NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

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Clinical Trial

¹ Numbers reported are subjects by age

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Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

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URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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The CHARGE Study: Childhood Autism Risks From Genetics and the Environment #2066

General
Experiments (0)
Shared Data
Publications (142)
Data Expected (16)
Associated Studies (5)

Collection Title	Collection Investigators	Collection Description
Collection Title:	The CHARGE Study: Childhood Autism Risks From Genetics and the Environment
Collection Investigators:	Irva Hertz-Picciotto
Collection Description:	Few rigorous epidemiologic studies have addressed the environmental causes and biologic underpinnings of autism spectrum disorder (ASD). The CHARGE (CHildhood Autism Risks from Genetics and Environment) Study is a large, population-based case-control investigation of environmental risk factors, broadly defined, in relation to ASD and developmental delay without ASD symptoms, with referents from the general population.Fieldwork began In 2003, and by now CHARGE has published widely on exposures such as air pollution,mercury, flame retardants, maternal nutritional status in the peri-conception, untreated fever during pregnancy,mitochondrial dysfunction, candidate genes, a wide array of functional immune markers in both the child and the mother, and maternal metabolic conditions including obesity and diabetes. This last finding is notable, given the epidemic of obesity and type 2 diabetes that has occurred in parallel with the steady rise in ASD over the last few decades. Moreover, an emerging literature implicates several endocrine disrupting chemicals as contributing to obesity and metabolic dysregulation, including hyper insulinemia, and to neurodevelopmental disorders as well. This project therefore builds upon these observations in several ways.First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challenge test (GCT) results for the first time, to determine associations not only with development of ASD and intellectual impairment in the children, but also with specific speech and language delays, behavioral phenotypes such as attention deficits or hyperactivity, and gene expression. Second, these maternal metabolic conditions will be evaluated for associations with markers of both metabolic and immune dysregulation to be measured in neonatal blood spots. Third, the predictive value of neonatal bloodspot markers for a later diagnosis of ASD or other child developmental and behavioral outcomes will be assessed. Fourth, the maternal metabolic conditions will be analyzed for potential links with upstream exposures to phthalates and antibacterial compounds, ubiquitous chemicals in common household products. Finally, this project will examine how gene variants that play a role in biochemical pathways relevant to the processes under study may influence susceptibility of the mother, the neonate or the child. To ensure adequate power for this analysis of gene-environment interaction, the sample size will be increased to 2400 children. This project addresses several goals set by the NIH Interagency Autism Coordinating Committee: 1) to discover environmental factors contributing to ASD, particularly in the prenatal period, 2) to understand biological mechanisms for ASD risk,including gene-by-environment interactions, and 3) to identify children at risk for ASD at earlier time points.Results of this detailed inquiry into early exposures, maternal pathophysiology and prognostic markers in the newborn will set the stage for developing prevention strategies.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	10/30/2013
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$4,624,873.00
Subjects Shared:	665

{"values":[]}

{"values":[["Autism Spectrum Affected",18],["Autism Spectrum Severely Affected",105],["Not Defined",41]]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

File Name	File Type	Description	Audience
QA-notification.txt	Other	Quality Assurance Notification	Qualified Researchers

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01ES015359-01	The Charge Study: Childhood Autism Risks from Genetics and the Environment	02/08/2007	01/31/2012	5608	5501	UNIVERSITY OF CALIFORNIA AT DAVIS	$2,146,125.00
R01ES015359-06	THE CHARGE STUDY: CHILDHOOD AUTISM RISKS FROM GENETICS AND THE ENVIRONMENT	08/19/2013	06/30/2018	7900	7874	UNIVERSITY OF CALIFORNIA AT DAVIS	$2,478,748.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Aberrant Behavior Checklist (ABC) - Community	Clinical Assessments	597
Autism Diagnostic Interview, Revised (ADI-R)	Clinical Assessments	414
Autism Diagnostic Observation Schedule (ADOS) - Module 1 (2007)	Clinical Assessments	64
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007)	Clinical Assessments	42
Autism Diagnostic Observation Schedule (ADOS)- Module 3 (2007)	Clinical Assessments	5
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1	Clinical Assessments	138
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2	Clinical Assessments	99
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3	Clinical Assessments	6
CHARGE Physical Exam	Clinical Assessments	376
Demographics	Clinical Assessments	599
Early Development Questionnaire	Clinical Assessments	550
Gastrointestinal History	Clinical Assessments	602
Mullen Scales of Early Learning	Clinical Assessments	598
Parent Chemical or Substance Exposure	Clinical Assessments	584
Research Subject	Clinical Assessments	598
Sleep History	Clinical Assessments	602
Social Communication Questionnaire (SCQ) - Lifetime	Clinical Assessments	255
Vineland I	Clinical Assessments	657

