithymia Scale - Version 01	Primary	185
Trail Making Test, Child and Adult - Version 01	Primary	147
Vineland I - Version 01	Primary	116
Vineland-II - Parent and Caregiver Rating Form (2005) - Version 03	Primary	142
Vineland-II - Survey Form (2005) - Version 05	Primary	552
Vital Signs - Version 01	Primary	42
WASI-2 - Version 01	Primary	331
Wechsler Abbreviated Scale of Intelligence (WASI) - Version 03	Primary	162
Wechsler Adult Intelligence Scale Fourth Edition [part 1] - Version 01	Primary	32
Wechsler Adult Intelligence Scale III - Version 01	Primary	134
Wechsler Intelligence Scale for Children - IV [part 1] - Version 02	Primary	17
Wechsler Intelligence Scale for Children - IV [part 2] - Version 02	Primary	17
Wechsler Intelligence Scale for Children III - Version 01	Primary	69
Wide Range Achievement Test 3 (WRAT3) - Version 01	Primary	77

Select	Data ElementFilter by Data Element	Primary/Secondary
No records found.

helpcenter.ndastudy.measures-tab

NDA Study - Measures Tab

As defined by the Study Owner, the Measures Tab lists the Data Structures from the NDA Data Dictionary used in the Study and whether they are Primary or Secondary measures. The NDA supports individual data structures, which would be an entire assessment (e.g. Mullen Scales of Early Learning) or individual data elements, which are preferred. To view the actual data definition for the defined Data Structure, click on the Measure name and the definition will open in another browser tab. For data elements, clicking on the 'i' informational icon, a popup of the description, value range, and any notes will be provided. Those that are authenticated may view the actual data in tabular form, supporting the cohort of the study.

Frequently Asked Questions

What is the benefit of adding Data Elements instead of just the Data Structure?

Defining the Data Elements and whether they are used as a Primary or Secondary outcome helps to further characterize the data used in the analysis. Furthermore, when you select Edit Measure at the Data Element level you will see and can further define the subject/age records specific to that measure and cohort.

Glossary

Analysis Study Type

The Analysis Study Type is primarily used to share a pipeline; however, it could be used to share a statistical analysis or method.
Clinical Trial Study Type

A Clinical Trial Study is a finding specific to a clinical trial.
Download Button

Adds all data from the current Collection or NDA Study to the Filter Cart.
Finding Study Type

The Finding Study Type associates data to a publication or some type of result.
Measures

Summarizes the count of Primary and Secondary Measures (data structures) used in the NDA Study's analysis.
Release Study Type

A static, curated data set.
Measures Status

Defines whether the Data Structure or Data Element is considered Primary or Secondary in the analysis.
Study ID Number

The Study ID number is a unique three digit number routinely expressed as S### that is assigned by the NDA.
NDA Study Owner

The NDA user, who does not necessarily have to be one of the Investigators listed in the NDA Study, primarily involved in creating the NDA Study who is serving as the point of contact. The NDA user who creates the NDA Study is automatically assigned as the Study Owner.
Study State

The Study State indicates whether the Study is viewable, searchable, and if the associated data can be accessed by users with appropriate data access Permissions. The default Study State is Private, which means that only the Collection Owner and users with Read Only Privileges. Only the Study Owner can Share the Study.
Study Title

The Study Title is generally the title of the publication or other public disclosure of analysis results. The publication title is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
Study Type

The NDA Study Type can be either Analysis (i.e. often associated with a computational pipeline), Clinical Trial, Finding (i.e. a result associated with a publication, or Release (i.e. a dataset release, often annually) to indicate the type of work defined in the NDA Study. Studies, once shared do not change.
Measures Subjects

Defines the number of subjects who data was used in the analysis for the identified measure (Data Structure or Data Element).
Edit Button

The Edit Button allows a user to modify or add information once authenticated and if the user has appropriate permissions.
Return Button (Study)

The Return Button brings the user back to the Data from Papers page.
Data Dictionary

