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1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

Collection - Use Existing Experiment
To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.
SelectExperiment IdExperiment NameExperiment Type
Created On
24HI-NGS_R1Omics02/16/2011
475MB1-10 (CHOP)Omics06/07/2016
490Illumina Infinium PsychArray BeadChip AssayOmics07/07/2016
501PharmacoBOLD Resting StatefMRI07/27/2016
506PVPREFOmics08/05/2016
509ABC-CT Resting v2EEG08/18/2016
13Comparison of FI expression in Autistic and Neurotypical Homo SapiensOmics12/28/2010
18AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics01/06/2011
22Stitching PCR SequencingOmics02/14/2011
26ASD_MethylationOmics03/01/2011
29Microarray family 03 (father, mother, sibling)Omics03/24/2011
37Standard paired-end sequencing of BCRsOmics04/19/2011
38Illumina Mate-Pair BCR sequencingOmics04/19/2011
39Custom Jumping LibrariesOmics04/19/2011
40Custom CapBPOmics04/19/2011
41ImmunofluorescenceOmics05/11/2011
43Autism brain sample genotyping, IlluminaOmics05/16/2011
47ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 SystemOmics08/01/2011
53AGRE Omni1-quadOmics10/11/2011
59AGP genotypingOmics04/03/2012
60Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controlsOmics06/23/2012
63Microemulsion PCR and Targeted Resequencing for Variant Detection in ASDOmics07/20/2012
76Whole Genome Sequencing in Autism FamiliesOmics01/03/2013
519RestingfMRI11/08/2016
90Genotyped IAN SamplesOmics07/09/2013
91NJLAGS Axiom Genotyping ArrayOmics07/16/2013
93AGP genotyping (CNV)Omics09/06/2013
106Longitudinal Sleep Study. H20 200. Channel set 2EEG11/07/2013
107Longitudinal Sleep Study. H20 200. Channel set 3EEG11/07/2013
108Longitudinal Sleep Study. AURA 200EEG11/07/2013
105Longitudinal Sleep Study. H20 200. Channel set 1EEG11/07/2013
109Longitudinal Sleep Study. AURA 400EEG11/07/2013
116Gene Expression Analysis WG-6Omics01/07/2014
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1Eye Tracking02/27/2014
132Jeste Lab UCLA ACEii: Animacy - Project 1Eye Tracking02/27/2014
133Jeste Lab UCLA ACEii: Mom Stranger - Project 2Eye Tracking02/27/2014
134Jeste Lab UCLA ACEii: Face Emotion - Project 3Eye Tracking02/27/2014
145AGRE/FMR1_Illumina.JHUOmics04/14/2014
146AGRE/MECP2_Sanger.JHUOmics04/14/2014
147AGRE/MECP2_Junior.JHUOmics04/14/2014
151Candidate Gene Identification in familial AutismOmics06/09/2014
152NJLAGS Whole Genome SequencingOmics07/01/2014
154Math Autism Study - Vinod MenonfMRI07/15/2014
155RestingfMRI07/25/2014
156SpeechfMRI07/25/2014
159EmotionfMRI07/25/2014
160syllable contrastEEG07/29/2014
167School-age naturalistic stimuliEye Tracking09/19/2014
44AGRE/Broad Affymetrix 5.0 Genotype ExperimentOmics06/27/2011
45Exome Sequencing of 20 Sporadic Cases of Autism Spectrum DisorderOmics07/15/2011
Collection - Add Experiment
Add Supporting Documentation
Select File