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38739245	Create Study	The Association Between Gastrointestinal Issues and Psychometric Scores in Children with Autism Spectrum Disorder, Developmental Delays, Down Syndrome, and Typical Development.	Journal of autism and developmental disorders	Sotelo-Orozco, Jennie; Hertz-Picciotto, Irva	May 13, 2024	Not Determined
38020477	Create Study	Ex vivo exposure to polybrominated diphenyl ether (PBDE) selectively affects the immune response in autistic children.	Brain, behavior, & immunity - health	Akintunde, Marjannie Eloi; Lin, Yan-Ping; Krakowiak, Paula; Pessah, Isaac N; Hertz-Picciotto, Irva; Puschner, Birgit; Ashwood, Paul; Van de Water, Judy	December 1, 2023	Not Determined
37956751	Create Study	Ultrafine particulate matter exposure during second year of life, but not before, associated with increased risk of autism spectrum disorder in BKMR mixtures model of multiple air pollutants.	Environmental research	Goodrich, Amanda J; Kleeman, Michael J; Tancredi, Daniel J; Ludeña, Yunin J; Bennett, Deborah H; Hertz-Picciotto, Irva; Schmidt, Rebecca J	February 1, 2024	Not Determined
37623848	Create Study	Assessing Repeated Urinary Proline Betaine Measures as a Biomarker of Usual Citrus Intake during Pregnancy: Sources of Within-Person Variation and Correlation with Reported Intake.	Metabolites	French, Caitlin D; Arnold, Charles D; Taha, Ameer Y; Engle-Stone, Reina; Schmidt, Rebecca J; Hertz-Picciotto, Irva; Slupsky, Carolyn M	August 2, 2023	Not Determined
37004853	Create Study	Parental occupational exposure to solvents and autism spectrum disorder: An exploratory look at gene-environment interactions.	Environmental research	McCanlies, Erin C; Gu, Ja Kook; Kashon, Michael; Yucesoy, Berran; Ma, Claudia C; Sanderson, Wayne T; Kim, Kyoungmi; Ludeña-Rodriguez, Yunin J; Hertz-Picciotto, Irva	July 1, 2023	Not Determined
36973347	Create Study	Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure.	Molecular psychiatry	Bruce, Matthew R; Couch, Amalie C M; Grant, Simone; McLellan, Janna; Ku, Katherine; Chang, Christina; Bachman, Angelica; Matson, Matthew; Berman, Robert F; Maddock, Richard J; Rowland, Douglas; Kim, Eugene; Ponzini, Matthew D; Harvey, Danielle; Taylor, Sandra L; Vernon, Anthony C; Bauman, Melissa D; Van de Water, Judy	May 1, 2023	Not Determined
36830973	Create Study	Preliminary Findings of Elevated Inflammatory Plasma Cytokines in Children with Autism Who Have Co-Morbid Gastrointestinal Symptoms.	Biomedicines	Ashwood, Paul	February 2, 2023	Not Determined
36144233	Create Study	Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort.	Metabolites	Parenti, Mariana; Schmidt, Rebecca J; Ozonoff, Sally; Shin, Hyeong-Moo; Tancredi, Daniel J; Krakowiak, Paula; Hertz-Picciotto, Irva; Walker, Cheryl K; Slupsky, Carolyn M	September 2, 2022	Not Determined
35943360	Create Study	Pilot Study of Maternal Autoantibody-Related Autism.	Journal of developmental and behavioral pediatrics : JDBP	Angkustsiri, Kathleen; Fussell, Jill J; Bennett, Amanda; Schauer, Joseph; Ramirez-Celis, Alexandra; Hansen, Robin L; Van de Water, Judy	October 1, 2022	Not Determined
35270242	Create Study	Selecting External Controls for Internal Cases Using Stratification Score Matching Methods.	International journal of environmental research and public health	Busgang, Stefanie A; Waller, Lance A; Colicino, Elena; D'Agostino Jr, Ralph; Hertz-Picciotto, Irva; Gennings, Chris	February 23, 2022	Not Determined
35085933	Create Study	Environmental exposures to pesticides, phthalates, phenols and trace elements are associated with neurodevelopment in the CHARGE study.	Environment international	Bennett, Deborah H; Busgang, Stefanie A; Kannan, Kurunthachalam; Parsons, Patrick J; Takazawa, Mari; Palmer, Christopher D; Schmidt, Rebecca J; Doucette, John T; Schweitzer, Julie B; Gennings, Chris; Hertz-Picciotto, Irva	March 1, 2022	Not Determined
34808292	Create Study	Neonatal chemokine markers predict subsequent diagnosis of autism spectrum disorder and delayed development.	Brain, behavior, and immunity	Kim, Danielle Hj; Krakowiak, Paula; Meltzer, Amory; Hertz-Picciotto, Irva; Van de Water, Judy	February 1, 2022	Not Determined
34561347	Create Study	The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study.	Epidemiology (Cambridge, Mass.)	Stratakis, Nikos; Garcia, Erika; Chandran, Aruna; Hsu, Tingju; Alshawabkeh, Akram; Aris, Izzuddin M; Aschner, Judy L; Breton, Carrie; Burbank, Allison; Camargo Jr, Carlos A; Carroll, Kecia N; Chen, Zhanghua; Claud, Erika C; Dabelea, Dana; Dunlop, Anne L; Elliott, Amy J; Ferrara, Assiamira; Ganiban, Jody M; Gern, James E; Gold, Diane R; Gower, William A; Hertz-Picciotto, Irva; Karagas, Margaret R; Karr, Catherine J; Lester, Barry; Leve, Leslie D; Litonjua, Augusto A; Ludena, Yunin; McEvoy, Cindy T; Miller, Rachel L; Mueller, Noel T; O'Connor, Thomas G; Oken, Emily; O'Shea, T Michael; Perera, Frederica; Stanford, Joseph B; Rivera-Spoljaric, Katherine; Rundle, Andrew; Trasande, Leonardo; Wright, Rosalind J; Zhang, Yue; Zhu, Yeyi; Berhane, Kiros; Gilliland, Frank; Chatzi, Lida; on behalf of program collaborators for Environmental Influences on Child Health Outcomes	January 1, 2022	Not Determined
34307452	Create Study	A Comparison of Serum and Plasma Blood Collection Tubes for the Integration of Epidemiological and Metabolomics Data.	Frontiers in molecular biosciences	Sotelo-Orozco, Jennie; Chen, Shin-Yu; Hertz-Picciotto, Irva; Slupsky, Carolyn M	January 1, 2021	Not Determined
34290368	Create Study	Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model.	Molecular psychiatry	Bruce, Matthew R; Jones, Karen L; Vernon, Anthony C; Silverman, Jill L; Crawley, Jacqueline N; Ellegood, Jacob; Lerch, Jason P; Van de Water, Judy	December 1, 2021	Not Determined
33750431	Create Study	Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.	Epigenetics & chromatin	Laufer, Benjamin I; Gomez, J Antonio; Jianu, Julia M; LaSalle, Janine M	March 9, 2021	Not Determined