The NDA Data Dictionary provides an electronic definition for each measure, questionnaire, assessment, etc that can be accepted into the NDA.
Data Element

Intended to be re-used as much as possible to honor harmonization standards, a Data Element is an individual item (variable/field) within a Data Structure that represents a question/field on an assessment or a discrete data point.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure

Contact NDA Help Desk

Observational

Controlled

Arms/Comparison

Arms/Comparison
- ADHD
- ADHD subphenotypes with co-occurring irritability
- ASD subphenotypes
- Behavioral
  - Behavioral
  - Placebo
- Brain imaging
- Cohorts
  - Case
  - Control
  - Healthy Variation
  - Healthy Variation
  - Mixed
- DNA methylation
- Dietary Supplement
  - Dietary Supplement
  - Placebo Comparator
- Drug
  - Active Comparator
  - High Dose
  - Low Dose
  - Normal Dose
  - Placebo Comparator
- Exposure
- Genomics
  - Bulk RNA-Seq
  - ChIP seq
  - Control
  - Polygenic Risk Score
  - SNP–expression associations
  - Single-Nucleus RNASequencing
  - Study Cohort
  - Whole Genome Sequencing
  - genome-wide DNA methylation analysis
- N/A
- Procedure
  - Procedure
  - Sham
- Psychopathological profiles
- Subgroup associated differentially methylated genes and pathways
- mRNA expression microarray
- single cell RNA sequencing

Description

Description
- Observation
  - Global molecular perspective
  - Direct
  - Disguised
  - Human
    - Admixture
  - Indirect
  - Mechanical
  - Non-Disguised
  - Non-Structured
  - Structured
- Observational Model
  - Case Only
  - Case/Control
  - Defined Population
  - Family Based
  - Natural History
  - Transdiagnostic (psychiatric)
- Primary Purpose
  - Diagnostic
  - Fundamental research
  - Prevention
  - Screening
  - Supportive Care
  - Treatment
- Settings
  - Contrived
  - Laboratory
  - Natural
  - Online
- Time Perspective
  - Cross-Sectional
  - Longitudinal
  - Prospective
  - Retrospective
  - Retrospective/Prospective

Intervention

Intervention
- Behavioral
  - Picture Exchange communication system (PECS)
  - Questionnaires
  - Social Recreational
  - Speech Therapy
  - Training Sessions
- Dietary Supplement
  - Choline supplement
  - Garcinia mangostana Linn (mangosteen) pericarp
  - Melatonin
- Drug
  - Acetyl-Choline Esterase Inhibitors
  - Atomoxetine
  - CM-AT
  - Donepezil hydrochloride
  - Galantamine
  - Klonopin
  - haloperidol decanoate
  - paliperidone palmitate
- EEG
- Genomics
  - Cell Counting
  - ChIP seq
  - Construct Polygenic scores
  - Gene expression microarray
  - Gene regulation/microarray
  - Genotyping/microarray
  - RNA-Seq
  - Single-Nucleus RNASequencing
  - Targeted Sequencing
  - Whole Exome Sequencing
  - Whole Genome Sequencing
  - genome-wide DNA methylation analysis
- Medical Claims
- N/A
- Procedure
  - Acupressure treatments and NAET treatments
  - Acupuncture
  - EEG
  - Eye tracking
  - Hippotherapy
  - Hyperbaric Oxygen Therapy (HBOT)
  - MRI
  - Physical Examination
  - Platelet binding
  - dMRI
  - fMRI
- Screen Time
- Writing
- structural MRI

helpcenter.ndastudy.types-tab

NDA Study - Types Tab

The Arms/Comparison, Description, and Intervention Type options defined by the NDA Study Owner for either an Observational Study or Controlled Study can be viewed on this tab and are highlighted in yellow. The NDA allows those that define a Study to define their own arms, descriptions or intervention types as needed, however, to support harmonization, these must first be approved by the NDA prior to sharing the study.

Frequently Asked Questions

How do I know the Study Type?