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions
Helen Tager-Flusberg 
Our ACE, located at Boston University, brings together researchers from across the university and collaborators from Harvard Medical School, Northeastern University and Albert Einstein College of Medicine. The interconnected projects in the ACE include: a novel intervention to promote spoken language in school-aged children with ASD (Project I); investigation of biological markers of treatment response and outcome (Projects I, II, and III); investigation of mechanisms that might underlie the failure to speak including (a) structural and functional connectivity impairments in key nodes of the speech production network according to the DIVA model (Project 11); (b) abnormalities in the perception, organization and analysis of auditory scenes as indexed in electrophysiological responses and neural oscillatory patterns (Project III); disruptions in excitatory and inhibitory neuronal pathways in key prefrontal cortical areas associated with language using high resolution methods to investigate white matter and axonal growth proteins in tissue samples (Project IV). The projects are united and served by an Administration and Data Management Core (A), a Research Training and Education Core (B) and a Clinical Core (C), which will carry out comprehensive assessments using standard and novel experimental measures to capture the heterogeneous phenotypes of minimally verbal children with ASD, and that will be used to explain variability in treatment response and mechanistic factors identified in the Projects. Together, the research conducted in our ACE will significantly advance our understanding of this neglected end of the autism spectrum, provide innovative approaches to assessment and treatment, pave the way for identifying biological markers predict who will fail to acquire speech, and highlight potential molecular targets for therapeutic interventions.
NIMH Data Archive
01/02/2013
Autism Centers of Excellence (ACE)
Funding Completed
Close Out
No
$9,415,528.00
180
Loading Chart...
NIH - Extramural None

QA-notification.txt Other Quality Assurance Notification Qualified Researchers


P50DC013027-01 Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions 09/04/2012 08/31/2019 890 302 BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) $9,415,528.00

helpcenter.collection.general-tab

NDA Help Center

Collection - General Tab

Fields available for edit on the top portion of the page include:

  • Collection Title
  • Investigators
  • Collection Description
  • Collection Phase
  • Funding Source
  • Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

  • Pre-Enrollment: The default entry made when the NDA Collection is created.
  • Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
  • Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
  • Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
    • The Data Expected Subphase indicates that NDA expects more data will be submitted
    • The Closeout Subphase indicates the data submission is complete.
    • The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

  • This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
  • Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
  • When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

  • How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?
    During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
  • How do I know when a NDA Collection has been created?
    When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
  • Is a single grant number ever associated with more than one Collection?
    The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
  • Why is there sometimes more than one grant included in a Collection?
    In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

  • Administrator Privilege
    A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
  • Collection Owner
    Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
  • Collection Phase
    The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
    • Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
    • Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
    • Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
    • Funding Completed: A grant/project has reached the project end date.
  • Collection Title
    An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
  • Grant
    Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
  • Supporting Documentation
    Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
  • NIH Research Initiative
    NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
  • Permission Group
    Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
  • Planned Enrollment
    Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
  • Actual Enrollment
    Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
  • NDA Collection
    A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
  • Data Use Limitations
    Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
  • Total Subjects Shared
    The total number of unique subjects for whom data have been shared and are available for users with permission to access data.
IDNameCreated DateStatusType
1332ACE fmri_runA07/15/2019ApprovedfMRI
1333ACE fmri_runB07/15/2019ApprovedfMRI
1334ACE fmri_runC07/15/2019ApprovedfMRI
1335ACE fmri_runD07/15/2019ApprovedfMRI
1336ACE fmri_runAShifted07/15/2019ApprovedfMRI
1337ACE fmri_runBShifted07/15/2019ApprovedfMRI
1338ACE fmri_RunCShifted07/15/2019ApprovedfMRI
1340ACE fmri_runDShifted07/15/2019ApprovedfMRI
1341Resting State07/15/2019ApprovedfMRI
1478Intensity MMN01/13/2020ApprovedEEG
helpcenter.collection.experiments-tab

NDA Help Center

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

  • Can an Experiment be associated with more than one Collection?

    Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:

    1. Copy the experiment with intent for modifications.
    2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

  • Experiment Status
    An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
  • Experiment ID
    The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.
ACE Family Medical History Clinical Assessments 149
ACE Subject Medical History Clinical Assessments 146
Aberrant Behavior Checklist (ABC) - Community Clinical Assessments 146
Adapted ADOS Module 1 Clinical Assessments 53
Adapted ADOS Module 2 Clinical Assessments 10
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 122
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 39
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 8
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 18
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 4 Clinical Assessments 48
Child/Adolescent Symptom Inventory Clinical Assessments 143
Children's Communication Checklist - 2 Clinical Assessments 83
Comprehensive Assessment of Spoken Language Clinical Assessments 64
Comprehensive Test of Phonological Processing (CTOPP) Clinical Assessments 63
Dean Handedness Inventory Clinical Assessments 150
EEG Subject Files Imaging 50
Early Social Communication Scale (ESCS) Clinical Assessments 59
Emotion Dysregulation Inventory (EDI) Clinical Assessments 140
Expressive Vocabulary Test Clinical Assessments 66
Image Imaging 40
Kaufman Speech Praxis Test Clinical Assessments 83
Language Environment Analysis Clinical Assessments 120
Leiter-3 Clinical Assessments 114
Mullen Scales of Early Learning Clinical Assessments 47
PQ Demographics Clinical Assessments 150
PQ Intervention History Clinical Assessments 124
Peabody Picture Vocabulary Test, Fourth Edition-Form A Clinical Assessments 160
Prosody Assessment Clinical Assessments 29
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 143
Research Subject Clinical Assessments 140
Sensory Profile Short Clinical Assessments 143
Vineland-II - Survey Form (2005) Clinical Assessments 130
WASI-2 Clinical Assessments 64
helpcenter.collection.shared-data-tab