33483694	Create Study	Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism.	Molecular psychiatry	Ramirez-Celis, Alexandra; Becker, Martin; Nuño, Miriam; Schauer, Joseph; Aghaeepour, Nima; Van de Water, Judy	May 1, 2021	Not Determined
33414730	Create Study	Association Between Plasma Metabolites and Psychometric Scores Among Children With Developmental Disabilities: Investigating Sex-Differences.	Frontiers in psychiatry	Sotelo-Orozco, Jennie; Abbeduto, Leonard; Hertz-Picciotto, Irva; Slupsky, Carolyn M	January 1, 2020	Not Determined
33001180	Create Study	Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profiles.	Human molecular genetics	Laufer, Benjamin I; Hwang, Hyeyeon; Jianu, Julia M; Mordaunt, Charles E; Korf, Ian F; Hertz-Picciotto, Irva; LaSalle, Janine M	January 6, 2021	Not Determined
32758449	Create Study	Episignatures Stratifying Helsmoortel-Van Der Aa Syndrome Show Modest Correlation with Phenotype.	American journal of human genetics	Breen, Michael S; Garg, Paras; Tang, Lara; Mendonca, Danielle; Levy, Tess; Barbosa, Mafalda; Arnett, Anne B; Kurtz-Nelson, Evangeline; Agolini, Emanuele; Battaglia, Agatino; Chiocchetti, Andreas G; Freitag, Christine M; Garcia-Alcon, Alicia; Grammatico, Paola; Hertz-Picciotto, Irva; Ludena-Rodriguez, Yunin; Moreno, Carmen; Novelli, Antonio; Parellada, Mara; Pascolini, Giulia; Tassone, Flora; Grice, Dorothy E; Di Marino, Daniele; Bernier, Raphael A; Kolevzon, Alexander; Sharp, Andrew J; Buxbaum, Joseph D; Siper, Paige M; De Rubeis, Silvia	September 3, 2020	Not Determined
32636769	Create Study	Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward.	Frontiers in psychiatry	Bush, Nicole R; Wakschlag, Lauren S; LeWinn, Kaja Z; Hertz-Picciotto, Irva; Nozadi, Sara S; Pieper, Sarah; Lewis, Johnnye; Biezonski, Dominik; Blair, Clancy; Deardorff, Julianna; Neiderhiser, Jenae M; Leve, Leslie D; Elliott, Amy J; Duarte, Cristiane S; Lugo-Candelas, Claudia; O'Shea, T Michael; Avalos, Lyndsay A; Page, Grier P; Posner, Jonathan	January 1, 2020	Not Determined
32361076	Create Study	Temporal trends and determinants of serum concentrations of per- and polyfluoroalkyl substances among Northern California mothers with a young child, 2009-2016.	Environmental research	Kim, Kyunghoon; Bennett, Deborah H; Calafat, Antonia M; Hertz-Picciotto, Irva; Shin, Hyeong-Moo	July 2020	Not Determined
32353786	Create Study	Modeled prenatal exposure to per- and polyfluoroalkyl substances in association with child autism spectrum disorder: A case-control study.	Environmental research	Shin, Hyeong-Moo; Bennett, Deborah H; Calafat, Antonia M; Tancredi, Daniel; Hertz-Picciotto, Irva	July 2020	Not Determined
31812776	Create Study	Peptides of neuron specific enolase as potential ASD biomarkers: From discovery to epitope mapping.	Brain, behavior, and immunity	Ramirez-Celis, Alexandra; Edmiston, Elizabeth; Schauer, Joseph; Vu, Tam; Van de Water, Judy	February 2020	Not Determined
31582732	Create Study	Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome.	Translational psychiatry	Orozco, Jennie Sotelo; Hertz-Picciotto, Irva; Abbeduto, Leonard; Slupsky, Carolyn M	October 2019	Not Determined
31248991	Create Study	The CHARGE study: an assessment of parental occupational exposures and autism spectrum disorder.	Occupational and environmental medicine	McCanlies, Erin C; Ma, Claudia C; Gu, Ja Kook; Fekedulegn, Desta; Sanderson, Wayne T; Ludeña-Rodriguez, Yunin J; Hertz-Picciotto, Irva	September 2019	Not Determined
31094097	Create Study	Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study.	Autism research : official journal of the International Society for Autism Research	Schmidt, Rebecca J; Niu, Qiaojuan; Eyles, Darryl W; Hansen, Robin L; Iosif, Ana-Maria	June 2019	Not Determined
30534090	Create Study	Anti-Candida albicans IgG Antibodies in Children With Autism Spectrum Disorders.	Frontiers in psychiatry	Hughes, Heather K; Ashwood, Paul	January 1, 2018	Not Determined
30520558	Create Study	Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Lee, Samuel C; Quinn, Thomas P; Lai, Jerry; Kong, Sek Won; Hertz-Picciotto, Irva; Glatt, Stephen J; Crowley, Tamsyn M; Venkatesh, Svetha; Nguyen, Thin	September 2019	Not Determined
30483058	Create Study	Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders.	Frontiers in cellular neuroscience	Hughes, Heather K; Mills Ko, Emily; Rose, Destanie; Ashwood, Paul	January 2018	Not Determined
30251184	Create Study	The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders.	Current neurology and neuroscience reports	Hughes, Heather K; Rose, Destanie; Ashwood, Paul	September 2018	Not Determined
30136409	Create Study	Comparison of maternal beliefs about causes of autism spectrum disorder and association with utilization of services and treatments.	Child: care, health and development	Chaidez, Virginia; Fernandez Y Garcia, Erik; Wang, Lulu W; Angkustsiri, Kathleen; Krakowiak, Paula; Hertz-Picciotto, Irva; Hansen, Robin L	November 2018	Not Determined
29955164	Create Study	Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism.	Molecular psychiatry	Jones, Karen L; Pride, Michael C; Edmiston, Elizabeth; Yang, Mu; Silverman, Jill L; Crawley, Jacqueline N; Van de Water, Judy	November 2020	Not Determined
29934547	Create Study	Maternal autoantibody related autism: mechanisms and pathways.	Molecular psychiatry	Jones, Karen L; Van de Water, Judy	February 2019	Not Determined
29594156	Create Study	Affectionate Interactions of Cats with Children Having Autism Spectrum Disorder.	Frontiers in veterinary science	Hart, Lynette A; Thigpen, Abigail P; Willits, Neil H; Lyons, Leslie A; Hertz-Picciotto, Irva; Hart, Benjamin L	January 2018	Not Determined
29573218	Create Study	Understanding environmental contributions to autism: Causal concepts and the state of science.	Autism research : official journal of the International Society for Autism Research	Hertz-Picciotto I, Schmidt RJ, Krakowiak P	April 2018	Not Determined