The appropriate Arms/Comparison, Description, and Intervention information is highlighted based on whether the Study Owner identified the Study Type as Observational or Controlled. The option trees are automatically expanded so the highlighted options are immediately viewable and there is no need to expand all items to check for highlighted options.

Glossary

Analysis Study Type

The Analysis Study Type is primarily used to share a pipeline; however, it could be used to share a statistical analysis or method.
Clinical Trial Study Type

A Clinical Trial Study is a finding specific to a clinical trial.
Owner Email

The email address of the Study Owner, which may be used to contact the Investigators involved in the NDA Study and/or the associated publication.
Private

The term 'Private' generally means not available to others; however, there are some slightly different meanings based on what is Private. The default state for an NDA Collection, NDA Study, Supporting Documentation, and data is Private and, therefore, accessible only to those users with appropriate Privileges so it will not be viewable and searchable publicly. A Collection may be Shared while the data and Supporting Documentation remain Private.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.
Finding Study Type

The Finding Study Type associates data to a publication or some type of result.
Study ID Number

The Study ID number is a unique three digit number routinely expressed as S### that is assigned by the NDA.
Release Study Type

A static, curated data set.
NDA Study Owner

The NDA user, who does not necessarily have to be one of the Investigators listed in the NDA Study, primarily involved in creating the NDA Study who is serving as the point of contact. The NDA user who creates the NDA Study is automatically assigned as the Study Owner.
Study State

The Study State indicates whether the Study is viewable, searchable, and if the associated data can be accessed by users with appropriate data access Permissions. The default Study State is Private, which means that only the Collection Owner and users with Read Only Privileges. Only the Study Owner can Share the Study.
Study Title

The Study Title is generally the title of the publication or other public disclosure of analysis results. The publication title is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
Study Type

The NDA Study Type can be either Analysis (i.e. often associated with a computational pipeline), Clinical Trial, Finding (i.e. a result associated with a publication, or Release (i.e. a dataset release, often annually) to indicate the type of work defined in the NDA Study. Studies, once shared do not change.
Edit Button

The Edit Button allows a user to modify or add information once authenticated and if the user has appropriate permissions.
Return Button (Study)

The Return Button brings the user back to the Data from Papers page.

Contact NDA Help Desk

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Genotyping/NGS

Data Transformation, QA/QC
- Autosome Heterozygosity
- Chromosomal Aberration Screening
- Cluster Plots of Probe Intensities
- Derivative Log Ratio Spread
- Family-Based QC
- Gender Misidentification
- LD pruning
- Multidimensional Outlier Detection
- Percentile-Based Winsorizing
- Population Stratification Correction
- QA Filtering
  - Call rates
  - HWE
  - Minor Allele Frequency (MAF)
- Quartile Summary Statistics
- Wave Detection and Correction
Genetic Model
- Additive model
- Allele test
- Dominant model
- Genotypic test
- Recessive model
Genotype Statistics by Marker and Sample
- Allele count
- Call rate
- FIsher's exact test for HWE p-value
- Genotype count
- Global sample test
- Hardy-Weinberg Equilibrium (HWE) p-value
- Minor allele frequency
- Signed HWE Correlation R
Linkage and Haplotype Analysis
- Haplotype Association Testing
- Haplotype Block analysis
- Haplotype frequency estimation
  - Case/Control Association
  - Composite Haplotype Method
  - Expectation Maximization
- LD plot
N/A
NGS Analysis
- ChIP seq
- Discovery of mosaic variants
- Discovery of mosaic variants
- Discovery of structural variants
- Gene expression microarray
- RNA-seq
  - Gene expression
- Rare Variant Burden and Association Testing
- Single-Nucleus RNASequencing
- Variant annotation
  - SnpEff Annotations
  - dbNSFP Annotations
- Variant filtering
  - Annotation tracks
  - De novo variants
  - Functional prediction
  - GERP Score
  - Gene tracks
  - Grantham Score
  - Inherited variants
  - PolyPhen-2 Prediction
  - Probe tracks
  - SIFT
  - phyloP
- Variant validation
  - Independent microarray experiments
  - Long-range PCR
  - Massive parallel amplicon sequencing
  - Multiplex ligation-dependent probe amplification
  - PCR
  - Sanger sequencing
  - Sequenom assay
  - Targeted aCGH
  - qPCR
- genome-wide DNA methylation analysis
Software
- ANNOVAR
- BWA
- BeadExpress
- BeadStudio
- CASAVA
- CNAM
- CNV Prediction
- CNVnator
- CoNIFER
- DNAStar
- FBAT
- FreeBayes
- GATK
- GCTA
- Golden Helix
- MosaicForecast
- MosaicHunter
- OmicSoft
- PLINK
- PennCNV
- Picard Tools
- QuantiSNP
- SAMtools
- SPLIT-READ
- Sequencher
- Seurat
- SnpEff
- SpectralGEM
- Strelka2
- XHMM
- dbNSFP
- iPattern
- mrsFAST
Test Correction
- Benjamini-Hochberg
- Bonferroni adjustment
- FDR
- Full scan permutation
- Single value permutation
Test Statistics
- Analysis of deviance
- Cohran-Armitage test
- Correlation/Trend test
- F-test
- Fisher's exact test
- Kolmogorov-Smirnov
- Linear regression
- Logistic regression
- Odds ratio
- Pearson's chi-square test
Type
- CNV
- Exome Sequencing
- GWAS
- Haplotype
- Linkage
- RNA-Seq
  - Splice isoform assembly and annotation
  - Strand-specific dUTP
- ROH
- SNP
- Single Cell DNA Sequencing
- Targeted Sequencing
- Whole Genome sequencing