NDA Help Center

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

  • How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?
    To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
  • Can I get a supplement to share data from a completed research project?
    Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
  • Can I get a supplement to share data from a research project that is still ongoing?
    Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Type
    A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
  • Shared
    The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
38104772Create StudyAdaptive thresholding increases sensitivity to detect changes in the rate of skin conductance responses to psychologically arousing stimuli in both laboratory and ambulatory settings.International journal of psychophysiology : official journal of the International Organization of PsychophysiologyKleckner, Ian R; Wormwood, Jolie B; Jones, Rebecca M; Culakova, Eva; Barrett, Lisa Feldman; Lord, Catherine; Quigley, Karen S; Goodwin, Matthew SFebruary 1, 2024Not Determined
37735966Create StudyAuditory evoked potentials in adolescents with autism: An investigation of brain development, intellectual impairment, and neural encoding.Autism research : official journal of the International Society for Autism ResearchSchwartz, Sophie; Wang, Le; Uribe, Sofia; Shinn-Cunningham, Barbara G; Tager-Flusberg, HelenOctober 1, 2023Not Determined
35754007Create StudyAuditory-motor mapping training: Testing an intonation-based spoken language treatment for minimally verbal children with autism spectrum disorder.Annals of the New York Academy of SciencesChenausky, Karen V; Norton, Andrea C; Tager-Flusberg, Helen; Schlaug, GottfriedSeptember 1, 2022Not Determined
35601992Create StudyIncreased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.Research in autism spectrum disordersHeller Murray, Elizabeth S; Segawa, Jennifer; Karahanoglu, F Isik; Tocci, Catherine; Tourville, Jason A; Nieto-Castanon, Alfonso; Tager-Flusberg, Helen; Manoach, Dara S; Guenther, Frank HJune 1, 2022Not Determined
35155817Create StudyHow do minimally verbal children and adolescents with autism spectrum disorder use communicative gestures to complement their spoken language abilities?Autism & developmental language impairmentsLa Valle, Chelsea; Chenausky, Karen; Tager-Flusberg, HelenJanuary 1, 2021Not Determined
35155816Create StudyMotor speech impairment predicts expressive language in minimally verbal, but not low verbal, individuals with autism spectrum disorder.Autism & developmental language impairmentsChenausky, Karen; Brignell, Amanda; Morgan, Angela; Tager-Flusberg, HelenJanuary 1, 2019Not Determined
33912683Create StudyAn experimental study of word learning in minimally verbal children and adolescents with autism spectrum disorder.Autism & developmental language impairmentsJoseph, Robert M; Skwerer, Daniela Plesa; Eggleston, Brady; Meyer, Steven R; Tager-Flusberg, HelenJanuary 1, 2019Not Determined
33852328Create StudyA Modeling-Guided Case Study of Disordered Speech in Minimally Verbal Children With Autism Spectrum Disorder.American journal of speech-language pathologyChenausky, Karen V; Brignell, Amanda; Morgan, Angela T; Norton, Andrea C; Tager-Flusberg, Helen B; Schlaug, Gottfried; Guenther, Frank HJune 18, 2021Not Determined
32909382Create StudyEliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism.Autism research : official journal of the International Society for Autism ResearchBarokova, Mihaela D; La Valle, Chelsea; Hassan, Sommer; Lee, Collin; Xu, Mengyuan; McKechnie, Riley; Johnston, Emily; Krol, Manon A; Leano, Jennifer; Tager-Flusberg, HelenJanuary 1, 2021Not Determined
32881387Create StudyAtypical Perception of Sounds in Minimally and Low Verbal Children and Adolescents With Autism as Revealed by Behavioral and Neural Measures.Autism research : official journal of the International Society for Autism ResearchSchwartz, Sophie; Wang, Le; Shinn-Cunningham, Barbara G; Tager-Flusberg, HelenOctober 2020Not Determined
32877838Create StudyFactor analysis of signs of childhood apraxia of speech.Journal of communication disordersChenausky, Karen V; Brignell, Amanda; Morgan, Angela; Gagné, Danielle; Norton, Andrea; Tager-Flusberg, Helen; Schlaug, Gottfried; Shield, Aaron; Green, Jordan RJanuary 1, 2020Not Determined
32842044Create StudyRelative Cost Differences of Initial Treatment Strategies for Newly Diagnosed Opioid Use Disorder: A Cohort Study.Medical careLarochelle, Marc R; Wakeman, Sarah E; Ameli, Omid; Chaisson, Christine E; McPheeters, Jeffrey T; Crown, William H; Azocar, Francisca; Sanghavi, Darshak MOctober 1, 2020Not Determined
32827357Create StudyNeural Evidence for Speech Processing Deficits During a Cocktail Party Scenario in Minimally and Low Verbal Adolescents and Young Adults with Autism.Autism research : official journal of the International Society for Autism ResearchSchwartz, Sophie; Wang, Le; Shinn-Cunningham, Barbara G; Tager-Flusberg, HelenNovember 1, 2020Not Determined
32640168Create StudyFunctional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review.American journal of speech-language pathologyButler, Lindsay K; Kiran, Swathi; Tager-Flusberg, HelenAugust 4, 2020Not Determined
32096124Create StudyComparing the Pragmatic Speech Profiles of Minimally Verbal and Verbally Fluent Individuals with Autism Spectrum Disorder.Journal of autism and developmental disordersLa Valle, Chelsea; Plesa-Skwerer, Daniela; Tager-Flusberg, HelenOctober 2020Not Determined
31225952Create StudyPredicting aggression to others in youth with autism using a wearable biosensor.Autism research : official journal of the International Society for Autism ResearchGoodwin MS, Mazefsky CA, Ioannidis S, Erdogmus D, Siegel MAugust 2019Not Determined
31187332Create StudyConcurrent Social Communication Predictors of Expressive Language in Minimally Verbal Children and Adolescents with Autism Spectrum Disorder.Journal of autism and developmental disordersPecukonis M, Plesa Skwerer D, Eggleston B, Meyer S, Tager-Flusberg HSeptember 2019Not Determined
31067982Create StudyDo minimally verbal and verbally fluent individuals with autism spectrum disorder differ in their viewing patterns of dynamic social scenes?Autism : the international journal of research and practicePlesa Skwerer, Daniela; Brukilacchio, Briana; Chu, Andrea; Eggleston, Brady; Meyer, Steven; Tager-Flusberg, HelenNovember 2019Not Determined