29571898	Create Study	Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.	Brain, behavior, and immunity	Rose, Destanie R; Yang, Houa; Serena, Gloria; Sturgeon, Craig; Ma, Bing; Careaga, Milo; Hughes, Heather K; Angkustsiri, Kathy; Rose, Melissa; Hertz-Picciotto, Irva; Van de Water, Judy; Hansen, Robin L; Ravel, Jacques; Fasano, Alessio; Ashwood, Paul	May 2018	Not Determined
29289663	Create Study	Identification of the antigenic epitopes of maternal autoantibodies in autism spectrum disorders.	Brain, behavior, and immunity	Edmiston, Elizabeth; Jones, Karen L; Vu, Tam; Ashwood, Paul; Van de Water, Judy	March 2018	Not Determined
29276530	Create Study	Inattention and hyperactivity in association with autism spectrum disorders in the CHARGE study.	Research in autism spectrum disorders	Lyall, Kristen; Schweitzer, Julie B; Schmidt, Rebecca J; Hertz-Picciotto, Irva; Solomon, Marjorie	March 2017	Not Determined
29120534	Create Study	Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder.	Autism research : official journal of the International Society for Autism Research	Goodrich, Amanda J; Volk, Heather E; Tancredi, Daniel J; McConnell, Rob; Lurmann, Fred W; Hansen, Robin L; Schmidt, Rebecca J	January 2018	Not Determined
28934093	Create Study	Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder.	Environmental health perspectives	Schmidt, Rebecca J; Kogan, Vladimir; Shelton, Janie F; Delwiche, Lora; Hansen, Robin L; Ozonoff, Sally; Ma, Claudia C; McCanlies, Erin C; Bennett, Deborah H; Hertz-Picciotto, Irva; Tancredi, Daniel J; Volk, Heather E	September 2017	Not Determined
28921105	Create Study	Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder.	Journal of autism and developmental disorders	Kerin, Tara; Volk, Heather; Li, Weiyan; Lurmann, Fred; Eckel, Sandrah; McConnell, Rob; Hertz-Picciotto, Irva	January 2018	Not Determined
28820892	Create Study	Maternal autoimmune antibodies alter the dendritic arbor and spine numbers in the infragranular layers of the cortex.	PloS one	Ariza, Jeanelle; Hurtado, Jesus; Rogers, Haille; Ikeda, Raymond; Dill, Michael; Steward, Craig; Creary, Donnay; Van de Water, Judy; Martínez-Cerdeño, Verónica	January 1, 2017	Not Determined
28448694	Create Study	The joint effect of air pollution exposure and copy number variation on risk for autism.	Autism research : official journal of the International Society for Autism Research	Kim, Dokyoon; Volk, Heather; Girirajan, Santhosh; Pendergrass, Sarah; Hall, Molly A; Verma, Shefali S; Schmidt, Rebecca J; Hansen, Robin L; Ghosh, Debashis; Ludena-Rodriguez, Yunin; Kim, Kyoungmi; Ritchie, Marylyn D; Hertz-Picciotto, Irva; Selleck, Scott B	September 2017	Not Determined
28340985	Create Study	Autoimmunity, Autoantibodies, and Autism Spectrum Disorder.	Biological psychiatry	Edmiston, Elizabeth; Ashwood, Paul; Van de Water, Judy	March 2017	Not Relevant
27862943	Create Study	Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Tylee, Daniel S; Hess, Jonathan L; Quinn, Thomas P; Barve, Rahul; Huang, Hailiang; Zhang-James, Yanli; Chang, Jeffrey; Stamova, Boryana S; Sharp, Frank R; Hertz-Picciotto, Irva; Faraone, Stephen V; Kong, Sek Won; Glatt, Stephen J	April 2017	Not Relevant
27846226	Create Study	Pleiotropic Mechanisms Indicated for Sex Differences in Autism.	PLoS genetics	Mitra, Ileena; Tsang, Kathryn; Ladd-Acosta, Christine; Croen, Lisa A; Aldinger, Kimberly A; Hendren, Robert L; Traglia, Michela; Lavillaureix, Alinoë; Zaitlen, Noah; Oldham, Michael C; Levitt, Pat; Nelson, Stanley; Amaral, David G; Hertz-Picciotto, Irva; Fallin, M Daniele; Weiss, Lauren A	November 1, 2016	Not Determined
27639855	Create Study	Sociodemographic Disparities in Intervention Service Utilization in Families of Children with Autism Spectrum Disorder.	Journal of autism and developmental disorders	Nguyen, Cathina T; Krakowiak, Paula; Hansen, Robin; Hertz-Picciotto, Irva; Angkustsiri, Kathleen	December 2016	Not Determined
27534269	Create Study	The Role of the Immune System in Autism Spectrum Disorder.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Meltzer, Amory; Van de Water, Judy	January 2017	Not Relevant
27312731	Create Study	Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions.	Autism research : official journal of the International Society for Autism Research	Krakowiak P, Walker CK, Tancredi D, Hertz-Picciotto I, Van De Water J	June 17, 2016	Not Determined
27071785	Create Study	Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure.	CNS & neurological disorders drug targets	Wong, Sarah; Giulivi, Cecilia	January 2016	Not Relevant
27033107	Create Study	Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study.	Pediatrics	Wong, Sarah; Napoli, Eleonora; Krakowiak, Paula; Tassone, Flora; Hertz-Picciotto, Irva; Giulivi, Cecilia	April 2016	Not Determined
27015098	Create Study	Spending by California''s Department of Developmental Services for Persons with Autism across Demographic and Expenditure Categories.	PloS one	Leigh, J Paul; Grosse, Scott D; Cassady, Diana; Melnikow, Joy; Hertz-Picciotto, Irva	January 2016	Not Relevant
26725748	Create Study	Risk factors in autism: Thinking outside the brain.	Journal of autoimmunity	Matelski L, Van De Water J	February 2016	Not Relevant
26392128	Create Study	Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder.	Biological psychiatry	Krakowiak, Paula; Goines, Paula E; Tancredi, Daniel J; Ashwood, Paul; Hansen, Robin L; Hertz-Picciotto, Irva; Van de Water, Judy	March 1, 2017	Not Determined
26298322	Create Study	Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma.	Journal of neuroimmunology	Akintunde, Marjannie Eloi; Rose, Melissa; Krakowiak, Paula; Heuer, Luke; Ashwood, Paul; Hansen, Robin; Hertz-Picciotto, Irva; Van de Water, Judy	September 15, 2015	Not Determined