Microarray/Protein Analysis

Algorithm
- ANOVA
- Bayesian Method
- Cluster Analysis
  - Hierarchical
  - Partition
- Mann-Whitney U test
- Pearson's correlation
- Permutation
- Two Group Comparison
Illumina Infinium HumanMethylation27K Beadchip
- Illumina Infinium HumanMethylation27K Beadchip
Illumina Infinium MethylationEPIC BeadChip
- Illumina Infinium HumanMethylation450 BeadChip
N/A
Normalization Method
- Global
- LOWESS
- Robust-Linear model
Pathway Analysis
- Genetic
- Identification of co-expressed gene pairs
- Identification of co-regulated gene pairs
- Metabolic
- Neural
- Protein Interaction
Significance
- FDR
  - <1%
  - <10%
  - <5%
- p-value
  - <0.001
  - <0.01
  - <0.05
Software
- ADM-2 Algorithm
- Acuity
- DAPPLE
- GeneMANIA
- GeneSpring
- GenomeStudio
- Gingko
- Ginkgo
- IPA
- MatLab
- SAM
- TM4 - MeV MultiExperiment Viewer
Type
- Antibody
- Comparative Genomic Hybridization
- Gene Expression
- Methylation
- RPPM

Neuro Signal Recordings

Criteria
- Anatomical
- Functional
DIPY
Experiment
- BOLD Contrast
  - Echo planar T2-weighted gradient echo sequence
  - T2-sensitive echo planar imaging pulse sequence
- High resolution anatomical volume
  - Coplanar high-resolution T2-weighted echo planar imaging volume
  - T1-weighted 3D-MPRAGE pulse sequence
    - T1-weighted 3D-MEMPRAGE pulse sequence
- Number of Scans
  - 4
  - 6
- Order
  - Non-random
  - Randon
- Stimuli
  - Still images
    - Image description
  - Taste
  - Video clips of movements
- Timing
  - Image
    - 750ms/750ms blank
  - Visual Stimulation
    - 9s/6s blank
- Type
  - Motor
    - Action Execution
    - Imitation
  - Taste
  - Visual
    - Movement Observation Experiment
- Visual Field
  - Left
  - Right
Method
- General linear model
- Mean Absolute Error
- Region of Interest
- Residual Error
- Statistical Parameter Mapping
Model
- Dynamic Causal Modelling
- Expected hemodynamic response
- Inverted Encoding
- Mean percentage signal change
- Single response time-course
- Within-subject response variability
N/A
Preprocessing and correction
- 3D motion correction
- Artifact Removal
- Extraction
  - Cortical Surface
    - Inner Cortical Surface
    - Outer Cortical Surface
  - Gray Matter Surface
- Gaussian filter
- Inflating
  - Gray matter
- Intensity
- Intensity
  - Correction
  - Normalization
- Removal
  - Skull
- Segmenting
  - Cerebrospinal Fluid
  - Gray matter
  - White matter
- Temporal high-pass filtering
  - Cutoff frequency
    - 10 cycles/scan
    - 6 cycles/scan
  - Orthogonal projection
  - Trilinear interpolation
Processing
- Alignment / Orientation
  - Image reorientation to match standard template images
  - Rigid-body linear registration algorithm
- Image Normalization
  - Field Based Correction
  - Fifth-order polynomial nonlinear warping
- Tractography
Scanner
- General Electric 1.5T
- General Electric 3.0T MR750
- General Electric 3.0T MRI with an Advanced Magnetic Resonance Imaging upgrade for echo planar imaging (EPI)
- Philips 3.0T Achieva
- Philips 3.0T Ingenia