30833910Create StudyPrevalence and Correlates of Psychiatric Symptoms in Minimally Verbal Children and Adolescents With ASD.Frontiers in psychiatryPlesa Skwerer, Daniela; Joseph, Robert M; Eggleston, Brady; Meyer, Steven R; Tager-Flusberg, HelenJanuary 2019Not Determined
30648545Create StudyAn analysis of stereotypical motor movements and cardiovascular coupling in individuals on the autism spectrum.Biological psychologyHeathers JAJ, Gilchrist KH, Hegarty-Craver M, Grego S, Goodwin MSMarch 2019Not Determined
30638310Create StudyHow effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts?Autism research : official journal of the International Society for Autism ResearchJones RM, Plesa Skwerer D, Pawar R, Hamo A, Carberry C, Ajodan EL, Caulley D, Silverman MR, Mcadoo S, Meyer S, Yoder A, Clements M, Lord C, Tager-Flusberg HApril 2019Not Determined
30441641Create StudyTime-Series Prediction of Proximal Aggression Onset in Minimally-Verbal Youth with Autism Spectrum Disorder Using Physiological Biosignals.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceOzdenizci, Ozan; Cumpanasoiu, Catalina; Mazefsky, Carla; Siegel, Matthew; Erdoggmus, Deniz; Ioannidis, Stratis; Goodwin, Matthew SJuly 2018Not Determined
30420938Create StudyPredicting Imminent Aggression Onset in Minimally-Verbal Youth with Autism Spectrum Disorder Using Preceding Physiological Signals.International Conference on Pervasive Computing Technologies for Healthcare : [proceedings]. International Conference on Pervasive Computing Technologies for HealthcareGoodwin, Matthew S; Özdenizci, Ozan; Cumpanasoiu, Catalina; Tian, Peng; Guo, Yuan; Stedman, Amy; Peura, Christine; Mazefsky, Carla; Siegel, Matthew; Erdoğmuş, Deniz; Ioannidis, StratisMay 2018Not Determined
30395694Create StudyCommunication interventions for autism spectrum disorder in minimally verbal children.The Cochrane database of systematic reviewsBrignell, Amanda; Chenausky, Karen V; Song, Huan; Zhu, Jianwei; Suo, Chen; Morgan, Angela TNovember 5, 2018Not Determined
30230700Create StudyBehavioral predictors of improved speech output in minimally verbal children with autism.Autism research : official journal of the International Society for Autism ResearchChenausky, Karen; Norton, Andrea; Tager-Flusberg, Helen; Schlaug, GottfriedOctober 2018Not Determined
29946509Create StudyDiffusion-weighted imaging evidence of altered white matter development from late childhood to early adulthood in Autism Spectrum Disorder.NeuroImage. ClinicalKarahanoğlu FI, Baran B, Nguyen QTH, Meskaldji DE, Yendiki A, Vangel M, Santangelo SL, Manoach DSJanuary 2018Not Determined
29508403Create StudyFrom intuition to intervention: developing an intonation-based treatment for autism.Annals of the New York Academy of SciencesChenausky, Karen V; Schlaug, GottfriedMarch 2018Not Determined
29408312Create StudyMeta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism.Neuroscience and biobehavioral reviewsSchwartz, Sophie; Shinn-Cunningham, Barbara; Tager-Flusberg, HelenApril 2018Not Determined
28976309Create StudySimple, Transparent, and Flexible Automated Quality Assessment Procedures for Ambulatory Electrodermal Activity Data.IEEE transactions on bio-medical engineeringKleckner IR, Jones RM, Wilder-Smith O, Wormwood JB, Akcakaya M, Quigley KS, Lord C, Goodwin MSOctober 2017Relevant
28928645Create StudyAuditory-Motor Mapping Training in a More Verbal Child with Autism.Frontiers in human neuroscienceChenausky, Karen V; Norton, Andrea C; Schlaug, GottfriedJanuary 2017Not Determined
28424605Create StudyWhite Matter Integrity and Treatment-Based Change in Speech Performance in Minimally Verbal Children with Autism Spectrum Disorder.Frontiers in human neuroscienceChenausky, Karen; Kernbach, Julius; Norton, Andrea; Schlaug, GottfriedJanuary 1, 2017Not Determined
28339140Create StudyAcquisition of voice onset time in toddlers at high and low risk for autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchChenausky K, Tager-Flusberg HJuly 2017Not Determined
28261082Create StudyAutomated Detection of Stereotypical Motor Movements in Autism Spectrum Disorder Using Recurrence Quantification Analysis.Frontiers in neuroinformaticsGroßekathöfer, Ulf; Manyakov, Nikolay V; Mihajlović, Vojkan; Pandina, Gahan; Skalkin, Andrew; Ness, Seth; Bangerter, Abigail; Goodwin, Matthew SJanuary 2017Not Determined
27829034Create StudyAuditory-Motor Mapping Training: Comparing the Effects of a Novel Speech Treatment to a Control Treatment for Minimally Verbal Children with Autism.PloS oneChenausky, Karen; Norton, Andrea; Tager-Flusberg, Helen; Schlaug, GottfriedJanuary 2016Not Relevant
27354431Create StudyConducting research with minimally verbal participants with autism spectrum disorder.Autism : the international journal of research and practiceTager-Flusberg H, Plesa Skwerer D, Joseph RM, Brukilacchio B, Decker J, Eggleston B, Meyer S, Yoder AOctober 2017Not Determined
26921410Create StudyInterpersonal Autonomic Physiology: A Systematic Review of the Literature.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, IncPalumbo RV, Marraccini ME, Weyandt LL, Wilder-Smith O, Mcgee HA, Liu S, Goodwin MSMay 2017Not Determined
26408635Create StudyComparing methods for assessing receptive language skills in minimally verbal children and adolescents with autism spectrum disorders.Autism : the international journal of research and practicePlesa Skwerer D, Jordan SE, Brukilacchio BH, Tager-Flusberg HJuly 2016Not Determined
26173965Create StudyA highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2.European journal of human genetics : EJHGFedorenko E, Morgan A, Murray E, Cardinaux A, Mei C, Tager-Flusberg H, Fisher SE, Kanwisher NFebruary 2016Not Determined
25294649Create StudyApplying machine learning to facilitate autism diagnostics: pitfalls and promises.Journal of autism and developmental disordersBone D, Goodwin MS, Black MP, Lee CC, Audhkhasi K, Narayanan SMay 2015Not Determined
24839879Create StudyPromoting communicative speech in minimally verbal children with autism spectrum disorder.Journal of the American Academy of Child and Adolescent PsychiatryTager-Flusberg HJune 2014Not Determined
24124067Create StudyMinimally verbal school-aged children with autism spectrum disorder: the neglected end of the spectrum.Autism research : official journal of the International Society for Autism ResearchTager-Flusberg H, Kasari CDecember 2013Not Determined
helpcenter.collection.publications-tab