26198445	Create Study	Prenatal mercury exposure, autism, and developmental delay, using pharmacokinetic combination of newborn blood concentrations and questionnaire data: a case control study.	Environmental health : a global access science source	McKean SJ, Bartell SM, Hansen RL, Barfod GH, Green PG, Hertz-Picciotto I	2015	Not Determined
26108271	Create Study	Phthalate concentrations in house dust in relation to autism spectrum disorder and developmental delay in the CHildhood Autism Risks from Genetics and the Environment (CHARGE) study.	Environmental health : a global access science source	Philippat C, Bennett DH, Krakowiak P, Rose M, Hwang HM, Hertz-Picciotto I	2015	Not Determined
26073892	Create Study	Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study.	Early human development	Schmidt, Rebecca J; Hansen, Robin L; Hartiala, Jaana; Allayee, Hooman; Sconberg, Jaime L; Schmidt, Linda C; Volk, Heather E; Tassone, Flora	August 2015	Not Determined
26030513	Create Study	Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies-reply.	JAMA pediatrics	Walker CK, Ashwood P, Hertz-Picciotto I	June 2015	Not Relevant
25929801	Create Study	Exposure to select phthalates and phenols through use of personal care products among Californian adults and their children.	Environmental research	Philippat, Claire; Bennett, Deborah; Calafat, Antonia M; Picciotto, Irva Hertz	July 1, 2015	Not Determined
25722050	Create Study	Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study.	Autism research : official journal of the International Society for Autism Research	Lyall, Kristen; Van de Water, Judy; Ashwood, Paul; Hertz-Picciotto, Irva	October 2015	Not Determined
25656730	Create Study	Maternal Recall Versus Medical Records of Metabolic Conditions from the Prenatal Period: A Validation Study.	Maternal and child health journal	Krakowiak P, Walker CK, Tancredi DJ, Hertz-Picciotto I	September 2015	Not Determined
25485869	Create Study	Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay.	JAMA pediatrics	Walker, Cheryl K; Krakowiak, Paula; Baker, Alice; Hansen, Robin L; Ozonoff, Sally; Hertz-Picciotto, Irva	February 2015	Not Determined
25249546	Create Study	Maternal intake of supplemental iron and risk of autism spectrum disorder.	American journal of epidemiology	Schmidt, Rebecca J; Tancredi, Daniel J; Krakowiak, Paula; Hansen, Robin L; Ozonoff, Sally	November 1, 2014	Not Determined
25072037	Create Study	Potential therapeutic use of the ketogenic diet in autism spectrum disorders.	Frontiers in pediatrics	Napoli, Eleonora; Dueñas, Nadia; Giulivi, Cecilia	January 1, 2014	Not Determined
24954055	Create Study	Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study.	Environmental health perspectives	Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I	October 2014	Not Determined
24809045	Create Study	Grand challenges in cellular biochemistry: the "next-gen" biochemistry.	Frontiers in chemistry	Giulivi, Cecilia	January 1, 2014	Not Determined
24753527	Create Study	Deficits in bioenergetics and impaired immune response in granulocytes from children with autism.	Pediatrics	Napoli E, Wong S, Hertz-Picciotto I, Giulivi C	May 2014	Not Determined
24733881	Create Study	Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay.	Pediatrics	Harrington RA, Lee LC, Crum RM, Zimmerman AW, Hertz-Picciotto I	May 2014	Not Determined
24613242	Create Study	Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice.	Behavioural brain research	Camacho, Jasmin; Jones, Karen; Miller, Elaine; Ariza, Jeanelle; Noctor, Stephen; de Water, Judy Van; Martínez-Cerdeño, Verónica	June 1, 2014	Not Determined
24518932	Create Study	Maternal lifestyle and environmental risk factors for autism spectrum disorders.	International journal of epidemiology	Lyall, Kristen; Schmidt, Rebecca J; Hertz-Picciotto, Irva	April 2014	Not Determined
24456651	Create Study	Autism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study.	Environmental health : a global access science source	Keil AP, Daniels JL, Hertz-Picciotto I	2014	Not Determined
24399100	Create Study	Utilization patterns of conventional and complementary/alternative treatments in children with autism spectrum disorders and developmental disabilities in a population-based study.	Journal of developmental and behavioral pediatrics : JDBP	Akins RS, Krakowiak P, Angkustsiri K, Hertz-Picciotto I, Hansen RL	January 2014	Not Determined
24389156	Create Study	Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder.	Brain, behavior, and immunity	Piras IS, Haapanen L, Napolioni V, Sacco R, Van de Water J, Persico AM	May 2014	Not Determined
24337796	Create Study	Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay.	Journal of autism and developmental disorders	Lyall, Kristen; Ashwood, Paul; Van de Water, Judy; Hertz-Picciotto, Irva	July 2014	Not Determined
24332449	Create Study	Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.	Neurobiology of aging	Pretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone F	May 2014	Not Determined
24240654	Create Study	Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene.	Epidemiology (Cambridge, Mass.)	Volk, Heather E; Kerin, Tara; Lurmann, Fred; Hertz-Picciotto, Irva; McConnell, Rob; Campbell, Daniel B	January 2014	Not Determined
24193577	Create Study	Gastrointestinal problems in children with autism, developmental delays or typical development.	Journal of autism and developmental disorders	Chaidez, Virginia; Hansen, Robin L; Hertz-Picciotto, Irva	May 2014	Not Determined
24174712	Create Study	Increased anti-phospholipid antibodies in autism spectrum disorders.	Mediators of inflammation	Careaga M, Hansen RL, Hertz-Piccotto I, Van de Water J, Ashwood P	2013	Not Determined
24174710	Create Study	Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring.	Mediators of inflammation	Giulivi, Cecilia; Napoli, Eleonora; Schwartzer, Jared; Careaga, Milo; Ashwood, Paul	2013	Not Determined