- Siemens 1.5T
- Siemens 3.0T Prisma MRI
- Siemens 3T Allegra MRI
- Siemens 3T Skyra
- iScan microarray scanner (Illumina)
Significance, correction
- Bonferroni method
- FDR
  - 0.01
  - 0.05
- Monte Carlo Simulation
- Network Based Statistics
- Percentile
  - above 95th
  - below 5th
- Threshold-Free Cluster Enhancement (TFCE)
- p-value
  - 0.001
  - 0.01
  - 0.05
Software
- AFNI
- BET
- BXH/XCEDE Tools
- Brain Voyager
- CIVET 2.1
- Connectome Workbench
- DIPY
- FSL
- FreeSurfer
- Horos
- MIPAV
- MMPS
- MMPS
- OsiriX
- SCILPY
- SPM
- Tractoflow
- fMRIPrep
Statistical Test
- ANOVA
- Linear regression
- Mixed effects model
- Randomization test
- T-test
  - paired
  - unpaired
Transformation
- Linear
- Linear
- Non-Linear
- Reverse Linear
- Talairach coordinate system
Type
- ASL
- CT
- DOT
- DTI
- EEG
- Eye Tracking
- MRI
- Magnetoencephalography
- PET
- Spectroscopy
- dMRI
- eDTI
- fMRI
- rs-fMRI
- sMRI-T1
- sMRI-T1
- sMRI-T2
- task-fMRI
rs-fMRI
sMRI-T1
sMRI-T2

Statistical

Comorbidity rates
Initial Transformation
- Categorical
- Inverse
- Log
- Normalization
- Square root
Machine Learning
Method
- ANCOVA
- ANOVA
- Analysis of Covariance Structural Equation Modeling
- Bayesian Probabilistic Principal Components Analysis
- Binomial test
- Canonical correlation analysis
- Chi-square test
- Convolutional Neural Network
- Correlation
- Decision tree algorithm
- Factor analysis
- Fisher Exact Test
- Fisher's Least Significant Difference Test
- Graph Theory
- Hidden Markov model
- Item Response Theory
- Kaplan-Meier
- Kruskal-Wallis test
- Latent Discrepancy Score Model
- MSWD
- Mann-Whitney U
- Mediation Analysis
- Meta-analysis
- Mixed Effects model
  - Linear mixed effects regression model
  - Mixed Effect Logistic Regression Model
  - Mixed Effect Negative Binomial Regression Model
- Monte Carlo
- Network Analysis
- Ordinary Least Squares Estimation
- Partial Least Squares Regression
- Pearson correlation
- Penalized Least Squares Estimation
- Polynomial regression model
- Positive Predictive Value
- Regression analysis
  - Logistic regression
  - Quantile regression
- Sensitivity/Specificity
- Spearman's rank correlation
- Student's t-test
- Survival Analysis
- Time series analysis
- Wald Test
- Weighted Least Squares Estimation
- Wilcoxon Rank Sum test
Prevalence rates
Propensity score matching
Qualitative Content Analysis
Significance
- FDR
  - <1%
  - <10%
  - <15%
  - <2%
  - <5%
- Network Based Statistics
- Permutation test
- Sensitivity
  - 80%
  - 90%
  - 95%
- Specificity
  - 100%
  - 90%
  - 95%
- p-value
  - <0.001
  - <0.01
  - <0.02
  - <0.05
Software
- Bioconductor
- Custom Python Script
- Custom R Markdown Script
- DIFAS v.5.0
- FSL
- Fisher's Least Significant Difference Test
- FreeSurfer QDEC
- GenomeStudio software
- JASP
- Jupyterlab
- MS' Excel
- MatLab
  - MatLab Main
  - SurfStat
- Mplus
  - Mplus v5.0
  - Mplus v6.0
- R-project
- SAS
- SPM12
- SPSS
- STATA
- Stan
- Weka
- fmriprep
- metilene
Structural Equation Model
Twin Modeling