NDA Help Center

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

  • How can I determine if a publication is relevant?
    Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
  • Where does the NDA get the publications?
    PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

  • Create Study
    A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
  • Not Determined Publication
    Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
  • Not Relevant Publication
    A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
  • PubMed
    PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
  • PubMed ID
    The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
  • Relevant Publication
    A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.
Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info icon
30001/15/2014
140
Approved
To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.
Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Mullen Scales of Early Learning info icon
5001/15/2015
47
Approved
ABC Community info icon
15001/15/2014
146
Approved
Leiter International Performance Scale-Revised (Leiter-R) info icon
12002/27/2018
114
Approved
ADOS info icon
30001/15/2014
176
Approved
Comprehensive Assessment of Spoken Language (CASL) info icon
26001/15/2014
64
Approved
ADI-R info icon
30001/15/2014
122
Approved
Expressive Vocabulary Test II (EVT II) info icon
6201/15/2015
66
Approved
Medical History info icon
30001/15/2015
151
Approved
Medical History info icon
30001/15/2014
151
Approved
Wechsler Abbreviated Scale of Intelligence (WASI) info icon
30001/15/2015
64
Approved
Comprehensive Test of Phonological Processing (CTOPP) info icon
30001/15/2015
63
Approved
Child and Adolescent Symptom Inventory (CASI) info icon
30001/15/2014
143
Approved
Demographics info icon
30001/15/2015
150
Approved
Childrens Communication Checklist-2 (CCC-2) info icon
26001/15/2014
83
Approved
Early Social Communication Scales (ESCS) info icon
5901/15/2015
59
Approved
Peabody Picture Vocabulary Test, Fourth Edition info icon
26001/15/2014
160
Approved
Repetitive Behavior Scale - Revised (RBS-R) info icon
30001/15/2014
143
Approved
Physical Exam info icon
2901/15/2014
29
Approved
Handedness Form info icon
34001/15/2014
150
Approved
Emotion Dysregulation Inventory (EDI) info icon
30001/15/2015
140
Approved
Sensory Profile info icon
30001/15/2014
143
Approved
Kaufman Speech Praxis Test info icon
21001/15/2014
83
Approved
Vineland (Parent and Caregiver) info icon
35001/15/2014
130
Approved
Imaging (Structural, fMRI, DTI, PET, microscopy) info icon
21001/15/2014
40
Approved
Language Environment Analysis info icon
12001/15/2014
120
Approved
EEG info icon
13007/15/2014
50
Approved
Structure not yet defined
No Status history for this Data Expected has been recorded yet
helpcenter.collection.data-expected-tab