23965925	Create Study	Infertility and its treatments in association with autism spectrum disorders: a review and results from the CHARGE study.	International journal of environmental research and public health	Lyall K, Baker A, Hertz-Picciotto I, Walker CK	August 2013	Not Determined
23838888	Create Study	Autism-specific maternal autoantibodies recognize critical proteins in developing brain.	Translational psychiatry	Braunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J	2013	Not Determined
23623455	Create Study	Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.	Biological psychiatry	Walker, Cheryl K; Anderson, Kaitlin W; Milano, Kristin M; Ye, Saier; Tancredi, Daniel J; Pessah, Isaac N; Hertz-Picciotto, Irva; Kliman, Harvey J	August 1, 2013	Not Determined
23535821	Create Study	Global increases in both common and rare copy number load associated with autism.	Human molecular genetics	Girirajan S, Johnson RL, Tassone F, Balciuniene J, Katiyar N, Fox K, Baker C, Srikanth A, Yeoh KH, Khoo SJ, Nauth TB, Hansen R, Ritchie M, Hertz-Picciotto I, Eichler EE, Pessah IN, Selleck SB	July 15, 2013	Not Determined
23404082	Create Study	Traffic-related air pollution, particulate matter, and autism.	JAMA psychiatry	Volk, Heather E; Lurmann, Fred; Penfold, Bryan; Hertz-Picciotto, Irva; McConnell, Rob	January 2013	Not Determined
23347615	Create Study	Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism.	Molecular autism	Napoli E, Wong S, Giulivi C	January 2013	Not Determined
23086694	Create Study	Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies.	Environmental health perspectives	Verner, Marc-André; Sonneborn, Dean; Lancz, Kinga; Muckle, Gina; Ayotte, Pierre; Dewailly, Éric; Kocan, Anton; Palkovicová, Lubica; Trnovec, Tomas; Haddad, Sami; Hertz-Picciotto, Irva; Eggesbø, Merete	January 2013	Not Determined
22854260	Create Study	Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction.	Journal of neuroimmunology	Heuer LS, Rose M, Ashwood P, Van de Water J	October 15, 2012	Not Determined
22833194	Create Study	Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression.	Translational psychiatry	Heuer L, Braunschweig D, Ashwood P, Van de Water J, Campbell DB	2011	Not Determined
22767137	Create Study	Identification of expanded alleles of the FMR1 Gene in the CHildhood Autism Risks from Genes and Environment (CHARGE) study.	Journal of autism and developmental disorders	Tassone F, Choudhary NS, Tassone F, Durbin-Johnson B, Hansen R, Hertz-Picciotto I, Pessah I	March 2013	Not Determined
22689191	Create Study	Maternal autoantibodies in autism.	Archives of neurology	Braunschweig D, Van de Water J	June 2012	Not Determined
22648721	Create Study	Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study.	The American journal of clinical nutrition	Schmidt, Rebecca J; Tancredi, Daniel J; Ozonoff, Sally; Hansen, Robin L; Hartiala, Jaana; Allayee, Hooman; Schmidt, Linda C; Tassone, Flora; Hertz-Picciotto, Irva	July 2012	Not Determined
22562209	Create Study	Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study.	Journal of autism and developmental disorders	Zerbo O, Iosif AM, Walker C, Ozonoff S, Hansen RL, Hertz-Picciotto I	January 2013	Not Determined
22534084	Create Study	Tipping the balance of autism risk: potential mechanisms linking pesticides and autism.	Environmental health perspectives	Shelton JF, Hertz-Picciotto I, Pessah IN	July 2012	Not Determined
22492772	Create Study	Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders.	Pediatrics	Krakowiak, Paula; Walker, Cheryl K; Bremer, Andrew A; Baker, Alice S; Ozonoff, Sally; Hansen, Robin L; Hertz-Picciotto, Irva	May 2012	Not Determined
22399446	Create Study	Autism spectrum disorders in Hispanics and non-Hispanics.	Autism : the international journal of research and practice	Chaidez V, Hansen RL, Hertz-Picciotto I	July 2012	Not Determined
22399411	Create Study	Parental occupational exposures and autism spectrum disorder.	Journal of autism and developmental disorders	McCanlies EC, Fekedulegn D, Mnatsakanova A, Burchfiel CM, Sanderson WT, Charles LE, Hertz-Picciotto I	November 2012	Not Determined
22275729	Create Study	Pre- and postnatal polychlorinated biphenyl concentrations and longitudinal measures of thymus volume in infants.	Environmental health perspectives	Jusko TA, Sonneborn D, Palkovicova L, Kocan A, Drobna B, Trnovec T, Hertz-Picciotto I	April 2012	Not Determined
21610500	Create Study	Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism.	Epidemiology (Cambridge, Mass.)	Schmidt, Rebecca J; Hansen, Robin L; Hartiala, Jaana; Allayee, Hooman; Schmidt, Linda C; Tancredi, Daniel J; Tassone, Flora; Hertz-Picciotto, Irva	July 2011	Not Determined
21610186	Create Study	Minor physical anomalies in children with autism spectrum disorders.	Autism : the international journal of research and practice	Angkustsiri K, Krakowiak P, Moghaddam B, Wardinsky T, Gardner J, Kalamkarian N, Hertz-Picciotto I, Hansen RL	November 2011	Not Determined
21543984	Create Study	Month of conception and risk of autism.	Epidemiology (Cambridge, Mass.)	Zerbo O, Iosif AM, Delwiche L, Walker C, Hertz-Picciotto I	July 2011	Not Determined
21538940	Create Study	MAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders.	Autism research : official journal of the International Society for Autism Research	Tassone, Flora; Qi, Lihong; Zhang, Wenting; Hansen, Robin L; Pessah, Isaac N; Hertz-Picciotto, Irva	August 2011	Not Determined
21205326	Create Study	Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study.	Environmental health : a global access science source	Hertz-Picciotto I, Bergman A, Fängström B, Rose M, Krakowiak P, Pessah I, Hansen R, Bennett DH	2011	Not Determined
21156395	Create Study	Residential proximity to freeways and autism in the CHARGE study.	Environmental health perspectives	Volk, Heather E; Hertz-Picciotto, Irva; Delwiche, Lora; Lurmann, Fred; McConnell, Rob	June 2011	Not Determined