helpcenter.ndastudy.data-analysis-tab

NDA Study - Data Analysis Tab

The Data Analysis Tab provides information on the type(s) of data analysis used in the NDA Study as defined by the Study Owner. The NDA allows those that define a Study to include their own data analysis methods as needed, however, to support harmonization, these must first be approved by the NDA prior to sharing the study. Additionally, files and links to other websites are also supported here as those documents generally, but not necessarily, relate to data analysis methods.

Frequently Asked Questions

How do I know which data analysis options were used in the NDA Study?

The appropriate Genotyping/NGS, Microarray/Protein Analysis, Neuro Signal Recordings, and Statistical options used by the researcher are highlighted in yellow. The option trees are automatically expanded so the highlighted options are immediately viewable so there is no need to expand all items to check for highlighted options.

Glossary

Download Button

Adds all data from the current Collection or NDA Study to the Filter Cart.
Owner Email

The email address of the Study Owner, which may be used to contact the Investigators involved in the NDA Study and/or the associated publication.
Private

The term 'Private' generally means not available to others; however, there are some slightly different meanings based on what is Private. The default state for an NDA Collection, NDA Study, Supporting Documentation, and data is Private and, therefore, accessible only to those users with appropriate Privileges so it will not be viewable and searchable publicly. A Collection may be Shared while the data and Supporting Documentation remain Private.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.
Study ID Number

The Study ID number is a unique three digit number routinely expressed as S### that is assigned by the NDA.
NDA Study Owner

The NDA user, who does not necessarily have to be one of the Investigators listed in the NDA Study, primarily involved in creating the NDA Study who is serving as the point of contact. The NDA user who creates the NDA Study is automatically assigned as the Study Owner.
Study State

The Study State indicates whether the Study is viewable, searchable, and if the associated data can be accessed by users with appropriate data access Permissions. The default Study State is Private, which means that only the Collection Owner and users with Read Only Privileges. Only the Study Owner can Share the Study.
Study Title

The Study Title is generally the title of the publication or other public disclosure of analysis results. The publication title is automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection. The field is editable.
Analysis Study Type

The Analysis Study Type is primarily used to share a pipeline; however, it could be used to share a statistical analysis or method.
Clinical Trial Study Type

A Clinical Trial Study is a finding specific to a clinical trial.
Finding Study Type

The Finding Study Type associates data to a publication or some type of result.
Release Study Type

A static, curated data set.
Study Type

The NDA Study Type can be either Analysis (i.e. often associated with a computational pipeline), Clinical Trial, Finding (i.e. a result associated with a publication, or Release (i.e. a dataset release, often annually) to indicate the type of work defined in the NDA Study. Studies, once shared do not change.
Edit Button

The Edit Button allows a user to modify or add information once authenticated and if the user has appropriate permissions.
Return Button (Study)

The Return Button brings the user back to the Data from Papers page.

Contact NDA Help Desk

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