NDA Help Center

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

  • Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
  • If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
  • Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

  • What is an NDA Data Structure?
    An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
  • What is the NDA Data Dictionary?
    The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

  • Analyzed Data
    Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
  • Data Item
    Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
  • Data Structure
    A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
  • Data Structure Category
    An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
  • Data Structure Group
    A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
  • Evaluated Data
    A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
  • Imaging Data
    Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
  • Initial Share Date
    Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
  • Initial Submission Date
    Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
  • Research Subject and Pedigree
    An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
  • Submission Cycle
    The NDA has two Submission Cycles per year - January 15 and July 15.
  • Submission Exemption
    An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Examining the validity of the use of ratio IQs in psychological assessments IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.47/17423Secondary AnalysisShared
The importance of low IQ to early diagnosis of autismSome individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood. 2/6323Secondary AnalysisShared
Prognostic early snapshot stratification of autism based on adaptive functioningA major goal of precision medicine is to predict prognosis based on individualized information at the earliest possible points in development. Using early snapshots of adaptive functioning and unsupervised data- driven discovery methods, we uncover highly stable early autism subtypes that yield information relevant to later prognosis. Data from the National Institute of Mental Health Data Archive (NDA) (n = 1,098) was used to uncover three early subtypes (<72 months) that generalize with 96% accuracy. Outcome data from NDA (n = 2,561; mean age, 13 years) also reproducibly clusters into three subtypes with 99% generalization accuracy. Early snapshot subtypes predict developmental trajectories in non-verbal cognitive, language and motor domains and are predictive of membership in different adaptive functioning outcome subtypes. Robust and prognosis- relevant subtyping of autism based on early snapshots of adaptive functioning may aid future research work via prediction of these subtypes with our reproducible stratification model.123/3517Secondary AnalysisShared
Investigating autism etiology and heterogeneity by decision tree algorithmAutism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism. 61/3382Secondary AnalysisShared
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitrySocial-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.57/1708Secondary AnalysisShared
Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findingsFemales with autism spectrum disorder (ASD) have been long overlooked in neuroscience research, but emerging evidence suggests they show distinct phenotypic trajectories and age-related brain differences. Sex-related biological factors (e.g., hormones, genes) may play a role in ASD etiology and have been shown to influence neurodevelopmental trajectories. Thus, a lifespan approach is warranted to understand brain-based sex differences in ASD. This systematic review on MRI-based sex differences in ASD was conducted to elucidate variations across the lifespan and inform biomarker discovery of ASD in females. We identified articles through two database searches. Fifty studies met criteria and underwent integrative review. We found that regions expressing replicable sex-by-diagnosis differences across studies overlapped with regions showing sex differences in neurotypical (NT) cohorts, in particular regions showing NT male>female volumes. Furthermore, studies investigating age-related brain differences across a broad age-span suggest distinct neurodevelopmental patterns in females with ASD. Qualitative comparison across youth and adult studies also supported this hypothesis. However, many studies collapsed across age, which may mask differences. Furthermore, accumulating evidence supports the female protective effect in ASD, although only one study examined brain circuits implicated in “protection.” When synthesized with the broader literature, brain-based sex differences in ASD may come from various sources, including genetic and endocrine processes involved in brain “masculinization” and “feminization” across early development, puberty, and other lifespan windows of hormonal transition. Furthermore, sex-related biology may interact with peripheral processes, in particular the stress axis and brain arousal system, to produce distinct neurodevelopmental patterns in males and females with ASD. Future research on neuroimaging-based sex differences in ASD would benefit from a lifespan approach in well-controlled and multivariate studies. Possible relationships between behavior, sex hormones, and brain development in ASD remain largely unexamined.1/759Secondary AnalysisShared
* Data not on individual level
helpcenter.collection.associated-studies-tab

NDA Help Center

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

  • How do I associate a study to my collection?
    Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

  • Associated Studies Tab
    A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.
Edit