21134442	Create Study	Autoantibodies to cerebellum in children with autism associate with behavior.	Brain, behavior, and immunity	Goines, Paula; Haapanen, Lori; Boyce, Robert; Duncanson, Paul; Braunschweig, Daniel; Delwiche, Lora; Hansen, Robin; Hertz-Picciotto, Irva; Ashwood, Paul; Van de Water, Judy	March 2011	Not Determined
21119085	Create Study	Mitochondrial dysfunction in autism.	JAMA	Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, Tassone F, Pessah IN	December 1, 2010	Not Determined
21095018	Create Study	Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders.	Journal of neuroimmunology	Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J	March 2011	Not Determined
20833247	Create Study	Altered T cell responses in children with autism.	Brain, behavior, and immunity	Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J	July 2011	Not Determined
20806403	Create Study	A comparison of multiple imputation and fully augmented weighted estimators for Cox regression with missing covariates.	Statistics in medicine	Qi L, Wang YF, He Y	November 10, 2010	Not Determined
20731829	Create Study	Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study.	Environmental health : a global access science source	Park HY, Hertz-Picciotto I, Sovcikova E, Kocan A, Drobna B, Trnovec T	2010	Not Determined
20705131	Create Study	Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.	Brain, behavior, and immunity	Ashwood, Paul; Krakowiak, Paula; Hertz-Picciotto, Irva; Hansen, Robin; Pessah, Isaac; Van de Water, Judy	January 2011	Not Determined
20466021	Create Study	Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins.	Neurotoxicology	Paul R, Pessah IN, Gane L, Ono M, Hagerman PJ, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman R	August 2010	Not Determined
20196589	Create Study	PBDEs in 2-5 year-old children from California and associations with diet and indoor environment.	Environmental science & technology	Rose M, Bennett DH, Bergman A, Fängström B, Pessah IN, Hertz-Picciotto I	April 1, 2010	Not Determined
20160651	Create Study	The immune system's role in the biology of autism.	Current opinion in neurology	Goines P, Van de Water J	April 2010	Not Determined
20143326	Create Study	Independent and dependent contributions of advanced maternal and paternal ages to autism risk.	Autism research : official journal of the International Society for Autism Research	Shelton JF, Tancredi DJ, Hertz-Picciotto I	February 2010	Not Determined
20056569	Create Study	Blood mercury concentrations in CHARGE Study children with and without autism.	Environmental health perspectives	Hertz-Picciotto, Irva; Green, Peter G; Delwiche, Lora; Hansen, Robin; Walker, Cheryl; Pessah, Isaac N	January 2010	Not Determined
20049980	Create Study	Geographic distribution of autism in California: a retrospective birth cohort analysis.	Autism research : official journal of the International Society for Autism Research	Van Meter KC, Christiansen LE, Delwiche LD, Azari R, Carpenter TE, Hertz-Picciotto I	February 2010	Not Determined
19937285	Create Study	Correlations between gene expression and mercury levels in blood of boys with and without autism.	Neurotoxicity research	Stamova, Boryana; Green, Peter G; Tian, Yingfang; Hertz-Picciotto, Irva; Pessah, Isaac N; Hansen, Robin; Yang, Xiaowei; Teng, Jennifer; Gregg, Jeffrey P; Ashwood, Paul; Van de Water, Judy; Sharp, Frank R	January 2011	Not Determined
19921347	Create Study	Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls.	Neurotoxicity research	Tian, Yingfang; Green, Peter G; Stamova, Boryana; Hertz-Picciotto, Irva; Pessah, Isaac N; Hansen, Robin; Yang, Xiaowei; Gregg, Jeffrey P; Ashwood, Paul; Jickling, Glen; Van de Water, Judy; Sharp, Frank R	January 2011	Not Determined
19800697	Create Study	Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders.	Journal of neuroimmunology	Onore, Charity; Enstrom, Amanda; Krakowiak, Paula; Hertz-Picciotto, Irva; Hansen, Robin; Van de Water, Judy; Ashwood, Paul	November 30, 2009	Not Determined
19737792	Create Study	Commentary: Diagnostic change and the increased prevalence of autism.	International journal of epidemiology	Hertz-Picciotto I	October 2009	Not Determined
19666104	Create Study	Differential monocyte responses to TLR ligands in children with autism spectrum disorders.	Brain, behavior, and immunity	Enstrom AM, Onore CE, Van de Water JA, Ashwood P	January 2010	Not Determined
19647017	Create Study	WITHDRAWN: Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity in a birth cohort.	Neurotoxicology	Park HY, Hertz-Picciotto I, Sovcikova E, Kocan A, Trnovec T	July 30, 2009	Not Determined
19360687	Create Study	The onset of autism: patterns of symptom emergence in the first years of life.	Autism research : official journal of the International Society for Autism Research	Ozonoff, Sally; Heung, Kelly; Byrd, Robert; Hansen, Robin; Hertz-Picciotto, Irva	December 2008	Not Determined
19343198	Create Study	Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms.	Autism research : official journal of the International Society for Autism Research	Heuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J	October 2008	Not Determined
19307110	Create Study	Plasma fatty acid profiles in autism: a case-control study.	Prostaglandins, leukotrienes, and essential fatty acids	Wiest MM, German JB, Harvey DJ, Watkins SM, Hertz-Picciotto I	April 2009	Not Determined
19234401	Create Study	The rise in autism and the role of age at diagnosis.	Epidemiology (Cambridge, Mass.)	Hertz-Picciotto, Irva; Delwiche, Lora	January 2009	Not Determined
19211157	Create Study	Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders.	Journal of neuroimmunology	Ashwood P, Schauer J, Pessah IN, Van de Water J	March 31, 2009	Not Determined
19136055	Create Study	Increased IgG4 levels in children with autism disorder.	Brain, behavior, and immunity	Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, Van de Water JA, Ashwood P	March 2009	Not Determined
19132145	Create Study	MECP2 promoter methylation and X chromosome inactivation in autism.	Autism research : official journal of the International Society for Autism Research	Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM	June 2008	Not Determined
18762342	Create Study	Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes.	Journal of neuroimmunology	Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, Ozonoff S, Pessah IN, Van de Water J	November 15, 2008	Not Determined
18762240	Create Study	Altered gene expression and function of peripheral blood natural killer cells in children with autism.	Brain, behavior, and immunity	Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P	January 2009	Not Determined
18627595	Create Study	A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio.	Environmental health : a global access science source	Hertz-Picciotto I, Jusko TA, Willman EJ, Baker RJ, Keller JA, Teplin SW, Charles MJ	2008	Not Determined
18507863	Create Study	A procedure to characterize geographic distributions of rare disorders in cohorts.	International journal of health geographics	Van Meter KC, Christiansen LE, Hertz-Picciotto I, Azari R, Carpenter TE	2008	Not Determined
18482108	Create Study	Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study.	Journal of sleep research	Krakowiak, Paula; Goodlin-Jones, Beth; Hertz-Picciotto, Irva; Croen, Lisa A; Hansen, Robin L	June 2008	Not Determined
18426515	Create Study	Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight.	Paediatric and perinatal epidemiology	Sonneborn D, Park HY, Petrik J, Kocan A, Palkovicova L, Trnovec T, Nguyen D, Hertz-Picciotto I	May 2008	Not Determined
18285840	Create Study	Serum PCB concentrations in relation to locally produced food items in eastern Slovakia.	Journal of exposure science & environmental epidemiology	Sonneborn D, Park HY, Babinska K, Palkovicova L, Trnovec T, Kocan A, Nguyen DV, Hertz-Picciotto I	November 2008	Not Determined
18191778	Create Study	Regression in autism: prevalence and associated factors in the CHARGE Study.	Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association	Hansen, Robin L; Ozonoff, Sally; Krakowiak, Paula; Angkustsiri, Kathleen; Jones, Carrie; Deprey, Lesley J; Le, Dung-Nghi; Croen, Lisa A; Hertz-Picciotto, Irva	January 2008	Not Determined
18078998	Create Study	Autism: maternally derived antibodies specific for fetal brain proteins.	Neurotoxicology	Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J	March 2008	Not Determined
18006270	Create Study	Gene expression changes in children with autism.	Genomics	Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR	January 2008	Not Determined
17347881	Create Study	Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype?	Journal of autism and developmental disorders	Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J	January 2008	Not Determined

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	11	05/13/2015	621	05/13/2015	598	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Mullen Scales of Early Learning	11	05/13/2015	621	05/13/2015	598	Approved
Genomics/omics	99	01/15/2015	0	05/15/2015	0	Approved
ABC Community	99	01/15/2015	622	05/15/2015	597	Approved
ADOS	99	01/15/2015	364	05/15/2015	354	Approved
ADI-R	336	07/15/2014	428	11/15/2014	414	Approved
Early Development Questionnaire	382	01/15/2015	572	05/15/2015	550	Approved
Medical History	700	07/15/2014	625	11/15/2014	602	Approved
Genetic Test	99	01/15/2015	0	05/15/2015	0	Approved
Social Communication Questionnaire (SCQ)	99	01/15/2015	263	05/15/2015	255	Approved
Demographics	700	01/15/2016	622	05/15/2016	599	Approved
Enviromental Evaluation	99	01/15/2015	606	05/15/2015	584	Approved
Sleep History	99	07/15/2015	624	11/15/2015	602	Approved
Physical Exam	99	01/15/2015	389	07/31/2018	376	Approved
Vineland (Parent and Caregiver)	700	07/15/2014	679	11/15/2014	657	Approved
Product Questionnaire	99	01/15/2015	0	05/15/2015	0	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Examining the validity of the use of ratio IQs in psychological assessments	IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.	476/17423	Secondary Analysis	Shared
The importance of low IQ to early diagnosis of autism	Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood.	460/6323	Secondary Analysis	Shared
Prognostic early snapshot stratification of autism based on adaptive functioning	A major goal of precision medicine is to predict prognosis based on individualized information at the earliest possible points in development. Using early snapshots of adaptive functioning and unsupervised data- driven discovery methods, we uncover highly stable early autism subtypes that yield information relevant to later prognosis. Data from the National Institute of Mental Health Data Archive (NDA) (n = 1,098) was used to uncover three early subtypes (<72 months) that generalize with 96% accuracy. Outcome data from NDA (n = 2,561; mean age, 13 years) also reproducibly clusters into three subtypes with 99% generalization accuracy. Early snapshot subtypes predict developmental trajectories in non-verbal cognitive, language and motor domains and are predictive of membership in different adaptive functioning outcome subtypes. Robust and prognosis- relevant subtyping of autism based on early snapshots of adaptive functioning may aid future research work via prediction of these subtypes with our reproducible stratification model.	22/3517	Secondary Analysis	Shared
Investigating autism etiology and heterogeneity by decision tree algorithm	Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism.	96/3382	Secondary Analysis	Shared
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitry	Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.	120/1708	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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